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Index > Protein center > IDE(Gene name) > Human
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  • IDE (Gene name),
  • Insulin-degrading enzyme (Protein name ),  IDE_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    IDE;
    Protein name:
    Insulin-degrading enzyme;
    Alternative:
    Insulin protease(Insulinase);Abeta-degrading protease;Insulysin;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer. Can form higher oligomers. Interacts (via N-terminus) with varicella-zoster virus (VZV) envelope glycoprotein E (via N-terminus); the membrane-associated isoform may function as an entry receptor for this virus.
    Function:
    Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.
    Subcellular Location:
    Cytoplasm Cell surface Present at the cell surface of neuron cells. The membrane-associated isoform is approximately 5 kDa larger than the known cytosolic isoform.
    Protein Attributes:
    Sequence length:
    1019
    Sequence:
    50:
    MRYRLAWLLH | PALPSTFRSV | LGARLPPPER | LCGFQKKTYS | KMNNPAIKRI | 
    100:
    GNHITKSPED | KREYRGLELA | NGIKVLLISD | PTTDKSSAAL | DVHIGSLSDP | 
    150:
    PNIAGLSHFC | EHMLFLGTKK | YPKENEYSQF | LSEHAGSSNA | FTSGEHTNYY | 
    200:
    FDVSHEHLEG | ALDRFAQFFL | CPLFDESCKD | REVNAVDSEH | EKNVMNDAWR | 
    250:
    LFQLEKATGN | PKHPFSKFGT | GNKYTLETRP | NQEGIDVRQE | LLKFHSAYYS | 
    300:
    SNLMAVCVLG | RESLDDLTNL | VVKLFSEVEN | KNVPLPEFPE | HPFQEEHLKQ | 
    350:
    LYKIVPIKDI | RNLYVTFPIP | DLQKYYKSNP | GHYLGHLIGH | EGPGSLLSEL | 
    400:
    KSKGWVNTLV | GGQKEGARGF | MFFIINVDLT | EEGLLHVEDI | ILHMFQYIQK | 
    450:
    LRAEGPQEWV | FQECKDLNAV | AFRFKDKERP | RGYTSKIAGI | LHYYPLEEVL | 
    500:
    TAEYLLEEFR | PDLIEMVLDK | LRPENVRVAI | VSKSFEGKTD | RTEEWYGTQY | 
    550:
    KQEAIPDEVI | KKWQNADLNG | KFKLPTKNEF | IPTNFEILPL | EKEATPYPAL | 
    600:
    IKDTAMSKLW | FKQDDKFFLP | KACLNFEFFS | PFAYVDPLHC | NMAYLYLELL | 
    650:
    KDSLNEYAYA | AELAGLSYDL | QNTIYGMYLS | VKGYNDKQPI | LLKKIIEKMA | 
    700:
    TFEIDEKRFE | IIKEAYMRSL | NNFRAEQPHQ | HAMYYLRLLM | TEVAWTKDEL | 
    750:
    KEALDDVTLP | RLKAFIPQLL | SRLHIEALLH | GNITKQAALG | IMQMVEDTLI | 
    800:
    EHAHTKPLLP | SQLVRYREVQ | LPDRGWFVYQ | QRNEVHNNCG | IEIYYQTDMQ | 
    850:
    STSENMFLEL | FCQIISEPCF | NTLRTKEQLG | YIVFSGPRRA | NGIQGLRFII | 
    900:
    QSEKPPHYLE | SRVEAFLITM | EKSIEDMTEE | AFQKHIQALA | IRRLDKPKKL | 
    950:
    SAECAKYWGE | IISQQYNFDR | DNTEVAYLKT | LTKEDIIKFY | KEMLAVDAPR | 
    1000:
    RHKVSVHVLA | REMDSCPVVG | EFPCQNDINL | SQAPALPQPE | VIQNMTEFKR | 
    1019:
    GLPLFPLVKP | HINFMAAKL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    Pfam:
    UniGene:
    String:
    SMR:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human Insulin-degrading enzyme
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    ELISA Kit for Human Insulin-degrading enzyme
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    ELISA Kit for Human Insulin-degrading enzyme
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    ELISA Kit for Human Insulin-degrading enzyme
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    CLIA Kit for Human Insulin-degrading enzyme
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    CLIA Kit for Human Insulin-degrading enzyme
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    Packing:
    96T
    CLIA Kit for Human Insulin-degrading enzyme
    Cat.:
    U1897h
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    MSDS:
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    Packing:
    96T
    Range:
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    CLIA Kit for Human Insulin-degrading enzyme
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    U1897m
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    Packing:
    96T
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    Polyclonal Antibody for Human Insulin-degrading enzyme
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    P1897Rb-m
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    40ug/0.2ml
    Polyclonal Antibody for Human Insulin-degrading enzyme
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    Polyclonal Antibody for Human Insulin-degrading enzyme
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    P1897Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Insulin-degrading enzyme
    Monoclonal Antibody for Human Insulin-degrading enzyme
    Monoclonal Antibody for Human Insulin-degrading enzyme
    Monoclonal Antibody for Human Insulin-degrading enzyme
    Monoclonal Antibody for Human Insulin-degrading enzyme
    Protein for Human Insulin-degrading enzyme
    Protein for Human Insulin-degrading enzyme
    Protein for Human Insulin-degrading enzyme
    Protein for Human Insulin-degrading enzyme

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    References
    1. 1.
