DIO2 ELISA Kit for Human(Homo sapiens) | EIAab.comDIO2 ELISA Kit for Human(Homo sapiens)

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DIO2 (Gene name),

Type II iodothyronine deiodinase (Protein name ), IOD2_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

DIO2(ITDI2;TXDI2);

Protein name:

Type II iodothyronine deiodinase;

Alternative:

DIOII;5DII;Type-II 5'-deiodinase;Type 2 DI;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with USP20 and USP33. Interacts with MARCH6.

Function:

Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development.

Subcellular Location:

Membrane Single-pass membrane protein

Protein Attributes:

Sequence length:

273

Sequence:

50:

100:

150:

200:

250:

273:

LQEVRHWLEK | NFSKRUKKTR | LAG

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.202354

KEGG:

hsa:1734

STRING:

9606.ENSP00000373490

MIM:

601413

String:

Q92813

Pfam:

PF00837

Uniprot:

Q92813

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ELISA Kit for Human Type II iodothyronine deiodinase

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E0578h

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ELISA Kit for Human Type II iodothyronine deiodinase

Cat.:

E0578r

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96T

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ELISA Kit for Human Type II iodothyronine deiodinase

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E0578m

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96T

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ELISA Kit for Human Type II iodothyronine deiodinase

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E0578b

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ELISA Kit for Human Type II iodothyronine deiodinase

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E0578c

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ELISA Kit for Human Type II iodothyronine deiodinase

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E0578p

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96T

CLIA Kit for Human Type II iodothyronine deiodinase

Cat.:

U0578c

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96T

CLIA Kit for Human Type II iodothyronine deiodinase

Cat.:

U0578b

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Packing:

96T

CLIA Kit for Human Type II iodothyronine deiodinase

Cat.:

U0578m

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Please sign in first.

Packing:

96T

CLIA Kit for Human Type II iodothyronine deiodinase

Cat.:

U0578h

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MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human Type II iodothyronine deiodinase

Cat.:

U0578r

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Packing:

96T

CLIA Kit for Human Type II iodothyronine deiodinase

Cat.:

U0578p

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96T

Polyclonal Antibody for Human Type II iodothyronine deiodinase

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P0578Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human Type II iodothyronine deiodinase

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P0578Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human Type II iodothyronine deiodinase

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P0578Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human Type II iodothyronine deiodinase

Monoclonal Antibody for Human Type II iodothyronine deiodinase

Protein for Human Type II iodothyronine deiodinase

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Cloning of the mammalian type II iodothyronine deiodinase. A selenoprotein differentially expressed and regulated in human and rat brain and other tissues."
Croteau W. , Davey J.C. , Galton V.A. , St Germain D.L.
J. Clin. Invest.98:405-417(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
2.

"The 3'-untranslated region of human type 2 iodothyronine deiodinase mRNA contains a functional selenocysteine insertion sequence element."
Buettner C. , Harney J.W. , Larsen P.R.
J. Biol. Chem.273:33374-33378(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
3.

"Identification of two novel splicing variants of human type II iodothyronine deiodinase mRNA."
Ohba K. , Yoshioka T. , Muraki T.
Mol. Cell. Endocrinol.172:169-175(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
tissue: Umbilical vein.
4.

"Sequencing of human chromosome 14q31 region."
Dickhoff R. , Madan A. , Qin S. , Abbasi N. , Dors M. , Rowen L. , Harrison G. , James R. , Loretz C. , Lasky S. , Madan A. , Prescott S. , Ratcliffe A. , Shaffer T. , Hood L.
Submitted (1999-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
5.

"The DNA sequence and analysis of human chromosome 14."
Heilig R. , Eckenberg R. , Petit J.-L. , Fonknechten N. , Da Silva C. , Cattolico L. , Levy M. , Barbe V. , De Berardinis V. , Ureta-Vidal A. , Pelletier E. , Vico V. , Anthouard V. , Rowen L. , Madan A. , Qin S. , Sun H. , Du H. , more...
Nature421:601-607(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Lung.
tissue: Testis.
7.

"Deubiquitination of type 2 iodothyronine deiodinase by von Hippel-Lindau protein-interacting deubiquitinating enzymes regulates thyroid hormone activation."
Curcio-Morelli C. , Zavacki A.M. , Christofollete M. , Gereben B. , de Freitas B.C. , Harney J.W. , Li Z. , Wu G. , Bianco A.C.
J. Clin. Invest.112:189-196(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION;DEUBIQUITINATION BY USP20 AND USP33;INTERACTION WITH USP20 AND USP33
8.

"The E3 ubiquitin ligase TEB4 mediates degradation of type 2 iodothyronine deiodinase."
Zavacki A.M. , Arrojo E Drigo R. , Freitas B.C. , Chung M. , Harney J.W. , Egri P. , Wittmann G. , Fekete C. , Gereben B. , Bianco A.C.
Mol. Cell. Biol.29:5339-5347(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION BY MARCH6;INTERACTION WITH MARCH6

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