IGF1R ELISA Kit for Human(Homo sapiens) | EIAab.comIGF1R ELISA Kit for Human(Homo sapiens)

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IGF1R (Gene name),

Insulin-like growth factor 1 receptor (Protein name ), IGF1R_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

IGF1R;

Protein name:

Insulin-like growth factor 1 receptor;

Alternative:

Insulin-like growth factor I receptor(IGF-I receptor);

CD:

CD221;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chain carries the kinase domain. Interacts with PIK3R1 and with the PTB/PID domains of IRS1 and SHC1 in vitro when autophosphorylated on tyrosine residues. Forms a hybrid receptor with INSR, the hybrid is a tetramer consisting of 1 alpha chain and 1 beta chain of INSR and 1 alpha chain and 1 beta chain of IGF1R. Interacts with ARRB1 and ARRB2. Interacts with GRB10. Interacts with GNB2L1/RACK1.

Function:

This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor with INSR, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin.

Subcellular Location:

Membrane Single-pass type I membrane protein

Protein Attributes:

Sequence length:

1367

Sequence:

50:

100:

150:

200:

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300:

350:

400:

450:

500:

550:

600:

650:

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850:

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1000:

1050:

1100:

1150:

1200:

1250:

1300:

1350:

1367:

GGRKNERALP | LPQSSTC

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.643120

KEGG:

hsa:3480

SMR:

P08069

STRING:

9606.ENSP00000268035

String:

P08069

Pfam:

PF00041

MIM:

147370

Uniprot:

P08069

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ELISA Kit for Human Insulin-like growth factor 1 receptor

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E1200h

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ELISA Kit for Human Insulin-like growth factor 1 receptor

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E1200p

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96T

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ELISA Kit for Human Insulin-like growth factor 1 receptor

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E1200b

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96T

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ELISA Kit for Human Insulin-like growth factor 1 receptor

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E1200r

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ELISA Kit for Human Insulin-like growth factor 1 receptor

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E1200m

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CLIA Kit for Human Insulin-like growth factor 1 receptor

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CLIA Kit for Human Insulin-like growth factor 1 receptor

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U1200p

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96T

CLIA Kit for Human Insulin-like growth factor 1 receptor

Cat.:

U1200m

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96T

CLIA Kit for Human Insulin-like growth factor 1 receptor

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U1200h

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96T

CLIA Kit for Human Insulin-like growth factor 1 receptor

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U1200r

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Polyclonal Antibody for Human Insulin-like growth factor 1 receptor

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P1200Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human Insulin-like growth factor 1 receptor

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P1200Rb-r

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Polyclonal Antibody for Human Insulin-like growth factor 1 receptor

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P1200Rb-m

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Polyclonal Antibody for Human Insulin-like growth factor 1 receptor

Monoclonal Antibody for Human Insulin-like growth factor 1 receptor

Protein for Human Insulin-like growth factor 1 receptor

R&D Technical Data

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Precision

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Recovery

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References

1.

"Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity."
Ullrich A. , Gray A. , Tam A.W. , Yang-Feng T. , Tsubokawa M. , Collins C. , Henzel W. , Bon T.L. , Kathuria S. , Chen E. , Jacobs S. , Francke U. , Ramachandran J. , Fujita-Yamaguchi Y.
EMBO J.5:2503-2512(1986) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 31-56; 446-453; 503-524; 561-579; 668-672 AND 721-729
tissue: Placenta.
2.

"Insulin-like growth factor I receptor gene structure."
Abbot A.M. , Bueno R. , Pedrini M.T. , Murray J.M. , Smith R.J.
J. Biol. Chem.267:10759-10763(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
3.

Nagase T. , Kikuno R.F. , Yamakawa H. , Ohara O.
Submitted (2008-02) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Fetal brain.
4.

NIEHS SNPs program
Submitted (2003-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS MET-388 AND HIS-605
5.

"Analysis of the DNA sequence and duplication history of human chromosome 15."
Zody M.C. , Garber M. , Sharpe T. , Young S.K. , Rowen L. , O'Neill K. , Whittaker C.A. , Kamal M. , Chang J.L. , Cuomo C.A. , Dewar K. , FitzGerald M.G. , Kodira C.D. , Madan A. , Qin S. , Yang X. , Abbasi N. , Abouelleil A. , more...
Nature440:671-675(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
7.

