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Index > Protein center > IFI16(Gene name) > Human
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  • IFI16 (Gene name),
  • Gamma-interferon-inducible protein 16 (Protein name ),  IF16_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    IFI16(IFNGIP1);
    Protein name:
    Gamma-interferon-inducible protein 16(Ifi-16);
    Alternative:
    Interferon-inducible myeloid differentiation transcriptional activator;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Isoform 1, isoform 2 and isoform 3 can homo- and hetero-dimerize. Binds double-stranded DNA and cell cycle regulatory factors including p53 and the retinoblastoma protein.
    Function:
    May function as a transcriptional repressor. Could have a role in the regulation of hematopoeitic differentiation through activation of unknown target genes. Controls cellular proliferation by modulating the functions of cell cycle regulatory factors including p53/TP53 and the retinoblastoma protein. May be involved in the senescence of prostate epithelial cells.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    785
    Sequence:
    50:
    MGKKYKNIVL | LKGLEVINDY | HFRMVKSLLS | NDLKLNLKMR | EEYDKIQIAD | 
    100:
    LMEEKFRGDA | GLGKLIKIFE | DIPTLEDLAE | TLKKEKLKVK | GPALSRKRKK | 
    150:
    EVDATSPAPS | TSSTVKTEGA | EATPGAQKRK | KSTKEKAGPK | GSKVSEEQTQ | 
    200:
    PPSPAGAGMS | TAMGRSPSPK | TSLSAPPNSS | STENPKTVAK | CQVTPRRNVL | 
    250:
    QKRPVIVKVL | STTKPFEYET | PEMEKKIMFH | ATVATQTQFF | HVKVLNTSLK | 
    300:
    EKFNGKKIII | ISDYLEYDSL | LEVNEESTVS | EAGPNQTFEV | PNKIINRAKE | 
    350:
    TLKIDILHKQ | ASGNIVYGVF | MLHKKTVNQK | TTIYEIQDDR | GKMDVVGTGQ | 
    400:
    CHNIPCEEGD | KLQLFCFRLR | KKNQMSKLIS | EMHSFIQIKK | KTNPRNNDPK | 
    450:
    SMKLPQEQRQ | LPYPSEASTT | FPESHLRTPQ | MPPTTPSSSF | FTKKSEDTIS | 
    500:
    KMNDFMRMQI | LKEGSHFPGP | FMTSIGPAES | HPHTPQMPPS | TPSSSFLTTK | 
    550:
    SEDTISKMND | FMRMQILKEG | SHFPGPFMTS | IGPAESHPHT | PQMPPSTPSS | 
    600:
    SFLTTLKPRL | KTEPEEVSIE | DSAQSDLKEV | MVLNATESFV | YEPKEQKKMF | 
    650:
    HATVATENEV | FRVKVFNIDL | KEKFTPKKII | AIANYVCRNG | FLEVYPFTLV | 
    700:
    ADVNADRNME | IPKGLIRSAS | VTPKINQLCS | QTKGSFVNGV | FEVHKKNVRG | 
    750:
    EFTYYEIQDN | TGKMEVVVHG | RLTTINCEEG | DKLKLTCFEL | APKSGNTGEL | 
    785:
    RSVIHSHIKV | IKTRKNKKDI | LNPDSSMETS | PDFFF
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    SMR:
    KEGG:
    MIM:
    String:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Ifi-16
    Cat.:
    E1900h
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Ifi-16
    Cat.:
    U1900h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    Polyclonal Antibody for Human Ifi-16
    Cat.:
    P1900Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Ifi-16
    Protein for Human Ifi-16

    R&D Technical Data
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Recovery
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Linearity
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "A novel gene constitutively expressed in human lymphoid cells is inducible with interferon-gamma in myeloid cells."
      Trapani J.A. , Browne K.A. , Dawson M.J. , Ramsay R.G. , Eddy R.L. , Show T.B. , White P.C. , Dupont B.
      Immunogenetics36:369-376(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);VARIANT HIS-103
      tissue: T-cell.
    2. 2.
      "Genomic organization of IFI16, an interferon-inducible gene whose expression is associated with human myeloid cell differentiation: correlation of predicted protein domains with exon organization."
      Trapani J.A. , Dawson M.J. , Apostolidis V.A. , Browne K.A.
      Immunogenetics40:415-424(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 2);VARIANT HIS-103
    3. 3.
      Jiang C. , Zhang D. , Peng Y. , Zhang X. , Han Z. , Fu G. , Chen Z.
