IFNAR2 ELISA Kit for Human(Homo sapiens) | EIAab.comIFNAR2 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > IFNAR2(Gene name) > Human

IFNAR2 (Gene name),

Interferon alpha/beta receptor 2 (Protein name ), INAR2_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

IFNAR2(IFNABR;IFNARB);

Protein name:

Interferon alpha/beta receptor 2(IFN-R-2;IFN-alpha binding protein;IFN-alpha/beta receptor 2);

Alternative:

Type I interferon receptor 2;Interferon alpha binding protein;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Heterodimer with IFNAR1; in presence of interferon alpha and/or beta ligands forms the type I interferon receptor. Isoform 1 interacts with the transcriptional factors STAT1 and STAT2. Interacts with JAK1.

Function:

Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 is a potent inhibitor of type I IFN receptor activity.

Subcellular Location:

Isoform 3 Secreted

Protein Attributes:

Sequence length:

515

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

515:

TSESDVDLGD | GYIMR

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

STRING:

9606.ENSP00000343957

UniGene:

Hs.708195

String:

P48551

KEGG:

hsa:3455

Pfam:

PF09294

SMR:

P48551

MIM:

602376

Uniprot:

P48551

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ELISA Kit for Human IFN-R-2

Cat.:

E1101h

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96T

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ELISA Kit for Human IFN-R-2

Cat.:

E1101m

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96T

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ELISA Kit for Human IFN-R-2

Cat.:

E1101b

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Packing:

96T

CLIA Kit for Human IFN-R-2

Cat.:

U1101m

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96T

CLIA Kit for Human IFN-R-2

Cat.:

U1101b

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Packing:

96T

CLIA Kit for Human IFN-R-2

Cat.:

U1101h

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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Polyclonal Antibody for Human IFN-R-2

Cat.:

P1101Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human IFN-R-2

Cat.:

P1101Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human IFN-R-2

Protein for Human IFN-R-2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"The human interferon alpha/beta receptor: characterization and molecular cloning."
Novick D. , Cohen B. , Rubinstein M.
Cell77:391-400(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);PARTIAL PROTEIN SEQUENCE;GLYCOSYLATION AT ASN-87 AND ASN-192;FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;VARIANT VAL-10
tissue: Monocyte.
2.

"Mutant U5A cells are complemented by an interferon-alpha beta receptor subunit generated by alternative processing of a new member of a cytokine receptor gene cluster."
Lutfalla G. , Holland S.J. , Cinato E. , Monneron D. , Reboul J. , Rogers N.C. , Smith J.M. , Stark G.R. , Gardiner K. , Mogensen K.E. , Kerr I.M. , Uze G.
EMBO J.14:5100-5108(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1; 2 AND 3);TISSUE SPECIFICITY
tissue: Lymphoblastoma.
3.

"Cloning and expression of a long form of the beta subunit of the interferon alpha beta receptor that is required for signaling."
Domanski P. , Witte M. , Kellum M. , Rubinstein M. , Hackett R. , Pitha P. , Colamonici O.R.
J. Biol. Chem.270:21606-21611(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION
tissue: Myeloma.
4.

"Soluble and membrane-anchored forms of the human IFN-alpha/beta receptor."
Novick D. , Cohen B. , Tal N. , Rubinstein M.
J. Leukoc. Biol.57:712-718(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3);PARTIAL PROTEIN SEQUENCE;FUNCTION;INTERACTION WITH JAK1;ALTERNATIVE SPLICING;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;PHOSPHORYLATION;VARIANT VAL-10
tissue: Blood.
5.

Cohen B. , Kim S.H. , Novick D. , Rubinstein M.
Submitted (1996-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT VAL-10
tissue: Blood.
6.

SeattleSNPs variation discovery resource
Submitted (2004-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS SER-8; VAL-10 AND VAL-196
7.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Uterus.
8.

"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
Submitted (2004-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
9.

