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Index > Protein center > IL26(Gene name) > Human
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  • IL26 (Gene name),
  • Interleukin-26 (Protein name ),  IL26_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    IL26(AK155);
    Protein name:
    Interleukin-26(IL-26);
    Alternative:
    Protein AK155;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer.
    Function:
    May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases proliferation of intestinal epithelial cells. Is inhibited by heparin.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    171
    Sequence:
    50:
    MLVNFILRCG | LLLVTLSLAI | AKHKQSSFTK | SCYPRGTLSQ | AVDALYIKAA | 
    100:
    WLKATIPEDR | IKNIRLLKKK | TKKQFMKNCQ | FQEQLLSFFM | EDVFGQLQLQ | 
    150:
    GCKKIRFVED | FHSLRQKLSH | CISCASSARE | MKSITRMKRI | FYRIGNKGIY | 
    171:
    KAISELDILL | SWIKKLLESS | Q
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    Pfam:
    SMR:
    KEGG:
    MIM:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human IL-26
    Cat.:
    E1695h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human IL-26
    Cat.:
    U1695h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    Polyclonal Antibody for Human IL-26
    Cat.:
    P1695Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human IL-26
    Protein for Human IL-26

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    Linearity
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    References
    1. 1.
      "Induction of a novel cellular homolog of interleukin-10, AK155, by transformation of T lymphocytes with herpesvirus saimiri."
      Knappe A. , Hor S. , Wittmann S. , Fickenscher H.
      J. Virol.74:3881-3887(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]
    2. 2.
      SeattleSNPs variation discovery resource
      Submitted (2003-12) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    4. 4.
      "The T-cell lymphokine interleukin-26 targets epithelial cells through the interleukin-20 receptor 1 and interleukin-10 receptor 2 chains."
      Hor S. , Pirzer H. , Dumoutier L. , Bauer F. , Wittmann S. , Sticht H. , Renauld J.C. , de Waal Malefyt R. , Fickenscher H.
      J. Biol. Chem.279:33343-33351(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    5. 5.
      "IL-26 signals through a novel receptor complex composed of IL-20 receptor 1 and IL-10 receptor 2."
      Sheikh F. , Baurin V.V. , Lewis-Antes A. , Shah N.K. , Smirnov S.V. , Anantha S. , Dickensheets H. , Dumoutier L. , Renauld J.-C. , Zdanov A. , Donnelly R.P. , Kotenko S.V.
      J. Immunol.172:2006-2010(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;RECEPTOR-BINDING
    6. 6.
      "The role of the novel Th17 cytokine IL-26 in intestinal inflammation."
      Dambacher J. , Beigel F. , Zitzmann K. , De Toni E.N. , Goke B. , Diepolder H.M. , Auernhammer C.J. , Brand S.
      Gut58:1207-1217(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;SUBCELLULAR LOCATION
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