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Index > Protein center > IL36G(Gene name) > Human
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  • IL36G (Gene name),
  • Interleukin-36 gamma (Protein name ),  IL36G_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    IL36G(UNQ2456/PRO5737;IL1E;IL1F9;IL1H1;IL1RP2);
    Protein name:
    Interleukin-36 gamma;
    Alternative:
    Interleukin-1 epsilon(IL-1 epsilon);IL-1-related protein 2(IL-1RP2);Interleukin-1 homolog 1(IL-1H1);Interleukin-1 family member 9(IL-1F9);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Function:
    Function as an agonist of NF-kappa B activation through the orphan IL-1-receptor-related protein 2. Could constitute part of an independent signaling system analogous to interleukin-1 alpha (IL-1A), beta (IL-1B) receptor agonist and interleukin-1 receptor type I (IL-1R1), that is present in epithelial barriers and takes part in local inflammatory response.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    169
    Sequence:
    50:
    MRGTPGDADG | GGRAVYQSMC | KPITGTINDL | NQQVWTLQGQ | NLVAVPRSDS | 
    100:
    VTPVTVAVIT | CKYPEALEQG | RGDPIYLGIQ | NPEMCLYCEK | VGEQPTLQLK | 
    150:
    EQKIMDLYGQ | PEPVKPFLFY | RAKTGRTSTL | ESVAFPDWFI | ASSKRDQPII | 
    169:
    LTSELGKSYN | TAFELNIND
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    MIM:
    String:
    SMR:
    UniGene:
    Pfam:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Interleukin-36 gamma
    Cat.:
    E2205h
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human Interleukin-36 gamma
    Cat.:
    E2205m
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    CLIA Kit for Human Interleukin-36 gamma
    Cat.:
    U2205m
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Interleukin-36 gamma
    Cat.:
    U2205h
    Price:
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human Interleukin-36 gamma
    Cat.:
    P2205Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Interleukin-36 gamma
    Cat.:
    P2205Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Interleukin-36 gamma
    Monoclonal Antibody for Human Interleukin-36 gamma
    Protein for Human Interleukin-36 gamma
    Protein for Human Interleukin-36 gamma

    R&D Technical Data
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    Recovery
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    Linearity
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    References
    1. 1.
      "Identification and initial characterization of four novel members of the interleukin-1 family."
      Kumar S. , McDonnell P.C. , Lehr R. , Tierney L. , Tzimas M.N. , Griswold D.E. , Capper E.A. , Tal-Singer R. , Wells G.I. , Doyle M.L. , Young P.R.
      J. Biol. Chem.275:10308-10314(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);INDUCTION
      tissue: Keratinocyte.
    2. 2.
      "Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2."
      Debets R. , Timans J.C. , Homey B. , Zurawski S. , Sana T.R. , Lo S. , Wagner J. , Edwards G. , Clifford T. , Menon S. , Bazan J.F. , Kastelein R.A.
      J. Immunol.167:1440-1446(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);CHARACTERIZATION
      tissue: Epithelium.
    3. 3.
      "Identification and gene organization of three novel members of the IL-1 family on human chromosome 2."
      Busfield S.J. , Comrack C.A. , Yu G. , Chickering T.W. , Smutko J.S. , Zhou H. , Leiby K.R. , Holmgren L.M. , Gearing D.P. , Pan Y.
      Genomics66:213-216(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    4. 4.
      "A sequence-based map of the nine genes of the human interleukin-1 cluster."
      Nicklin M.J.H. , Barton J.L. , Nguyen M. , Fitzgerald M.G. , Duff W.G. , Kornman K.
      Genomics79:718-725(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    5. 5.
      "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
      Clark H.F. , Gurney A.L. , Abaya E. , Baker K. , Baldwin D.T. , Brush J. , Chen J. , Chow B. , Chui C. , Crowley C. , Currell B. , Deuel B. , Dowd P. , Eaton D. , Foster J.S. , Grimaldi C. , Gu Q. , Hass P.E. , more...
      Genome Res.13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
    6. 6.
      SeattleSNPs variation discovery resource
      Submitted (2005-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    7. 7.
      "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
      Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    9. 9.
      "Regulation and function of the IL-1 family cytokine IL-1F9 in human bronchial epithelial cells."
      Chustz R.T. , Nagarkar D.R. , Poposki J.A. , Favoreto S. Jr. , Avila P.C. , Schleimer R.P. , Kato A.
      Am. J. Respir. Cell Mol. Biol.45:145-153(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;SUBCELLULAR LOCATION
    10. 10.
      "Interleukin-36 (IL-36) ligands require processing for full agonist (IL-36alpha, IL-36beta, and IL-36gamma) or antagonist (IL-36Ra) activity."
      Towne J.E. , Renshaw B.R. , Douangpanya J. , Lipsky B.P. , Shen M. , Gabel C.A. , Sims J.E.
      J. Biol. Chem.286:42594-42602(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PROCESSING
    11. 11.
      "IL-36gamma/IL-1F9, an innate T-bet target in myeloid cells."
      Bachmann M. , Scheiermann P. , Hardle L. , Pfeilschifter J. , Muhl H.
      J. Biol. Chem.287:41684-41696(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
    12. 12.
      "The IL-36 receptor pathway regulates Aspergillus fumigatus-induced Th1 and Th17 responses."
      Gresnigt M.S. , Roesler B. , Jacobs C.W. , Becker K.L. , Joosten L.A. , van der Meer J.W. , Netea M.G. , Dinarello C.A. , van de Veerdonk F.L.
      Eur. J. Immunol.43:416-426(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION
    13. 13.
      "IL-36 promotes myeloid cell infiltration, activation, and inflammatory activity in skin."
      Foster A.M. , Baliwag J. , Chen C.S. , Guzman A.M. , Stoll S.W. , Gudjonsson J.E. , Ward N.L. , Johnston A.
      J. Immunol.192:6053-6061(2014) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
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