      Submitted (1999-11) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);VARIANT HIS-103
      tissue: Bone marrow.
    4. 4.
      "Role of IFI 16, a member of the interferon-inducible p200-protein family, in prostate epithelial cellular senescence."
      Xin H. , Curry J. , Johnstone R.W. , Nickoloff B.J. , Choubey D.
      Oncogene22:4831-4840(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);FUNCTION;TISSUE SPECIFICITY;INDUCTION;VARIANTS THR-179; SER-409 AND ASN-413
    5. 5.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4);VARIANTS THR-179; SER-409 AND ASN-413
      tissue: Hippocampus.
      tissue: Thalamus.
    6. 6.
      Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S. , Ohara O. , Nagase T. , Kikuno R.F.
      Submitted (2005-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);VARIANTS SER-409 AND ASN-413
      tissue: Brain.
    7. 7.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);VARIANTS THR-179; SER-409 AND ASN-413
      tissue: Uterus.
    9. 9.
      "Isotypic variants of the interferon-inducible transcriptional repressor IFI 16 arise through differential mRNA splicing."
      Johnstone R.W. , Kershaw M.H. , Trapani J.A.
      Biochemistry37:11924-11931(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING;SUBUNIT;PHOSPHORYLATION;GLYCOSYLATION
    10. 10.
      "IFI 16 gene encodes a nuclear protein whose expression is induced by interferons in human myeloid leukaemia cell lines."
      Dawson M.J. , Trapani J.A.
      J. Cell. Biochem.57:39-51(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION;SUBCELLULAR LOCATION;DNA-BINDING
    11. 11.
      "The closely linked genes encoding the myeloid nuclear differentiation antigen (MNDA) and IFI16 exhibit contrasting haemopoietic expression."
      Dawson M.J. , Trapani J.A. , Briggs R.C. , Nicholl J.K. , Sutherland G.R. , Baker E.
      Immunogenetics41:40-43(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE-SPECIFIC INDUCTION
    12. 12.
      "The IFN-inducible nucleoprotein IFI 16 is expressed in cells of the monocyte lineage, but is rapidly and markedly down-regulated in other myeloid precursor populations."
      Dawson M.J. , Elwood N.J. , Johnstone R.W. , Trapani J.A.
      J. Leukoc. Biol.64:546-554(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFIC INDUCTION
    13. 13.
      "The human interferon-inducible protein, IFI 16, is a repressor of transcription."
      Johnstone R.W. , Kerry J.A. , Trapani J.A.
      J. Biol. Chem.273:17172-17177(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    14. 14.
      "Functional interaction between p53 and the interferon-inducible nucleoprotein IFI 16."
      Johnstone R.W. , Wei W. , Greenway A. , Trapani J.A.
      Oncogene19:6033-6042(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH TP53
    15. 15.
      "A member of the Pyrin family, IFI16, is a novel BRCA1-associated protein involved in the p53-mediated apoptosis pathway."
      Aglipay J.A. , Lee S.W. , Okada S. , Fujiuchi N. , Ohtsuka T. , Kwak J.C. , Wang Y. , Johnstone R.W. , Deng C. , Qin J. , Ouchi T.
      Oncogene22:8931-8938(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH BRCA1
    16. 16.
      "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
      Beausoleil S.A. , Villen J. , Gerber S.A. , Rush J. , Gygi S.P.
      Nat. Biotechnol.24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-106;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    17. 17.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-106 AND SER-153;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    18. 18.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-106 AND SER-153;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    19. 19.
      "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
      Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-214;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    20. 20.
      "In vivo identification of sumoylation sites by a signature tag and cysteine-targeted affinity purification."
      Blomster H.A. , Imanishi S.Y. , Siimes J. , Kastu J. , Morrice N.A. , Eriksson J.E. , Sistonen L.
      J. Biol. Chem.285:19324-19329(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUMOYLATION AT LYS-561
      tissue: Cervix carcinoma.
    21. 21.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DNA-BINDING;INTERACTION WITH TMEM173;INDUCTION
    22. 22.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-106; SER-153 AND SER-575;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    23. 23.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    24. 24.
      "IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection."
      Kerur N. , Veettil M.V. , Sharma-Walia N. , Bottero V. , Sadagopan S. , Otageri P. , Chandran B.
      Cell Host Microbe9:363-375(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH PYCARD AND CASP1
    25. 25.
      "IFI16 induction by glucose restriction in human fibroblasts contributes to autophagy through activation of the ATM/AMPK/p53 pathway."
