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Index > Protein center > WWC1(Gene name) > Human
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  • WWC1 (Gene name),
  • Protein KIBRA (Protein name ),  KIBRA_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    WWC1(KIAA0869);
    Protein name:
    Protein KIBRA;
    Alternative:
    Kidney and brain protein(KIBRA);HBeAg-binding protein 3;WW domain-containing protein 1;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer. Interacts with DDN. Interacts with DYNLL1 and histone H3. The interaction with DYNLL1 is mandatory for the recruitment and transactivation functions of ESR1 or DYNLL1 to the target chromatin and the interaction with histone H3 ensures proper regulatory interaction of WWC1-DYNLL1-ESR1 complexes with target chromatin. Interacts (via WW domains) with DDR1 (via PPxY motif) in a collagen-regulated manner. Interacts with PRKCZ (via the protein kinase domain). Forms a tripartite complex with DDR1 and PRKCZ, but predominantly in the absence of collagen. Interacts (via the ADDV motif) with INADL (via PDZ domain 8). Interacts (via WW domains) with SYNPO (via PPxY motifs). Interacts with NF2 and SNX4.
    Function:
    Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation. Regulates collagen-stimulated activation of the ERK/MAPK cascade. Modulates directional migration of podocytes. Acts as a substrate for PRKCZ and may be associated with memory performance.
    Subcellular Location:
    Cytoplasm Cytoplasm perinuclear region Nucleus Cell projection ruffle membrane Co-localizes with PRKCZ in the perinuclear region.
    Protein Attributes:
    Sequence length:
    1113
    Sequence:
    50:
    MPRPELPLPE | GWEEARDFDG | KVYYIDHTNR | TTSWIDPRDR | YTKPLTFADC | 
    100:
    ISDELPLGWE | EAYDPQVGDY | FIDHNTKTTQ | IEDPRVQWRR | EQEHMLKDYL | 
    150:
    VVAQEALSAQ | KEIYQVKQQR | LELAQQEYQQ | LHAVWEHKLG | SQVSLVSGSS | 
    200:
    SSSKYDPEIL | KAEIATAKSR | VNKLKREMVH | LQHELQFKER | GFQTLKKIDK | 
    250:
    KMSDAQGSYK | LDEAQAVLRE | TKAIKKAITC | GEKEKQDLIK | SLAMLKDGFR | 
    300:
    TDRGSHSDLW | SSSSSLESSS | FPLPKQYLDV | SSQTDISGSF | GINSNNQLAE | 
    350:
    KVRLRLRYEE | AKRRIANLKI | QLAKLDSEAW | PGVLDSERDR | LILINEKEEL | 
    400:
    LKEMRFISPR | KWTQGEVEQL | EMARKRLEKD | LQAARDTQSK | ALTERLKLNS | 
    450:
    KRNQLVRELE | EATRQVATLH | SQLKSLSSSM | QSLSSGSSPG | SLTSSRGSLV | 
    500:
    ASSLDSSTSA | SFTDLYYDPF | EQLDSELQSK | VEFLLLEGAT | GFRPSGCITT | 
    550:
    IHEDEVAKTQ | KAEGGGRLQA | LRSLSGTPKS | MTSLSPRSSL | SSPSPPCSPL | 
    600:
    MADPLLAGDA | FLNSLEFEDP | ELSATLCELS | LGNSAQERYR | LEEPGTEGKQ | 
    650:
    LGQAVNTAQG | CGLKVACVSA | AVSDESVAGD | SGVYEASVQR | LGASEAAAFD | 
    700:
    SDESEAVGAT | RIQIALKYDE | KNKQFAILII | QLSNLSALLQ | QQDQKVNIRV | 
    750:
    AVLPCSESTT | CLFRTRPLDA | SDTLVFNEVF | WVSMSYPALH | QKTLRVDVCT | 
    800:
    TDRSHLEECL | GGAQISLAEV | CRSGERSTRW | YNLLSYKYLK | KQSRELKPVG | 
    850:
    VMAPASGPAS | TDAVSALLEQ | TAVELEKRQE | GRSSTQTLED | SWRYEETSEN | 
    900:
    EAVAEEEEEE | VEEEEGEEDV | FTEKASPDMD | GYPALKVDKE | TNTETPAPSP | 
    950:
    TVVRPKDRRV | GTPSQGPFLR | GSTIIRSKTF | SPGPQSQYVC | RLNRSDSDSS | 
    1000:
    TLSKKPPFVR | NSLERRSVRM | KRPSSVKSLR | SERLIRTSLD | LELDLQATRT | 
    1050:
    WHSQLTQEIS | VLKELKEQLE | QAKSHGEKEL | PQWLREDERF | RLLLRMLEKR | 
    1100:
    QMDRAEHKGE | LQTDKMMRAA | AKDVHRLRGQ | SCKEPPEVQS | FREKMAFFTR | 
    1113:
    PRMNIPALSA | DDV
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    String:
    Pfam:
    UniGene:
    MIM:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Protein KIBRA
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    ELISA Kit for Human Protein KIBRA
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    Packing:
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    CLIA Kit for Human Protein KIBRA
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    Packing:
    96T
    CLIA Kit for Human Protein KIBRA
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    U2983h
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human Protein KIBRA
    Cat.:
    P2983Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Protein KIBRA
    Cat.:
    P2983Rb-m
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Protein KIBRA
    Monoclonal Antibody for Human Protein KIBRA
    Protein for Human Protein KIBRA
    Protein for Human Protein KIBRA

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);INTERACTION WITH DDN;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
      tissue: Brain.
