IFI16 ELISA Kit for Human(Homo sapiens) | EIAab.comIFI16 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > IFI16(Gene name) > Human

IFI16 (Gene name),

Gamma-interferon-inducible protein 16 (Protein name ), IF16_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

IFI16(IFNGIP1);

Protein name:

Gamma-interferon-inducible protein 16(Ifi-16);

Alternative:

Interferon-inducible myeloid differentiation transcriptional activator;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Isoform 1, isoform 2 and isoform 3 can homo- and hetero-dimerize. Binds double-stranded DNA and cell cycle regulatory factors including p53 and the retinoblastoma protein.

Function:

May function as a transcriptional repressor. Could have a role in the regulation of hematopoeitic differentiation through activation of unknown target genes. Controls cellular proliferation by modulating the functions of cell cycle regulatory factors including p53/TP53 and the retinoblastoma protein. May be involved in the senescence of prostate epithelial cells.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

785

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

785:

RSVIHSHIKV | IKTRKNKKDI | LNPDSSMETS | PDFFF

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.380250

SMR:

Q16666

KEGG:

hsa:3428

MIM:

147586

String:

Q16666

Pfam:

PF02760

Uniprot:

Q16666

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ELISA Kit for Human Ifi-16

Cat.:

E1900h

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Manual:

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MSDS:

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Packing:

96T

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CLIA Kit for Human Ifi-16

Cat.:

U1900h

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Manual:

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Packing:

96T

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Polyclonal Antibody for Human Ifi-16

Cat.:

P1900Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Ifi-16

Protein for Human Ifi-16

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"A novel gene constitutively expressed in human lymphoid cells is inducible with interferon-gamma in myeloid cells."
Trapani J.A. , Browne K.A. , Dawson M.J. , Ramsay R.G. , Eddy R.L. , Show T.B. , White P.C. , Dupont B.
Immunogenetics36:369-376(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);VARIANT HIS-103
tissue: T-cell.
2.

"Genomic organization of IFI16, an interferon-inducible gene whose expression is associated with human myeloid cell differentiation: correlation of predicted protein domains with exon organization."
Trapani J.A. , Dawson M.J. , Apostolidis V.A. , Browne K.A.
Immunogenetics40:415-424(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 2);VARIANT HIS-103
3.

Jiang C. , Zhang D. , Peng Y. , Zhang X. , Han Z. , Fu G. , Chen Z.
Submitted (1999-11) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);VARIANT HIS-103
tissue: Bone marrow.
4.

"Role of IFI 16, a member of the interferon-inducible p200-protein family, in prostate epithelial cellular senescence."
Xin H. , Curry J. , Johnstone R.W. , Nickoloff B.J. , Choubey D.
Oncogene22:4831-4840(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);FUNCTION;TISSUE SPECIFICITY;INDUCTION;VARIANTS THR-179; SER-409 AND ASN-413
5.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4);VARIANTS THR-179; SER-409 AND ASN-413
tissue: Hippocampus.
tissue: Thalamus.
6.

Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S. , Ohara O. , Nagase T. , Kikuno R.F.
Submitted (2005-03) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);VARIANTS SER-409 AND ASN-413
tissue: Brain.
7.

"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);VARIANTS THR-179; SER-409 AND ASN-413
tissue: Uterus.
9.

"Isotypic variants of the interferon-inducible transcriptional repressor IFI 16 arise through differential mRNA splicing."
Johnstone R.W. , Kershaw M.H. , Trapani J.A.
Biochemistry37:11924-11931(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING;SUBUNIT;PHOSPHORYLATION;GLYCOSYLATION
10.

"IFI 16 gene encodes a nuclear protein whose expression is induced by interferons in human myeloid leukaemia cell lines."
Dawson M.J. , Trapani J.A.
J. Cell. Biochem.57:39-51(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION;SUBCELLULAR LOCATION;DNA-BINDING
11.

"The closely linked genes encoding the myeloid nuclear differentiation antigen (MNDA) and IFI16 exhibit contrasting haemopoietic expression."
Dawson M.J. , Trapani J.A. , Briggs R.C. , Nicholl J.K. , Sutherland G.R. , Baker E.
Immunogenetics41:40-43(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE-SPECIFIC INDUCTION
12.

"The IFN-inducible nucleoprotein IFI 16 is expressed in cells of the monocyte lineage, but is rapidly and markedly down-regulated in other myeloid precursor populations."
Dawson M.J. , Elwood N.J. , Johnstone R.W. , Trapani J.A.
J. Leukoc. Biol.64:546-554(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFIC INDUCTION
13.

"The human interferon-inducible protein, IFI 16, is a repressor of transcription."
Johnstone R.W. , Kerry J.A. , Trapani J.A.
J. Biol. Chem.273:17172-17177(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
14.

"Functional interaction between p53 and the interferon-inducible nucleoprotein IFI 16."
Johnstone R.W. , Wei W. , Greenway A. , Trapani J.A.
Oncogene19:6033-6042(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH TP53
15.

"A member of the Pyrin family, IFI16, is a novel BRCA1-associated protein involved in the p53-mediated apoptosis pathway."
Aglipay J.A. , Lee S.W. , Okada S. , Fujiuchi N. , Ohtsuka T. , Kwak J.C. , Wang Y. , Johnstone R.W. , Deng C. , Qin J. , Ouchi T.
Oncogene22:8931-8938(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH BRCA1
16.

"A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
Beausoleil S.A. , Villen J. , Gerber S.A. , Rush J. , Gygi S.P.
Nat. Biotechnol.24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-106;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
17.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-106 AND SER-153;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
18.

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-106 AND SER-153;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
19.

