Protein name:
Interleukin-6 receptor subunit alpha (IL-6 receptor subunit alpha;IL-6R subunit alpha;IL-6R-alpha;IL-6RA) ;
Alternative:
Membrane glycoprotein 80 (gp80) ;IL-6R 1 ;
CD:
CD126 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Hexamer of two molecules each of IL6, IL6R and IL6ST.
Function:
Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity.
Subcellular Location:
Isoform 2
Secreted
Protein Attributes:
50:
MLAVGCALLA | ALLAAPGAAL | APRRCPAQEV | ARGVLTSLPG | DSVTLTCPGV |
100:
EPEDNATVHW | VLRKPAAGSH | PSRWAGMGRR | LLLRSVQLHD | SGNYSCYRAG |
150:
RPAGTVHLLV | DVPPEEPQLS | CFRKSPLSNV | VCEWGPRSTP | SLTTKAVLLV |
200:
RKFQNSPAED | FQEPCQYSQE | SQKFSCQLAV | PEGDSSFYIV | SMCVASSVGS |
250:
KFSKTQTFQG | CGILQPDPPA | NITVTAVARN | PRWLSVTWQD | PHSWNSSFYR |
300:
LRFELRYRAE | RSKTFTTWMV | KDLQHHCVIH | DAWSGLRHVV | QLRAQEEFGQ |
350:
GEWSEWSPEA | MGTPWTESRS | PPAENEVSTP | MQALTTNKDD | DNILFRDSAN |
400:
ATSLPVQDSS | SVPLPTFLVA | GGSLAFGTLL | CIAIVLRFKK | TWKLRALKEG |
450:
KTSMHPPYSL | GQLVPERPRP | TPVLVPLISP | PVSPSSLGSD | NTSSHNRPDA |
468:
RDPRSPYDIS | NTDYFFPR
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Pig
ELISA Kit for Human IL-6 receptor subunit alpha
ELISA Kit for Human IL-6 receptor subunit alpha
ELISA Kit for Human IL-6 receptor subunit alpha
CLIA Kit for Human IL-6 receptor subunit alpha
CLIA Kit for Human IL-6 receptor subunit alpha
CLIA Kit for Human IL-6 receptor subunit alpha
Polyclonal Antibody for Human IL-6 receptor subunit alpha
Polyclonal Antibody for Human IL-6 receptor subunit alpha
Polyclonal Antibody for Human IL-6 receptor subunit alpha
Monoclonal Antibody for Human IL-6 receptor subunit alpha
Monoclonal Antibody for Human IL-6 receptor subunit alpha
Monoclonal Antibody for Human IL-6 receptor subunit alpha
Protein for Human IL-6 receptor subunit alpha
Protein for Human IL-6 receptor subunit alpha
Protein for Human IL-6 receptor subunit alpha
R&D Technical Data
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Precision
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Recovery
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Linearity
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
2.
"Molecular structure of interleukin 6 receptor."
Yamasaki K.
,
Taga T.
,
Hirata Y.
,
Yawata H.
,
Kawanishi Y.
,
Seed B.
,
Taniguchi T.
,
Hirano T.
,
Kishimoto T.
Proc. Jpn. Acad., B, Phys. Biol. Sci.64:209-211(1988)
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
4.
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T.
,
Suzuki Y.
,
Nishikawa T.
,
Otsuki T.
,
Sugiyama T.
,
Irie R.
,
Wakamatsu A.
,
Hayashi K.
,
Sato H.
,
Nagai K.
,
Kimura K.
,
Makita H.
,
Sekine M.
,
Obayashi M.
,
Nishi T.
,
Shibahara T.
,
Tanaka T.
,
Ishii S.
,
Yamamoto J.
,
Saito K.
,
Kawai Y.
,
Isono Y.
,
Nakamura Y.
,
Nagahari K.
,
Murakami K.
,
Yasuda T.
,
Iwayanagi T.
,
Wagatsuma M.
,
Shiratori A.
,
Sudo H.
,
Hosoiri T.
,
Kaku Y.
,
Kodaira H.
,
Kondo H.
,
Sugawara M.
,
Takahashi M.
,
Kanda K.
,
Yokoi T.
,
Furuya T.
,
Kikkawa E.
,
Omura Y.
,
Abe K.
,
Kamihara K.
,
Katsuta N.
,
Sato K.
,
Tanikawa M.
,
Yamazaki M.
,
Ninomiya K.
,
Ishibashi T.
,
Yamashita H.
,
Murakawa K.
,
Fujimori K.
,
Tanai H.
,
Kimata M.
,
Watanabe M.
