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Index > Protein center > DIO1(Gene name) > Human
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  • DIO1 (Gene name),
  • Type I iodothyronine deiodinase (Protein name ),  IOD1_HUMAN from NCBI database.
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  • General Annotation
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  • Gene name:
    DIO1(ITDI1;TXDI1);
    Protein name:
    Type I iodothyronine deiodinase;
    Alternative:
    DIOI;5DI;Type-I 5'-deiodinase;Type 1 DI;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine). Plays a role in providing a source of plasma T3 by deiodination of T4 in peripheral tissues such as liver and kidney.
    Subcellular Location:
    Endoplasmic reticulum membrane Single-pass membrane protein
    Protein Attributes:
    Sequence length:
    249
    Sequence:
    50:
    MGLPQPGLWL | KRLWVLLEVA | VHVVVGKVLL | ILFPDRVKRN | ILAMGEKTGM | 
    100:
    TRNPHFSHDN | WIPTFFSTQY | FWFVLKVRWQ | RLEDTTELGG | LAPNCPVVRL | 
    150:
    SGQRCNIWEF | MQGNRPLVLN | FGSCTUPSFM | FKFDQFKRLI | EDFSSIADFL | 
    200:
    VIYIEEAHAS | DGWAFKNNMD | IRNHQNLQDR | LQAAHLLLAR | SPQCPVVVDT | 
    249:
    MQNQSSQLYA | ALPERLYIIQ | EGRILYKGKS | GPWNYNPEEV | RAVLEKLHS
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    KEGG:
    MIM:
    String:
    Pfam:
    UniGene:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human Type I iodothyronine deiodinase
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    E12262r
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    ELISA Kit for Human Type I iodothyronine deiodinase
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    E12262h
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    ELISA Kit for Human Type I iodothyronine deiodinase
    MSDS:
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    ELISA Kit for Human Type I iodothyronine deiodinase
    MSDS:
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    ELISA Kit for Human Type I iodothyronine deiodinase
    Cat.:
    E12262c
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    96T
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    ELISA Kit for Human Type I iodothyronine deiodinase
    Cat.:
    E12262m
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    Packing:
    96T
    ELISA Kit for Human Type I iodothyronine deiodinase
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    CLIA Kit for Human Type I iodothyronine deiodinase
    Cat.:
    U12262r
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Type I iodothyronine deiodinase
    Cat.:
    U12262m
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Type I iodothyronine deiodinase
    Cat.:
    U12262h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Type I iodothyronine deiodinase
    MSDS:
    Please sign in first.
    CLIA Kit for Human Type I iodothyronine deiodinase
    MSDS:
    Please sign in first.
    CLIA Kit for Human Type I iodothyronine deiodinase
    MSDS:
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    CLIA Kit for Human Type I iodothyronine deiodinase
    MSDS:
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    Polyclonal Antibody for Human Type I iodothyronine deiodinase
    Polyclonal Antibody for Human Type I iodothyronine deiodinase
    Polyclonal Antibody for Human Type I iodothyronine deiodinase
    Polyclonal Antibody for Human Type I iodothyronine deiodinase
    Polyclonal Antibody for Human Type I iodothyronine deiodinase
    Polyclonal Antibody for Human Type I iodothyronine deiodinase
    Polyclonal Antibody for Human Type I iodothyronine deiodinase
    Cat.:
    P12262Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Type I iodothyronine deiodinase
    Monoclonal Antibody for Human Type I iodothyronine deiodinase
    Monoclonal Antibody for Human Type I iodothyronine deiodinase
    Monoclonal Antibody for Human Type I iodothyronine deiodinase
    Monoclonal Antibody for Human Type I iodothyronine deiodinase
    Monoclonal Antibody for Human Type I iodothyronine deiodinase
    Monoclonal Antibody for Human Type I iodothyronine deiodinase
    Protein for Human Type I iodothyronine deiodinase
    Protein for Human Type I iodothyronine deiodinase
    Protein for Human Type I iodothyronine deiodinase
    Protein for Human Type I iodothyronine deiodinase
    Protein for Human Type I iodothyronine deiodinase
    Protein for Human Type I iodothyronine deiodinase
    Protein for Human Type I iodothyronine deiodinase

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    References
    1. 1.
      "Cloning and in vitro expression of the human selenoprotein, type I iodothyronine deiodinase."
      Mandel S.J. , Berry M.J. , Kieffer J.D. , Harney J.W. , Warne R.L. , Larsen P.R.
      J. Clin. Endocrinol. Metab.75:1133-1139(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      "Type I iodothyronine deiodinase splice variants in human liver."
      Wassen F.J.W.S. , Kuiper G.G.J.M. , Visser T.J.
      Submitted (2004-02) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4; 5; 6; 7; 8 AND 9)
      tissue: Liver.
    3. 3.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 5)
      tissue: Kidney.
    5. 5.
      "A novel retinoid X receptor-independent thyroid hormone response element is present in the human type 1 deiodinase gene."
      Toyoda N. , Zavacki A.M. , Maia A.L. , Harney J.W. , Larsen P.R.
      Mol. Cell. Biol.15:5100-5112(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-25
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