"Analysis of the human type I insulin-like growth factor receptor promoter region."
Cooke D.W. , Bankert L.A. , Roberts C.T. Jr. , Leroith D. , Casella S.J.
Biochem. Biophys. Res. Commun.177:1113-1120(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-31
8.

"Characterization of human placental insulin-like growth factor-I/insulin hybrid receptors by protein microsequencing and purification."
Kasuya J. , Paz I.B. , Maddux B.A. , Goldfine I.D. , Hefta S.A. , Fujita-Yamaguchi Y.
Biochemistry32:13531-13536(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 31-45 AND 741-750;FUNCTION;FORMATION OF A HYBRID RECEPTOR WITH INSR
tissue: Placenta.
9.

"A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes."
Lee S.-T. , Strunk K.M. , Spritz R.A.
Oncogene8:3403-3410(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1137-1193;TISSUE SPECIFICITY
tissue: Melanocyte.
10.

"Interaction of the alpha beta dimers of the insulin-like growth factor I receptor is required for receptor autophosphorylation."
Tollefsen S.E. , Stoszek R.M. , Thompson K.
Biochemistry30:48-54(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBUNIT;AUTOPHOSPHORYLATION
11.

"Purified hybrid insulin/insulin-like growth factor-I receptors bind insulin-like growth factor-I, but not insulin, with high affinity."
Soos M.A. , Field C.E. , Siddle K.
Biochem. J.290:419-426(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;FORMATION OF A HYBRID RECEPTOR WITH INSR
12.

"Role of tyrosine kinase activity in signal transduction by the insulin-like growth factor-I (IGF-I) receptor. Characterization of kinase-deficient IGF-I receptors and the action of an IGF-I-mimetic antibody (alpha IR-3)."
Kato H. , Faria T.N. , Stannard B. , Roberts C.T. Jr. , LeRoith D.
J. Biol. Chem.268:2655-2661(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY;AUTOPHOSPHORYLATION
13.

"Non-SH2 domains within insulin receptor substrate-1 and SHC mediate their phosphotyrosine-dependent interaction with the NPEY motif of the insulin-like growth factor I receptor."
Craparo A. , O'Neill T.J. , Gustafson T.A.
J. Biol. Chem.270:15639-15643(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH IRS1; SHC1 AND PIK3R1;MUTAGENESIS OF TYR-980 AND LYS-1033;PHOSPHORYLATION AT TYR-980
14.

"Insulin receptor/IGF-I receptor hybrids are widely distributed in mammalian tissues: quantification of individual receptor species by selective immunoprecipitation and immunoblotting."
Bailyes E.M. , Nave B.T. , Soos M.A. , Orr S.R. , Hayward A.C. , Siddle K.
Biochem. J.327:209-215(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FORMATION OF A HYBRID RECEPTOR WITH INSR;TISSUE SPECIFICITY
15.

"14-3-3 proteins interact with the insulin-like growth factor receptor but not the insulin receptor."
Furlanetto R.W. , Dey B.R. , Lopaczynski W. , Nissley S.P.
Biochem. J.327:765-771(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH 14-3-3 PROTEINS
16.

"Distribution of insulin/insulin-like growth factor-I hybrid receptors in human tissues."
Federici M. , Porzio O. , Zucaro L. , Fusco A. , Borboni P. , Lauro D. , Sesti G.
Mol. Cell. Endocrinol.129:121-126(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FORMATION OF A HYBRID RECEPTOR WITH INSR;TISSUE SPECIFICITY
17.

"Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor."
Dey B.R. , Spence S.L. , Nissley P. , Furlanetto R.W.
J. Biol. Chem.273:24095-24101(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SOCS1 AND SOCS2
18.

"beta-arrestins regulate mitogenic signaling and clathrin-mediated endocytosis of the insulin-like growth factor I receptor."
Lin F.-T. , Daaka Y. , Lefkowitz R.J.
J. Biol. Chem.273:31640-31643(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ARRB1 AND ARRB2
19.

