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Index > Protein center > IL4R(Gene name) > Human
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  • IL4R (Gene name),
  • Interleukin-4 receptor subunit alpha (Protein name ),  IL4RA_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    IL4R(582J2.1;IL4RA);
    Protein name:
    Interleukin-4 receptor subunit alpha(IL-4 receptor subunit alpha;IL-4R subunit alpha;IL-4R-alpha;IL-4RA);
    Alternative:

    CD:
    CD124;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    The functional IL4 receptor is formed by initial binding of IL4 to IL4R. Subsequent recruitment to the complex of the common gamma chain, in immune cells, creates a type I receptor and, in non-immune cells, of IL13RA1 forms a type II receptor. IL4R can also interact with the IL13/IL13RA1 complex to form a similar type II receptor. Interacts with PIK3C3 (By similarity). Interacts with the SH2-containing phosphatases, PTPN6/SHIP1, PTPN11/SHIP2 and INPP5D/SHIP (By similarity). Interacts with JAK1 through a Box 1-containing region. In Th1 cells, binds the N-terminal 50 amino acids of SOCS5, which inhibits JAK1 interaction, STAT6 activation and Th2 cell differentiation. SOCS5 interaction is independent of tyrosine phosphorylation.
    Function:
    Soluble IL4R (sIL4R) inhibits IL4-mediated cell proliferation and IL5 up-regulation by T-cells.
    Subcellular Location:
    Isoform 2 Secreted
    Protein Attributes:
    Sequence length:
    825
    Sequence:
    50:
    MGWLCSGLLF | PVSCLVLLQV | ASSGNMKVLQ | EPTCVSDYMS | ISTCEWKMNG | 
    100:
    PTNCSTELRL | LYQLVFLLSE | AHTCIPENNG | GAGCVCHLLM | DDVVSADNYT | 
    150:
    LDLWAGQQLL | WKGSFKPSEH | VKPRAPGNLT | VHTNVSDTLL | LTWSNPYPPD | 
    200:
    NYLYNHLTYA | VNIWSENDPA | DFRIYNVTYL | EPSLRIAAST | LKSGISYRAR | 
    250:
    VRAWAQCYNT | TWSEWSPSTK | WHNSYREPFE | QHLLLGVSVS | CIVILAVCLL | 
    300:
    CYVSITKIKK | EWWDQIPNPA | RSRLVAIIIQ | DAQGSQWEKR | SRGQEPAKCP | 
    350:
    HWKNCLTKLL | PCFLEHNMKR | DEDPHKAAKE | MPFQGSGKSA | WCPVEISKTV | 
    400:
    LWPESISVVR | CVELFEAPVE | CEEEEEVEEE | KGSFCASPES | SRDDFQEGRE | 
    450:
    GIVARLTESL | FLDLLGEENG | GFCQQDMGES | CLLPPSGSTS | AHMPWDEFPS | 
    500:
    AGPKEAPPWG | KEQPLHLEPS | PPASPTQSPD | NLTCTETPLV | IAGNPAYRSF | 
    550:
    SNSLSQSPCP | RELGPDPLLA | RHLEEVEPEM | PCVPQLSEPT | TVPQPEPETW | 
    600:
    EQILRRNVLQ | HGAAAAPVSA | PTSGYQEFVH | AVEQGGTQAS | AVVGLGPPGE | 
    650:
    AGYKAFSSLL | ASSAVSPEKC | GFGASSGEEG | YKPFQDLIPG | CPGDPAPVPV | 
    700:
    PLFTFGLDRE | PPRSPQSSHL | PSSSPEHLGL | EPGEKVEDMP | KPPLPQEQAT | 
    750:
    DPLVDSLGSG | IVYSALTCHL | CGHLKQCHGQ | EDGGQTPVMA | SPCCGCCCGD | 
    800:
    RSSPPTTPLR | APDPSPGGVP | LEASLCPASL | APSGISEKSK | SSSSFHPAPG | 
    825:
    NAQSSSQTPK | IVNFVSVGPT | YMRVS
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    Pfam:
    MIM:
    UniGene:
    SMR:
    String:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human IL-4 receptor subunit alpha
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    E2031h
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    ELISA Kit for Human IL-4 receptor subunit alpha
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    E2031m
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    ELISA Kit for Human IL-4 receptor subunit alpha
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    E2031r
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    ELISA Kit for Human IL-4 receptor subunit alpha
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    E2031p
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    96T
    CLIA Kit for Human IL-4 receptor subunit alpha
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    U2031r
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    Packing:
    96T
    CLIA Kit for Human IL-4 receptor subunit alpha
