Nfkbia ELISA Kit for Rat(Rattus norvegicus) | EIAab.comNfkbia ELISA Kit for Rat(Rattus norvegicus)

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Index > Protein center > Nfkbia(Gene name) > Rat

Nfkbia (Gene name),

NF-kappa-B inhibitor alpha (Protein name ), IKBA_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Citations (2)

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Gene name:

Nfkbia(Ikba);

Protein name:

NF-kappa-B inhibitor alpha;

Alternative:

RL/IF-1;I-kappa-B-alpha(IkB-alpha;IkappaBalpha);

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Interacts with RELA; the interaction requires the nuclear import signal. Interacts with NKIRAS1 and NKIRAS2. Part of a 70-90 kDa complex at least consisting of CHUK, IKBKB, NFKBIA, RELA, IKBKAP and MAP3K14. Interacts with HBV protein X. Interacts with RWDD3; the interaction enhances sumoylation. Interacts (when phosphorylated at the 2 serine residues in the destruction motif D-S-G-X(2,3,4)-S) with BTRC. Associates with the SCF(BTRC) complex, composed of SKP1, CUL1 and BTRC; the association is mediated via interaction with BTRC. Part of a SCF(BTRC)-like complex lacking CUL1, which is associated with RELA; RELA interacts directly with NFKBIA (By similarity). Interacts with PRMT2.

Function:

Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to tranlocate to the nucleus and activate transcription.

Subcellular Location:

Cytoplasm Nucleus Shuttles between the nucleus and the cytoplasm by a nuclear localization signal (NLS) and a CRM1-dependent nuclear export.

Protein Attributes:

Sequence length:

314

Sequence:

50:

100:

150:

200:

250:

300:

314:

PYDDCVFGGQ | RLTL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

Q63746

UniGene:

Rn.12550

KEGG:

rno:25493

STRING:

10116.ENSRNOP00000009894

Pfam:

PF12796

SMR:

Q63746

Uniprot:

Q63746

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ELISA Kit for Rat NF-kappa-B inhibitor alpha

Cat.:

E1848h

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96T

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ELISA Kit for Rat NF-kappa-B inhibitor alpha

Cat.:

E1848r

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96T

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ELISA Kit for Rat NF-kappa-B inhibitor alpha

Cat.:

E1848p

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96T

ELISA Kit for Rat NF-kappa-B inhibitor alpha

Cat.:

E1848m

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Packing:

96T

ELISA Kit for Rat NF-kappa-B inhibitor alpha

Cat.:

E1848c

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Packing:

96T

CLIA Kit for Rat NF-kappa-B inhibitor alpha

Cat.:

U1848m

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MSDS:

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Packing:

96T

CLIA Kit for Rat NF-kappa-B inhibitor alpha

Cat.:

U1848c

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MSDS:

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Packing:

96T

CLIA Kit for Rat NF-kappa-B inhibitor alpha

Cat.:

U1848r

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MSDS:

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Packing:

96T

CLIA Kit for Rat NF-kappa-B inhibitor alpha

Cat.:

U1848p

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MSDS:

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Packing:

96T

CLIA Kit for Rat NF-kappa-B inhibitor alpha

Cat.:

U1848h

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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Polyclonal Antibody for Rat NF-kappa-B inhibitor alpha

Cat.:

P1848Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat NF-kappa-B inhibitor alpha

Cat.:

P1848Rb-h

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40ug/0.2ml

Polyclonal Antibody for Rat NF-kappa-B inhibitor alpha

Cat.:

P1848Rb-m

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Packing:

40ug/0.2ml

Monoclonal Antibody for Rat NF-kappa-B inhibitor alpha

Protein for Rat NF-kappa-B inhibitor alpha

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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Citations

[1].

"Effects of palmitic acid on lipid metabolism homeostasis and apoptosis in goose primary hepatocytes"

Zhixiong Pan , Jiwen Wang , Hui Tang , Liang Li , Jia Lv , Lu Xia , Chunchun Han , Feng Xu , Hua He , Hengyong Xu , Bo Kang

From:Mol Cell Biochem

[2].

"Inhibitory effect of ginsenoside-Rd on carrageenan-induced inflammation in rats"

L Wang, Y Zhang, Z Wang, et al.

From:Canadian journal of physiology and pharmacology

References

1.

"Sequence of rat RL/IF-1 encoding an IkappaB, and comparison with related proteins containing Notch-like repeats."
Tewari M. , Mohn K.L. , Yue F.E. , Taub R.A.
Nucleic Acids Res.20:607-607(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

Tewari M. , Mohn K.L. , Yue F.E. , Taub R.A.
Nucleic Acids Res.20:2624-2624(1992)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
3.

Tewari M. , Mohn K.L. , Yue F.E. , Taub R.A.
Nucleic Acids Res.20:2931-2931(1992)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
4.

Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Pituitary.
6.

"Rapid induction in regenerating liver of RL/IF-1 (an I kappa B that inhibits NF-kappa B, RelB-p50, and c-Rel-p50) and PHF, a novel kappa B site-binding complex."
Tewari M. , Dobrzanski P. , Mohn K.L. , Cressman D.E. , Hsu J.C. , Bravo R. , Taub R.
Mol. Cell. Biol.12:2898-2908(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION

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