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Index > Protein center > IGFBP7(Gene name) > Human
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  • IGFBP7 (Gene name),
  • Insulin-like growth factor-binding protein 7 (Protein name ),  IBP7_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    IGFBP7(MAC25;PSF);
    Protein name:
    Insulin-like growth factor-binding protein 7(IBP-7;IGF-binding protein 7;IGFBP-7);
    Alternative:
    MAC25 protein;IGFBP-rP1;Prostacyclin-stimulating factor;PGI2-stimulating factor;Tumor-derived adhesion factor(TAF);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    May interact with VPS24/CHMP3; the relevance of such interaction however remains unclear.
    Function:
    Binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    282
    Sequence:
    50:
    MERPSLRALL | LGAAGLLLLL | LPLSSSSSSD | TCGPCEPASC | PPLPPLGCLL | 
    100:
    GETRDACGCC | PMCARGEGEP | CGGGGAGRGY | CAPGMECVKS | RKRRKGKAGA | 
    150:
    AAGGPGVSGV | CVCKSRYPVC | GSDGTTYPSG | CQLRAASQRA | ESRGEKAITQ | 
    200:
    VSKGTCEQGP | SIVTPPKDIW | NVTGAQVYLS | CEVIGIPTPV | LIWNKVKRGH | 
    250:
    YGVQRTELLP | GDRDNLAIQT | RGGPEKHEVT | GWVLVSPLSK | EDAGEYECHA | 
    282:
    SNSQGQASAS | AKITVVDALH | EIPVKKGEGA | EL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    KEGG:
    Pfam:
    SMR:
    MIM:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human IBP-7
    Cat.:
    E9341h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human IBP-7
    Cat.:
    E9341m
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human IBP-7
    Cat.:
    U9341m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human IBP-7
    Cat.:
    U9341h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human IBP-7
    Cat.:
    P9341Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human IBP-7
    Cat.:
    P9341Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human IBP-7
    Monoclonal Antibody for Human IBP-7
    Protein for Human IBP-7
    Protein for Human IBP-7

    R&D Technical Data
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    Precision
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Identification and characterization of genes differentially expressed in meningiomas."
      Murphy M. , Pykett M.J. , Harnish P. , Zang K.D. , George D.L.
      Cell Growth Differ.4:715-722(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT PHE-11;RNA EDITING OF POSITION 95
      tissue: Leptomeninges.
    2. 2.
      "Purification and molecular cloning of prostacyclin-stimulating factor from serum-free conditioned medium of human diploid fibroblast cells."
      Yamauchi T. , Umeda F. , Masakado M. , Isaji M. , Mizushima S. , Nawata H.
      Biochem. J.303:591-598(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    3. 3.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2003-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    4. 4.
      NIEHS SNPs program
      Submitted (2004-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT PHE-11
    5. 5.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Thalamus.
      tissue: Trachea.
    6. 6.
      "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
      Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Testis.
      tissue: Uterus.
    8. 8.
      "Cell adhesion activity of a 30-kDa major secreted protein from human bladder carcinoma cells."
      Akaogi K. , Okabe Y. , Funahashi K. , Yoshitake Y. , Nishikawa K. , Yasumitsu H. , Umeda M. , Miyazaki K.
      Biochem. Biophys. Res. Commun.198:1046-1053(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 27-46;FUNCTION
      tissue: Urinary bladder carcinoma.
    9. 9.
      "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z. , Henzel W.J.
      Protein Sci.13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 27-41
    10. 10.
      "Synthesis and characterization of insulin-like growth factor-binding protein (IGFBP)-7. Recombinant human mac25 protein specifically binds IGF-I and -II."
      Oh Y. , Nagalla S.R. , Yamanaka Y. , Kim H.-S. , Wilson E. , Rosenfeld R.G.
      J. Biol. Chem.271:30322-30325(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 27-36;FUNCTION;GLYCOSYLATION
    11. 11.
      "Interaction of IGF-binding protein-related protein 1 with a novel protein, neuroendocrine differentiation factor, results in neuroendocrine differentiation of prostate cancer cells."
      Wilson E.M. , Oh Y. , Hwa V. , Rosenfeld R.G.
      J. Clin. Endocrinol. Metab.86:4504-4511(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POSSIBLE INTERACTION WITH CHMP3
    12. 12.
      "Screening of human SNP database identifies recoding sites of A-to-I RNA editing."
      Gommans W.M. , Tatalias N.E. , Sie C.P. , Dupuis D. , Vendetti N. , Smith L. , Kaushal R. , Maas S.
      RNA14:2074-2085(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: RNA EDITING OF POSITIONS 78 AND 95
    13. 13.
      "Mutation of IGFBP7 causes upregulation of BRAF/MEK/ERK pathway and familial retinal arterial macroaneurysms."
      Abu-Safieh L. , Abboud E.B. , Alkuraya H. , Shamseldin H. , Al-Enzi S. , Al-Abdi L. , Hashem M. , Colak D. , Jarallah A. , Ahmad H. , Bobis S. , Nemer G. , Bitar F. , Alkuraya F.S.
      Am. J. Hum. Genet.89:313-319(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN RAMSVPS
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