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Index > Protein center > IL2RA(Gene name) > Human
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  • IL2RA (Gene name),
  • Interleukin-2 receptor subunit alpha (Protein name ),  IL2RA_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Gene name:
    IL2RA;
    Protein name:
    Interleukin-2 receptor subunit alpha(IL-2 receptor subunit alpha;IL-2-RA;IL-2R subunit alpha;IL2-RA);
    Alternative:
    p55;TAC antigen;
    CD:
    CD25;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit.
    Function:
    Receptor for interleukin-2.
    Subcellular Location:
    Membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    272
    Sequence:
    50:
    MDSYLLMWGL | LTFIMVPGCQ | AELCDDDPPE | IPHATFKAMA | YKEGTMLNCE | 
    100:
    CKRGFRRIKS | GSLYMLCTGN | SSHSSWDNQC | QCTSSATRNT | TKQVTPQPEE | 
    150:
    QKERKTTEMQ | SPMQPVDQAS | LPGHCREPPP | WENEATERIY | HFVVGQMVYY | 
    200:
    QCVQGYRALH | RGPAESVCKM | THGKTRWTQP | QLICTGEMET | SQFPGEEKPQ | 
    250:
    ASPEGRPESE | TSCLVTTTDF | QIQTEMAATM | ETSIFTTEYQ | VAVAGCVFLL | 
    272:
    ISVLLLSGLT | WQRRQRKSRR | TI
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    MIM:
    String:
    UniGene:
    Pfam:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human IL-2 receptor subunit alpha
    Cat.:
    E0229p
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    ELISA Kit for Human IL-2 receptor subunit alpha
    Cat.:
    E0229m
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    Packing:
    96T
    ELISA Kit for Human IL-2 receptor subunit alpha
    Cat.:
    E0229b
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    96T
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    ELISA Kit for Human IL-2 receptor subunit alpha
    Cat.:
    E0229h
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    96T
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    ELISA Kit for Human IL-2 receptor subunit alpha
    Cat.:
    E0229r
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    Packing:
    96T
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    ELISA Kit for Human IL-2 receptor subunit alpha
    Cat.:
    E0229d
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human IL-2 receptor subunit alpha
    Cat.:
    U0229d
    Price:
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human IL-2 receptor subunit alpha
    Cat.:
    U0229p
    Price:
    Please sign in first.
    MSDS:
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    Packing:
    96T
    CLIA Kit for Human IL-2 receptor subunit alpha
    Cat.:
    U0229b
    Price:
    Please sign in first.
    MSDS:
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    Packing:
    96T
    CLIA Kit for Human IL-2 receptor subunit alpha
    Cat.:
    U0229r
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    CLIA Kit for Human IL-2 receptor subunit alpha
    Cat.:
    U0229h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human IL-2 receptor subunit alpha
    Cat.:
    U0229m
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    Please sign in first.
    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human IL-2 receptor subunit alpha
    Cat.:
    P0229Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human IL-2 receptor subunit alpha
    Cat.:
    P0229Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human IL-2 receptor subunit alpha
    Polyclonal Antibody for Human IL-2 receptor subunit alpha
    Polyclonal Antibody for Human IL-2 receptor subunit alpha
    Polyclonal Antibody for Human IL-2 receptor subunit alpha
    Cat.:
    P0229Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human IL-2 receptor subunit alpha
    Monoclonal Antibody for Human IL-2 receptor subunit alpha
    Monoclonal Antibody for Human IL-2 receptor subunit alpha
    Monoclonal Antibody for Human IL-2 receptor subunit alpha
    Monoclonal Antibody for Human IL-2 receptor subunit alpha
    Monoclonal Antibody for Human IL-2 receptor subunit alpha
    Protein for Human IL-2 receptor subunit alpha
    Protein for Human IL-2 receptor subunit alpha
    Protein for Human IL-2 receptor subunit alpha
    Protein for Human IL-2 receptor subunit alpha
    Protein for Human IL-2 receptor subunit alpha
    Protein for Human IL-2 receptor subunit alpha

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    Linearity

     

     

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    References
    1. 1.
      "Molecular cloning of cDNA encoding human interleukin-2 receptor."
      Nikaido T. , Shimizu A. , Ishida N. , Sabe H. , Teshigawara K. , Maeda M. , Uchiyama T. , Yodoi J. , Honjo T.
      Nature311:631-635(1984) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "Molecular cloning and expression of cDNAs for the human interleukin-2 receptor."
      Leonard W.J. , Depper J.M. , Crabtree G.R. , Rudikoff S. , Pumphrey J. , Robb R.J. , Kroenke M. , Svetlik P.B. , Peffer N.J. , Waldmann T.A. , Greene W.C.
      Nature311:626-631(1984) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    3. 3.
      "Molecular cloning and structure of the human interleukin 2 receptor gene."
      Ishida N. , Kanamori H. , Noma T. , Nikaido T. , Sabe H. , Suzuki N. , Shimizu A. , Honjo T.
      Nucleic Acids Res.13:7579-7589(1985) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    5. 5.
      SeattleSNPs variation discovery resource
      Submitted (2004-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT THR-272
    6. 6.
      "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P. , Earthrowl M.E. , Grafham D.V. , Rubenfield M. , French L. , Steward C.A. , Sims S.K. , Jones M.C. , Searle S. , Scott C. , Howe K. , Hunt S.E. , Andrews T.D. , Gilbert J.G.R. , Swarbreck D. , Ashurst J.L. , Taylor A. , Battles J. , more...
      Nature429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      "Regulation of the human interleukin-2 receptor alpha chain promoter: activation of a nonfunctional promoter by the transactivator gene of HTLV-I."
      Cross S.L. , Feinberg M.B. , Wolf J.B. , Holbrook N.J. , Wong-Stall F. , Leonard W.J.
      Cell49:47-56(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-21
    9. 9.
      "Structural analysis of recombinant soluble human interleukin-2 receptor. Primary structure, assignment of disulfide bonds and core IL-2 binding structure."
      Miedel M.C. , Hulmes J.D. , Weber D.V. , Bailon P. , Pan Y.C.
      Biochem. Biophys. Res. Commun.154:372-379(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISULFIDE BONDS;GLYCOSYLATION AT ASN-70; ASN-89; THR-218; THR-224; THR-229 AND THR-237
    10. 10.
      "The interleukin-2 and interleukin-4 receptors studied by molecular modelling."
      Bamborough P. , Hedgecock C.J. , Richards W.G.
      Structure2:839-851(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: 3D-STRUCTURE MODELING OF 23-83
    11. 11.
      "Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors."
      Wang X. , Rickert M. , Garcia K.C.
      Science310:1159-1163(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 22-238 IN COMPLEX WITH IL2; IL2RB AND IL2RC;DISULFIDE BONDS
    12. 12.
      "Crystal structure of the IL-2 signaling complex: paradigm for a heterotrimeric cytokine receptor."
      Stauber D.J. , Debler E.W. , Horton P.A. , Smith K.A. , Wilson I.A.
      Proc. Natl. Acad. Sci. U.S.A.103:2788-2793(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 22-233 IN COMPLEX WITH IL2; IL2RB AND IL2RC;DISULFIDE BONDS
    13. 13.
      "Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes."
      Lowe C.E. , Cooper J.D. , Brusko T. , Walker N.M. , Smyth D.J. , Bailey R. , Bourget K. , Plagnol V. , Field S. , Atkinson M. , Clayton D.G. , Wicker L.S. , Todd J.A.
      Nat. Genet.39:1074-1082(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN IDDM10
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