      Duan X. , Ponomareva L. , Veeranki S. , Choubey D.
      PLoS ONE6:E19532-E19532(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION
    26. 26.
      "IFI16 protein mediates the anti-inflammatory actions of the type-I interferons through suppression of activation of caspase-1 by inflammasomes."
      Veeranki S. , Duan X. , Panchanathan R. , Liu H. , Choubey D.
      PLoS ONE6:E27040-E27040(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH AIM2
    27. 27.
      "Preferential binding of IFI16 protein to cruciform structure and superhelical DNA."
      Brazda V. , Coufal J. , Liao J.C. , Arrowsmith C.H.
      Biochem. Biophys. Res. Commun.422:716-720(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DNA-BINDING
    28. 28.
      "The intracellular DNA sensor IFI16 gene acts as restriction factor for human cytomegalovirus replication."
      Gariano G.R. , Dell'Oste V. , Bronzini M. , Gatti D. , Luganini A. , De Andrea M. , Gribaudo G. , Gariglio M. , Landolfo S.
      PLoS Pathog.8:E1002498-E1002498(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH SP1
    29. 29.
      "Nuclear IFI16 induction of IRF-3 signaling during herpesviral infection and degradation of IFI16 by the viral ICP0 protein."
      Orzalli M.H. , DeLuca N.A. , Knipe D.M.
      Proc. Natl. Acad. Sci. U.S.A.109:E3008-E3017(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;PROTEASOMAL DEGRADATION
    30. 30.
      "Acetylation modulates cellular distribution and DNA sensing ability of interferon-inducible protein IFI16."
      Li T. , Diner B.A. , Chen J. , Cristea I.M.
      Proc. Natl. Acad. Sci. U.S.A.109:10558-10563(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;IDENTIFICATION BY MASS SPECTROMETRY;PHOSPHORYLATION AT SER-106; SER-153; SER-168; SER-174 AND SER-780;ACETYLATION AT LYS-45; LYS-99; LYS-128; LYS-214; LYS-444; LYS-451; LYS-561; LYS-598 AND LYS-614;MUTAGENESIS OF 96-ARG--LYS-100; LYS-99; LYS-128; 128-LYS--LYS-131; 134-LYS--LYS-136 AND 140-LYS--LYS-143
    31. 31.
      "Nuclear interferon-inducible protein 16 promotes silencing of herpesviral and transfected DNA."
      Orzalli M.H. , Conwell S.E. , Berrios C. , DeCaprio J.A. , Knipe D.M.
      Proc. Natl. Acad. Sci. U.S.A.110:E4492-E4501(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
    32. 32.
      "Differential regulation of estrogen receptor alpha expression in breast cancer cells by metastasis-associated protein 1."
      Kang H.J. , Lee M.H. , Kang H.L. , Kim S.H. , Ahn J.R. , Na H. , Na T.Y. , Kim Y.N. , Seong J.K. , Lee M.O.
      Cancer Res.74:1484-1494(2014) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH MTA1;SUBCELLULAR LOCATION
    33. 33.
      "Interferon-inducible protein 16: insight into the interaction with tumor suppressor p53."
      Liao J.C. , Lam R. , Brazda V. , Duan S. , Ravichandran M. , Ma J. , Xiao T. , Tempel W. , Zuo X. , Wang Y.X. , Chirgadze N.Y. , Arrowsmith C.H.
      Structure19:418-429(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 192-393;MUTAGENESIS OF TYR-218; GLU-222; TYR-267 AND GLU-272
    34. 34.
      "Structures of the HIN domain:DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor."
      Jin T. , Perry A. , Jiang J. , Smith P. , Curry J.A. , Unterholzner L. , Jiang Z. , Horvath G. , Rathinam V.A. , Johnstone R.W. , Hornung V. , Latz E. , Bowie A.G. , Fitzgerald K.A. , Xiao T.S.
      Immunity36:561-571(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS) OF 571-766 IN COMPLEX WITH DOUBLE-STRANDED DNA;MUTAGENESIS OF LYS-627; LYS-663; ARG-667; SER-670; LYS-674; LYS-732; LYS-734 AND LYS-759
    35. 35.
      "Crystal structure of the first HIN-200 domain of interferon-inducible protein 16."
      Northeast structural genomics consortium (NESG)
      Submitted (2007-02) to the PDB data bank
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 192-393
    36. 36.
      "Crystal structure analysis of the second HIN domain of IFI16."
      Northeast structural genomics consortium (NESG)
      Submitted (2007-11) to the PDB data bank
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS) OF 571-766
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