Protein name:
Kinesin heavy chain isoform 5A ;
Alternative:
Neuronal kinesin heavy chain (NKHC) ;Kinesin heavy chain neuron-specific 1 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Oligomer composed of two heavy chains and two light chains. Interacts with GRIP1.
Function:
Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL).
Subcellular Location:
Cytoplasm
perinuclear region
Cytoplasm
cytoskeleton
Concentrated in the cell body of the neurons, particularly in the perinuclear region.
Protein Attributes:
50:
MAETNNECSI | KVLCRFRPLN | QAEILRGDKF | IPIFQGDDSV | VIGGKPYVFD |
100:
RVFPPNTTQE | QVYHACAMQI | VKDVLAGYNG | TIFAYGQTSS | GKTHTMEGKL |
150:
HDPQLMGIIP | RIARDIFNHI | YSMDENLEFH | IKVSYFEIYL | DKIRDLLDVT |
200:
KTNLSVHEDK | NRVPFVKGCT | ERFVSSPEEI | LDVIDEGKSN | RHVAVTNMNE |
250:
HSSRSHSIFL | INIKQENMET | EQKLSGKLYL | VDLAGSEKVS | KTGAEGAVLD |
300:
EAKNINKSLS | ALGNVISALA | EGTKSYVPYR | DSKMTRILQD | SLGGNCRTTM |
350:
FICCSPSSYN | DAETKSTLMF | GQRAKTIKNT | ASVNLELTAE | QWKKKYEKEK |
400:
EKTKAQKETI | AKLEAELSRW | RNGENVPETE | RLAGEEAALG | AELCEETPVN |
450:
DNSSIVVRIA | PEERQKYEEE | IRRLYKQLDD | KDDEINQQSQ | LIEKLKQQML |
500:
DQEELLVSTR | GDNEKVQREL | SHLQSENDAA | KDEVKEVLQA | LEELAVNYDQ |
550:
KSQEVEEKSQ | QNQLLVDELS | QKVATMLSLE | SELQRLQEVS | GHQRKRIAEV |
600:
LNGLMKDLSE | FSVIVGNGEI | KLPVEISGAI | EEEFTVARLY | ISKIKSEVKS |
650:
VVKRCRQLEN | LQVECHRKME | VTGRELSSCQ | LLISQHEAKI | RSLTEYMQSV |
700:
ELKKRHLEES | YDSLSDELAK | LQAQETVHEV | ALKDKEPDTQ | DADEVKKALE |
750:
LQMESHREAH | HRQLARLRDE | INEKQKTIDE | LKDLNQKLQL | ELEKLQADYE |
800:
KLKSEEHEKS | TKLQELTFLY | ERHEQSKQDL | KGLEETVARE | LQTLHNLRKL |
850:
FVQDVTTRVK | KSAEMEPEDS | GGIHSQKQKI | SFLENNLEQL | TKVHKQLVRD |
900:
NADLRCELPK | LEKRLRATAE | RVKALEGALK | EAKEGAMKDK | RRYQQEVDRI |
950:
KEAVRYKSSG | KRGHSAQIAK | PVRPGHYPAS | SPTNPYGTRS | PECISYTNSL |
1000:
FQNYQNLYLQ | ATPSSTSDMY | FANSCTSSGA | TSSGGPLASY | QKANMDNGNA |
1032:
TDINDNRSDL | PCGYEAEDQA | KLFPLHQETA | AS
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Mouse
ELISA Kit for Human Kinesin heavy chain isoform 5A
ELISA Kit for Human Kinesin heavy chain isoform 5A
ELISA Kit for Human Kinesin heavy chain isoform 5A
CLIA Kit for Human Kinesin heavy chain isoform 5A
CLIA Kit for Human Kinesin heavy chain isoform 5A
CLIA Kit for Human Kinesin heavy chain isoform 5A
Polyclonal Antibody for Human Kinesin heavy chain isoform 5A
Polyclonal Antibody for Human Kinesin heavy chain isoform 5A
Polyclonal Antibody for Human Kinesin heavy chain isoform 5A
Monoclonal Antibody for Human Kinesin heavy chain isoform 5A
Monoclonal Antibody for Human Kinesin heavy chain isoform 5A
Monoclonal Antibody for Human Kinesin heavy chain isoform 5A
Protein for Human Kinesin heavy chain isoform 5A
Protein for Human Kinesin heavy chain isoform 5A
Protein for Human Kinesin heavy chain isoform 5A
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
tissue :
Hippocampus .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Brain .
3.
Mural R.J.
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Istrail S.
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Sutton G.G.
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Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
7.
"A kinesin heavy chain (KIF5A) mutation in hereditary spastic paraplegia (SPG10)."
Reid E.
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Kloos M.
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Ashley-Koch A.
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Hughes L.
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Bevan S.
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Svenson I.K.
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Graham F.L.
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Am. J. Hum. Genet.71:1189-1194(2002)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT SPG10 SER-256
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT SPG10 CYS-280
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT SPG10 VAL-361
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT SPG10 CYS-276
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT ASN-253;CHARACTERIZATION OF VARIANT ASN-253;CHARACTERIZATION OF VARIANTS SPG10 SER-256 AND VAL-361;MUTAGENESIS OF ARG-280
12.
"SPG10 is a rare cause of spastic paraplegia in European families."
Schuele R.
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Kremer B.P.H.
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Kassubek J.
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Auer-Grumbach M.
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Kostic V.
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J. Neurol. Neurosurg. Psych.79:584-587(2008)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS SPG10 ASN-253 AND ASN-256 DEL
13.
"Complicated forms of autosomal dominant hereditary spastic paraplegia are frequent in SPG10."
Goizet C.
,
Boukhris A.
,
Mundwiller E.
,
Tallaksen C.
,
Forlani S.
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Toutain A.
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Carriere N.
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Hum. Mutat.30:E376-E385(2009)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS SPG10 CYS-63; THR-198; GLN-204; LYS-251; ASN-257; CYS-280; LEU-280 AND HIS-280
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT SPG10 CYS-203