ITGB2 ELISA Kit for Human(Homo sapiens) | EIAab.comITGB2 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > ITGB2(Gene name) > Human

ITGB2 (Gene name),

Integrin beta-2 (Protein name ), ITB2_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

ITGB2(CD18;MFI7);

Protein name:

Integrin beta-2;

Alternative:

Complement receptor C3 subunit beta;Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta;

CD:

CD18;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Heterodimer of an alpha and a beta subunit. Beta-2 associates with either alpha-L, alpha-M, alpha-X or alpha-D. Interacts with FGR (By similarity). Interacts with COPS5 and RANBP9.

Function:

Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1.

Subcellular Location:

Membrane Single-pass type I membrane protein

Protein Attributes:

Sequence length:

769

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

769:

NPLFKSATTT | VMNPKFAES

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

STRING:

9606.ENSP00000303242

String:

P05107

Pfam:

PF08725

KEGG:

hsa:3689

UniGene:

Hs.375957

MIM:

116920

SMR:

P05107

Uniprot:

P05107

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ELISA Kit for Human Integrin beta-2

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E0236h

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Manual:

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96T

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ELISA Kit for Human Integrin beta-2

Cat.:

E0236p

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96T

ELISA Kit for Human Integrin beta-2

Cat.:

E0236b

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96T

ELISA Kit for Human Integrin beta-2

Cat.:

E0236m

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96T

CLIA Kit for Human Integrin beta-2

Cat.:

U0236b

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Packing:

96T

CLIA Kit for Human Integrin beta-2

Cat.:

U0236m

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MSDS:

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Packing:

96T

CLIA Kit for Human Integrin beta-2

Cat.:

U0236p

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MSDS:

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Packing:

96T

CLIA Kit for Human Integrin beta-2

Cat.:

U0236h

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Packing:

96T

Polyclonal Antibody for Human Integrin beta-2

Cat.:

P0236Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human Integrin beta-2

Cat.:

P0236Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human Integrin beta-2

Monoclonal Antibody for Human Integrin beta-2

Protein for Human Integrin beta-2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Cloning of the beta subunit of the leukocyte adhesion proteins: homology to an extracellular matrix receptor defines a novel supergene family."
Kishimoto T.K. , O'Connor K. , Lee A. , Roberts T.M. , Springer T.A.
Cell48:681-690(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT HIS-354
2.

"The gene organisation of the human beta 2 integrin subunit (CD18)."
Weitzman J.B. , Wells C.E. , Wright A.H. , Clark P.A. , Law S.K.A.
FEBS Lett.294:97-103(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT HIS-354
3.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT HIS-354
tissue: Synovial cell.
4.

Suzuki Y. , Sugano S. , Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S.
Submitted (2005-04) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT HIS-354
tissue: Adipose tissue.
5.

"The DNA sequence of human chromosome 21."
Hattori M. , Fujiyama A. , Taylor T.D. , Watanabe H. , Yada T. , Park H.-S. , Toyoda A. , Ishii K. , Totoki Y. , Choi D.-K. , Groner Y. , Soeda E. , Ohki M. , Takagi T. , Sakaki Y. , Taudien S. , Blechschmidt K. , Polley A. , more...
Nature405:311-319(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT HIS-354
7.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT HIS-354
tissue: Muscle.
8.

"The primary structure of the beta-subunit of the cell surface adhesion glycoproteins LFA-1, CR3 and p150,95 and its relationship to the fibronectin receptor."
Law S.K.A. , Gagnon J. , Hildreth J.E. , Wells C.E. , Willis A.C. , Wong A.J.
EMBO J.6:915-919(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 9-769;PARTIAL PROTEIN SEQUENCE;PYROGLUTAMATE FORMATION AT GLN-23;VARIANT HIS-354
tissue: Spleen.
9.

"Familial genetic defect in a case of leukocyte adhesion deficiency."
Ohashi Y. , Yambe T. , Tsuchiya S. , Kikuchi H. , Konno T.
Hum. Mutat.2:458-467(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 124-199;VARIANT LAD1 LEU-178
tissue: Lymphoblast.
10.

"Genetic cause of leukocyte adhesion molecule deficiency. Abnormal splicing and a missense mutation in a conserved region of CD18 impair cell surface expression of beta 2 integrins."
Nelson C. , Rabb H. , Arnaout M.A.
J. Biol. Chem.267:3351-3357(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 347-355;VARIANTS LAD1 SER-351 AND TRP-586;VARIANT HIS-354
11.

"Integrin LFA-1 interacts with the transcriptional co-activator JAB1 to modulate AP-1 activity."
Bianchi E. , Denti S. , Granata A. , Bossi G. , Geginat J. , Villa A. , Rogge L. , Pardi R.
Nature404:617-621(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH COPS5
12.

