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Index > Protein center > KRT10(Gene name) > Human
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  • KRT10 (Gene name),
  • Keratin, type I cytoskeletal 10 (Protein name ),  K1C10_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    KRT10(KPP);
    Protein name:
    Keratin, type I cytoskeletal 10;
    Alternative:
    Keratin-10(K10);Cytokeratin-10(CK-10);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Heterotetramer of two type I and two type II keratins. keratin-10 is generally associated with keratin-1.
    Function:
    Subcellular Location:
    Protein Attributes:
    Sequence length:
    584
    Sequence:
    50:
    MSVRYSSSKH | YSSSRSGGGG | GGGGCGGGGG | VSSLRISSSK | GSLGGGFSSG | 
    100:
    GFSGGSFSRG | SSGGGCFGGS | SGGYGGLGGF | GGGSFRGSYG | SSSFGGSYGG | 
    150:
    IFGGGSFGGG | SFGGGSFGGG | GFGGGGFGGG | FGGGFGGDGG | LLSGNEKVTM | 
    200:
    QNLNDRLASY | LDKVRALEES | NYELEGKIKE | WYEKHGNSHQ | GEPRDYSKYY | 
    250:
    KTIDDLKNQI | LNLTTDNANI | LLQIDNARLA | ADDFRLKYEN | EVALRQSVEA | 
    300:
    DINGLRRVLD | ELTLTKADLE | MQIESLTEEL | AYLKKNHEEE | MKDLRNVSTG | 
    350:
    DVNVEMNAAP | GVDLTQLLNN | MRSQYEQLAE | QNRKDAEAWF | NEKSKELTTE | 
    400:
    IDNNIEQISS | YKSEITELRR | NVQALEIELQ | SQLALKQSLE | ASLAETEGRY | 
    450:
    CVQLSQIQAQ | ISALEEQLQQ | IRAETECQNT | EYQQLLDIKI | RLENEIQTYR | 
    500:
    SLLEGEGSSG | GGGRGGGSFG | GGYGGGSSGG | GSSGGGHGGG | HGGSSGGGYG | 
    550:
    GGSSGGGSSG | GGYGGGSSSG | GHGGSSSGGY | GGGSSGGGGG | GYGGGSSGGG | 
    584:
    SSSGGGYGGG | SSSGGHKSSS | SGSVGESSSK | GPRY
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    KEGG:
    Pfam:
    UniGene:
    String:
    SMR:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human Keratin, type I cytoskeletal 10
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    ELISA Kit for Human Keratin, type I cytoskeletal 10
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    ELISA Kit for Human Keratin, type I cytoskeletal 10
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    ELISA Kit for Human Keratin, type I cytoskeletal 10
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    E2288b
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    ELISA Kit for Human Keratin, type I cytoskeletal 10
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    CLIA Kit for Human Keratin, type I cytoskeletal 10
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    U2288d
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    CLIA Kit for Human Keratin, type I cytoskeletal 10
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    U2288r
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    CLIA Kit for Human Keratin, type I cytoskeletal 10
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    U2288h
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    CLIA Kit for Human Keratin, type I cytoskeletal 10
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    U2288b
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    CLIA Kit for Human Keratin, type I cytoskeletal 10
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    Packing:
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    Polyclonal Antibody for Human Keratin, type I cytoskeletal 10
    Polyclonal Antibody for Human Keratin, type I cytoskeletal 10
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    P2288Rb-m
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    Packing:
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    Polyclonal Antibody for Human Keratin, type I cytoskeletal 10
    Polyclonal Antibody for Human Keratin, type I cytoskeletal 10
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    P2288Rb-r
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    Polyclonal Antibody for Human Keratin, type I cytoskeletal 10
    Cat.:
    P2288Rb-h
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Keratin, type I cytoskeletal 10
    Monoclonal Antibody for Human Keratin, type I cytoskeletal 10
    Monoclonal Antibody for Human Keratin, type I cytoskeletal 10
    Monoclonal Antibody for Human Keratin, type I cytoskeletal 10
    Monoclonal Antibody for Human Keratin, type I cytoskeletal 10
    Protein for Human Keratin, type I cytoskeletal 10
    Protein for Human Keratin, type I cytoskeletal 10
    Protein for Human Keratin, type I cytoskeletal 10
    Protein for Human Keratin, type I cytoskeletal 10
    Protein for Human Keratin, type I cytoskeletal 10

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    References
    1. 1.
      "The complete sequence of the human intermediate filament chain keratin 10. Subdomainal divisions and model for folding of end domain sequences."
      Zhou X.M. , Idler W.W. , Steven A.C. , Roop D.R. , Steinert P.M.
      J. Biol. Chem.263:15584-15589(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANTS SER-101 AND TYR-487
      tissue: Foreskin.
    2. 2.
      "Identification of an orthologous mammalian cytokeratin gene. High degree of intron sequence conservation during evolution of human cytokeratin 10."
      Rieger M. , Franke W.W.
      J. Mol. Biol.204:841-856(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT TYR-487
    3. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANTS SER-101 AND TYR-487
      tissue: Skin.
    4. 5.
      "Sequence of a cDNA encoding human keratin No 10 selected according to structural homologies of keratins and their tissue-specific expression."
      Darmon M.Y. , Semat A. , Darmon M.C. , Vasseur M.
      Mol. Biol. Rep.12:277-283(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 130-584;VARIANT TYR-487
    5. 6.