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Thalamus.
    3. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 36-1113 (ISOFORM 2)
      tissue: Fetal brain.
    4. 5.
      "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T. , Ishikawa K. , Suyama M. , Kikuno R. , Hirosawa M. , Miyajima N. , Tanaka A. , Kotani H. , Nomura N. , Ohara O.
      DNA Res.5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 225-1113 (ISOFORM 2)
      tissue: Brain.
    5. 6.
      "Screening and cloning of interaction protein 3 of HBeAg."
      Lu Y. , Liu Y. , Cheng J.
      Submitted (2002-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 202-1113 (ISOFORM 1)
      tissue: Liver.
    6. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 782-1113 (ISOFORM 1)
      tissue: Liver.
      tissue: Placenta.
    7. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBUNIT;INTERACTION WITH PRKCZ;PHOSPHORYLATION AT SER-975 AND SER-978
    8. 9.
      "Essential role of KIBRA in co-activator function of dynein light chain 1 in mammalian cells."
      Rayala S.K. , den Hollander P. , Manavathi B. , Talukder A.H. , Song C. , Peng S. , Barnekow A. , Kremerskothen J. , Kumar R.
      J. Biol. Chem.281:19092-19099(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;PHOSPHORYLATION;INTERACTION WITH DYNLL1 AND HISTONE H3
    9. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POLYMORPHISM;INVOLVEMENT IN MEMRYQTL
    10. 11.
      "SNX4 coordinates endosomal sorting of TfnR with dynein-mediated transport into the endocytic recycling compartment."
      Traer C.J. , Rutherford A.C. , Palmer K.J. , Wassmer T. , Oakley J. , Attar N. , Carlton J.G. , Kremerskothen J. , Stephens D.J. , Cullen P.J.
      Nat. Cell Biol.9:1370-1380(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SNX4
    11. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH SYNPO AND INADL;TISSUE SPECIFICITY
    12. 13.
      "KIBRA interacts with discoidin domain receptor 1 to modulate collagen-induced signalling."
      Hilton H.N. , Stanford P.M. , Harris J. , Oakes S.R. , Kaplan W. , Daly R.J. , Ormandy C.J.
      Biochim. Biophys. Acta1783:383-393(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;PHOSPHORYLATION;INDUCTION;INTERACTION WITH DDR1 AND PRKCZ;TISSUE SPECIFICITY
    13. 14.
      "Temporal-spatial expression and novel biochemical properties of the memory-related protein KIBRA."
      Johannsen S. , Duning K. , Pavenstaedt H. , Kremerskothen J. , Boeckers T.M.
      Neuroscience155:1165-1173(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBUNIT;TISSUE SPECIFICITY;DOMAIN C2
    14. 15.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-912; THR-929 AND SER-931;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    15. 16.
      "Kibra functions as a tumor suppressor protein that regulates Hippo signaling in conjunction with Merlin and Expanded."
      Yu J. , Zheng Y. , Dong J. , Klusza S. , Deng W.-M. , Pan D.
      Dev. Cell18:288-299(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    16. 17.
      "Kibra Is a regulator of the Salvador/Warts/Hippo signaling network."
      Genevet A. , Wehr M.C. , Brain R. , Thompson B.J. , Tapon N.
      Dev. Cell18:300-308(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NF2
    17. 18.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-947;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    18. 19.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POLYMORPHISM;INVOLVEMENT IN MEMRYQTL
    19. 20.
      "Phospho-regulation of KIBRA by CDK1 and CDC14 phosphatase controls cell-cycle progression."
      Ji M. , Yang S. , Chen Y. , Xiao L. , Zhang L. , Dong J.
      Biochem. J.447:93-102(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-542 AND SER-931 BY CDK1;DEPHOSPHORYLATION BY CDC14B
    20. 21.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION OF C2 DOMAIN;VARIANTS ILE-734 AND ALA-735;CHARACTERIZATION OF VARIANTS ILE-734 AND ALA-735
    21. 22.
      "Crystal structure of C2 domain of KIBRA protein."
      RIKEN structural genomics initiative (RSGI)
      Submitted (2009-02) to the PDB data bank
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 638-785
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