Protein name:
Interleukin-27 subunit beta(IL-27 subunit beta;IL-27B);
Alternative:
IL35;Epstein-Barr virus-induced gene 3 protein(EBV-induced gene 3 protein);
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Heterodimer with IL27. IL-27 is an heterodimer composed IL27 and EBI3. EBI3 is also a component of the IL-12 heterodimer. Interacts with SQSTM1.
Function:
Cytokine with pro- and anti-inflammatory properties, that can regulate T helper cell development, suppress T-cell proliferation, stimulate cytotoxic T cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines.
Subcellular Location:
Secreted
Protein Attributes:
50:
MTPQLLLALV | LWASCPPCSG | RKGPPAALTL | PRVQCRASRY | PIAVDCSWTL |
100:
PPAPNSTSPV | SFIATYRLGM | AARGHSWPCL | QQTPTSTSCT | ITDVQLFSMA |
150:
PYVLNVTAVH | PWGSSSSFVP | FITEHIIKPD | PPEGVRLSPL | AERQLQVQWE |
200:
PPGSWPFPEI | FSLKYWIRYK | RQGAARFHRV | GPIEATSFIL | RAVRPRARYY |
229:
VQVAAQDLTD | YGELSDWSLP | ATATMSLGK
Vaild Sequence:
Related Databases
Uniprot:
