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Index > Protein center > IQGAP1(Gene name) > Human
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  • IQGAP1 (Gene name),
  • Ras GTPase-activating-like protein IQGAP1 (Protein name ),  IQGA1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    IQGAP1(KIAA0051);
    Protein name:
    Ras GTPase-activating-like protein IQGAP1;
    Alternative:
    p195;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with CDC42; the interaction is demonstrated with IQGAP1 in GTP-bound and in nucleotide-free state. Interacts with RAC1. Does not interact with RHOA. Interacts with TSG101. Interacts with PAK6.
    Function:
    Binds to activated CDC42 but does not stimulate its GTPase activity. It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth.
    Subcellular Location:
    Cell membrane
    Protein Attributes:
    Sequence length:
    1657
    Sequence:
    50:
    MSAADEVDGL | GVARPHYGSV | LDNERLTAEE | MDERRRQNVA | YEYLCHLEEA | 
    100:
    KRWMEACLGE | DLPPTTELEE | GLRNGVYLAK | LGNFFSPKVV | SLKKIYDREQ | 
    150:
    TRYKATGLHF | RHTDNVIQWL | NAMDEIGLPK | IFYPETTDIY | DRKNMPRCIY | 
    200:
    CIHALSLYLF | KLGLAPQIQD | LYGKVDFTEE | EINNMKTELE | KYGIQMPAFS | 
    250:
    KIGGILANEL | SVDEAALHAA | VIAINEAIDR | RIPADTFAAL | KNPNAMLVNL | 
    300:
    EEPLASTYQD | ILYQAKQDKM | TNAKNRTENS | ERERDVYEEL | LTQAEIQGNI | 
    350:
    NKVNTFSALA | NIDLALEQGD | ALALFRALQS | PALGLRGLQQ | QNSDWYLKQL | 
    400:
    LSDKQQKRQS | GQTDPLQKEE | LQSGVDAANS | AAQQYQRRLA | AVALINAAIQ | 
    450:
    KGVAEKTVLE | LMNPEAQLPQ | VYPFAADLYQ | KELATLQRQS | PEHNLTHPEL | 
    500:
    SVAVEMLSSV | ALINRALESG | DVNTVWKQLS | SSVTGLTNIE | EENCQRYLDE | 
    550:
    LMKLKAQAHA | ENNEFITWND | IQACVDHVNL | VVQEEHERIL | AIGLINEALD | 
    600:
    EGDAQKTLQA | LQIPAAKLEG | VLAEVAQHYQ | DTLIRAKREK | AQEIQDESAV | 
    650:
    LWLDEIQGGI | WQSNKDTQEA | QKFALGIFAI | NEAVESGDVG | KTLSALRSPD | 
    700:
    VGLYGVIPEC | GETYHSDLAE | AKKKKLAVGD | NNSKWVKHWV | KGGYYYYHNL | 
    750:
    ETQEGGWDEP | PNFVQNSMQL | SREEIQSSIS | GVTAAYNREQ | LWLANEGLIT | 
    800:
    RLQARCRGYL | VRQEFRSRMN | FLKKQIPAIT | CIQSQWRGYK | QKKAYQDRLA | 
    850:
    YLRSHKDEVV | KIQSLARMHQ | ARKRYRDRLQ | YFRDHINDII | KIQAFIRANK | 
    900:
    ARDDYKTLIN | AEDPPMVVVR | KFVHLLDQSD | QDFQEELDLM | KMREEVITLI | 
    950:
    RSNQQLENDL | NLMDIKIGLL | VKNKITLQDV | VSHSKKLTKK | NKEQLSDMMM | 
    1000:
    INKQKGGLKA | LSKEKREKLE | AYQHLFYLLQ | TNPTYLAKLI | FQMPQNKSTK | 
    1050:
    FMDSVIFTLY | NYASNQREEY | LLLRLFKTAL | QEEIKSKVDQ | IQEIVTGNPT | 
    1100:
    VIKMVVSFNR | GARGQNALRQ | ILAPVVKEIM | DDKSLNIKTD | PVDIYKSWVN | 
    1150:
    QMESQTGEAS | KLPYDVTPEQ | ALAHEEVKTR | LDSSIRNMRA | VTDKFLSAIV | 
    1200:
    SSVDKIPYGM | RFIAKVLKDS | LHEKFPDAGE | DELLKIIGNL | LYYRYMNPAI | 
    1250:
    VAPDAFDIID | LSAGGQLTTD | QRRNLGSIAK | MLQHAASNKM | FLGDNAHLSI | 
    1300:
    INEYLSQSYQ | KFRRFFQTAC | DVPELQDKFN | VDEYSDLVTL | TKPVIYISIG | 
    1350:
    EIINTHTLLL | DHQDAIAPEH | NDPIHELLDD | LGEVPTIESL | IGESSGNLND | 
    1400:
    PNKEALAKTE | VSLTLTNKFD | VPGDENAEMD | ARTILLNTKR | LIVDVIRFQP | 
    1450:
    GETLTEILET | PATSEQEAEH | QRAMQRRAIR | DAKTPDKMKK | SKSVKEDSNL | 
    1500:
    TLQEKKEKIQ | TGLKKLTELG | TVDPKNKYQE | LINDIARDIR | NQRRYRQRRK | 
    1550:
    AELVKLQQTY | AALNSKATFY | GEQVDYYKSY | IKTCLDNLAS | KGKVSKKPRE | 
    1600:
    MKGKKSKKIS | LKYTAARLHE | KGVLLEIEDL | QVNQFKNVIF | EISPTEEVGD | 
    1650:
    FEVKAKFMGV | QMETFMLHYQ | DLLQLQYEGV | AVMKLFDRAK | VNVNLLIFLL | 
    1657:
    NKKFYGK
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    Pfam:
    SMR:
    String:
    KEGG:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human Ras GTPase-activating-like protein IQGAP1
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    E10893h
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    ELISA Kit for Human Ras GTPase-activating-like protein IQGAP1
    Cat.:
    E10893m
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Ras GTPase-activating-like protein IQGAP1
    Cat.:
    U10893m
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Ras GTPase-activating-like protein IQGAP1
    Cat.:
    U10893h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Ras GTPase-activating-like protein IQGAP1