"The DNA sequence of human chromosome 21."
Hattori M. , Fujiyama A. , Taylor T.D. , Watanabe H. , Yada T. , Park H.-S. , Toyoda A. , Ishii K. , Totoki Y. , Choi D.-K. , Groner Y. , Soeda E. , Ohki M. , Takagi T. , Sakaki Y. , Taudien S. , Blechschmidt K. , Polley A. , more...
Nature405:311-319(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
10.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
11.

"Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling."
Li X. , Leung S. , Kerr I.M. , Stark G.R.
Mol. Cell. Biol.17:2048-2056(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH STAT1 AND STAT2
12.

"Formation of a uniquely stable type I interferon receptor complex by interferon beta is dependent upon particular interactions between interferon beta and its receptor and independent of tyrosine phosphorylation."
Russell-Harde D. , Wagner T.C. , Perez H.D. , Croze E.
Biochem. Biophys. Res. Commun.255:539-544(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH IFNAR1
13.

"Interferon signaling is dependent on specific tyrosines located within the intracellular domain of IFNAR2c. Expression of IFNAR2c tyrosine mutants in U5A cells."
Wagner T.C. , Velichko S. , Vogel D. , Rani M.R. , Leung S. , Ransohoff R.M. , Stark G.R. , Perez H.D. , Croze E.
J. Biol. Chem.277:1493-1499(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION AT TYR-337 AND TYR-512;MUTAGENESIS OF TYR-269; TYR-306; TYR-316; TYR-318; TYR-337; TYR-411 AND TYR-512
14.

"STAT3 activation by type I interferons is dependent on specific tyrosines located in the cytoplasmic domain of interferon receptor chain 2c. Activation of multiple STATS proceeds through the redundant usage of two tyrosine residues."
Velichko S. , Wagner T.C. , Turkson J. , Jove R. , Croze E.
J. Biol. Chem.277:35635-35641(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION AT TYR-337 AND TYR-512;MUTAGENESIS OF TYR-269; TYR-306; TYR-316; TYR-318; TYR-337; TYR-411 AND TYR-512
15.

"The human type I interferon receptor: NMR structure reveals the molecular basis of ligand binding."
Chill J.H. , Quadt S.R. , Levy R. , Schreiber G. , Anglister J.
Structure11:791-802(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 28-237;DISULFIDE BONDS
16.

"Class II cytokine receptor gene cluster is a major locus for hepatitis B persistence."
Frodsham A.J. , Zhang L. , Dumpis U. , Taib N.A.M. , Best S. , Durham A. , Hennig B.J.W. , Hellier S. , Knapp S. , Wright M. , Chiaramonte M. , Bell J.I. , Graves M. , Whittle H.C. , Thomas H.C. , Thursz M.R. , Hill A.V.S.
Proc. Natl. Acad. Sci. U.S.A.103:9148-9153(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO HBV INFECTION;VARIANTS SER-8 AND VAL-10;CHARACTERIZATION OF VARIANT SER-8
17.

"Determination of the human type I interferon receptor binding site on human interferon-alpha2 by cross saturation and an NMR-based model of the complex."
Quadt-Akabayov S.R. , Chill J.H. , Levy R. , Kessler N. , Anglister J.
Protein Sci.15:2656-2668(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 28-239 IN COMPLEX WITH IFNA2;DISULFIDE BONDS
18.

"Intermolecular interactions in a 44 kDa interferon-receptor complex detected by asymmetric reverse-protonation and two-dimensional NOESY."
Nudelman I. , Akabayov S.R. , Schnur E. , Biron Z. , Levy R. , Xu Y. , Yang D. , Anglister J.
Biochemistry49:5117-5133(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 28-239 IN COMPLEX WITH IFNA2;DISULFIDE BONDS
19.

"Structural linkage between ligand discrimination and receptor activation by type I interferons."
Thomas C. , Moraga I. , Levin D. , Krutzik P.O. , Podoplelova Y. , Trejo A. , Lee C. , Yarden G. , Vleck S.E. , Glenn J.S. , Nolan G.P. , Piehler J. , Schreiber G. , Garcia K.C.
Cell146:621-632(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.5 ANGSTROMS) OF 28-436 IN COMPLEX WITH IFNAR1 AND IFNW1;DISULFIDE BONDS

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