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Index > Protein center > ISG20(Gene name) > Human
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  • ISG20 (Gene name),
  • Interferon-stimulated gene 20 kDa protein (Protein name ),  ISG20_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    ISG20(HEM45);
    Protein name:
    Interferon-stimulated gene 20 kDa protein;
    Alternative:
    Estrogen-regulated transcript 45 protein;Promyelocytic leukemia nuclear body-associated protein ISG20;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Associates with PML and SP100 in the PML NB complex.
    Function:
    Exonuclease with specificity for single-stranded RNA and, to a lesser extent for DNA. Degrades RNA at a rate that is approximately 35-fold higher than its rate for single-stranded DNA. Involved in the antiviral function of IFN against RNA viruses.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    181
    Sequence:
    50:
    MAGSREVVAM | DCEMVGLGPH | RESGLARCSL | VNVHGAVLYD | KFIRPEGEIT | 
    100:
    DYRTRVSGVT | PQHMVGATPF | AVARLEILQL | LKGKLVVGHD | LKHDFQALKE | 
    150:
    DMSGYTIYDT | STDRLLWREA | KLDHCRRVSL | RVLSERLLHK | SIQNSLLGHS | 
    181:
    SVEDARATME | LYQISQRIRA | RRGLPRLAVS | D
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    Pfam:
    MIM:
    String:
    KEGG:
    UniGene:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human Interferon-stimulated gene 20 kDa protein
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    E1755h
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    ELISA Kit for Human Interferon-stimulated gene 20 kDa protein
    Cat.:
    E1755m
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    Packing:
    96T
    ELISA Kit for Human Interferon-stimulated gene 20 kDa protein
    Cat.:
    E1755p
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    Packing:
    96T
    CLIA Kit for Human Interferon-stimulated gene 20 kDa protein
    Cat.:
    U1755p
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Interferon-stimulated gene 20 kDa protein
    Cat.:
    U1755h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Interferon-stimulated gene 20 kDa protein
    Cat.:
    U1755m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Interferon-stimulated gene 20 kDa protein
    Cat.:
    P1755Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Interferon-stimulated gene 20 kDa protein
    Cat.:
    P1755Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Interferon-stimulated gene 20 kDa protein
    Monoclonal Antibody for Human Interferon-stimulated gene 20 kDa protein
    Monoclonal Antibody for Human Interferon-stimulated gene 20 kDa protein
    Monoclonal Antibody for Human Interferon-stimulated gene 20 kDa protein
    Protein for Human Interferon-stimulated gene 20 kDa protein
    Protein for Human Interferon-stimulated gene 20 kDa protein
    Protein for Human Interferon-stimulated gene 20 kDa protein

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    Linearity
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    References
    1. 1.
      "Molecular cloning of a new interferon-induced PML nuclear bodies-associated protein."
      Gongora C. , David G. , Pintard L. , Tissot C. , Hua T.D. , Dejean A. , Mechti N.
      J. Biol. Chem.272:19457-19463(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);SUBCELLULAR LOCATION;TISSUE SPECIFICITY;IDENTIFICATION IN PML NB COMPLEX;INDUCTION
    2. 2.
      "Expression and estrogen regulation of the HEM45 mRNA in human tumor lines and in the rat uterus."
      Pentecost B.T.
      J. Steroid Biochem. Mol. Biol.64:25-33(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY
    3. 3.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2003-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    4. 4.
      "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: B-cell.
      tissue: Brain.
    6. 6.
      "The human interferon- and estrogen-regulated ISG20/HEM45 gene product degrades single-stranded RNA and DNA in vitro."
      Nguyen L.H. , Espert L. , Mechti N. , Wilson D.M. III
      Biochemistry40:7174-7179(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;ENZYME REGULATION
    7. 7.
      "ISG20, a new interferon-induced RNase specific for single-stranded RNA, defines an alternative antiviral pathway against RNA genomic viruses."
      Espert L. , Degols G. , Gongora C. , Blondel D. , Williams B.R. , Silverman R.H. , Mechti N.
      J. Biol. Chem.278:16151-16158(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    8. 8.
      "Interferon-induced exonuclease ISG20 exhibits an antiviral activity against human immunodeficiency virus type 1."
      Espert L. , Degols G. , Lin Y.L. , Vincent T. , Benkirane M. , Mechti N.
      J. Gen. Virol.86:2221-2229(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    9. 9.
      "The exonuclease ISG20 mainly localizes in the nucleolus and the Cajal (Coiled) bodies and is associated with nuclear SMN protein-containing complexes."
      Espert L. , Eldin P. , Gongora C. , Bayard B. , Harper F. , Chelbi-Alix M.K. , Bertrand E. , Degols G. , Mechti N.
      J. Cell. Biochem.98:1320-1333(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;INTERACTION WITH SMN COMPLEX AND SNRNAS
    10. 10.
      "ISG20, an actor of the innate immune response."
      Degols G. , Eldin P. , Mechti N.
      Biochimie89:831-835(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION
    11. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    12. 12.
      "Antiviral activities of ISG20 in positive-strand RNA virus infections."
      Zhou Z. , Wang N. , Woodson S.E. , Dong Q. , Wang J. , Liang Y. , Rijnbrand R. , Wei L. , Nichols J.E. , Guo J.T. , Holbrook M.R. , Lemon S.M. , Li K.
      Virology409:175-188(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN HCV; HAV AND YFV RESTRICTION;SUBCELLULAR LOCATION
    13. 13.
      "Crystal structure of human ISG20, an interferon-induced antiviral ribonuclease."
      Horio T. , Murai M. , Inoue T. , Hamasaki T. , Tanaka T. , Ohgi T.
      FEBS Lett.577:111-116(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) IN COMPLEX WITH UMP;COFACTOR;MANGANESE-BINDING SITES
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