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Index > Protein center > SPAG9(Gene name) > Human
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  • SPAG9 (Gene name),
  • C-Jun-amino-terminal kinase-interacting protein 4 (Protein name ),  JIP4_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    SPAG9(HLC6;HSS;KIAA0516;MAPK8IP4;SYD1);
    Protein name:
    C-Jun-amino-terminal kinase-interacting protein 4(JIP-4;JNK-interacting protein 4);
    Alternative:
    Sunday driver 1;Human lung cancer oncogene 6 protein(HLC-6);Cancer/testis antigen 89(CT89);Mitogen-activated protein kinase 8-interacting protein 4;JNK-associated leucine-zipper protein(JLP);Protein highly expressed in testis(PHET);Proliferation-inducing protein 6;Sperm-associated antigen 9;Sperm surface protein;Sperm-specific protein;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homooligomer. Interacts with MAX, MAPK8, MAPK9, MAPK10, MAPK14, MAP3K3, MYC, KNS2 and MAP2K4. Interaction with KNS2 is important in the formation of ternary complex with MAPK8. Interacts with NFKB1.
    Function:
    The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Isoform 5 may play a role in spermatozoa-egg-interaction.
    Subcellular Location:
    Isoform 5 Cytoplasmic vesicle secretory vesicle acrosome Associated with the plasma membrane of the acrosomal compartment and also localizes in the acrosome matrix.
    Protein Attributes:
    Sequence length:
    1321
    Sequence:
    50:
    MELEDGVVYQ | EEPGGSGAVM | SERVSGLAGS | IYREFERLIG | RYDEEVVKEL | 
    100:
    MPLVVAVLEN | LDSVFAQDQE | HQVELELLRD | DNEQLITQYE | REKALRKHAE | 
    150:
    EKFIEFEDSQ | EQEKKDLQTR | VESLESQTRQ | LELKAKNYAD | QISRLEEREA | 
    200:
    ELKKEYNALH | QRHTEMIHNY | MEHLERTKLH | QLSGSDQLES | TAHSRIRKER | 
    250:
    PISLGIFPLP | AGDGLLTPDA | QKGGETPGSE | QWKFQELSQP | RSHTSLKVSN | 
    300:
    SPEPQKAVEQ | EDELSDVSQG | GSKATTPAST | ANSDVATIPT | DTPLKEENEG | 
    350:
    FVKVTDAPNK | SEISKHIEVQ | VAQETRNVST | GSAENEEKSE | VQAIIESTPE | 
    400:
    LDMDKDLSGY | KGSSTPTKGI | ENKAFDRNTE | SLFEELSSAG | SGLIGDVDEG | 
    450:
    ADLLGMGREV | ENLILENTQL | LETKNALNIV | KNDLIAKVDE | LTCEKDVLQG | 
    500:
    ELEAVKQAKL | KLEEKNRELE | EELRKARAEA | EDARQKAKDD | DDSDIPTAQR | 
    550:
    KRFTRVEMAR | VLMERNQYKE | RLMELQEAVR | WTEMIRASRE | NPAMQEKKRS | 
    600:
    SIWQFFSRLF | SSSSNTTKKP | EPPVNLKYNA | PTSHVTPSVK | KRSSTLSQLP | 
    650:
    GDKSKAFDFL | SEETEASLAS | RREQKREQYR | QVKAHVQKED | GRVQAFGWSL | 
    700:
    PQKYKQVTNG | QGENKMKNLP | VPVYLRPLDE | KDTSMKLWCA | VGVNLSGGKT | 
    750:
    RDGGSVVGAS | VFYKDVAGLD | TEGSKQRSAS | QSSLDKLDQE | LKEQQKELKN | 
    800:
    QEELSSLVWI | CTSTHSATKV | LIIDAVQPGN | ILDSFTVCNS | HVLCIASVPG | 
    850:
    ARETDYPAGE | DLSESGQVDK | ASLCGSMTSN | SSAETDSLLG | GITVVGCSAE | 
    900:
    GVTGAATSPS | TNGASPVMDK | PPEMEAENSE | VDENVPTAEE | ATEATEGNAG | 
    950:
    SAEDTVDISQ | TGVYTEHVFT | DPLGVQIPED | LSPVYQSSND | SDAYKDQISV | 
    1000:
    LPNEQDLVRE | EAQKMSSLLP | TMWLGAQNGC | LYVHSSVAQW | RKCLHSIKLK | 
    1050:
    DSILSIVHVK | GIVLVALADG | TLAIFHRGVD | GQWDLSNYHL | LDLGRPHHSI | 
    1100:
    RCMTVVHDKV | WCGYRNKIYV | VQPKAMKIEK | SFDAHPRKES | QVRQLAWVGD | 
    1150:
    GVWVSIRLDS | TLRLYHAHTY | QHLQDVDIEP | YVSKMLGTGK | LGFSFVRITA | 
    1200:
    LMVSCNRLWV | GTGNGVIISI | PLTETNKTSG | VPGNRPGSVI | RVYGDENSDK | 
    1250:
    VTPGTFIPYC | SMAHAQLCFH | GHRDAVKFFV | AVPGQVISPQ | SSSSGTDLTG | 
    1300:
    DKAGPSAQEP | GSQTPLKSML | VISGGEGYID | FRMGDEGGES | ELLGEDLPLE | 
    1321:
    PSVTKAERSH | LIVWQVMYGN | E
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    Pfam:
    MIM:
    UniGene:
    KEGG:
    SMR:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human JIP-4
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    E12202m
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    ELISA Kit for Human JIP-4
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    E12202h
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    CLIA Kit for Human JIP-4
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    CLIA Kit for Human JIP-4
    Cat.:
    U12202m
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human JIP-4
    Polyclonal Antibody for Human JIP-4
    Cat.:
    P12202Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human JIP-4
    Monoclonal Antibody for Human JIP-4
    Protein for Human JIP-4
    Protein for Human JIP-4

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "JLP: a scaffolding protein that tethers JNK/p38MAPK signaling modules and transcription factors."