      "Human insulin-degrading enzyme shares structural and functional homologies with E. coli protease III."
      Affholter J.A. , Fried V.A. , Roth R.A.
      Science242:1415-1418(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PARTIAL PROTEIN SEQUENCE
    2. 2.
      "Insulin-degrading enzyme: stable expression of the human complementary DNA, characterization of its protein product, and chromosomal mapping of the human and mouse genes."
      Affholter J.A. , Hsieh C.L. , Francke U. , Roth R.A.
      Mol. Endocrinol.4:1125-1135(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);SEQUENCE REVISION
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Testis.
    4. 4.
      "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P. , Earthrowl M.E. , Grafham D.V. , Rubenfield M. , French L. , Steward C.A. , Sims S.K. , Jones M.C. , Searle S. , Scott C. , Howe K. , Hunt S.E. , Andrews T.D. , Gilbert J.G.R. , Swarbreck D. , Ashurst J.L. , Taylor A. , Battles J. , more...
      Nature429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    7. 7.
      "Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme."
      Vekrellis K. , Ye Z. , Qiu W.Q. , Walsh D. , Hartley D. , Chesneau V. , Rosner M.R. , Selkoe D.J.
      J. Neurosci.20:1657-1665(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
    8. 8.
      "Insulin degrading enzyme is a cellular receptor mediating varicella-zoster virus infection and cell-to-cell spread."
      Li Q. , Ali M.A. , Cohen J.I.
      Cell127:305-316(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;INTERACTION WITH VZV GLYCOPROTEIN E
    9. 9.
      "The amino terminus of varicella-zoster virus (VZV) glycoprotein E is required for binding to insulin-degrading enzyme, a VZV receptor."
      Li Q. , Krogmann T. , Ali M.A. , Tang W.-J. , Cohen J.I.
      J. Virol.81:8525-8532(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH VZV GLYCOPROTEIN E
    10. 10.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    11. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    12. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    13. 13.
      "Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism."
      Shen Y. , Joachimiak A. , Rosner M.R. , Tang W.-J.
      Nature443:870-874(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 42-1019 OF MUTANT GLN-111 IN COMPLEXES WITH ZINC IONS; IAPP; INSULIN; AMYLOID AND GLUCAGON;MUTAGENESIS OF GLU-111; SER-132; ASN-184; ASP-426; GLU-817; GLN-828 AND LYS-899;COFACTOR;SUBUNIT;ACTIVE SITE
    14. 14.
      "Structure of substrate-free human insulin-degrading enzyme (IDE) and biophysical analysis of ATP-induced conformational switch of IDE."
      Im H. , Manolopoulou M. , Malito E. , Shen Y. , Zhao J. , Neant-Fery M. , Sun C.-Y. , Meredith S.C. , Sisodia S.S. , Leissring M.A. , Tang W.-J.
      J. Biol. Chem.282:25453-25463(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 43-1018 OF MUTANT PHE-831 IN COMPLEX WITH ZINC IONS AND SUBSTRATE PEPTIDE;CATALYTIC ACTIVITY;ENZYME REGULATION;ATP-BINDING;SUBUNIT;MUTAGENESIS OF ASP-426 AND LYS-899;FUNCTION
    15. 15.
      "Molecular bases for the recognition of short peptide substrates and cysteine-directed modifications of human insulin-degrading enzyme."
      Malito E. , Ralat L.A. , Manolopoulou M. , Tsay J.L. , Wadlington N.L. , Tang W.-J.
      Biochemistry47:12822-12834(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.96 ANGSTROMS) OF 42-1019 OF MUTANT GLN-111 IN COMPLEX WITH BRADYKININ;FUNCTION;ENZYME REGULATION
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