Protein KIBRA (Protein name
), KIBRA_HUMAN from NCBI database.
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General Annotation
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Gene name:
WWC1(KIAA0869);
Protein name:
Protein KIBRA;
Alternative:
Kidney and brain protein(KIBRA);HBeAg-binding protein 3;WW domain-containing protein 1;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Homodimer. Interacts with DDN. Interacts with DYNLL1 and histone H3. The interaction with DYNLL1 is mandatory for the recruitment and transactivation functions of ESR1 or DYNLL1 to the target chromatin and the interaction with histone H3 ensures proper regulatory interaction of WWC1-DYNLL1-ESR1 complexes with target chromatin. Interacts (via WW domains) with DDR1 (via PPxY motif) in a collagen-regulated manner. Interacts with PRKCZ (via the protein kinase domain). Forms a tripartite complex with DDR1 and PRKCZ, but predominantly in the absence of collagen. Interacts (via the ADDV motif) with INADL (via PDZ domain 8). Interacts (via WW domains) with SYNPO (via PPxY motifs). Interacts with NF2 and SNX4.
Function:
Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation. Regulates collagen-stimulated activation of the ERK/MAPK cascade. Modulates directional migration of podocytes. Acts as a substrate for PRKCZ and may be associated with memory performance.
Subcellular Location:
Cytoplasm
Cytoplasm
perinuclear region
Nucleus
Cell projection
ruffle membrane
Co-localizes with PRKCZ in the perinuclear region.
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);INTERACTION WITH DDN;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 36-1113 (ISOFORM 2)
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 225-1113 (ISOFORM 2)
"Screening and cloning of interaction protein 3 of HBeAg." Lu Y.
,
Liu Y.
,
Cheng J.
Submitted (2002-07) to the EMBL/GenBank/DDBJ databases
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 202-1113 (ISOFORM 1)
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 782-1113 (ISOFORM 1)
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Cited for: FUNCTION;SUBUNIT;INTERACTION WITH PRKCZ;PHOSPHORYLATION AT SER-975 AND SER-978
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Cited for: FUNCTION;SUBCELLULAR LOCATION;PHOSPHORYLATION;INTERACTION WITH DYNLL1 AND HISTONE H3
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Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH SYNPO AND INADL;TISSUE SPECIFICITY
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Cited for: FUNCTION;SUBCELLULAR LOCATION;PHOSPHORYLATION;INDUCTION;INTERACTION WITH DDR1 AND PRKCZ;TISSUE SPECIFICITY
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Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-912; THR-929 AND SER-931;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-947;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: PHOSPHORYLATION AT SER-542 AND SER-931 BY CDK1;DEPHOSPHORYLATION BY CDC14B
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Cited for: FUNCTION OF C2 DOMAIN;VARIANTS ILE-734 AND ALA-735;CHARACTERIZATION OF VARIANTS ILE-734 AND ALA-735
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Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 638-785