IQGAP1 ELISA Kit for Human(Homo sapiens) | EIAab.comIQGAP1 ELISA Kit for Human(Homo sapiens)

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IQGAP1 (Gene name),

Ras GTPase-activating-like protein IQGAP1 (Protein name ), IQGA1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

IQGAP1(KIAA0051);

Protein name:

Ras GTPase-activating-like protein IQGAP1;

Alternative:

p195;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with CDC42; the interaction is demonstrated with IQGAP1 in GTP-bound and in nucleotide-free state. Interacts with RAC1. Does not interact with RHOA. Interacts with TSG101. Interacts with PAK6.

Function:

Binds to activated CDC42 but does not stimulate its GTPase activity. It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth.

Subcellular Location:

Cell membrane

Protein Attributes:

Sequence length:

1657

Sequence:

50:

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350:

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1150:

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1250:

1300:

1350:

1400:

1450:

1500:

1550:

1600:

1650:

1657:

NKKFYGK

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.430551

Pfam:

PF00307

SMR:

P46940

String:

P46940

KEGG:

hsa:8826

MIM:

603379

STRING:

9606.ENSP00000268182

Uniprot:

P46940

FOR

ELISA Kit for Human Ras GTPase-activating-like protein IQGAP1

Cat.:

E10893h

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Manual:

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Packing:

96T

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ELISA Kit for Human Ras GTPase-activating-like protein IQGAP1

Cat.:

E10893m

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MSDS:

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Packing:

96T

CLIA Kit for Human Ras GTPase-activating-like protein IQGAP1

Cat.:

U10893m

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MSDS:

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Packing:

96T

CLIA Kit for Human Ras GTPase-activating-like protein IQGAP1

Cat.:

U10893h

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human Ras GTPase-activating-like protein IQGAP1

Cat.:

P10893Rb-h

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Ras GTPase-activating-like protein IQGAP1

Monoclonal Antibody for Human Ras GTPase-activating-like protein IQGAP1

Protein for Human Ras GTPase-activating-like protein IQGAP1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Identification of a human rasGAP-related protein containing calmodulin-binding motifs."
Weissbach L. , Settleman J. , Kalady M.F. , Snijders A.J. , Murthy A.E. , Yan Y.-X. , Bernards A.
J. Biol. Chem.269:20517-20521(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Liver.
tissue: Placenta.
2.

"Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1."
Nomura N. , Nagase T. , Miyajima N. , Sazuka T. , Tanaka A. , Sato S. , Seki N. , Kawarabayasi Y. , Ishikawa K. , Tabata S.
DNA Res.1:223-229(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Bone marrow.
3.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
5.

Bienvenut W.V. , Lilla S. , Zebisch A. , Kolch W.
Submitted (2009-03) to the UniProtKB

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-25; 81-88; 112-143; 192-230; 466-477; 557-585; 923-935; 989-997; 1391-1397; 1466-1475 AND 1506-1516;CLEAVAGE OF INITIATOR METHIONINE;ACETYLATION AT SER-2;IDENTIFICATION BY MASS SPECTROMETRY
tissue: Colon carcinoma.
6.

"Phosphorylation of IQGAP1 modulates its binding to Cdc42, revealing a new type of rho-GTPase regulator."
Grohmanova K. , Schlaepfer D. , Hess D. , Gutierrez P. , Beck M. , Kroschewski R.
J. Biol. Chem.279:48495-48504(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 1441-1455;PHOSPHORYLATION AT SER-1443;INTERACTION WITH CDC42 AND RAC1;DOMAIN;SUBCELLULAR LOCATION;IDENTIFICATION BY MASS SPECTROMETRY
7.

"IQGAP1 promotes neurite outgrowth in a phosphorylation-dependent manner."
Li Z. , McNulty D.E. , Marler K.J.M. , Lim L. , Hall C. , Annan R.S. , Sacks D.B.
J. Biol. Chem.280:13871-13878(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 1441-1455;PHOSPHORYLATION AT SER-1441 AND SER-1443;MUTAGENESIS OF SER-1441 AND SER-1443;FUNCTION;IDENTIFICATION BY MASS SPECTROMETRY
8.

"IQGAP1, a calmodulin-binding protein with a rasGAP-related domain, is a potential effector for cdc42Hs."
Hart M.J. , Callow M.G. , Souza B. , Polakis P.
EMBO J.15:2997-3005(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION
9.

"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
10.

"Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis."
Morita E. , Sandrin V. , Chung H.Y. , Morham S.G. , Gygi S.P. , Rodesch C.K. , Sundquist W.I.
EMBO J.26:4215-4227(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TSG101
11.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1443;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
12.

"Increased PAK6 expression in prostate cancer and identification of PAK6 associated proteins."
Kaur R. , Yuan X. , Lu M.L. , Balk S.P.
Prostate68:1510-1516(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PAK6
13.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2;PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2; SER-330 AND SER-1443;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
14.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
15.

"Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
Bienvenut W.V. , Sumpton D. , Martinez A. , Lilla S. , Espagne C. , Meinnel T. , Giglione C.
Mol. Cell. Proteomics11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
16.

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P. , Lasa M. , Polevoda B. , Gazquez C. , Elosegui-Artola A. , Kim D.S. , De Juan-Pardo E. , Demeyer K. , Hole K. , Larrea E. , Timmerman E. , Prieto J. , Arnesen T. , Sherman F. , Gevaert K. , Aldabe R.
Proc. Natl. Acad. Sci. U.S.A.109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
17.

"Solution structure of the carboxyl-terminal RGC domain in human IQGAP1."
RIKEN structural genomics initiative (RSGI)
Submitted (2005-09) to the PDB data bank

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 1559-1657

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