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Index > Protein center > ITGAM(Gene name) > Human
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  • ITGAM (Gene name),
  • Integrin alpha-M (Protein name ),  ITAM_HUMAN from NCBI database.
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  • General Annotation
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  • Gene name:
    ITGAM(CD11B;CR3A);
    Protein name:
    Integrin alpha-M;
    Alternative:
    CR-3 alpha chain;CD11 antigen-like family member B;Leukocyte adhesion receptor MO1;Cell surface glycoprotein MAC-1 subunit alpha;Neutrophil adherence receptor;
    CD:
    CD11b;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Heterodimer of an alpha and a beta subunit. Alpha-M associates with beta-2. Interacts with JAM3.
    Function:
    Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.
    Subcellular Location:
    Membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    1152
    Sequence:
    50:
    MALRVLLLTA | LTLCHGFNLD | TENAMTFQEN | ARGFGQSVVQ | LQGSRVVVGA | 
    100:
    PQEIVAANQR | GSLYQCDYST | GSCEPIRLQV | PVEAVNMSLG | LSLAATTSPP | 
    150:
    QLLACGPTVH | QTCSENTYVK | GLCFLFGSNL | RQQPQKFPEA | LRGCPQEDSD | 
    200:
    IAFLIDGSGS | IIPHDFRRMK | EFVSTVMEQL | KKSKTLFSLM | QYSEEFRIHF | 
    250:
    TFKEFQNNPN | PRSLVKPITQ | LLGRTHTATG | IRKVVRELFN | ITNGARKNAF | 
    300:
    KILVVITDGE | KFGDPLGYED | VIPEADREGV | IRYVIGVGDA | FRSEKSRQEL | 
    350:
    NTIASKPPRD | HVFQVNNFEA | LKTIQNQLRE | KIFAIEGTQT | GSSSSFEHEM | 
    400:
    SQEGFSAAIT | SNGPLLSTVG | SYDWAGGVFL | YTSKEKSTFI | NMTRVDSDMN | 
    450:
    DAYLGYAAAI | ILRNRVQSLV | LGAPRYQHIG | LVAMFRQNTG | MWESNANVKG | 
    500:
    TQIGAYFGAS | LCSVDVDSNG | STDLVLIGAP | HYYEQTRGGQ | VSVCPLPRGR | 
    550:
    ARWQCDAVLY | GEQGQPWGRF | GAALTVLGDV | NGDKLTDVAI | GAPGEEDNRG | 
    600:
    AVYLFHGTSG | SGISPSHSQR | IAGSKLSPRL | QYFGQSLSGG | QDLTMDGLVD | 
    650:
    LTVGAQGHVL | LLRSQPVLRV | KAIMEFNPRE | VARNVFECND | QVVKGKEAGE | 
    700:
    VRVCLHVQKS | TRDRLREGQI | QSVVTYDLAL | DSGRPHSRAV | FNETKNSTRR | 
    750:
    QTQVLGLTQT | CETLKLQLPN | CIEDPVSPIV | LRLNFSLVGT | PLSAFGNLRP | 
    800:
    VLAEDAQRLF | TALFPFEKNC | GNDNICQDDL | SITFSFMSLD | CLVVGGPREF | 
    850:
    NVTVTVRNDG | EDSYRTQVTF | FFPLDLSYRK | VSTLQNQRSQ | RSWRLACESA | 
    900:
    SSTEVSGALK | STSCSINHPI | FPENSEVTFN | ITFDVDSKAS | LGNKLLLKAN | 
    950:
    VTSENNMPRT | NKTEFQLELP | VKYAVYMVVT | SHGVSTKYLN | FTASENTSRV | 
    1000:
    MQHQYQVSNL | GQRSLPISLV | FLVPVRLNQT | VIWDRPQVTF | SENLSSTCHT | 
    1050:
    KERLPSHSDF | LAELRKAPVV | NCSIAVCQRI | QCDIPFFGIQ | EEFNATLKGN | 
    1100:
    LSFDWYIKTS | HNHLLIVSTA | EILFNDSVFT | LLPGQGAFVR | SQTETKVEPF | 
    1150:
    EVPNPLPLIV | GSSVGGLLLL | ALITAALYKL | GFFKRQYKDM | MSEGGPPGAE | 
    1152:
    PQ
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    UniGene:
    String:
    MIM:
    KEGG:
    SMR:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Integrin alpha-M
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    E1685m
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    ELISA Kit for Human Integrin alpha-M
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    96T
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    CLIA Kit for Human Integrin alpha-M
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    U1685h
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    Packing:
    96T
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    CLIA Kit for Human Integrin alpha-M
    Cat.:
    U1685m
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human Integrin alpha-M
    Cat.:
    P1685Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Integrin alpha-M
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    P1685Rb-h
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Integrin alpha-M
    Cat.:
    M1685h
    Price:
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    Packing:
    40ug
    Monoclonal Antibody for Human Integrin alpha-M
    Protein for Human Integrin alpha-M
    Protein for Human Integrin alpha-M

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "The human leukocyte adhesion glycoprotein Mac-1 (complement receptor type 3, CD11b) alpha subunit. Cloning, primary structure, and relation to the integrins, von Willebrand factor and factor B."
