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Index > Protein center > Jun(Gene name) > Rat
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  • Jun (Gene name),
  • Transcription factor AP-1 (Protein name ),  JUN_RAT from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Gene name:
    Jun(Rjg-9);
    Protein name:
    Transcription factor AP-1;
    Alternative:
    Proto-oncogene c-Jun;Activator protein 1(AP1);V-jun avian sarcoma virus 17 oncogene homolog;
    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    Heterodimer with either FOS or BATF3 or ATF7 (By similarity). The ATF7/JUN heterodimer is essential for ATF7 transactivation activity. Interacts with MYBBP1A, SP1, SPIB and TCF20. Interacts with COPS5; indirectly leading to its phosphorylation. Interacts with DSIPI; this interaction inhibits the binding of active AP1 to its target DNA. Interacts with HIVEP3. Component of the SMAD3/SMAD4/JUN/FOS/complex which forms at the AP1 promoter site. The SMAD3/SMAD4 heterodimer acts syngernistically with the JUN/FOS heterodimer to activate transcription in response to TGF-beta. Interacts (via its basic DNA binding and leucine zipper domains) with SMAD3 (via an N-terminal domain); the interaction is required for TGF-beta-mediated transactivation of the SMAD3/SMAD4/JUN/FOS/complex (By similarity). Binds to HIPK3 (By similarity). Interacts with RNF187.
    Function:
    Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    334
    Sequence:
    50:
    MTAKMETTFY | DDALNASFLQ | SESGAYGYSN | PKILKQSMTL | NLADPVGNLK | 
    100:
    PHLRAKNSDL | LTSPDVGLLK | LASPELERLI | IQSSNGHITT | TPTPTQFLCP | 
    150:
    KNVTDEQEGF | AEGFVRALAE | LHSQNTLPSV | TSAAQPVSGA | GMVAPAVASV | 
    200:
    AGAGGGGGYS | ASLHSEPPVY | ANLSNFNPGA | LSSGGGAPSY | GATGLAFPSQ | 
    250:
    PQQQQQPPQP | PHHLPQQIPV | QHPRLQALKE | EPQTVPEMPG | ETPPLSPIDM | 
    300:
    ESQERIKAER | KRMRNRIAAS | KCRKRKLERI | ARLEEKVKTL | KAQNSELAST | 
    334:
    ANMLREQVAQ | LKQKVMNHVN | SGCQLMLTQQ | LQTF
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    KEGG:
    Pfam:
    UniGene:
    UniGene:
    SMR:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Rat Transcription factor AP-1
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    ELISA Kit for Rat Transcription factor AP-1
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    ELISA Kit for Rat Transcription factor AP-1
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    ELISA Kit for Rat Transcription factor AP-1
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    ELISA Kit for Rat Transcription factor AP-1
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    CLIA Kit for Rat Transcription factor AP-1
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    U1292c
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    CLIA Kit for Rat Transcription factor AP-1
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    CLIA Kit for Rat Transcription factor AP-1
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    U1292b
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    96T
    CLIA Kit for Rat Transcription factor AP-1
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    U1292h
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    96T
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    CLIA Kit for Rat Transcription factor AP-1
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    U1292r
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    96T
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    CLIA Kit for Rat Transcription factor AP-1
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    U1292m
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    MSDS:
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    Packing:
    96T
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    Polyclonal Antibody for Rat Transcription factor AP-1
    Polyclonal Antibody for Rat Transcription factor AP-1
    Polyclonal Antibody for Rat Transcription factor AP-1
    Cat.:
    P1292Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Transcription factor AP-1
    Polyclonal Antibody for Rat Transcription factor AP-1
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    P1292Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Transcription factor AP-1
    Cat.:
    P1292Rb-r
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Rat Transcription factor AP-1
    Monoclonal Antibody for Rat Transcription factor AP-1
    Monoclonal Antibody for Rat Transcription factor AP-1
    Monoclonal Antibody for Rat Transcription factor AP-1
    Monoclonal Antibody for Rat Transcription factor AP-1
    Monoclonal Antibody for Rat Transcription factor AP-1
    Protein for Rat Transcription factor AP-1
    Protein for Rat Transcription factor AP-1
    Protein for Rat Transcription factor AP-1
    Protein for Rat Transcription factor AP-1
    Protein for Rat Transcription factor AP-1
    Protein for Rat Transcription factor AP-1

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    References
    1. 1.
      "Structure and expression of the rat c-jun messenger RNA: tissue distribution and increase during chemical hepatocarcinogenesis."
      Sakai M. , Okuda A. , Hatayama I. , Sato K. , Nishi S. , Muramatsu M.
      Cancer Res.49:5633-5637(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Liver.
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
      strain: Fischer.
    3. 3.
      "Transcriptional regulation of the c-jun gene by retinoic acid and E1A during differentiation of F9 cells."
      Kitabayashi I. , Kawakami Z. , Chiu R. , Ozawa K. , Matsuoka T. , Toyoshima S. , Umesono K. , Evans R.M. , Gachelin G. , Yokoyama K.
      EMBO J.11:167-175(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: Fischer.
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Lung.
    5. 5.
      "Isolation of an AP-1 repressor by a novel method for detecting protein-protein interactions."
      Aronheim A. , Zandi E. , Hennemann H. , Elledge S.J. , Karin M.
      Mol. Cell. Biol.17:3094-3102(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BATF3
    6. 6.
      "Identification of a co-activator that links growth factor signalling to c-Jun/AP-1 activation."
      Davies C.C. , Chakraborty A. , Cipriani F. , Haigh K. , Haigh J.J. , Behrens A.
      Nat. Cell Biol.12:963-972(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RNF187
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