      Lee C.M. , Onesime D. , Reddy C.D. , Dhanasekaran N. , Reddy E.P.
      Proc. Natl. Acad. Sci. U.S.A.99:14189-14194(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
      tissue: Liver.
    2. 2.
      "Humoral detection of leukaemia-associated antigens in presentation acute myeloid leukaemia."
      Guinn B.-A. , Bland E.A. , Lodi U. , Liggins A.P. , Tobal K. , Petters S. , Wells J.W. , Banham A.H. , Mufti G.J.
      Biochem. Biophys. Res. Commun.335:1293-1304(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4);TISSUE SPECIFICITY
    3. 3.
      "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
      Nagase T. , Ishikawa K. , Miyajima N. , Tanaka A. , Kotani H. , Nomura N. , Ohara O.
      DNA Res.5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Brain.
    4. 4.
      "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
      Nakajima D. , Okazaki N. , Yamakawa H. , Kikuno R. , Ohara O. , Nagase T.
      DNA Res.9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION
    5. 5.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 6)
      tissue: Brain.
      tissue: Testis.
    6. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 6);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-478 (ISOFORMS 2/4/5)
      tissue: Eye.
      tissue: Kidney.
    7. 8.
      "Cloning of a novel human testis mRNA specifically expressed in testicular haploid germ cells, having unique palindromic sequences and encoding a leucine zipper dimerization motif."
      Shankar S. , Mohapatra B. , Suri A.
      Biochem. Biophys. Res. Commun.243:561-565(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 130-1321 (ISOFORM 5);TISSUE SPECIFICITY
      tissue: Testis.
    8. 9.
      "A novel protein highly expressed in testis is overexpressed in systemic sclerosis fibroblasts and targeted by autoantibodies."
      Yasuoka H. , Ihn H. , Medsger T.A. Jr. , Hirakata M. , Kawakami Y. , Ikeda Y. , Kuwana M.
      J. Immunol.171:6883-6890(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 162-1321 (ISOFORM 3);TISSUE SPECIFICITY;SUBCELLULAR LOCATION;INDUCTION
      tissue: Testis.
    9. 10.
      "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."
      Brill L.M. , Salomon A.R. , Ficarro S.B. , Mukherji M. , Stettler-Gill M. , Peters E.C.
      Anal. Chem.76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    10. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH NFKB1
    11. 12.
      "Characterization of a novel human sperm-associated antigen 9 (SPAG9) having structural homology with c-Jun N-terminal kinase-interacting protein."
      Jagadish N. , Rana R. , Selvi R. , Mishra D. , Garg M. , Yadav S. , Herr J.C. , Okumura K. , Hasegawa A. , Koyama K. , Suri A.
      Biochem. J.389:73-82(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH MAPK9; MAPK10 AND MAPK8;SUBCELLULAR LOCATION;IDENTIFICATION BY MASS SPECTROMETRY
    12. 13.
      "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
      Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-203 AND THR-217;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    13. 14.
      "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
      Matsuoka S. , Ballif B.A. , Smogorzewska A. , McDonald E.R. III , Hurov K.E. , Luo J. , Bakalarski C.E. , Zhao Z. , Solimini N. , Lerenthal Y. , Shiloh Y. , Gygi S.P. , Elledge S.J.
      Science316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-109; SER-265; SER-272 AND THR-418;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Embryonic kidney.
    14. 15.
      "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T. , Yi W. , Lu B. , Park S.K. , Xu T. , Lee J.-D. , Yates J.R. III
      J. Proteome Res.7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    15. 16.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-183; SER-185; THR-217; SER-311; SER-329; SER-332; THR-418; THR-586 AND SER-733;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    16. 17.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    17. 18.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-203; THR-217 AND SER-733;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    18. 19.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-183; SER-194; SER-203; THR-217; SER-251; SER-265; SER-268; SER-272; SER-329; SER-332; SER-347; THR-348; THR-418; SER-730 AND SER-733;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    19. 20.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    20. 21.
      "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
      Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-183; SER-185; SER-329 AND SER-332;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    21. 22.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    22. 23.
      "The structural basis of Arf effector specificity: the crystal structure of ARF6 in a complex with JIP4."
      Isabet T. , Montagnac G. , Regazzoni K. , Raynal B. , El Khadali F. , England P. , Franco M. , Chavrier P. , Houdusse A. , Menetrey J.
      EMBO J.28:2835-2845(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.93 ANGSTROMS) OF 406-476 IN COMPLEX WITH ARF6;COILED COIL;SUBUNIT;INTERACTION WITH ARF6
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