Protein name:
Transcription factor AP-1 ;
Alternative:
Proto-oncogene c-Jun ;Activator protein 1 (AP1) ;V-jun avian sarcoma virus 17 oncogene homolog ;
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Heterodimer with either FOS or BATF3 or ATF7 (By similarity). The ATF7/JUN heterodimer is essential for ATF7 transactivation activity. Interacts with MYBBP1A, SP1, SPIB and TCF20. Interacts with COPS5; indirectly leading to its phosphorylation. Interacts with DSIPI; this interaction inhibits the binding of active AP1 to its target DNA. Interacts with HIVEP3. Component of the SMAD3/SMAD4/JUN/FOS/complex which forms at the AP1 promoter site. The SMAD3/SMAD4 heterodimer acts syngernistically with the JUN/FOS heterodimer to activate transcription in response to TGF-beta. Interacts (via its basic DNA binding and leucine zipper domains) with SMAD3 (via an N-terminal domain); the interaction is required for TGF-beta-mediated transactivation of the SMAD3/SMAD4/JUN/FOS/complex (By similarity). Binds to HIPK3 (By similarity). Interacts with RNF187.
Function:
Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation.
Subcellular Location:
Nucleus
Protein Attributes:
50:
MTAKMETTFY | DDALNASFLQ | SESGAYGYSN | PKILKQSMTL | NLADPVGNLK |
100:
PHLRAKNSDL | LTSPDVGLLK | LASPELERLI | IQSSNGHITT | TPTPTQFLCP |
150:
KNVTDEQEGF | AEGFVRALAE | LHSQNTLPSV | TSAAQPVSGA | GMVAPAVASV |
200:
AGAGGGGGYS | ASLHSEPPVY | ANLSNFNPGA | LSSGGGAPSY | GATGLAFPSQ |
250:
PQQQQQPPQP | PHHLPQQIPV | QHPRLQALKE | EPQTVPEMPG | ETPPLSPIDM |
300:
ESQERIKAER | KRMRNRIAAS | KCRKRKLERI | ARLEEKVKTL | KAQNSELAST |
334:
ANMLREQVAQ | LKQKVMNHVN | SGCQLMLTQQ | LQTF
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Rat
Human
Bovine
Chicken
Pig
ELISA Kit for Rat Transcription factor AP-1
ELISA Kit for Rat Transcription factor AP-1
ELISA Kit for Rat Transcription factor AP-1
ELISA Kit for Rat Transcription factor AP-1
ELISA Kit for Rat Transcription factor AP-1
ELISA Kit for Rat Transcription factor AP-1
CLIA Kit for Rat Transcription factor AP-1
CLIA Kit for Rat Transcription factor AP-1
CLIA Kit for Rat Transcription factor AP-1
CLIA Kit for Rat Transcription factor AP-1
CLIA Kit for Rat Transcription factor AP-1
CLIA Kit for Rat Transcription factor AP-1
Polyclonal Antibody for Rat Transcription factor AP-1
Polyclonal Antibody for Rat Transcription factor AP-1
Polyclonal Antibody for Rat Transcription factor AP-1
Polyclonal Antibody for Rat Transcription factor AP-1
Polyclonal Antibody for Rat Transcription factor AP-1
Polyclonal Antibody for Rat Transcription factor AP-1
Monoclonal Antibody for Rat Transcription factor AP-1
Monoclonal Antibody for Rat Transcription factor AP-1
Monoclonal Antibody for Rat Transcription factor AP-1
Monoclonal Antibody for Rat Transcription factor AP-1
Monoclonal Antibody for Rat Transcription factor AP-1
Monoclonal Antibody for Rat Transcription factor AP-1
Protein for Rat Transcription factor AP-1
Protein for Rat Transcription factor AP-1
Protein for Rat Transcription factor AP-1
Protein for Rat Transcription factor AP-1
Protein for Rat Transcription factor AP-1
Protein for Rat Transcription factor AP-1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
tissue :
Liver .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
strain :
Fischer .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
strain :
Fischer .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Lung .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH BATF3
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH RNF187