      "Prenatal diagnosis of epidermolytic hyperkeratosis by direct gene sequencing."
      Rothnagel J.A. , Longley M.A. , Holder R.A. , Kuster W. , Roop D.R.
      J. Invest. Dermatol.102:13-16(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 147-161;VARIANTS EHK HIS-156 AND ASN-160
    6. 7.
      "Identification of mutational hot spots in the suprabasal keratin genes from patients with epidermolytic hyperkeratosis."
      Rothnagel J.J. , Dominey A. , Fisher M. , Axtell S. , Pittelkow M. , Anton-Lamprecht I. , Hohl D. , Roop D.
      Submitted (1993-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 147-161;VARIANT EHK CYS-156
    7. 8.
      "Exons I and VII of the gene (Ker10) encoding human keratin 10 undergo structural rearrangements within repeats."
      Tkachenko A.V. , Buchman V.L. , Bliskovsky V.V. , Shvets Y.P. , Kisselev L.L.
      Gene116:245-251(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 197-584
    8. 9.
      "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes."
      Rasmussen H.H. , van Damme J. , Puype M. , Gesser B. , Celis J.E. , Vandekerckhove J.
      Electrophoresis13:960-969(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 180-184 AND 568-580
      tissue: Keratinocyte.
    9. 10.
      "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H. , Olsen J.V. , Bairlein M. , Gnad F. , Oppermann F.S. , Korner R. , Greff Z. , Keri G. , Stemmann O. , Mann M.
      Mol. Cell31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16 AND SER-42;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    10. 11.
      "Mitotic recombination in patients with ichthyosis causes reversion of dominant mutations in KRT10."
      Choate K.A. , Lu Y. , Zhou J. , Choi M. , Elias P.M. , Farhi A. , Nelson-Williams C. , Crumrine D. , Williams M.L. , Nopper A.J. , Bree A. , Milstone L.M. , Lifton R.P.
      Science330:94-97(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN CRIE
    11. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    12. 13.
      "The genetic basis of epidermolytic hyperkeratosis: a disorder of differentiation-specific epidermal keratin genes."
      Cheng J. , Syder A.J. , Yu Q.-C. , Letai A. , Paller A.S. , Fuchs E.
      Cell70:811-819(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT EHK HIS-156
    13. 14.
      "Extensive size polymorphism of the human keratin 10 chain resides in the C-terminal V2 subdomain due to variable numbers and sizes of glycine loops."
      Korge B.P. , Gan S.-Q. , McBridge O.W. , Mischke D. , Steinert P.M.
      Proc. Natl. Acad. Sci. U.S.A.89:910-914(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS
    14. 15.
      "Mutations in the rod domains of keratins 1 and 10 in epidermolytic hyperkeratosis."
      Rothnagel J.A. , Dominey A.M. , Dempsey L.D. , Longley M.A. , Greenhalgh D.A. , Gagne T.A. , Huber M. , Frenk E. , Hohl D. , Roop D.R.
      Science257:1128-1130(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS EHK HIS-156 AND SER-161
    15. 16.
      "Preferential sites in keratin 10 that are mutated in epidermolytic hyperkeratosis."
      Chipev C.C. , Yang J.-M. , Digiovanna J.J. , Steinert P.M. , Marekov L. , Compton J.G. , Bale S.J.
      Am. J. Hum. Genet.54:179-190(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS EHK HIS-154; CYS-156; HIS-156; ASP-160 AND GLN-442
    16. 17.
      "Genetic mutations in the K1 and K10 genes of patients with epidermolytic hyperkeratosis. Correlation between location and disease severity."
      Syder A.J. , Yu Q.-C. , Paller A.S. , Giudice G. , Pearson R. , Fuchs E.
      J. Clin. Invest.93:1533-1542(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS EHK ARG-150; CYS-156 AND GLU-439;VARIANT SER-126
    17. 18.
      "Mutations in the rod 1A domain of keratins 1 and 10 in bullous congenital ichthyosiform erythroderma (BCIE)."
      McLean W.H.I. , Eady R.A.J. , Dopping-Hepenstal P.J.C. , McMillan J.R. , Leigh I.M. , Navsaria H.A. , Higgins C. , Harper J.I. , Paige D.G. , Morley S.M.
      J. Invest. Dermatol.102:24-30(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS EHK PRO-156 AND SER-156
    18. 19.
      "Genetic and clinical mosaicism in a type of epidermal nevus."
      Paller A.S. , Syder A.J. , Chan Y.-M. , Yu Q.-C. , Hutton M.E. , Tadini G. , Fuchs E.
      N. Engl. J. Med.331:1408-1415(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT THR-150
    19. 20.
      "A novel dinucleotide mutation in keratin 10 in the annular epidermolytic ichthyosis variant of bullous congenital ichthyosiform erythroderma."
      Joh G.-Y. , Traupe H. , Metze D. , Nashan D. , Huber M. , Hohl D. , Longley M.A. , Rothnagel J.A. , Roop D.R.
      J. Invest. Dermatol.108:357-361(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT AEI GLU-422
    20. 21.
      "A novel helix termination mutation in keratin 10 in annular epidermolytic ichthyosis, a variant of bullous congenital ichthyosiform erythroderma."
      Suga Y. , Duncan K.O. , Heald P.W. , Roop D.R.
      J. Invest. Dermatol.111:1220-1223(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT AEI THR-446
    21. 22.
      "A novel substitution in keratin 10 in epidermolytic hyperkeratosis."
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      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT EHK SER-160
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