"The IGF-I receptor in cancer research."
Baserga R.
Exp. Cell Res.253:1-6(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN CANCER
20.

"Grb10, a positive, stimulatory signaling adapter in platelet-derived growth factor BB-, insulin-like growth factor I-, and insulin-mediated mitogenesis."
Wang J. , Dai H. , Yousaf N. , Moussaif M. , Deng Y. , Boufelliga A. , Swamy O.R. , Leone M.E. , Riedel H.
Mol. Cell. Biol.19:6217-6228(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GRB10;MUTAGENESIS OF TYR-980; TYR-1280; TYR-1281 AND TYR-1346
21.

"Suppressor of cytokine signaling (SOCS)-3 protein interacts with the insulin-like growth factor-I receptor."
Dey B.R. , Furlanetto R.W. , Nissley P.
Biochem. Biophys. Res. Commun.278:38-43(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SOCS3
22.

"Autophosphorylation of the insulin-like growth factor I receptor cytoplasmic domain."
Lopaczynski W. , Terry C. , Nissley P.
Biochem. Biophys. Res. Commun.279:955-960(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: AUTOPHOSPHORYLATION
23.

"Mechanism of STAT3 activation by insulin-like growth factor I receptor."
Zong C.S. , Chan J. , Levy D.E. , Horvath C. , Sadowski H.B. , Wang L.H.
J. Biol. Chem.275:15099-15105(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN ACTIVATION OF STAT3
24.

"Expression of the type 1 insulin-like growth factor receptor is up-regulated in primary prostate cancer and commonly persists in metastatic disease."
Hellawell G.O. , Turner G.D. , Davies D.R. , Poulsom R. , Brewster S.F. , Macaulay V.M.
Cancer Res.62:2942-2950(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
25.

"Insulin/insulin-like growth factor I hybrid receptors have different biological characteristics depending on the insulin receptor isoform involved."
Pandini G. , Frasca F. , Mineo R. , Sciacca L. , Vigneri R. , Belfiore A.
J. Biol. Chem.277:39684-39695(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;FORMATION OF A HYBRID RECEPTOR WITH INSR
26.

"RACK1, an insulin-like growth factor I (IGF-I) receptor-interacting protein, modulates IGF-I-dependent integrin signaling and promotes cell spreading and contact with extracellular matrix."
Hermanto U. , Zong C.S. , Li W. , Wang L.H.
Mol. Cell. Biol.22:2345-2365(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GNB2L1
27.

"Type 1 insulin-like growth factor receptor (IGF-IR) signaling inhibits apoptosis signal-regulating kinase 1 (ASK1)."
Galvan V. , Logvinova A. , Sperandio S. , Ichijo H. , Bredesen D.E.
J. Biol. Chem.278:13325-13332(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH MAP3K5
28.

"Mdm2-dependent ubiquitination and degradation of the insulin-like growth factor 1 receptor."
Girnita L. , Girnita A. , Larsson O.
Proc. Natl. Acad. Sci. U.S.A.100:8247-8252(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION BY MDM2;INTERACTION WITH MDM2
29.

"Cyclolignans as inhibitors of the insulin-like growth factor-1 receptor and malignant cell growth."
Girnita A. , Girnita L. , del Prete F. , Bartolazzi A. , Larsson O. , Axelson M.
Cancer Res.64:236-242(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION
30.

"{beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase."
Girnita L. , Shenoy S.K. , Sehat B. , Vasilcanu R. , Girnita A. , Lefkowitz R.J. , Larsson O.
J. Biol. Chem.280:24412-24419(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ARRB1 AND ARRB2
31.

"JAK/STAT3 pathway is involved in survival of neurons in response to insulin-like growth factor and negatively regulated by suppressor of cytokine signaling-3."
Yadav A. , Kalita A. , Dhillon S. , Banerjee K.
J. Biol. Chem.280:31830-31840(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH STAT3
32.

"Hybrid receptors formed by insulin receptor (IR) and insulin-like growth factor I receptor (IGF-IR) have low insulin and high IGF-1 affinity irrespective of the IR splice variant."
Slaaby R. , Schaeffer L. , Lautrup-Larsen I. , Andersen A.S. , Shaw A.C. , Mathiasen I.S. , Brandt J.
J. Biol. Chem.281:25869-25874(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;FORMATION OF A HYBRID RECEPTOR WITH INSR
33.