      Corbi A.L. , Kishimoto T.K. , Miller L.J. , Springer T.A.
      J. Biol. Chem.263:12403-12411(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
    2. 2.
      "Molecular cloning of the alpha subunit of human and guinea pig leukocyte adhesion glycoprotein Mo1: chromosomal localization and homology to the alpha subunits of integrins."
      Arnaout M.A. , Remold-O'Donnell E. , Pierce M.W. , Harris P. , Tenen D.G.
      Proc. Natl. Acad. Sci. U.S.A.85:2776-2780(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    3. 3.
      "Amino acid sequence of the alpha subunit of human leukocyte adhesion receptor Mo1 (complement receptor type 3)."
      Arnaout M.A. , Gupta S.K. , Pierce M.W. , Tenen D.G.
      J. Cell Biol.106:2153-2158(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    4. 4.
      "Structural analysis of the CD11b gene and phylogenetic analysis of the alpha-integrin gene family demonstrate remarkable conservation of genomic organization and suggest early diversification during evolution."
      Fleming J.C. , Pahl H.L. , Gonzalez D.A. , Smith T.F. , Tenen D.G.
      J. Immunol.150:480-490(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1)
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANTS HIS-77; THR-441; VAL-858 AND SER-1146
    6. 6.
      "cDNA sequence for the alpha M subunit of the human neutrophil adherence receptor indicates homology to integrin alpha subunits."
      Hickstein D.D. , Hickey M.J. , Ozols J. , Baker D.M. , Back A.L. , Roth G.J.
      Proc. Natl. Acad. Sci. U.S.A.86:257-261(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 9-1152 (ISOFORM 2)
    7. 7.
      "The promoter of the CD11b gene directs myeloid-specific and developmentally regulated expression."
      Shelley C.S. , Arnaout M.A.
      Proc. Natl. Acad. Sci. U.S.A.88:10525-10529(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-9
    8. 8.
      "Characterization of the myeloid-specific CD11b promoter."
      Pahl H.L. , Rosmarin A.G. , Tenen D.G.
      Blood79:865-870(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-9
      tissue: Blood.
    9. 9.
      "N-terminal sequence of human leukocyte glycoprotein Mo1: conservation across species and homology to platelet IIb/IIIa."
      Pierce M.W. , Remold-O'Donnell E. , Todd R.F. III , Arnaout M.A.
      Biochim. Biophys. Acta874:368-371(1986) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 17-31
    10. 10.
      "The junctional adhesion molecule 3 (JAM-3) on human platelets is a counterreceptor for the leukocyte integrin Mac-1."
      Santoso S. , Sachs U.J.H. , Kroll H. , Linder M. , Ruf A. , Preissner K.T. , Chavakis T.
      J. Exp. Med.196:679-691(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH JAM3
    11. 11.
      "JAM-C is a component of desmosomes and a ligand for CD11b/CD18-mediated neutrophil transepithelial migration."
      Zen K. , Babbin B.A. , Liu Y. , Whelan J.B. , Nusrat A. , Parkos C.A.
      Mol. Biol. Cell15:3926-3937(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH JAM3
    12. 12.
      "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
      J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-900; ASN-940 AND ASN-946
      tissue: Liver.
    13. 13.
      "Crystal structure of the A domain from the alpha subunit of integrin CR3 (CD11b/CD18)."
      Lee J.O. , Rieu P. , Arnaout M.A. , Liddington R.
      Cell80:631-638(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 148-331
    14. 14.
      "Two conformations of the integrin A-domain (I-domain): a pathway for activation?"
      Lee J.O. , Bankston L.A. , Arnaout M.A. , Liddington R.C.
      Structure3:1333-1340(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 148-334
    15. 15.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 148-337
    16. 16.
      "Experimental support for a beta-propeller domain in integrin alpha-subunits and a calcium binding site on its lower surface."
      Oxvig C. , Springer T.A.
      Proc. Natl. Acad. Sci. U.S.A.95:4870-4875(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: 3D-STRUCTURE MODELING OF 17-616
    17. 17.
      "A nonsynonymous functional variant in integrin-alpha(M) (encoded by ITGAM) is associated with systemic lupus erythematosus."
      Nath S.K. , Han S. , Kim-Howard X. , Kelly J.A. , Viswanathan P. , Gilkeson G.S. , Chen W. , Zhu C. , McEver R.P. , Kimberly R.P. , Alarcon-Riquelme M.E. , Vyse T.J. , Li Q.-Z. , Wakeland E.K. , Merrill J.T. , James J.A. , Kaufman K.M. , Guthridge J.M. , more...
      Nat. Genet.40:152-154(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO SLE;VARIANT HIS-77
    18. 18.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO SLE
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