Gene name:
Spag9 (Jip4;Jsap2;Kiaa0516;Mapk8ip4) ;
Protein name:
C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4;JNK-interacting protein 4) ;
Alternative:
JNK/SAPK-associated protein 2 (JSAP2) ;JNK-associated leucine-zipper protein (JLP) ;Sperm-associated antigen 9 ;Mitogen-activated protein kinase 8-interacting protein 4 ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Homooligomer. Interacts with MAX, MAPK8, MAPK14, MAPK10, MAPK14, MAP3K3, MYC, KNS2, and MAP2K4. Interaction with KNS2 is important in the formation of ternary complex with MAPK8.
Function:
The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module.
Subcellular Location:
Cytoplasm
Cytoplasm
perinuclear region
Perinuclear distribution in response to stress signals such as UV radiation.
Protein Attributes:
50:
MELEDGVVYQ | EEPGGSGAVM | SERVSGLAGS | IYREFERLIG | RYDEEVVKEL |
100:
MPLVVAVLEN | LDSVFAQDQE | HQVELELLRD | DNEQLITQYE | REKALRKHAE |
150:
EKFIEFEDSQ | EQEKKDLQTR | VESLESQTRQ | LELKAKNYAD | QISRLEEREA |
200:
ELKKEYNALH | QRHTEMIHNY | MEHLERTKLH | QLSGSDQLEA | TAHSRIRKER |
250:
PISLGIFPLP | AGDGLLTPDT | QKGGETPGSE | QWKFQELSQP | RSHTSLKVSH |
300:
SPEPPKAVEQ | EDELSDISQG | GSKATTPAST | ANSDVSAIPP | DTPSKEDNEG |
350:
FVKGTDTSNK | SEISKHIEVQ | VAQETRNVST | ESGENEEKSE | VQAIIESTPE |
400:
LDMDKDLSGY | KGSSTPTKGI | ENKAFDRNTE | SLFEELSSAG | SGLIGDVDEG |
450:
ADLLGMGREV | ENLILENTQL | LETKNALNVV | KNDLIAKVDE | LTCEKDVLQG |
500:
ELEAVKQAKL | KLEDKNRELE | EELRKARAEA | EDARQKAKDD | DDSDIPTAQR |
550:
KRFTRVEMAR | VLMERNQYKE | RLMELQEAVR | WTEMIRASRE | NPAMQEKKRS |
600:
SIWQFFSRLF | SSSSNATKKP | EPPVNLKYNA | PTSHVTPSVK | KRSSTLSQLP |
650:
GDKSKAFDFL | SEETEASLAS | RREQKREQYR | QVKAHVQKED | GRVQAFGWSL |
700:
PQKYKQVANG | QGETKMKNLP | VPVYLRPLDE | KDASMKLWCA | VGVNLSGGKT |
750:
RDGGSVVGAS | VFYKDIAGLD | TEGSKQRSAS | QSSLDKLDQE | LKEQQKEFKN |
800:
QEELSSQVWI | CTSTHSTTKV | IIIDAVQPGN | ILDSFTVCNS | HVLCIASVPG |
850:
ARETDYPAGE | ELSESGQVDK | ASLCGSMTSN | SSAEMDSLLG | GITVVGCSTE |
900:
GLTGAATSPS | TNGASPVIEK | PPEMETENSE | VDENIPTAEE | ATEATEGNAG |
950:
STEDTVDISQ | PGVYTEHVFT | DPLGVQIPED | LSPVFQSSND | SDVYKDQISV |
1000:
LPNEQDLARE | EAQKMSSLLP | TMWLGAQNGC | LYVHSSVAQW | RKCLHSIKLK |
1050:
DSILSIVHVK | GIVLVALADG | TLAIFHRGVD | GQWDLSNYHL | LDLGRPHHSI |
1100:
RCMTVVHDKV | WCGYRNKIYV | VQPKAMKIEK | SFDAHPRKES | QVRQLAWVGD |
1150:
GVWVSIRLDS | TLRLYHAHTY | QHLQDVDIEP | YVSKMLGTGK | LGFSFVRITA |
1200:
LMVSCNRLWV | GTGNGVIISI | PLTETNKTSG | TPGNRPGSVI | RVYGDENSDK |
1250:
VTPGTFIPYC | SMAHAQLCFH | GHRDAVKFFV | AVPGQVISPQ | SSSGGADLTA |
1300:
DKAGSSAQEP | SSQTPLKSML | VISGGEGYID | FRMGDEGGES | ELLGEDLPLE |
1321:
PSVTKAERSH | LIVWQVMCGN | E
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
ELISA Kit for Mouse JIP-4
ELISA Kit for Mouse JIP-4
Polyclonal Antibody for Mouse JIP-4
Polyclonal Antibody for Mouse JIP-4
Monoclonal Antibody for Mouse JIP-4
Monoclonal Antibody for Mouse JIP-4
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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C57BL/6J .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];ALTERNATIVE SPLICING
strain :
C57BL/6J .
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5)
strain :
C57BL/6 .
tissue :
Brain .
tissue :
Olfactory epithelium .
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH KNS2;INDUCTION
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-733;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Liver .
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-217 AND THR-365;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Embryonic fibroblast .