    Cat.:
    U2031m
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    Packing:
    96T
    CLIA Kit for Human IL-4 receptor subunit alpha
    Cat.:
    U2031p
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human IL-4 receptor subunit alpha
    Cat.:
    U2031h
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    Polyclonal Antibody for Human IL-4 receptor subunit alpha
    Cat.:
    P2031Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human IL-4 receptor subunit alpha
    Polyclonal Antibody for Human IL-4 receptor subunit alpha
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    P2031Rb-r
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human IL-4 receptor subunit alpha
    Cat.:
    P2031Rb-h
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human IL-4 receptor subunit alpha
    Monoclonal Antibody for Human IL-4 receptor subunit alpha
    Monoclonal Antibody for Human IL-4 receptor subunit alpha
    Monoclonal Antibody for Human IL-4 receptor subunit alpha
    Protein for Human IL-4 receptor subunit alpha
    Protein for Human IL-4 receptor subunit alpha
    Protein for Human IL-4 receptor subunit alpha
    Protein for Human IL-4 receptor subunit alpha

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Human interleukin 4 receptor confers biological responsiveness and defines a novel receptor superfamily."
      Idzerda R.L. , March C.J. , Mosley B. , Lyman S.D. , Bos T.V. , Gimpel S.D. , Din W.S. , Grabstein K.H. , Widmer M.B. , Park L.S. , Cosman D. , Beckmann M.P.
      J. Exp. Med.171:861-873(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Peripheral blood.
    2. 2.
      "Molecular cloning of a cDNA encoding the human interleukin 4 receptor."
      Galizzi J.-P. , Zuber C.E. , Harada N. , Gorman D.M. , Djossou O. , Kastelein R. , Banchereau J. , Howard M. , Miyajima A.
      Int. Immunol.2:669-675(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Myeloid leukemia cell.
    3. 3.
      "Characterization of the membrane-bound and a soluble form of human IL-4 receptor alpha produced by alternative splicing."
      Kruse S. , Forster J. , Kuehr J. , Deichmann K.A.
      Int. Immunol.11:1965-1970(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];ALTERNATIVE SPLICING
      tissue: Blood.
    4. 4.
      "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q."
      Loftus B.J. , Kim U.-J. , Sneddon V.P. , Kalush F. , Brandon R. , Fuhrmann J. , Mason T. , Crosby M.L. , Barnstead M. , Cronin L. , Mays A.D. , Cao Y. , Xu R.X. , Kang H.-L. , Mitchell S. , Eichler E.E. , Harris P.C. , Venter J.C. , more...
      Genomics60:295-308(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORM 1)
    5. 5.
      SeattleSNPs variation discovery resource
      Submitted (2001-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS VAL-75; ALA-400; ARG-431; LEU-436; PRO-503; ARG-576; ILE-579; SER-675 AND ALA-752
    6. 6.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
      tissue: Thymus.
    7. 7.
      "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J. , Han C. , Gordon L.A. , Terry A. , Prabhakar S. , She X. , Xie G. , Hellsten U. , Chan Y.M. , Altherr M. , Couronne O. , Aerts A. , Bajorek E. , Black S. , Blumer H. , Branscomb E. , Brown N.C. , Bruno W.J. , more...
      Nature432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Testis.
    9. 9.
      "Identification of a novel single-nucleotide polymorphism (Val554Ile) and definition of eight common alleles for human IL4RA exon 11."
      Lozano F. , Places L. , Vila J.-M. , Padilla O. , Arman M. , Gimferrer I. , Suarez B. , Lopez de la Iglesia A. , Miserachs N. , Vives J.
      Tissue Antigens57:216-220(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 301-825 (ISOFORM 1);VARIANTS ALA-400; ARG-431; LEU-436; PRO-503; ARG-576 AND ILE-579
    10. 10.