    Cat.:
    P10893Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Ras GTPase-activating-like protein IQGAP1
    Monoclonal Antibody for Human Ras GTPase-activating-like protein IQGAP1
    Monoclonal Antibody for Human Ras GTPase-activating-like protein IQGAP1
    Protein for Human Ras GTPase-activating-like protein IQGAP1
    Protein for Human Ras GTPase-activating-like protein IQGAP1

    R&D Technical Data
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Identification of a human rasGAP-related protein containing calmodulin-binding motifs."
      Weissbach L. , Settleman J. , Kalady M.F. , Snijders A.J. , Murthy A.E. , Yan Y.-X. , Bernards A.
      J. Biol. Chem.269:20517-20521(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Liver.
      tissue: Placenta.
    2. 2.
      "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1."
      Nomura N. , Nagase T. , Miyajima N. , Sazuka T. , Tanaka A. , Sato S. , Seki N. , Kawarabayasi Y. , Ishikawa K. , Tabata S.
      DNA Res.1:223-229(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Bone marrow.
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    5. 5.
      Bienvenut W.V. , Lilla S. , Zebisch A. , Kolch W.
      Submitted (2009-03) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-25; 81-88; 112-143; 192-230; 466-477; 557-585; 923-935; 989-997; 1391-1397; 1466-1475 AND 1506-1516;CLEAVAGE OF INITIATOR METHIONINE;ACETYLATION AT SER-2;IDENTIFICATION BY MASS SPECTROMETRY
      tissue: Colon carcinoma.
    6. 6.
      "Phosphorylation of IQGAP1 modulates its binding to Cdc42, revealing a new type of rho-GTPase regulator."
      Grohmanova K. , Schlaepfer D. , Hess D. , Gutierrez P. , Beck M. , Kroschewski R.
      J. Biol. Chem.279:48495-48504(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 1441-1455;PHOSPHORYLATION AT SER-1443;INTERACTION WITH CDC42 AND RAC1;DOMAIN;SUBCELLULAR LOCATION;IDENTIFICATION BY MASS SPECTROMETRY
    7. 7.
      "IQGAP1 promotes neurite outgrowth in a phosphorylation-dependent manner."
      Li Z. , McNulty D.E. , Marler K.J.M. , Lim L. , Hall C. , Annan R.S. , Sacks D.B.
      J. Biol. Chem.280:13871-13878(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 1441-1455;PHOSPHORYLATION AT SER-1441 AND SER-1443;MUTAGENESIS OF SER-1441 AND SER-1443;FUNCTION;IDENTIFICATION BY MASS SPECTROMETRY
    8. 8.
      "IQGAP1, a calmodulin-binding protein with a rasGAP-related domain, is a potential effector for cdc42Hs."
      Hart M.J. , Callow M.G. , Souza B. , Polakis P.
      EMBO J.15:2997-3005(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION
    9. 9.
      "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
      Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    10. 10.
      "Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis."
      Morita E. , Sandrin V. , Chung H.Y. , Morham S.G. , Gygi S.P. , Rodesch C.K. , Sundquist W.I.
      EMBO J.26:4215-4227(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TSG101
    11. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1443;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    12. 12.
      "Increased PAK6 expression in prostate cancer and identification of PAK6 associated proteins."
      Kaur R. , Yuan X. , Lu M.L. , Balk S.P.
      Prostate68:1510-1516(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PAK6
    13. 13.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2;PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2; SER-330 AND SER-1443;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    14. 14.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    15. 15.
      "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V. , Sumpton D. , Martinez A. , Lilla S. , Espagne C. , Meinnel T. , Giglione C.
      Mol. Cell. Proteomics11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    16. 16.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    17. 17.
      "Solution structure of the carboxyl-terminal RGC domain in human IQGAP1."
      RIKEN structural genomics initiative (RSGI)
      Submitted (2005-09) to the PDB data bank
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 1559-1657
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