KAT8 ELISA Kit for Human(Homo sapiens) | EIAab.comKAT8 ELISA Kit for Human(Homo sapiens)

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KAT8 (Gene name),

Histone acetyltransferase KAT8 (Protein name ), KAT8_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

KAT8(PP7073;MOF;MYST1);

Protein name:

Histone acetyltransferase KAT8;

Alternative:

MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1(MYST-1;hMOF);Lysine acetyltransferase 8;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Component of a multisubunit histone acetyltransferase complex (MSL) at least composed of the MOF/KAT8, MSL1/hampin, MSL2L1 and MSL3L1. Component of some MLL1/MLL complex, at least composed of the core components MLL, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components C17orf49, CHD8, E2F6, HSP70, IN80C, KIAA1267, LAS1L, MAX, MCRS1, MGA, MOF/KAT8, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with the chromodomain of MORF4L1/MRG15. Interacts with ATM through the chromodomain.

Function:

Histone acetyltransferase which may be involved in transcriptional activation. May influence the function of ATM.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

458

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

458:

KQVKLSKK

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.533803

MIM:

609912

Pfam:

PF01853

SMR:

Q9H7Z6

String:

Q9H7Z6

KEGG:

hsa:84148

Uniprot:

Q9H7Z6

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ELISA Kit for Human Histone acetyltransferase KAT8

Cat.:

E2934h

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96T

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ELISA Kit for Human Histone acetyltransferase KAT8

MSDS:

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ELISA Kit for Human Histone acetyltransferase KAT8

Cat.:

E2934r

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Looking for manual.

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96T

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CLIA Kit for Human Histone acetyltransferase KAT8

Cat.:

U2934h

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Packing:

96T

CLIA Kit for Human Histone acetyltransferase KAT8

Cat.:

U2934m

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96T

CLIA Kit for Human Histone acetyltransferase KAT8

Cat.:

U2934r

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96T

Polyclonal Antibody for Human Histone acetyltransferase KAT8

Cat.:

P2934Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human Histone acetyltransferase KAT8

Cat.:

P2934Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Histone acetyltransferase KAT8

Cat.:

P2934Rb-r

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Histone acetyltransferase KAT8

Protein for Human Histone acetyltransferase KAT8

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Embryo.
2.

"The sequence and analysis of duplication-rich human chromosome 16."
Martin J. , Han C. , Gordon L.A. , Terry A. , Prabhakar S. , She X. , Xie G. , Hellsten U. , Chan Y.M. , Altherr M. , Couronne O. , Aerts A. , Bajorek E. , Black S. , Blumer H. , Branscomb E. , Brown N.C. , Bruno W.J. , more...
Nature432:988-994(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
3.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue: Brain.
5.

"Structure and function of the human MYST family: MOZ2, MYST1 and MYST2."
Borrow J. , Housman D.E.
Submitted (1999-12) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-458 (ISOFORM 1)
6.

"A new human member of the MYST family of histone acetyl transferases with high sequence similarity to Drosophila MOF."
Neal K.C. , Pannuti A. , Smith E.R. , Lucchesi J.C.
Biochim. Biophys. Acta1490:170-174(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 29-458 (ISOFORM 1);CATALYTIC ACTIVITY;SUBCELLULAR LOCATION
tissue: Heart.
7.

"Large-scale cDNA transfection screening for genes related to cancer development and progression."
Wan D. , Gong Y. , Qin W. , Zhang P. , Li J. , Wei L. , Zhou X. , Li H. , Qiu X. , Zhong F. , He L. , Yu J. , Yao G. , Jiang H. , Qian L. , Yu Y. , Shu H. , Chen X. , more...
Proc. Natl. Acad. Sci. U.S.A.101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 153-458 (ISOFORM 1)
8.

"The full-ORF clone resource of the German cDNA consortium."
Bechtel S. , Rosenfelder H. , Duda A. , Schmidt C.P. , Ernst U. , Wellenreuther R. , Mehrle A. , Schuster C. , Bahr A. , Bloecker H. , Heubner D. , Hoerlein A. , Michel G. , Wedler H. , Koehrer K. , Ottenwaelder B. , Poustka A. , Wiemann S. , more...
BMC Genomics8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 201-458 (ISOFORM 2)
tissue: Uterus.
9.

"MRG15, a novel chromodomain protein, is present in two distinct multiprotein complexes involved in transcriptional activation."
Pardo P.S. , Leung J.K. , Lucchesi J.C. , Pereira-Smith O.M.
J. Biol. Chem.277:50860-50866(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MORF4L1;FUNCTION
10.

"Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF."
Dou Y. , Milne T.A. , Tackett A.J. , Smith E.R. , Fukuda A. , Wysocka J. , Allis C.D. , Chait B.T. , Hess J.L. , Roeder R.G.
Cell121:873-885(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE MLL1/MLL COMPLEX
11.

"Involvement of human MOF in ATM function."
Gupta A. , Sharma G.G. , Young C.S.H. , Agarwal M. , Smith E.R. , Paull T.T. , Lucchesi J.C. , Khanna K.K. , Ludwig T. , Pandita T.K.
Mol. Cell. Biol.25:5292-5305(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ATM;FUNCTION
12.