      "An IL-4 receptor region containing an insulin receptor motif is important for IL-4-mediated IRS-1 phosphorylation and cell growth."
      Keegan A.D. , Nelms K. , White M. , Wang L.-M. , Pierce J.H. , Paul W.E.
      Cell76:811-820(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN IRS1 ACTIVATION;MUTAGENESIS OF TYR-497
    11. 11.
      "Activation of JAK3, but not JAK1, is critical to interleukin-4 (IL4) stimulated proliferation and requires a membrane-proximal region of IL4 receptor alpha."
      Malabarba M.G. , Kirken R.A. , Rui H. , Koettnitz K. , Kawamura M. , O'Shea J.J. , Kalthoff F.S. , Farrar W.L.
      J. Biol. Chem.270:9630-9637(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DOMAIN JAK3 ACTIVATION
    12. 12.
      "The primary binding subunit of the human interleukin-4 receptor is also a component of the interleukin-13 receptor."
      Zurawski S.M. , Chomarat P. , Djossou O. , Bidaud C. , McKenzie A.N. , Miossec P. , Banchereau J. , Zurawski G.
      J. Biol. Chem.270:13869-13878(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH IL13RA1
    13. 13.
      "JAK3 associates with the human interleukin 4 receptor and is tyrosine phosphorylated following receptor triggering."
      Rolling C. , Treton D. , Beckmann P. , Galanaud P. , Richard Y.
      Oncogene10:1757-1761(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH JAK3
    14. 14.
      "IL4 and IL13 receptors share the gamma c chain and activate STAT6, STAT3 and STAT5 proteins in normal human B cells."
      Rolling C. , Treton D. , Pellegrini S. , Galanaud P. , Richard Y.
      FEBS Lett.393:53-56(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH IL13RA1;PHOSPHORYLATION
    15. 15.
      "Growth and gene expression are predominantly controlled by distinct regions of the human IL-4 receptor."
      Ryan J.J. , McReynolds L.J. , Keegan A. , Wang L.-H. , Garfein E. , Rothman P. , Nelms K. , Paul W.E.
      Immunity4:123-132(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DOMAIN STAT6 ACTIVATION;MUTAGENESIS OF TYR-575; TYR-603 AND TYR-631
    16. 16.
      "Soluble human interleukin-4 receptor is produced by activated T cells under the control of metalloproteinases."
      Jung T. , Schrader N. , Hellwig M. , Enssle K.H. , Neumann C.
      Int. Arch. Allergy Immunol.119:23-30(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEOLYTIC PROCESSING
    17. 17.
      "Immunoreceptor tyrosine-based inhibitory motif of the IL-4 receptor associates with SH2-containing phosphatases and regulates IL-4-induced proliferation."
      Kashiwada M. , Giallourakis C.C. , Pan P.-Y. , Rothman P.B.
      J. Immunol.167:6382-6387(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PTPN6; PTPN11 AND INPP5D;STAT6 ACTIVATION;MUTAGENESIS OF TYR-713
    18. 18.
      "The high-affinity interaction of human IL-4 and the receptor alpha chain is constituted by two independent binding clusters."
      Zhang J.-L. , Simeonowa I. , Wang Y. , Sebald W.
      J. Mol. Biol.315:399-407(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: LIGAND-BINDING SITES;MUTAGENESIS OF TYR-38; MET-39; SER-40; LEU-64; PHE-66; LEU-67; LEU-68; ASP-91; ASP-92; VAL-93; VAL-94; SER-95; ASP-97; ASN-98; TYR-99; LYS-116; PRO-117; SER-118; GLU-119; ASP-150; ASN-151; TYR-152; LEU-153; TYR-154 AND TYR-208
    19. 19.
      "Regulation of the dephosphorylation of Stat6. Participation of Tyr-713 in the interleukin-4 receptor alpha, the tyrosine phosphatase SHP-1, and the proteasome."
      Hanson E.M. , Dickensheets H. , Qu C.K. , Donnelly R.P. , Keegan A.D.
      J. Biol. Chem.278:3903-3911(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STAT6 ACTIVATION;INHIBITION BY TYROSINE PHOSPHATASE SHP1
    20. 20.
