Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-23.
Function:
Associates with IL12B to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to an heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
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Precision
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Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.
Intra-Assay CV: ≤6.1%
Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.
Inter-Assay CV: ≤8.2%
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Recovery
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Recovery was determined by spiking various levels of IL23A into serum and plasma .
Sample Type
Average(%)
Recovery Range(%)
Serum
101
94-105
Plasma
100
93-106
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Linearity
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The linearity of the kit was assayed by testing samples spiked with appropriate concentration of IL23A and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.
Sample
1:2
1:4
1:8
1:16
serum(n=5)
94-105%
95-103%
96-105%
97-109%
EDTA plasma(n=5)
93-99%
94-105%
92-99%
95-106%
heparin plasma(n=5)
95-104%
94-109%
99-107%
93-108%
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References
1.
"Rattus norvegicus IL-23 mRNA." Tran G.
,
Hodgkinson S.
Submitted (2001-09) to the EMBL/GenBank/DDBJ databases
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Cited for: NUCLEOTIDE SEQUENCE [MRNA]