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Index > Protein center > IL6R(Gene name) > Human
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  • IL6R (Gene name),
  • Interleukin-6 receptor subunit alpha (Protein name ),  IL6RA_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    IL6R;
    Protein name:
    Interleukin-6 receptor subunit alpha(IL-6 receptor subunit alpha;IL-6R subunit alpha;IL-6R-alpha;IL-6RA);
    Alternative:
    Membrane glycoprotein 80(gp80);IL-6R 1;
    CD:
    CD126;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Hexamer of two molecules each of IL6, IL6R and IL6ST.
    Function:
    Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity.
    Subcellular Location:
    Isoform 2 Secreted
    Protein Attributes:
    Sequence length:
    468
    Sequence:
    50:
    MLAVGCALLA | ALLAAPGAAL | APRRCPAQEV | ARGVLTSLPG | DSVTLTCPGV | 
    100:
    EPEDNATVHW | VLRKPAAGSH | PSRWAGMGRR | LLLRSVQLHD | SGNYSCYRAG | 
    150:
    RPAGTVHLLV | DVPPEEPQLS | CFRKSPLSNV | VCEWGPRSTP | SLTTKAVLLV | 
    200:
    RKFQNSPAED | FQEPCQYSQE | SQKFSCQLAV | PEGDSSFYIV | SMCVASSVGS | 
    250:
    KFSKTQTFQG | CGILQPDPPA | NITVTAVARN | PRWLSVTWQD | PHSWNSSFYR | 
    300:
    LRFELRYRAE | RSKTFTTWMV | KDLQHHCVIH | DAWSGLRHVV | QLRAQEEFGQ | 
    350:
    GEWSEWSPEA | MGTPWTESRS | PPAENEVSTP | MQALTTNKDD | DNILFRDSAN | 
    400:
    ATSLPVQDSS | SVPLPTFLVA | GGSLAFGTLL | CIAIVLRFKK | TWKLRALKEG | 
    450:
    KTSMHPPYSL | GQLVPERPRP | TPVLVPLISP | PVSPSSLGSD | NTSSHNRPDA | 
    468:
    RDPRSPYDIS | NTDYFFPR
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    MIM:
    KEGG:
    UniGene:
    Pfam:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human IL-6 receptor subunit alpha
    Cat.:
    E1815h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human IL-6 receptor subunit alpha
    Cat.:
    E1815r
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    Please sign in first.
    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human IL-6 receptor subunit alpha
    Cat.:
    E1815p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human IL-6 receptor subunit alpha
    Cat.:
    U1815r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human IL-6 receptor subunit alpha
    Cat.:
    U1815h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human IL-6 receptor subunit alpha
    Cat.:
    U1815p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human IL-6 receptor subunit alpha
    Polyclonal Antibody for Human IL-6 receptor subunit alpha
    Cat.:
    P1815Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human IL-6 receptor subunit alpha
    Cat.:
    P1815Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human IL-6 receptor subunit alpha
    Monoclonal Antibody for Human IL-6 receptor subunit alpha
    Monoclonal Antibody for Human IL-6 receptor subunit alpha
    Protein for Human IL-6 receptor subunit alpha
    Protein for Human IL-6 receptor subunit alpha
    Protein for Human IL-6 receptor subunit alpha

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Cloning and expression of the human interleukin-6 (BSF-2/IFN beta 2) receptor."
      Yamasaki K. , Taga T. , Hirata Y. , Yawata H. , Kawanishi Y. , Seed B. , Taniguchi T. , Hirano T. , Kishimoto T.
      Science241:825-828(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    3. 3.
      "Structural and functional studies on the human hepatic interleukin-6 receptor. Molecular cloning and overexpression in HepG2 cells."
      Schooltink H. , Stoyan T. , Lenz D. , Schmitz H. , Hirano T. , Kishimoto T. , Heinrich P.C. , Rose-John S.
      Biochem. J.277:659-664(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2);VARIANT ALA-358
      tissue: Trachea.
    5. 5.
      Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S.
      Submitted (2005-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Kidney.
    6. 6.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Lymph.
    9. 9.
      "Soluble interleukin-6 receptors released from T cell or granulocyte/macrophage cell lines and human peripheral blood mononuclear cells are generated through an alternative splicing mechanism."
      Horiuchi S. , Koyanagi Y. , Zhou Y. , Miyamoto H. , Tanaka Y. , Waki M. , Matsumoto A. , Yamamoto M. , Yamamoto N.
      Eur. J. Immunol.24:1945-1948(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 313-365 (ISOFORM 2)
    10. 10.
      "Disulfide bond structure and N-glycosylation sites of the extracellular domain of the human interleukin-6 receptor."
      Cole A.R. , Hall N.E. , Treutlein H.R. , Eddes J.S. , Reid G.E. , Moritz R.L. , Simpson R.J.
      J. Biol. Chem.274:7207-7215(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL PROTEIN SEQUENCE;GLYCOSYLATION AT ASN-55; ASN-93 AND ASN-221;LACK OF GLYCOSYLATION AT ASN-245;DISULFIDE BONDS
    11. 11.
      "Soluble cytokine receptors are present in normal human urine."
      Novick D. , Engelmann H. , Wallach D. , Rubinstein M.
      J. Exp. Med.170:1409-1414(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 20-49;SUBCELLULAR LOCATION
    12. 12.
      "Structure-function analysis of human IL-6 receptor: dissociation of amino acid residues required for IL-6-binding and for IL-6 signal transduction through gp130."
      Yawata H. , Yasukawa K. , Natsuka S. , Murakami M. , Yamasaki K. , Hibi M. , Taga T. , Kishimoto T.
      EMBO J.12:1705-1712(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS
    13. 13.
      "The cytoplasmic domain of the interleukin-6 receptor gp80 mediates its basolateral sorting in polarized Madin-Darby canine kidney cells."
      Martens A.S. , Bode J.G. , Heinrich P.C. , Graeve L.
      J. Cell Sci.113:3593-3602(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    14. 14.
      "Increased association with detergent-resistant membranes/lipid rafts of apically targeted mutants of the interleukin-6 receptor gp80."
      Buk D.M. , Renner O. , Graeve L.
      Eur. J. Cell Biol.84:819-831(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
    15. 15.
      "Structure of the extracellular domains of the human interleukin-6 receptor alpha-chain."
      Varghese J.N. , Moritz R.L. , Lou M.-Z. , Van Donkelaar A. , Ji H. , Ivancic N. , Branson K.M. , Hall N.E. , Simpson R.J.
      Proc. Natl. Acad. Sci. U.S.A.99:15959-15964(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 20-344
    16. 16.
      "Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex."
      Boulanger M.J. , Chow D.-C. , Brevnova E.E. , Garcia K.C.
      Science300:2101-2104(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.65 ANGSTROMS) OF 115-315
    17. 17.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POLYMORPHISM;VARIANT ALA-358;ASSOCIATION OF VARIANT ALA-358 WITH IL6 AND SOLUBLE IL6R SERUM LEVELS
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