"The insulin-like growth factor 1 (IGF-1) receptor is a substrate for gamma-secretase-mediated intramembrane proteolysis."
McElroy B. , Powell J.C. , McCarthy J.V.
Biochem. Biophys. Res. Commun.358:1136-1141(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;PROTEOLYTIC PROCESSING
34.

"The insulin-like growth factor 1 receptor in cancer: old focus, new future."
Hartog H. , Wesseling J. , Boezen H.M. , van der Graaf W.T.
Eur. J. Cancer43:1895-1904(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON IGF1R IN CANCER
35.

"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H. , Olsen J.V. , Bairlein M. , Gnad F. , Oppermann F.S. , Korner R. , Greff Z. , Keri G. , Stemmann O. , Mann M.
Mol. Cell31:438-448(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
36.

"Large-scale proteomics analysis of the human kinome."
Oppermann F.S. , Gnad F. , Olsen J.V. , Hornberger R. , Greff Z. , Keri G. , Mann M. , Daub H.
Mol. Cell. Proteomics8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
37.

"Development and validation of a method for profiling post-translational modification activities using protein microarrays."
Del Rincon S.V. , Rogers J. , Widschwendter M. , Sun D. , Sieburg H.B. , Spruck C.
PLoS ONE5:E11332-E11332(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUMOYLATION
38.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
39.

"Polyubiquitination of insulin-like growth factor I receptor (IGF-IR) activation loop promotes antibody-induced receptor internalization and down-regulation."
Mao Y. , Shang Y. , Pham V.C. , Ernst J.A. , Lill J.R. , Scales S.J. , Zha J.
J. Biol. Chem.286:41852-41861(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION AT LYS-1168 AND LYS-1171
40.

"Crystal structure of the first three domains of the type-1 insulin-like growth factor receptor."
Garrett T.P. , McKern N.M. , Lou M. , Frenkel M.J. , Bentley J.D. , Lovrecz G.O. , Elleman T.C. , Cosgrove L.J. , Ward C.W.
Nature394:395-399(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) OF 31-492;DISULFIDE BONDS;GLYCOSYLATION AT ASN-51; ASN-135; ASN-244 AND ASN-314
41.

"Structure and autoregulation of the insulin-like growth factor 1 receptor kinase."
Favelyukis S. , Till J.H. , Hubbard S.R. , Miller W.T.
Nat. Struct. Biol.8:1058-1063(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) OF 988-1286 IN COMPLEX WITH AMP-PCP AND PEPTIDE SUBSTRATE;CATALYTIC ACTIVITY;ACTIVE SITE;ENZYME REGULATION;IDENTIFICATION BY MASS SPECTROMETRY;PHOSPHORYLATION AT TYR-1161; TYR-1165 AND TYR-1166
42.

"Crystal structure of bisphosphorylated IGF-1 receptor kinase: insight into domain movements upon kinase activation."
Pautsch A. , Zoephel A. , Ahorn H. , Spevak W. , Hauptmann R. , Nar H.
Structure9:955-965(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) OF 981-1286 IN COMPLEX WITH ANP;AUTOPHOSPHORYLATION;ACTIVE SITE;IDENTIFICATION BY MASS SPECTROMETRY
43.

"Crystal structure of the Apo, unactivated insulin-like growth factor-1 receptor kinase. Implication for inhibitor specificity."
Munshi S. , Kornienko M. , Hall D.L. , Reid J.C. , Waxman L. , Stirdivant S.M. , Darke P.L. , Kuo L.C.
J. Biol. Chem.277:38797-38802(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.70 ANGSTROMS) OF 974-1294
44.

"Structure of apo, unactivated insulin-like growth factor-1 receptor kinase at 1.5 A resolution."
Munshi S. , Hall D.L. , Kornienko M. , Darke P.L. , Kuo L.C.
Acta Crystallogr. D59:1725-1730(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.50 ANGSTROMS) OF 974-1294
45.

