ISG20 ELISA Kit for Human(Homo sapiens) | EIAab.comISG20 ELISA Kit for Human(Homo sapiens)

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ISG20 (Gene name),

Interferon-stimulated gene 20 kDa protein (Protein name ), ISG20_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

ISG20(HEM45);

Protein name:

Interferon-stimulated gene 20 kDa protein;

Alternative:

Estrogen-regulated transcript 45 protein;Promyelocytic leukemia nuclear body-associated protein ISG20;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Associates with PML and SP100 in the PML NB complex.

Function:

Exonuclease with specificity for single-stranded RNA and, to a lesser extent for DNA. Degrades RNA at a rate that is approximately 35-fold higher than its rate for single-stranded DNA. Involved in the antiviral function of IFN against RNA viruses.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

181

Sequence:

50:

100:

150:

181:

SVEDARATME | LYQISQRIRA | RRGLPRLAVS | D

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF00929

MIM:

604533

String:

Q96AZ6

KEGG:

hsa:3669

UniGene:

Hs.459265

SMR:

Q96AZ6

STRING:

9606.ENSP00000306565

Uniprot:

Q96AZ6

FOR

ELISA Kit for Human Interferon-stimulated gene 20 kDa protein

Cat.:

E1755h

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Manual:

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MSDS:

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Packing:

96T

Range:

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ELISA Kit for Human Interferon-stimulated gene 20 kDa protein

Cat.:

E1755m

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MSDS:

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Packing:

96T

ELISA Kit for Human Interferon-stimulated gene 20 kDa protein

Cat.:

E1755p

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MSDS:

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Packing:

96T

CLIA Kit for Human Interferon-stimulated gene 20 kDa protein

Cat.:

U1755p

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human Interferon-stimulated gene 20 kDa protein

Cat.:

U1755h

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human Interferon-stimulated gene 20 kDa protein

Cat.:

U1755m

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human Interferon-stimulated gene 20 kDa protein

Cat.:

P1755Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Interferon-stimulated gene 20 kDa protein

Cat.:

P1755Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Human Interferon-stimulated gene 20 kDa protein

Monoclonal Antibody for Human Interferon-stimulated gene 20 kDa protein

Protein for Human Interferon-stimulated gene 20 kDa protein

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"Molecular cloning of a new interferon-induced PML nuclear bodies-associated protein."
Gongora C. , David G. , Pintard L. , Tissot C. , Hua T.D. , Dejean A. , Mechti N.
J. Biol. Chem.272:19457-19463(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);SUBCELLULAR LOCATION;TISSUE SPECIFICITY;IDENTIFICATION IN PML NB COMPLEX;INDUCTION
2.

"Expression and estrogen regulation of the HEM45 mRNA in human tumor lines and in the rat uterus."
Pentecost B.T.
J. Steroid Biochem. Mol. Biol.64:25-33(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY
3.

"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
Submitted (2003-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
4.

"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
Submitted (2004-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
tissue: B-cell.
tissue: Brain.
6.

"The human interferon- and estrogen-regulated ISG20/HEM45 gene product degrades single-stranded RNA and DNA in vitro."
Nguyen L.H. , Espert L. , Mechti N. , Wilson D.M. III
Biochemistry40:7174-7179(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;ENZYME REGULATION
7.

"ISG20, a new interferon-induced RNase specific for single-stranded RNA, defines an alternative antiviral pathway against RNA genomic viruses."
Espert L. , Degols G. , Gongora C. , Blondel D. , Williams B.R. , Silverman R.H. , Mechti N.
J. Biol. Chem.278:16151-16158(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
8.

"Interferon-induced exonuclease ISG20 exhibits an antiviral activity against human immunodeficiency virus type 1."
Espert L. , Degols G. , Lin Y.L. , Vincent T. , Benkirane M. , Mechti N.
J. Gen. Virol.86:2221-2229(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
9.

"The exonuclease ISG20 mainly localizes in the nucleolus and the Cajal (Coiled) bodies and is associated with nuclear SMN protein-containing complexes."
Espert L. , Eldin P. , Gongora C. , Bayard B. , Harper F. , Chelbi-Alix M.K. , Bertrand E. , Degols G. , Mechti N.
J. Cell. Biochem.98:1320-1333(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;INTERACTION WITH SMN COMPLEX AND SNRNAS
10.

"ISG20, an actor of the innate immune response."
Degols G. , Eldin P. , Mechti N.
Biochimie89:831-835(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION
11.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
12.

"Antiviral activities of ISG20 in positive-strand RNA virus infections."
Zhou Z. , Wang N. , Woodson S.E. , Dong Q. , Wang J. , Liang Y. , Rijnbrand R. , Wei L. , Nichols J.E. , Guo J.T. , Holbrook M.R. , Lemon S.M. , Li K.
Virology409:175-188(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN HCV; HAV AND YFV RESTRICTION;SUBCELLULAR LOCATION
13.

"Crystal structure of human ISG20, an interferon-induced antiviral ribonuclease."
Horio T. , Murai M. , Inoue T. , Hamasaki T. , Tanaka T. , Ohgi T.
FEBS Lett.577:111-116(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) IN COMPLEX WITH UMP;COFACTOR;MANGANESE-BINDING SITES

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