      "Crystal structure of the interleukin-4/receptor alpha chain complex reveals a mosaic binding interface."
      Hage T. , Sebald W. , Reinemer P.
      Cell97:271-281(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 26-232 IN COMPLEX WITH IL4
    21. 21.
      "Common polymorphisms in the coding part of the IL4-receptor gene."
      Deichmann K. , Bardutzky J. , Forster J. , Heinzmann A. , Kuehr J.
      Biochem. Biophys. Res. Commun.231:696-697(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS VAL-75; ALA-400; ARG-431; LEU-436 AND PRO-786
    22. 22.
      "The association of atopy with a gain-of-function mutation in the alpha subunit of the interleukin-4 receptor."
      Hershey G.K.K. , Friedrich M.F. , Esswein L.A. , Thomas M.L. , Chatila T.A.
      N. Engl. J. Med.337:1720-1725(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ARG-576
    23. 23.
      "Ile50Val variant of IL4R alpha upregulates IgE synthesis and associates with atopic asthma."
      Mitsuyasu H. , Izuhara K. , Mao X.-Q. , Gao P.S. , Arinobu Y. , Enomoto T. , Kawai M. , Sasaki S. , Dake Y. , Hamasaki N. , Shirakawa T. , Hopkin J.M.
      Nat. Genet.19:119-120(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT VAL-75
    24. 24.
      "No association between atopy/asthma and the Ile50Val polymorphism of IL-4 receptor."
      Noguchi E. , Shibasaki M. , Arinami T. , Takeda K. , Yokouchi Y. , Kobayashi K. , Imoto N. , Nakahara S. , Matsui A. , Hamaguchi H.
      Am. J. Respir. Crit. Care Med.160:342-345(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT VAL-75
    25. 25.
      "The polymorphisms S503P and Q576R in the interleukin-4 receptor alpha gene are associated with atopy and influence the signal transduction."
      Kruse S. , Japha T. , Tedner M. , Sparholt S.H. , Forster J. , Kuehr J. , Deichmann K.A.
      Immunology96:365-371(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PRO-503 AND ARG-576
    26. 26.
      "Effects of an allergy-associated mutation in the human IL-4R alpha (Q576R) on human IL-4-induced signal transduction."
      Wang H.Y. , Shelburne C.P. , Zamorano J. , Kelly A.E. , Ryan J.J. , Keegan A.D.
      J. Immunol.162:4385-4389(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF VARIANT ARG-576;MUTAGENESIS OF TYR-575
    27. 27.
      "Variation in the interleukin 4-receptor alpha gene confers susceptibility to asthma and atopy in ethnically diverse populations."
      Ober C. , Leavitt S.A. , Tsalenko A. , Howard T.D. , Hoki D.M. , Daniel R. , Newman D.L. , Wu X. , Parry R. , Lester L.A. , Solway J. , Blumenthal M. , King R.A. , Xu J. , Meyers D.A. , Bleecker E.R. , Cox N.J.
      Am. J. Hum. Genet.66:517-526(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ALA-752
    28. 28.
      "Interleukin 4 receptor alpha chain polymorphism Gln551Arg is associated with adult atopic dermatitis in Japan."
      Oiso N. , Fukai K. , Ishii M.
      Br. J. Dermatol.142:1003-1006(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ARG-576
    29. 29.
      "Analysis of the Ser786Pro interleukin-4 receptor alpha allelic variant in allergic and nonallergic asthma and its functional consequences."
      Andrews R.P. , Burrell L. , Rosa-Rosa L. , Cunningham C.M. , Brzezinski J.L. , Bernstein J.A. , Khurana Hershey G.K.
      Clin. Immunol.100:298-304(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PRO-786
    30. 30.
      "High contribution contrast between the genes of eosinophil peroxidase and IL-4 receptor alpha-chain in Japanese cedar pollinosis."
      Nakamura H. , Miyagawa K. , Ogino K. , Endo T. , Imai T. , Ozasa K. , Motohashi Y. , Matsuzaki I. , Sasahara S. , Hatta K. , Eboshida A.
      J. Allergy Clin. Immunol.112:1127-1131(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS VAL-75 AND ALA-400;POLYMORPHISM
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