"Phosphorylation of the cytoplasmic domain of the integrin CD18 chain by protein kinase C isoforms in leukocytes."
Fagerholm S. , Morrice N. , Gahmberg C.G. , Cohen P.
J. Biol. Chem.277:1728-1738(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-745; SER-756; THR-758 AND THR-760
13.

"RanBPM is a phosphoprotein that associates with the plasma membrane and interacts with the integrin LFA-1."
Denti S. , Sirri A. , Cheli A. , Rogge L. , Innamorati G. , Putignano S. , Fabbri M. , Pardi R. , Bianchi E.
J. Biol. Chem.279:13027-13034(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RANBP9
14.

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-212
tissue: Plasma.
15.

"Nonmuscle myosin light-chain kinase mediates neutrophil transmigration in sepsis-induced lung inflammation by activating beta2 integrins."
Xu J. , Gao X.-P. , Ramchandran R. , Zhao Y.-Y. , Vogel S.M. , Malik A.B.
Nat. Immunol.9:880-886(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION DURING LUNG INJURY
16.

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-50 AND ASN-212
tissue: Liver.
17.

"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
Wollscheid B. , Bausch-Fluck D. , Henderson C. , O'Brien R. , Bibel M. , Schiess R. , Aebersold R. , Watts J.D.
Nat. Biotechnol.27:378-386(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-50; ASN-116; ASN-212; ASN-213 AND ASN-215
tissue: Leukemic T-cell.
18.

"Structure of an integrin with an alphaI domain, complement receptor type 4."
Xie C. , Zhu J. , Chen X. , Mi L. , Nishida N. , Springer T.A.
EMBO J.29:666-679(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.5 ANGSTROMS) OF 23-699 IN COMPLEX WITH ITGAX;GLYCOSYLATION AT ASN-116;DISULFIDE BONDS;CALCIUM-BINDING SITES;SUBUNIT
19.

"Point mutations impairing cell surface expression of the common beta subunit (CD18) in a patient with leukocyte adhesion molecule (Leu-CAM) deficiency."
Arnaout M.A. , Dana N. , Gupta S.K. , Tenen D.G. , Fathallah D.M.
J. Clin. Invest.85:977-981(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS LAD1 THR-196 AND CYS-593
20.

"Distinct mutations in two patients with leukocyte adhesion deficiency and their functional correlates."
Wardlaw A.J. , Hibbs M.L. , Stacker S.A. , Springer T.A.
J. Exp. Med.172:335-345(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS LAD1 PRO-149 AND ARG-169
21.

"Leukocyte adhesion deficiency: identification of novel mutations in two Japanese patients with a severe form."
Matsuura S. , Kishi F. , Tsukahara M. , Nunoi H. , Matsuda I. , Kobayashi K. , Kajii T.
Biochem. Biophys. Res. Commun.184:1460-1467(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LAD1 ASN-128
22.

"Molecular basis for a severe case of leukocyte adhesion deficiency."
Corbi A. , Vara A. , Ursa A. , Rodriguez M.C.G. , Fontan G. , Sanchez-Madrid F.
Eur. J. Immunol.22:1877-1881(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LAD1 ARG-169
23.

"Identification of two molecular defects in a child with leukocyte adherence deficiency."
Back L.L. , Kwok W.W. , Hickstein D.D.
J. Biol. Chem.267:5482-5487(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LAD1 LEU-178
24.

"A point mutation associated with leukocyte adhesion deficiency type 1 of moderate severity."
Back L.A. , Kerkering M. , Baker D. , Bauer T.R. , Embree L.J. , Hickstein D.D.
Biochem. Biophys. Res. Commun.193:912-918(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LAD1 SER-284
25.

"A novel leukocyte adhesion deficiency caused by expressed but nonfunctional beta2 integrins Mac-1 and LFA-1."
Hogg N. , Stewart M.P. , Scarth S.L. , Newton R. , Shaw J.M. , Law S.K.A. , Klein N.
J. Clin. Invest.103:97-106(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS LAD1 PRO-138 AND ARG-273
26.

"A novel point mutation in CD18 causing leukocyte adhesion deficiency in a Chinese patient."
Li L. , Jin Y.Y. , Cao R.M. , Chen T.X.
Chin. Med. J.123:1278-1282(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LAD1 VAL-300
27.

"Characterization of 11 new cases of leukocyte adhesion deficiency type 1 with seven novel mutations in the ITGB2 gene."
Parvaneh N. , Mamishi S. , Rezaei A. , Rezaei N. , Tamizifar B. , Parvaneh L. , Sherkat R. , Ghalehbaghi B. , Kashef S. , Chavoshzadeh Z. , Isaeian A. , Ashrafi F. , Aghamohammadi A.
J. Clin. Immunol.30:756-760(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS LAD1 TYR-128; THR-239 AND ALA-716

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