"Discovery and initial SAR of 3-(1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-ones as inhibitors of insulin-like growth factor 1-receptor (IGF-1R)."
Velaparthi U. , Wittman M. , Liu P. , Stoffan K. , Zimmermann K. , Sang X. , Carboni J. , Li A. , Attar R. , Gottardis M. , Greer A. , Chang C.Y. , Jacobsen B.L. , Sack J.S. , Sun Y. , Langley D.R. , Balasubramanian B. , Vyas D.
Bioorg. Med. Chem. Lett.17:2317-2321(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 982-1286 IN COMPLEX WITH BENZIMIDAZOLE PYRIDINONE INHIBITOR;CATALYTIC ACTIVITY;ENZYME REGULATION
46.

"Lead identification to generate isoquinolinedione inhibitors of insulin-like growth factor receptor (IGF-1R) for potential use in cancer treatment."
Mayer S.C. , Banker A.L. , Boschelli F. , Di L. , Johnson M. , Kenny C.H. , Krishnamurthy G. , Kutterer K. , Moy F. , Petusky S. , Ravi M. , Tkach D. , Tsou H.R. , Xu W.
Bioorg. Med. Chem. Lett.18:3641-3645(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 981-1286;PHOSPHORYLATION AT TYR-1161; TYR-1165 AND TYR-1166
47.

"Small-molecule inhibition and activation-loop trans-phosphorylation of the IGF1 receptor."
Wu J. , Li W. , Craddock B.P. , Foreman K.W. , Mulvihill M.J. , Ji Q.S. , Miller W.T. , Hubbard S.R.
EMBO J.27:1985-1994(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 986-1286 IN COMPLEX WITH INHIBITOR PQIP;SUBUNIT;AUTOPHOSPHORYLATION;CATALYTIC ACTIVITY;ACTIVE SITE;ENZYME REGULATION
48.

"Lead identification to generate 3-cyanoquinoline inhibitors of insulin-like growth factor receptor (IGF-1R) for potential use in cancer treatment."
Miller L.M. , Mayer S.C. , Berger D.M. , Boschelli D.H. , Boschelli F. , Di L. , Du X. , Dutia M. , Floyd M.B. , Johnson M. , Kenny C.H. , Krishnamurthy G. , Moy F. , Petusky S. , Tkach D. , Torres N. , Wu B. , Xu W.
Bioorg. Med. Chem. Lett.19:62-66(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.90 ANGSTROMS) OF 981-1286 IN COMPLEX WITH 3-CYANOQUINOLINE INHIBITOR;CATALYTIC ACTIVITY;ENZYME REGULATION;PHOSPHORYLATION AT TYR-1161; TYR-1165 AND TYR-1166
49.

"Discovery of a 2,4-disubstituted pyrrolo[1,2-f][1,2,4]triazine inhibitor (BMS-754807) of insulin-like growth factor receptor (IGF-1R) kinase in clinical development."
Wittman M.D. , Carboni J.M. , Yang Z. , Lee F.Y. , Antman M. , Attar R. , Balimane P. , Chang C. , Chen C. , Discenza L. , Frennesson D. , Gottardis M.M. , Greer A. , Hurlburt W. , Johnson W. , Langley D.R. , Li A. , Li J. , more...
J. Med. Chem.52:7360-7363(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.08 ANGSTROMS) OF 982-1286 IN COMPLEX WITH BMS-754807;CATALYTIC ACTIVITY;ENZYME REGULATION
50.

"Allosteric IGF-1R Inhibitors."
Heinrich T. , Graedler U. , Boettcher H. , Blaukat A. , Shutes A.
ACS Med. Chem. Lett.1:199-203(2010)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.79 ANGSTROMS) OF 983-1286 IN COMPLEX WITH MSC1609119A-1;CATALYTIC ACTIVITY;ENZYME REGULATION
51.

"Proline isosteres in a series of 2,4-disubstituted pyrrolo[1,2-f][1,2,4]triazine inhibitors of IGF-1R kinase and IR kinase."
Sampognaro A.J. , Wittman M.D. , Carboni J.M. , Chang C. , Greer A.F. , Hurlburt W.W. , Sack J.S. , Vyas D.M.
Bioorg. Med. Chem. Lett.20:5027-5030(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.11 ANGSTROMS) OF 982-1286 IN COMPLEXES WITH INHIBITORS;CATALYTIC ACTIVITY;ENZYME REGULATION
52.