"A human protein complex homologous to the Drosophila MSL complex is responsible for the majority of histone H4 acetylation at lysine 16."
Smith E.R. , Cayrou C. , Huang R. , Lane W.S. , Cote J. , Lucchesi J.C.
Mol. Cell. Biol.25:9175-9188(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION OF MSL COMPLEX COMPONENTS;IDENTIFICATION BY MASS SPECTROMETRY
13.

Smith E.R. , Cayrou C. , Huang R. , Lane W.S. , Cote J. , Lucchesi J.C.
Mol. Cell. Biol.26:387-387(2006)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
14.

"Nuclear pore components are involved in the transcriptional regulation of dosage compensation in Drosophila."
Mendjan S. , Taipale M. , Kind J. , Holz H. , Gebhardt P. , Schelder M. , Vermeulen M. , Buscaino A. , Duncan K. , Mueller J. , Wilm M. , Stunnenberg H.G. , Saumweber H. , Akhtar A.
Mol. Cell21:811-823(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH KANSL1
15.

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
16.

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-113;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
17.

"Subunit composition and substrate specificity of a MOF-containing histone acetyltransferase distinct from the male-specific lethal (MSL) complex."
Cai Y. , Jin J. , Swanson S.K. , Cole M.D. , Choi S.H. , Florens L. , Washburn M.P. , Conaway J.W. , Conaway R.C.
J. Biol. Chem.285:4268-4272(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN HISTONE H4 ACETYLATION;IDENTIFICATION IN NSL COMPLEX;SUBCELLULAR LOCATION
18.

"The nonspecific lethal complex is a transcriptional regulator in Drosophila."
Raja S.J. , Charapitsa I. , Conrad T. , Vaquerizas J.M. , Gebhardt P. , Holz H. , Kadlec J. , Fraterman S. , Luscombe N.M. , Akhtar A.
Mol. Cell38:827-841(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH KANSL1
19.

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P. , Lasa M. , Polevoda B. , Gazquez C. , Elosegui-Artola A. , Kim D.S. , De Juan-Pardo E. , Demeyer K. , Hole K. , Larrea E. , Timmerman E. , Prieto J. , Arnesen T. , Sherman F. , Gevaert K. , Aldabe R.
Proc. Natl. Acad. Sci. U.S.A.109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
20.

"MYST histone acetyltransferase 1."
Structural genomics consortium (SGC)
Submitted (2007-05) to the PDB data bank

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.45 ANGSTROMS) OF 174-449 IN COMPLEX WITH ACETYL-COA AND ZINC;ACETYLATION AT LYS-274
21.

"Regulation of the histone acetyltransferase activity of hMOF via autoacetylation of Lys274."
Sun B. , Guo S. , Tang Q. , Li C. , Zeng R. , Xiong Z. , Zhong C. , Ding J.
Cell Res.21:1262-1266(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) OF 174-449 IN COMPLEX WITH ZINC IONS;ACETYLATION AT LYS-274
22.

"Structural basis for MOF and MSL3 recruitment into the dosage compensation complex by MSL1."
Kadlec J. , Hallacli E. , Lipp M. , Holz H. , Sanchez-Weatherby J. , Cusack S. , Akhtar A.
Nat. Struct. Mol. Biol.18:142-149(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.70 ANGSTROMS) OF 174-458 IN COMPLEX WITH MSL1; ZINC ION AND ACETYL-COA;FUNCTION;CATALYTIC ACTIVITY;ACTIVE SITE;IDENTIFICATION BY MASS SPECTROMETRY;ACETYLATION AT LYS-274;INTERACTION WITH KANSL1; MSL1 AND MSL3;MUTAGENESIS OF LYS-274; CYS-316 AND GLU-350
23.

"Structural insight into the regulation of MOF in the male-specific lethal complex and the non-specific lethal complex."
Huang J. , Wan B. , Wu L. , Yang Y. , Dou Y. , Lei M.
Cell Res.22:1078-1081(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.05 ANGSTROMS) OF 170-458 IN COMPLEX WITH MSL1;ACETYLATION AT LYS-274;FUNCTION IN MSL AND NSL COMPLEX;FUNCTION;CATALYTIC ACTIVITY;INTERACTION WITH KANSL1; MSL1 AND MSL3
24.

"MYST protein acetyltransferase activity requires active site lysine autoacetylation."
Yuan H. , Rossetto D. , Mellert H. , Dang W. , Srinivasan M. , Johnson J. , Hodawadekar S. , Ding E.C. , Speicher K. , Abshiru N. , Perry R. , Wu J. , Yang C. , Zheng Y.G. , Speicher D.W. , Thibault P. , Verreault A. , Johnson F.B. , more...
EMBO J.31:58-70(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 177-458 IN COMPLEX WITH ZINC;FUNCTION;CATALYTIC ACTIVITY;ACTIVE SITE;ACETYLATION AT LYS-274;IDENTIFICATION BY MASS SPECTROMETRY;MUTAGENESIS OF LYS-274

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