ITGAM ELISA Kit for Human(Homo sapiens) | EIAab.comITGAM ELISA Kit for Human(Homo sapiens)

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ITGAM (Gene name),

Integrin alpha-M (Protein name ), ITAM_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

ITGAM(CD11B;CR3A);

Protein name:

Integrin alpha-M;

Alternative:

CR-3 alpha chain;CD11 antigen-like family member B;Leukocyte adhesion receptor MO1;Cell surface glycoprotein MAC-1 subunit alpha;Neutrophil adherence receptor;

CD:

CD11b;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Heterodimer of an alpha and a beta subunit. Alpha-M associates with beta-2. Interacts with JAM3.

Function:

Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.

Subcellular Location:

Membrane Single-pass type I membrane protein

Protein Attributes:

Sequence length:

1152

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

900:

950:

1000:

1050:

1100:

1150:

1152:

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.172631

String:

P11215

STRING:

9606.ENSP00000287497

MIM:

120980

KEGG:

hsa:3684

SMR:

P11215

Pfam:

PF01839

Uniprot:

P11215

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ELISA Kit for Human Integrin alpha-M

Cat.:

E1685m

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96T

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ELISA Kit for Human Integrin alpha-M

Cat.:

E1685h

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96T

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CLIA Kit for Human Integrin alpha-M

Cat.:

U1685h

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Looking for manual.

MSDS:

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Packing:

96T

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CLIA Kit for Human Integrin alpha-M

Cat.:

U1685m

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human Integrin alpha-M

Cat.:

P1685Rb-m

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Integrin alpha-M

Cat.:

P1685Rb-h

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Integrin alpha-M

Cat.:

M1685h

Price:

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Packing:

40ug

Monoclonal Antibody for Human Integrin alpha-M

Protein for Human Integrin alpha-M

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"The human leukocyte adhesion glycoprotein Mac-1 (complement receptor type 3, CD11b) alpha subunit. Cloning, primary structure, and relation to the integrins, von Willebrand factor and factor B."
Corbi A.L. , Kishimoto T.K. , Miller L.J. , Springer T.A.
J. Biol. Chem.263:12403-12411(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
2.

"Molecular cloning of the alpha subunit of human and guinea pig leukocyte adhesion glycoprotein Mo1: chromosomal localization and homology to the alpha subunits of integrins."
Arnaout M.A. , Remold-O'Donnell E. , Pierce M.W. , Harris P. , Tenen D.G.
Proc. Natl. Acad. Sci. U.S.A.85:2776-2780(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
3.

"Amino acid sequence of the alpha subunit of human leukocyte adhesion receptor Mo1 (complement receptor type 3)."
Arnaout M.A. , Gupta S.K. , Pierce M.W. , Tenen D.G.
J. Cell Biol.106:2153-2158(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
4.

"Structural analysis of the CD11b gene and phylogenetic analysis of the alpha-integrin gene family demonstrate remarkable conservation of genomic organization and suggest early diversification during evolution."
Fleming J.C. , Pahl H.L. , Gonzalez D.A. , Smith T.F. , Tenen D.G.
J. Immunol.150:480-490(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1)
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANTS HIS-77; THR-441; VAL-858 AND SER-1146
6.

"cDNA sequence for the alpha M subunit of the human neutrophil adherence receptor indicates homology to integrin alpha subunits."
Hickstein D.D. , Hickey M.J. , Ozols J. , Baker D.M. , Back A.L. , Roth G.J.
Proc. Natl. Acad. Sci. U.S.A.86:257-261(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 9-1152 (ISOFORM 2)
7.

"The promoter of the CD11b gene directs myeloid-specific and developmentally regulated expression."
Shelley C.S. , Arnaout M.A.
Proc. Natl. Acad. Sci. U.S.A.88:10525-10529(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-9
8.

"Characterization of the myeloid-specific CD11b promoter."
Pahl H.L. , Rosmarin A.G. , Tenen D.G.
Blood79:865-870(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-9
tissue: Blood.
9.

"N-terminal sequence of human leukocyte glycoprotein Mo1: conservation across species and homology to platelet IIb/IIIa."
Pierce M.W. , Remold-O'Donnell E. , Todd R.F. III , Arnaout M.A.
Biochim. Biophys. Acta874:368-371(1986) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 17-31
10.

"The junctional adhesion molecule 3 (JAM-3) on human platelets is a counterreceptor for the leukocyte integrin Mac-1."
Santoso S. , Sachs U.J.H. , Kroll H. , Linder M. , Ruf A. , Preissner K.T. , Chavakis T.
J. Exp. Med.196:679-691(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH JAM3
11.

"JAM-C is a component of desmosomes and a ligand for CD11b/CD18-mediated neutrophil transepithelial migration."
Zen K. , Babbin B.A. , Liu Y. , Whelan J.B. , Nusrat A. , Parkos C.A.
Mol. Biol. Cell15:3926-3937(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH JAM3
12.

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-900; ASN-940 AND ASN-946
tissue: Liver.
13.

"Crystal structure of the A domain from the alpha subunit of integrin CR3 (CD11b/CD18)."
Lee J.O. , Rieu P. , Arnaout M.A. , Liddington R.
Cell80:631-638(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 148-331
14.

"Two conformations of the integrin A-domain (I-domain): a pathway for activation?"
Lee J.O. , Bankston L.A. , Arnaout M.A. , Liddington R.C.
Structure3:1333-1340(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 148-334
15.

"Cation binding to the integrin CD11b I domain and activation model assessment."
Baldwin E.T. , Sarver R.W. , Bryant G.L. Jr. , Curry K.A. , Fairbanks M.B. , Finzel B.C. , Garlick R.L. , Heinrikson R.L. , Horton N.C. , Kelley L.L. , Mildner A.M. , Moon J.B. , Mott J.E. , Mutchler V.T. , Tomich C.S. , Watenpaugh K.D. , Wiley V.H.
Structure6:923-935(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 148-337
16.

"Experimental support for a beta-propeller domain in integrin alpha-subunits and a calcium binding site on its lower surface."
Oxvig C. , Springer T.A.
Proc. Natl. Acad. Sci. U.S.A.95:4870-4875(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: 3D-STRUCTURE MODELING OF 17-616
17.

"A nonsynonymous functional variant in integrin-alpha(M) (encoded by ITGAM) is associated with systemic lupus erythematosus."
Nath S.K. , Han S. , Kim-Howard X. , Kelly J.A. , Viswanathan P. , Gilkeson G.S. , Chen W. , Zhu C. , McEver R.P. , Kimberly R.P. , Alarcon-Riquelme M.E. , Vyse T.J. , Li Q.-Z. , Wakeland E.K. , Merrill J.T. , James J.A. , Kaufman K.M. , Guthridge J.M. , more...
Nat. Genet.40:152-154(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO SLE;VARIANT HIS-77
18.

"Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci."
Harley J.B. , Alarcon-Riquelme M.E. , Criswell L.A. , Jacob C.O. , Kimberly R.P. , Moser K.L. , Tsao B.P. , Vyse T.J. , Langefeld C.D. , Nath S.K. , Guthridge J.M. , Cobb B.L. , Mirel D.B. , Marion M.C. , Williams A.H. , Divers J. , Wang W. , Frank S.G. , more...
Nat. Genet.40:204-210(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO SLE

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