DIO3 ELISA Kit for Human(Homo sapiens) | EIAab.comDIO3 ELISA Kit for Human(Homo sapiens)

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DIO3 (Gene name),

Type III iodothyronine deiodinase (Protein name ), IOD3_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

DIO3(ITDI3;TXDI3);

Protein name:

Type III iodothyronine deiodinase;

Alternative:

DIOIII;5DIII;Type-III 5'-deiodinase;Type 3 DI;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer. May undergo minor heretodimerization with DIO1 and DIO2.

Function:

Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into RT3 (3,3',5'-triiodothyronine) and of T3 (3,5,3'-triiodothyronine) into T2 (3,3'-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development.

Subcellular Location:

Cell membrane Single-pass type II membrane protein Endosome membrane Single-pass type II membrane protein

Protein Attributes:

Sequence length:

278

Sequence:

50:

100:

150:

200:

250:

278:

PDGYQVSELR | TWLERYDEQL | HGARPRRV

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

hsa:1735

STRING:

9606.ENSP00000352273

MIM:

601038

UniGene:

Hs.49322

String:

P55073

Pfam:

PF00837

SMR:

P55073

Uniprot:

P55073

FOR

ELISA Kit for Human Type III iodothyronine deiodinase

Cat.:

E12263r

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Manual:

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Packing:

96T

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ELISA Kit for Human Type III iodothyronine deiodinase

Cat.:

E12263h

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96T

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ELISA Kit for Human Type III iodothyronine deiodinase

MSDS:

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ELISA Kit for Human Type III iodothyronine deiodinase

MSDS:

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ELISA Kit for Human Type III iodothyronine deiodinase

Cat.:

E12263c

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96T

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ELISA Kit for Human Type III iodothyronine deiodinase

Cat.:

E12263m

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Packing:

96T

CLIA Kit for Human Type III iodothyronine deiodinase

MSDS:

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CLIA Kit for Human Type III iodothyronine deiodinase

MSDS:

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CLIA Kit for Human Type III iodothyronine deiodinase

MSDS:

Please sign in first.

CLIA Kit for Human Type III iodothyronine deiodinase

Cat.:

U12263m

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human Type III iodothyronine deiodinase

Cat.:

U12263r

Price:

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MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human Type III iodothyronine deiodinase

Cat.:

U12263h

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human Type III iodothyronine deiodinase

Cat.:

P12263Rb-h

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Type III iodothyronine deiodinase

Monoclonal Antibody for Human Type III iodothyronine deiodinase

Protein for Human Type III iodothyronine deiodinase

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Type 3 iodothyronine deiodinase: cloning, in vitro expression, and functional analysis of the placental selenoenzyme."
Salvatore D. , Low S.C. , Berry M. , Maia A.L. , Harney J.W. , Croteau W. , St Germain D.L. , Larsen P.R.
J. Clin. Invest.96:2421-2430(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION
tissue: Placenta.
2.

"The DNA sequence and analysis of human chromosome 14."
Heilig R. , Eckenberg R. , Petit J.-L. , Fonknechten N. , Da Silva C. , Cattolico L. , Levy M. , Barbe V. , De Berardinis V. , Ureta-Vidal A. , Pelletier E. , Vico V. , Anthouard V. , Rowen L. , Madan A. , Qin S. , Sun H. , Du H. , more...
Nature421:601-607(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-304
tissue: Duodenum.
4.

"Substitution of cysteine for selenocysteine in the catalytic center of type III iodothyronine deiodinase reduces catalytic efficiency and alters substrate preference."
Kuiper G.G. , Klootwijk W. , Visser T.J.
Endocrinology144:2505-2513(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF SEC-170;BIOPHYSICOCHEMICAL PROPERTIES
5.

"Human type 3 iodothyronine selenodeiodinase is located in the plasma membrane and undergoes rapid internalization to endosomes."
Baqui M. , Botero D. , Gereben B. , Curcio C. , Harney J.W. , Salvatore D. , Sorimachi K. , Larsen P.R. , Bianco A.C.
J. Biol. Chem.278:1206-1211(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
6.

"The thyroid hormone-inactivating deiodinase functions as a homodimer."
Sagar G.D. , Gereben B. , Callebaut I. , Mornon J.P. , Zeold A. , Curcio-Morelli C. , Harney J.W. , Luongo C. , Mulcahey M.A. , Larsen P.R. , Huang S.A. , Bianco A.C.
Mol. Endocrinol.22:1382-1393(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT

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