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Index > Protein center > CAMKK2(Gene name) > Human
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  • CAMKK2 (Gene name),
  • Calcium/calmodulin-dependent protein kinase kinase 2 (Protein name ),  KKCC2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    CAMKK2(CAMKKB;KIAA0787);
    Protein name:
    Calcium/calmodulin-dependent protein kinase kinase 2(CaM-KK 2;CaM-kinase kinase 2;CaMKK 2);
    Alternative:
    Calcium/calmodulin-dependent protein kinase kinase beta(CaM-KK beta;CaM-kinase kinase beta;CaMKK beta);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with calmodulin.
    Function:
    Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Seems to be involved in hippocampal activation of CREB1.
    Subcellular Location:
    Cytoplasm
    Protein Attributes:
    Sequence length:
    588
    Sequence:
    50:
    MSSCVSSQPS | SNRAAPQDEL | GGRGSSSSES | QKPCEALRGL | SSLSIHLGME | 
    100:
    SFIVVTECEP | GCAVDLGLAR | DRPLEADGQE | VPLDTSGSQA | RPHLSGRKLS | 
    150:
    LQERSQGGLA | AGGSLDMNGR | CICPSLPYSP | VSSPQSSPRL | PRRPTVESHH | 
    200:
    VSITGMQDCV | QLNQYTLKDE | IGKGSYGVVK | LAYNENDNTY | YAMKVLSKKK | 
    250:
    LIRQAGFPRR | PPPRGTRPAP | GGCIQPRGPI | EQVYQEIAIL | KKLDHPNVVK | 
    300:
    LVEVLDDPNE | DHLYMVFELV | NQGPVMEVPT | LKPLSEDQAR | FYFQDLIKGI | 
    350:
    EYLHYQKIIH | RDIKPSNLLV | GEDGHIKIAD | FGVSNEFKGS | DALLSNTVGT | 
    400:
    PAFMAPESLS | ETRKIFSGKA | LDVWAMGVTL | YCFVFGQCPF | MDERIMCLHS | 
    450:
    KIKSQALEFP | DQPDIAEDLK | DLITRMLDKN | PESRIVVPEI | KLHPWVTRHG | 
    500:
    AEPLPSEDEN | CTLVEVTEEE | VENSVKHIPS | LATVILVKTM | IRKRSFGNPF | 
    550:
    EGSRREERSL | SAPGNLLTKK | PTRECESLSE | LKEARQRRQP | PGHRPAPRGG | 
    588:
    GGSALVRGSP | CVESCWAPAP | GSPARMHPLR | PEEAMEPE
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    MIM:
    String:
    SMR:
    Pfam:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human CaM-KK 2
    Cat.:
    E2536h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human CaM-KK 2
    Cat.:
    E2536m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human CaM-KK 2
    Cat.:
    E2536r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human CaM-KK 2
    Cat.:
    U2536r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human CaM-KK 2
    Cat.:
    U2536m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human CaM-KK 2
    Cat.:
    U2536h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    Polyclonal Antibody for Human CaM-KK 2
    Cat.:
    P2536Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human CaM-KK 2
    Cat.:
    P2536Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human CaM-KK 2
    Cat.:
    P2536Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human CaM-KK 2
    Monoclonal Antibody for Human CaM-KK 2
    Monoclonal Antibody for Human CaM-KK 2
    Protein for Human CaM-KK 2
    Protein for Human CaM-KK 2
    Protein for Human CaM-KK 2

    R&D Technical Data
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    Linearity
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    References
    1. 1.
      "Human Ca2+/calmodulin-dependent protein kinase kinase beta gene encodes multiple isoforms that display distinct kinase activity."
      Hsu L.-S. , Chen G.-D. , Lee L.-S. , Chi C.-W. , Cheng J.-F. , Chen J.-Y.
      J. Biol. Chem.276:31113-31123(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1; 2; 3; 4; 5 AND 6);FUNCTION;VARIANT SER-85
    2. 2.
      "Components of a calmodulin-dependent protein kinase cascade. Molecular cloning, functional characterization and cellular localization of Ca2+/calmodulin-dependent protein kinase kinase beta."
      Anderson K.A. , Means R.L. , Huang Q.-H. , Kemp B.E. , Goldstein E.G. , Selbert M.A. , Edelman A.M. , Fremeau R.T. , Means A.R.
      J. Biol. Chem.273:31880-31889(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Brain cortex.
    3. 3.
      "Identification and characterization of novel components of a Ca2+/calmodulin-dependent protein kinase cascade in HeLa cells."
      Ishikawa Y. , Tokumitsu H. , Inuzuka H. , Murata-Hori M. , Hosoya H. , Kobayashi R.
      FEBS Lett.550:57-63(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3);FUNCTION IN PHOSPHORYLATION OF CAMK1D
    4. 4.
      "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T. , Ishikawa K. , Suyama M. , Kikuno R. , Miyajima N. , Tanaka A. , Kotani H. , Nomura N. , Ohara O.
      DNA Res.5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7);VARIANT SER-85
      tissue: Brain.
    5. 5.
      "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
      Nakajima D. , Okazaki N. , Yamakawa H. , Kikuno R. , Ohara O. , Nagase T.
      DNA Res.9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION
    6. 6.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
      tissue: Stomach.
    7. 7.
      "The finished DNA sequence of human chromosome 12."
      Scherer S.E. , Muzny D.M. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , Jackson A. , Khan Z.M. , Kovar-Smith C. , Lewis L.R. , more...
      Nature440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 233-588 (ISOFORM 5);VARIANT SER-85
      tissue: Placenta.
    9. 9.
      "Cloning, expression and chromosomal localization of human Ca2+/calmodulin-dependent protein kinase kinase."
      Hsu L.-S. , Tsou A.-P. , Chi C.-W. , Lee C.-H. , Chen J.-Y.
      J. Biomed. Sci.5:141-149(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 117-588 (ISOFORM 2);FUNCTION IN PHOSPHORYLATION OF CAMK1;TISSUE SPECIFICITY
    10. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 254-588 (ISOFORM 7)
      tissue: Amygdala.
    11. 11.
      "Full-insert sequence of mapped XREF EST."
      Barrow I.K.-P. , Boguski M.S. , Touchman J.W. , Spencer F.
      Submitted (1998-08) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 338-533 (ISOFORM 2)
    12. 12.
      "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H. , Olsen J.V. , Bairlein M. , Gnad F. , Oppermann F.S. , Korner R. , Greff Z. , Keri G. , Stemmann O. , Mann M.
      Mol. Cell31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-495;PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-522 (ISOFORM 3);PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-479 (ISOFORM 5);IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    13. 13.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    14. 14.
      "Differential effects of PKA-controlled CaMKK2 variants on neuronal differentiation."
      Cao W. , Sohail M. , Liu G. , Koumbadinga G.A. , Lobo V.G. , Xie J.
      RNA Biol.8:1061-1072(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;AUTOPHOSPHORYLATION;PHOSPHORYLATION BY PKA;INDUCTION OF ISOFORM 1
    15. 15.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
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