"Design of potent IGF1-R inhibitors related to bis-azaindoles."
Nemecek C. , Metz W.A. , Wentzler S. , Ding F.X. , Venot C. , Souaille C. , Dagallier A. , Maignan S. , Guilloteau J.P. , Bernard F. , Henry A. , Grapinet S. , Lesuisse D.
Chem. Biol. Drug Des.76:100-106(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.00 ANGSTROMS) OF 951-1286 IN COMPLEX WITH BIS-AZAINDOLE INHIBITOR;AUTOPHOSPHORYLATION;ENZYME REGULATION
53.

"Discovery of the first non-ATP competitive IGF-1R kinase inhibitors: advantages in comparison with competitive inhibitors."
Lesuisse D. , Mauger J. , Nemecek C. , Maignan S. , Boiziau J. , Harlow G. , Hittinger A. , Ruf S. , Strobel H. , Nair A. , Ritter K. , Malleron J.L. , Dagallier A. , El-Ahmad Y. , Guilloteau J.P. , Guizani H. , Bouchard H. , Venot C.
Bioorg. Med. Chem. Lett.21:2224-2228(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) OF 982-1286 IN COMPLEX WITH HYDANTOIN DERIVATIVE;CATALYTIC ACTIVITY;ENZYME REGULATION
54.

"Discovery of 2,4-bis-arylamino-1,3-pyrimidines as insulin-like growth factor-1 receptor (IGF-1R) inhibitors."
Buchanan J.L. , Newcomb J.R. , Carney D.P. , Chaffee S.C. , Chai L. , Cupples R. , Epstein L.F. , Gallant P. , Gu Y. , Harmange J.C. , Hodge K. , Houk B.E. , Huang X. , Jona J. , Joseph S. , Jun H.T. , Kumar R. , Li C. , more...
Bioorg. Med. Chem. Lett.21:2394-2399(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.90 ANGSTROMS) OF 988-1286 IN COMPLEX WITH 2,4-BIS-ARYLAMINO-1,3-PYRIMIDINE INHIBITOR;CATALYTIC ACTIVITY;ENZYME REGULATION
55.

"IGF-I receptor mutations resulting in intrauterine and postnatal growth retardation."
The intrauterine growth retardation (IUGR) study group , Abuzzahab M.J. , Schneider A. , Goddard A. , Grigorescu F. , Lautier C. , Keller E. , Kiess W. , Klammt J. , Kratzsch J. , Osgood D. , Pfaeffle R. , Raile K. , Seidel B. , Smith R.J. , Chernausek S.D.
N. Engl. J. Med.349:2211-2222(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS IGF1RES GLN-138 AND ASN-145;CHARACTERIZATION OF VARIANTS IGF1RES GLN-138 AND ASN-145
56.

"Mutation at cleavage site of insulin-like growth factor receptor in a short-stature child born with intrauterine growth retardation."
Kawashima Y. , Kanzaki S. , Yang F. , Kinoshita T. , Hanaki K. , Nagaishi J. , Ohtsuka Y. , Hisatome I. , Ninomoya H. , Nanba E. , Fukushima T. , Takahashi S.
J. Clin. Endocrinol. Metab.90:4679-4687(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT IGF1RES GLN-739;CHARACTERIZATION OF VARIANT IGF1RES GLN-739
57.

"Patterns of somatic mutation in human cancer genomes."
Greenman C. , Stephens P. , Smith R. , Dalgliesh G.L. , Hunter C. , Bignell G. , Davies H. , Teague J. , Butler A. , Stevens C. , Edkins S. , O'Meara S. , Vastrik I. , Schmidt E.E. , Avis T. , Barthorpe S. , Bhamra G. , Buck G. , more...
Nature446:153-158(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS [LARGE SCALE ANALYSIS] LEU-105; HIS-437; HIS-595; SER-857; THR-1338 AND VAL-1347

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