Gene name:
IFNAR1 (IFNAR) ;
Protein name:
Interferon alpha/beta receptor 1 (IFN-R-1;IFN-alpha/beta receptor 1) ;
Alternative:
Cytokine receptor family 2 member 1 (CRF2-1) ;Cytokine receptor class-II member 1 ;Type I interferon receptor 1 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Heterodimer with IFNAR2; in presence of interferon alpha and beta ligands, the heterodimer forms the type I interferon receptor. Interacts with STAT1 and STAT2; the interaction requires its phosphorylation at Tyr-466. Interacts with IFNAR2.
Function:
Associates with IFNAR2 to form the type I interferon receptor. Receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves.
Subcellular Location:
Isoform 1
Membrane
Single-pass type I membrane protein
Protein Attributes:
50:
MMVVLLGATT | LVLVAVAPWV | LSAAAGGKNL | KSPQKVEVDI | IDDNFILRWN |
100:
RSDESVGNVT | FSFDYQKTGM | DNWIKLSGCQ | NITSTKCNFS | SLKLNVYEEI |
150:
KLRIRAEKEN | TSSWYEVDSF | TPFRKAQIGP | PEVHLEAEDK | AIVIHISPGT |
200:
KDSVMWALDG | LSFTYSLVIW | KNSSGVEERI | ENIYSRHKIY | KLSPETTYCL |
250:
KVKAALLTSW | KIGVYSPVHC | IKTTVENELP | PPENIEVSVQ | NQNYVLKWDY |
300:
TYANMTFQVQ | WLHAFLKRNP | GNHLYKWKQI | PDCENVKTTQ | CVFPQNVFQK |
350:
GIYLLRVQAS | DGNNTSFWSE | EIKFDTEIQA | FLLPPVFNIR | SLSDSFHIYI |
400:
GAPKQSGNTP | VIQDYPLIYE | IIFWENTSNA | ERKIIEKKTD | VTVPNLKPLT |
450:
VYCVKARAHT | MDEKLNKSSV | FSDAVCEKTK | PGNTSKIWLI | VGICIALFAL |
500:
PFVIYAAKVF | LRCINYVFFP | SLKPSSSIDE | YFSEQPLKNL | LLSTSEEQIE |
550:
KCFIIENIST | IATVEETNQT | DEDHKKYSSQ | TSQDSGNYSN | EDESESKTSE |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Bovine
Mouse
Pig
ELISA Kit for Human IFN-R-1
ELISA Kit for Human IFN-R-1
ELISA Kit for Human IFN-R-1
ELISA Kit for Human IFN-R-1
CLIA Kit for Human IFN-R-1
CLIA Kit for Human IFN-R-1
CLIA Kit for Human IFN-R-1
CLIA Kit for Human IFN-R-1
Polyclonal Antibody for Human IFN-R-1
Polyclonal Antibody for Human IFN-R-1
Polyclonal Antibody for Human IFN-R-1
Polyclonal Antibody for Human IFN-R-1
Monoclonal Antibody for Human IFN-R-1
Monoclonal Antibody for Human IFN-R-1
Monoclonal Antibody for Human IFN-R-1
Monoclonal Antibody for Human IFN-R-1
Protein for Human IFN-R-1
Protein for Human IFN-R-1
Protein for Human IFN-R-1
Protein for Human IFN-R-1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT LEU-168
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT LEU-168
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Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4)
tissue :
Lung .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT LEU-168
tissue :
Liver .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS ILE-307 AND MET-359
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Brain .
tissue :
Ovary .
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 398-514 (ISOFORM 3);NUCLEOTIDE SEQUENCE [MRNA] OF 419-557 (ISOFORM 2);TISSUE SPECIFICITY;ALTERNATIVE SPLICING
tissue :
Myeloma .
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION BY TYK2
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH STAT1 AND STAT2
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH IFNAR2
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PALMITOYLATION AT CYS-463
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-58; ASN-110 AND ASN-313
tissue :
Leukemic T-cell .
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-495;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Leukemic T-cell .
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Cell146:621-632(2011)
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Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (3.5 ANGSTROMS) OF 28-436 IN COMPLEX WITH IFNAR2 AND IFNW1;DISULFIDE BONDS;GLYCOSYLATION AT ASN-172