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Index > Protein center > Il23a(Gene name) > Mouse
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  • Il23a (Gene name),
  • Interleukin-23 subunit alpha (Protein name ),  IL23A_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Gene name:
    Il23a;
    Protein name:
    Interleukin-23 subunit alpha(IL-23 subunit alpha;IL-23-A);
    Alternative:
    Interleukin-23 subunit p19(IL-23p19);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-23.
    Function:
    Associates with IL12B to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to an heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
    Subcellular Location:
    Secreted Secreted upon association with IL12B.
    Protein Attributes:
    Sequence length:
    196
    Sequence:
    50:
    MLDCRAVIML | WLLPWVTQGL | AVPRSSSPDW | AQCQQLSRNL | CMLAWNAHAP | 
    100:
    AGHMNLLREE | EDEETKNNVP | RIQCEDGCDP | QGLKDNSQFC | LQRIRQGLAF | 
    150:
    YKHLLDSDIF | KGEPALLPDS | PMEQLHTSLL | GLSQLLQPED | HPRETQQMPS | 
    196:
    LSSSQQWQRP | LLRSKILRSL | QAFLAIAARV | FAHGAATLTE | PLVPTA
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    KEGG:
    Pfam:
    String:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse IL-23 subunit alpha
    Cat.:
    E0384m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse IL-23 subunit alpha
    Cat.:
    E0384h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse IL-23 subunit alpha
    Cat.:
    E0384r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse IL-23 subunit alpha
    Cat.:
    E0384p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse IL-23 subunit alpha
    Cat.:
    U0384h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse IL-23 subunit alpha
    Cat.:
    U0384m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse IL-23 subunit alpha
    Cat.:
    U0384p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse IL-23 subunit alpha
    Cat.:
    U0384r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse IL-23 subunit alpha
    Cat.:
    P0384Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse IL-23 subunit alpha
    Polyclonal Antibody for Mouse IL-23 subunit alpha
    Cat.:
    P0384Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse IL-23 subunit alpha
    Cat.:
    P0384Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse IL-23 subunit alpha
    Monoclonal Antibody for Mouse IL-23 subunit alpha
    Monoclonal Antibody for Mouse IL-23 subunit alpha
    Monoclonal Antibody for Mouse IL-23 subunit alpha
    Protein for Mouse IL-23 subunit alpha
    Protein for Mouse IL-23 subunit alpha
    Protein for Mouse IL-23 subunit alpha
    Protein for Mouse IL-23 subunit alpha

    R&D Technical Data
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Precision
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    Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

    Intra-Assay CV: ≤6.1%

    Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

    Inter-Assay CV: ≤8.2%

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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    Recovery was determined by spiking various levels of IL23A into serum and plasma .

    Sample Type

    Average(%)

    Recovery Range(%)

    Serum

    101

    94-105

    Plasma

    100

    93-106

     

     

     

     

    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    The linearity of the kit was assayed by testing samples spiked with appropriate concentration of IL23A and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.  

     

    Sample

    1:2

    1:4

    1:8

    1:16

    serum(n=5)

    94-105%

    95-103%

    96-105%

    97-109%

    EDTA plasma(n=5)

    93-99%

    94-105%

    92-99%

    95-106%

    heparin plasma(n=5)

    95-104%

     

    94-109%

    99-107%

    93-108%

     

    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12."
      Oppmann B. , Lesley R. , Blom B. , Timans J.C. , Xu Y. , Hunte B. , Vega F. , Yu N. , Wang J. , Singh K.P. , Zonin F. , Vaisberg E. , Churakova T. , Liu M.-R. , Gorman D. , Wagner J. , Zurawski S. , Liu Y.-J. , more...
      Immunity13:715-725(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;INTERACTION WITH IL12B;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
      tissue: Monocyte.
    2. 2.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: FVB/N.
      tissue: Mammary tumor.
    3. 3.
      "Ubiquitous transgenic expression of the IL-23 subunit p19 induces multiorgan inflammation, runting, infertility, and premature death."
      Wiekowski M.T. , Leach M.W. , Evans E.W. , Sullivan L. , Chen S.-C. , Vassileva G. , Bazan J.F. , Gorman D.M. , Kastelein R.A. , Narula S. , Lira S.A.
      J. Immunol.166:7563-7570(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    4. 4.
      "Mice lacking bioactive IL-12 can generate protective, antigen-specific cellular responses to mycobacterial infection only if the IL-12 p40 subunit is present."
      Cooper A.M. , Kipnis A. , Turner J. , Magram J. , Ferrante J. , Orme I.M.
      J. Immunol.168:1322-1327(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION BY MYCOBACTERIAL INFECTION
    5. 5.
      "Herpes simplex virus type 1 infection induces upregulation of interleukin-23 (p19) mRNA expression in trigeminal ganglia of BALB/c mice."
      Broberg E.K. , Setaelae N. , Eraelinna J.-P. , Salmi A.A. , Roeyttae M. , Hukkanen V.
      J. Interferon Cytokine Res.22:641-651(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION BY HERPES SIMPLEX VIRUS TYPE 1 INFECTION
    6. 6.
      "Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation."
      Murphy C.A. , Langrish C.L. , Chen Y. , Blumenschein W. , McClanahan T.K. , Kastelein R.A. , Sedgwick J.D. , Cua D.J.
      J. Exp. Med.198:1951-1957(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    8. 8.
      "Differential expression and regulation of IL-23 and IL-12 subunits and receptors in adult mouse microglia."
      Li J. , Gran B. , Zhang G.-X. , Ventura E.S. , Siglienti I. , Rostami A. , Kamoun M.
      J. Neurol. Sci.215:95-103(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION BY LPS AND IFNG
    9. 9.
      "Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain."
      Cua D.J. , Sherlock J. , Chen Y. , Murphy C.A. , Joyce B. , Seymour B. , Lucian L. , To W. , Kwan S. , Churakova T. , Zurawski S. , Wiekowski M.T. , Lira S.A. , Gorman D. , Kastelein R.A. , Sedgwick J.D.
      Nature421:744-748(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
    10. 10.
      "Compromised humoral and delayed-type hypersensitivity responses in IL-23-deficient mice."
      Ghilardi N. , Kljavin N. , Chen Q. , Lucas S. , Gurney A.L. , de Sauvage F.J.
      J. Immunol.172:2827-2833(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
    11. 11.
      "Divergent roles of IL-23 and IL-12 in host defense against Klebsiella pneumoniae."
      Happel K.I. , Dubin P.J. , Zheng M. , Ghilardi N. , Lockhart C. , Quinton L.J. , Odden A.R. , Shellito J.E. , Bagby G.J. , Nelson S. , Kolls J.K.
      J. Exp. Med.202:761-769(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
    12. 12.
      "Fas ligand induces cell-autonomous IL-23 production in dendritic cells, a mechanism for Fas ligand-induced IL-17 production."
      Kidoya H. , Umemura M. , Kawabe T. , Matsuzaki G. , Yahagi A. , Imamura R. , Suda T.
      J. Immunol.175:8024-8031(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION BY FASLG
    13. 13.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
    14. 14.
      "Transforming growth factor-beta induces development of the T(H)17 lineage."
      Mangan P.R. , Harrington L.E. , O'Quinn D.B. , Helms W.S. , Bullard D.C. , Elson C.O. , Hatton R.D. , Wahl S.M. , Schoeb T.R. , Weaver C.T.
      Nature441:231-234(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    15. 15.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
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