,
Hiraoka S.
,
Chiba Y.
,
Ishida S.
,
Ono Y.
,
Takiguchi S.
,
Watanabe S.
,
Yosida M.
,
Hotuta T.
,
Kusano J.
,
Kanehori K.
,
Takahashi-Fujii A.
,
Hara H.
,
Tanase T.-O.
,
Nomura Y.
,
Togiya S.
,
Komai F.
,
Hara R.
,
Takeuchi K.
,
Arita M.
,
Imose N.
,
Musashino K.
,
Yuuki H.
,
Oshima A.
,
Sasaki N.
,
Aotsuka S.
,
Yoshikawa Y.
,
Matsunawa H.
,
Ichihara T.
,
Shiohata N.
,
Sano S.
,
Moriya S.
,
Momiyama H.
,
Satoh N.
,
Takami S.
,
Terashima Y.
,
Suzuki O.
,
Nakagawa S.
,
Senoh A.
,
Mizoguchi H.
,
Goto Y.
,
Shimizu F.
,
Wakebe H.
,
Hishigaki H.
,
Watanabe T.
,
Sugiyama A.
,
Takemoto M.
,
Kawakami B.
,
Yamazaki M.
,
Watanabe K.
,
Kumagai A.
,
Itakura S.
,
Fukuzumi Y.
,
Fujimori Y.
,
Komiyama M.
,
Tashiro H.
,
Tanigami A.
,
Fujiwara T.
,
Ono T.
,
Yamada K.
,
Fujii Y.
,
Ozaki K.
,
Hirao M.
,
Ohmori Y.
,
Kawabata A.
,
Hikiji T.
,
Kobatake N.
,
Inagaki H.
,
Ikema Y.
,
Okamoto S.
,
Okitani R.
,
Kawakami T.
,
Noguchi S.
,
Itoh T.
,
Shigeta K.
,
Senba T.
,
Matsumura K.
,
Nakajima Y.
,
Mizuno T.
,
Morinaga M.
,
Sasaki M.
,
Togashi T.
,
Oyama M.
,
Hata H.
,
Watanabe M.
,
Komatsu T.
,
Mizushima-Sugano J.
,
Satoh T.
,
Shirai Y.
,
Takahashi Y.
,
Nakagawa K.
,
Okumura K.
,
Nagase T.
,
Nomura N.
,
Kikuchi H.
,
Masuho Y.
,
Yamashita R.
,
Nakai K.
,
Yada T.
,
Nakamura Y.
,
Ohara O.
,
Isogai T.
,
Sugano S.
more...
Nat. Genet.36:40-45(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2);VARIANT ALA-358
tissue :
Trachea .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Kidney .
6.
"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G.
,
Barlow K.F.
,
McLay K.E.
,
Kaul R.
,
Swarbreck D.
,
Dunham A.
,
Scott C.E.
,
Howe K.L.
,
Woodfine K.
,
Spencer C.C.A.
,
Jones M.C.
,
Gillson C.
,
Searle S.
,
Zhou Y.
,
Kokocinski F.
,
McDonald L.
,
Evans R.
,
Phillips K.
,
Atkinson A.
,
Cooper R.
,
Jones C.
,
Hall R.E.
,
Andrews T.D.
,
Lloyd C.
,
Ainscough R.
,
Almeida J.P.
,
Ambrose K.D.
,
Anderson F.
,
Andrew R.W.
,
Ashwell R.I.S.
,
Aubin K.
,
Babbage A.K.
,
Bagguley C.L.
,
Bailey J.
,
Beasley H.
,
Bethel G.
,
Bird C.P.
,
Bray-Allen S.
,
Brown J.Y.
,
Brown A.J.
,
Buckley D.
,
Burton J.
,
Bye J.
,
Carder C.
,
Chapman J.C.
,
Clark S.Y.
,
Clarke G.
,
Clee C.
,
Cobley V.
,
Collier R.E.
,
Corby N.
,
Coville G.J.
,
Davies J.
,
Deadman R.
,
Dunn M.
,
Earthrowl M.
,
Ellington A.G.
,
Errington H.
,
Frankish A.
,
Frankland J.
,
French L.
,
Garner P.
,
Garnett J.
,
Gay L.
,
Ghori M.R.J.
,
Gibson R.
,
Gilby L.M.
,
Gillett W.
,
Glithero R.J.
,
Grafham D.V.
,
Griffiths C.
,
Griffiths-Jones S.
,
Grocock R.
,
Hammond S.
,
Harrison E.S.I.
,
Hart E.
,
Haugen E.
,
Heath P.D.
