Protein name:
Insulin-degrading enzyme ;
Alternative:
Insulysin ;Insulin protease (Insulinase) ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Homodimer. Can form higher oligomers.
Function:
Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP.
Subcellular Location:
Cytoplasm
Protein Attributes:
50:
MRNGLVWLLH | PALPGTLRSI | LGARPPPAKR | LCGFPKQTYS | TMSNPAIQRI |
100:
EDQIVKSPED | KREYRGLELA | NGIKVLLISD | PTTDKSSAAL | DVHIGSLSDP |
150:
PNIPGLSHFC | EHMLFLGTKK | YPKENEYSQF | LSEHAGSSNA | FTSGEHTNYY |
200:
FDVSHEHLEG | ALDRFAQFFL | CPLLDASCKD | REVNAVDSEH | EKNVMNDAWR |
250:
LFQLEKATGN | PKHPFSKFGT | GNKYTLETRP | NQEGIDVREE | LLKFHSTYYS |
300:
SNLMAICVLG | RESLDDLTNL | VVKLFSEVEN | KNVPLPEFPE | HPFQEEHLRQ |
350:
LYKIVPIKDI | RNLYVTFPIP | DLQQYYKSNP | GYYLGHLIGH | EGPGSLLSEL |
400:
KSKGWVNTLV | GGQKEGARGF | MFFIINVDLT | EEGLLHVEDI | ILHMFQYIQK |
450:
LRAEGPQEWV | FQECKDLNAV | AFRFKDKERP | RGYTSKIAGK | LHYYPLNGVL |
500:
TAEYLLEEFR | PDLIDMVLDK | LRPENVRVAI | VSKSFEGKTD | RTEQWYGTQY |
550:
KQEAIPEDVI | QKWQNADLNG | KFKLPTKNEF | IPTNFEILSL | EKDATPYPAL |
600:
IKDTAMSKLW | FKQDDKFFLP | KACLNFEFFS | PFAYVDPLHC | NMAYLYLELL |
650:
KDSLNEYAYA | AELAGLSYDL | QNTIYGMYLS | VKRYNDKQPI | LLKKITEKMA |
700:
TFEIDKKRFE | IIKEAYMRSL | NNFRAEQPHQ | HAMYYLRLLM | TEVAWTKDEL |
750:
KEALDDVTLP | RLKAFIPQLL | SRLHIEALLH | GNITKQAALG | VMQMVEDTLI |
800:
EHAHTKPLLP | SQLVRYREVQ | LPDRGWFVYQ | QRNEVHNNCG | IEIYYQTDMQ |
850:
STSENMFLEL | FCQIISEPCF | NTLRTKEQLG | YIVFSGPRRA | NGIQGLRFII |
900:
QSEKPPHYLE | SRVEAFLITM | EKAIEDMTEE | AFQKHIQALA | IRRLDKPKKL |
950:
SAECAKYWGE | IISQQYNYDR | DNIEVAYLKT | LTKDDIIRFY | QEMLAVDAPR |
1000:
RHKVSVHVLA | REMDSCPVVG | EFPSQNDINL | SEAPPLPQPE | VIHNMTEFKR |
1019:
GLPLFPLVKP | HINFMAAKL
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
Rat
Bovine
ELISA Kit for Mouse Insulin-degrading enzyme
ELISA Kit for Mouse Insulin-degrading enzyme
ELISA Kit for Mouse Insulin-degrading enzyme
ELISA Kit for Mouse Insulin-degrading enzyme
CLIA Kit for Mouse Insulin-degrading enzyme
CLIA Kit for Mouse Insulin-degrading enzyme
CLIA Kit for Mouse Insulin-degrading enzyme
CLIA Kit for Mouse Insulin-degrading enzyme
Polyclonal Antibody for Mouse Insulin-degrading enzyme
Polyclonal Antibody for Mouse Insulin-degrading enzyme
Polyclonal Antibody for Mouse Insulin-degrading enzyme
Polyclonal Antibody for Mouse Insulin-degrading enzyme
Monoclonal Antibody for Mouse Insulin-degrading enzyme
Monoclonal Antibody for Mouse Insulin-degrading enzyme
Monoclonal Antibody for Mouse Insulin-degrading enzyme
Monoclonal Antibody for Mouse Insulin-degrading enzyme
Protein for Mouse Insulin-degrading enzyme
Protein for Mouse Insulin-degrading enzyme
Protein for Mouse Insulin-degrading enzyme
Protein for Mouse Insulin-degrading enzyme
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"Search for PTS1-containing protein in mammals."
Van Veldhoven P.P.
Submitted (2000-06) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION;IDENTIFICATION OF SLYX MOTIF;MUTAGENESIS OF 853-GLU--TYR-858
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INDUCTION
4.
"SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
Park J.
,
Chen Y.
,
Tishkoff D.X.
,
Peng C.
,
Tan M.
,
Dai L.
,
Xie Z.
,
Zhang Y.
,
Zwaans B.M.
,
Skinner M.E.
,
Lombard D.B.
,
Zhao Y.
Mol. Cell50:919-930(2013)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-192 AND LYS-697;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Liver .