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-214;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
20.

"In vivo identification of sumoylation sites by a signature tag and cysteine-targeted affinity purification."
Blomster H.A. , Imanishi S.Y. , Siimes J. , Kastu J. , Morrice N.A. , Eriksson J.E. , Sistonen L.
J. Biol. Chem.285:19324-19329(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUMOYLATION AT LYS-561
tissue: Cervix carcinoma.
21.

"IFI16 is an innate immune sensor for intracellular DNA."
Unterholzner L. , Keating S.E. , Baran M. , Horan K.A. , Jensen S.B. , Sharma S. , Sirois C.M. , Jin T. , Latz E. , Xiao T.S. , Fitzgerald K.A. , Paludan S.R. , Bowie A.G.
Nat. Immunol.11:997-1004(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DNA-BINDING;INTERACTION WITH TMEM173;INDUCTION
22.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-106; SER-153 AND SER-575;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
23.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
24.

"IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection."
Kerur N. , Veettil M.V. , Sharma-Walia N. , Bottero V. , Sadagopan S. , Otageri P. , Chandran B.
Cell Host Microbe9:363-375(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH PYCARD AND CASP1
25.

"IFI16 induction by glucose restriction in human fibroblasts contributes to autophagy through activation of the ATM/AMPK/p53 pathway."
Duan X. , Ponomareva L. , Veeranki S. , Choubey D.
PLoS ONE6:E19532-E19532(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION
26.

"IFI16 protein mediates the anti-inflammatory actions of the type-I interferons through suppression of activation of caspase-1 by inflammasomes."
Veeranki S. , Duan X. , Panchanathan R. , Liu H. , Choubey D.
PLoS ONE6:E27040-E27040(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH AIM2
27.

"Preferential binding of IFI16 protein to cruciform structure and superhelical DNA."
Brazda V. , Coufal J. , Liao J.C. , Arrowsmith C.H.
Biochem. Biophys. Res. Commun.422:716-720(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DNA-BINDING
28.

"The intracellular DNA sensor IFI16 gene acts as restriction factor for human cytomegalovirus replication."
Gariano G.R. , Dell'Oste V. , Bronzini M. , Gatti D. , Luganini A. , De Andrea M. , Gribaudo G. , Gariglio M. , Landolfo S.
PLoS Pathog.8:E1002498-E1002498(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH SP1
29.

"Nuclear IFI16 induction of IRF-3 signaling during herpesviral infection and degradation of IFI16 by the viral ICP0 protein."
Orzalli M.H. , DeLuca N.A. , Knipe D.M.
Proc. Natl. Acad. Sci. U.S.A.109:E3008-E3017(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;PROTEASOMAL DEGRADATION
30.

"Acetylation modulates cellular distribution and DNA sensing ability of interferon-inducible protein IFI16."
Li T. , Diner B.A. , Chen J. , Cristea I.M.
Proc. Natl. Acad. Sci. U.S.A.109:10558-10563(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;IDENTIFICATION BY MASS SPECTROMETRY;PHOSPHORYLATION AT SER-106; SER-153; SER-168; SER-174 AND SER-780;ACETYLATION AT LYS-45; LYS-99; LYS-128; LYS-214; LYS-444; LYS-451; LYS-561; LYS-598 AND LYS-614;MUTAGENESIS OF 96-ARG--LYS-100; LYS-99; LYS-128; 128-LYS--LYS-131; 134-LYS--LYS-136 AND 140-LYS--LYS-143
31.

"Nuclear interferon-inducible protein 16 promotes silencing of herpesviral and transfected DNA."
Orzalli M.H. , Conwell S.E. , Berrios C. , DeCaprio J.A. , Knipe D.M.
Proc. Natl. Acad. Sci. U.S.A.110:E4492-E4501(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
32.

"Differential regulation of estrogen receptor alpha expression in breast cancer cells by metastasis-associated protein 1."
Kang H.J. , Lee M.H. , Kang H.L. , Kim S.H. , Ahn J.R. , Na H. , Na T.Y. , Kim Y.N. , Seong J.K. , Lee M.O.
Cancer Res.74:1484-1494(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH MTA1;SUBCELLULAR LOCATION
33.

"Interferon-inducible protein 16: insight into the interaction with tumor suppressor p53."
Liao J.C. , Lam R. , Brazda V. , Duan S. , Ravichandran M. , Ma J. , Xiao T. , Tempel W. , Zuo X. , Wang Y.X. , Chirgadze N.Y. , Arrowsmith C.H.
Structure19:418-429(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 192-393;MUTAGENESIS OF TYR-218; GLU-222; TYR-267 AND GLU-272
34.

"Structures of the HIN domain:DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor."
Jin T. , Perry A. , Jiang J. , Smith P. , Curry J.A. , Unterholzner L. , Jiang Z. , Horvath G. , Rathinam V.A. , Johnstone R.W. , Hornung V. , Latz E. , Bowie A.G. , Fitzgerald K.A. , Xiao T.S.
Immunity36:561-571(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS) OF 571-766 IN COMPLEX WITH DOUBLE-STRANDED DNA;MUTAGENESIS OF LYS-627; LYS-663; ARG-667; SER-670; LYS-674; LYS-732; LYS-734 AND LYS-759
35.

"Crystal structure of the first HIN-200 domain of interferon-inducible protein 16."
Northeast structural genomics consortium (NESG)
Submitted (2007-02) to the PDB data bank

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 192-393
36.

"Crystal structure analysis of the second HIN domain of IFI16."
Northeast structural genomics consortium (NESG)
Submitted (2007-11) to the PDB data bank

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS) OF 571-766

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