,
Holmes S.
,
Holt K.
,
Howden P.J.
,
Hunt A.R.
,
Hunt S.E.
,
Hunter G.
,
Isherwood J.
,
James R.
,
Johnson C.
,
Johnson D.
,
Joy A.
,
Kay M.
,
Kershaw J.K.
,
Kibukawa M.
,
Kimberley A.M.
,
King A.
,
Knights A.J.
,
Lad H.
,
Laird G.
,
Lawlor S.
,
Leongamornlert D.A.
,
Lloyd D.M.
,
Loveland J.
,
Lovell J.
,
Lush M.J.
,
Lyne R.
,
Martin S.
,
Mashreghi-Mohammadi M.
,
Matthews L.
,
Matthews N.S.W.
,
McLaren S.
,
Milne S.
,
Mistry S.
,
Moore M.J.F.
,
Nickerson T.
,
O'Dell C.N.
,
Oliver K.
,
Palmeiri A.
,
Palmer S.A.
,
Parker A.
,
Patel D.
,
Pearce A.V.
,
Peck A.I.
,
Pelan S.
,
Phelps K.
,
Phillimore B.J.
,
Plumb R.
,
Rajan J.
,
Raymond C.
,
Rouse G.
,
Saenphimmachak C.
,
Sehra H.K.
,
Sheridan E.
,
Shownkeen R.
,
Sims S.
,
Skuce C.D.
,
Smith M.
,
Steward C.
,
Subramanian S.
,
Sycamore N.
,
Tracey A.
,
Tromans A.
,
Van Helmond Z.
,
Wall M.
,
Wallis J.M.
,
White S.
,
Whitehead S.L.
,
Wilkinson J.E.
,
Willey D.L.
,
Williams H.
,
Wilming L.
,
Wray P.W.
,
Wu Z.
,
Coulson A.
,
Vaudin M.
,
Sulston J.E.
,
Durbin R.M.
,
Hubbard T.
,
Wooster R.
,
Dunham I.
,
Carter N.P.
,
McVean G.
,
Ross M.T.
,
Harrow J.
,
Olson M.V.
,
Beck S.
,
Rogers J.
,
Bentley D.R.
more...
Nature441:315-321(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.
Mural R.J.
,
Istrail S.
,
Sutton G.G.
,
Florea L.
,
Halpern A.L.
,
Mobarry C.M.
,
Lippert R.
,
Walenz B.
,
Shatkay H.
,
Dew I.
,
Miller J.R.
,
Flanigan M.J.
,
Edwards N.J.
,
Bolanos R.
,
Fasulo D.
,
Halldorsson B.V.
,
Hannenhalli S.
,
Turner R.
,
Yooseph S.
,
Lu F.
,
Nusskern D.R.
,
Shue B.C.
,
Zheng X.H.
,
Zhong F.
,
Delcher A.L.
,
Huson D.H.
,
Kravitz S.A.
,
Mouchard L.
,
Reinert K.
,
Remington K.A.
,
Clark A.G.
,
Waterman M.S.
,
Eichler E.E.
,
Adams M.D.
,
Hunkapiller M.W.
,
Myers E.W.
,
Venter J.C.
more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue :
Lymph .
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 313-365 (ISOFORM 2)
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PARTIAL PROTEIN SEQUENCE;GLYCOSYLATION AT ASN-55; ASN-93 AND ASN-221;LACK OF GLYCOSYLATION AT ASN-245;DISULFIDE BONDS
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 20-49;SUBCELLULAR LOCATION
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : MUTAGENESIS
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 20-344
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (3.65 ANGSTROMS) OF 115-315
17.
"Admixture mapping of an allele affecting interleukin 6 soluble receptor and interleukin 6 levels."
Health, Aging and Body Composition (Health ABC) Study
,
Reich D.
,
Patterson N.
,
Ramesh V.
,
De Jager P.L.
,
McDonald G.J.
,
Tandon A.
,
Choy E.
,
Hu D.
,
Tamraz B.
,
Pawlikowska L.
,
Wassel-Fyr C.
,
Huntsman S.
,
Waliszewska A.
,
Rossin E.
,
Li R.
,
Garcia M.
,
Reiner A.
,
Ferrell R.
,
Cummings S.
,
Kwok P.Y.
,
Harris T.
,
Zmuda J.M.
,
Ziv E.
more...
Am. J. Hum. Genet.80:716-726(2007)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : POLYMORPHISM;VARIANT ALA-358;ASSOCIATION OF VARIANT ALA-358 WITH IL6 AND SOLUBLE IL6R SERUM LEVELS