Gene name:
CAMKK2 (CAMKKB;KIAA0787) ;
Protein name:
Calcium/calmodulin-dependent protein kinase kinase 2 (CaM-KK 2;CaM-kinase kinase 2;CaMKK 2) ;
Alternative:
Calcium/calmodulin-dependent protein kinase kinase beta (CaM-KK beta;CaM-kinase kinase beta;CaMKK beta) ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with calmodulin.
Function:
Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Seems to be involved in hippocampal activation of CREB1.
Subcellular Location:
Cytoplasm
Protein Attributes:
50:
MSSCVSSQPS | SNRAAPQDEL | GGRGSSSSES | QKPCEALRGL | SSLSIHLGME |
100:
SFIVVTECEP | GCAVDLGLAR | DRPLEADGQE | VPLDTSGSQA | RPHLSGRKLS |
150:
LQERSQGGLA | AGGSLDMNGR | CICPSLPYSP | VSSPQSSPRL | PRRPTVESHH |
200:
VSITGMQDCV | QLNQYTLKDE | IGKGSYGVVK | LAYNENDNTY | YAMKVLSKKK |
250:
LIRQAGFPRR | PPPRGTRPAP | GGCIQPRGPI | EQVYQEIAIL | KKLDHPNVVK |
300:
LVEVLDDPNE | DHLYMVFELV | NQGPVMEVPT | LKPLSEDQAR | FYFQDLIKGI |
350:
EYLHYQKIIH | RDIKPSNLLV | GEDGHIKIAD | FGVSNEFKGS | DALLSNTVGT |
400:
PAFMAPESLS | ETRKIFSGKA | LDVWAMGVTL | YCFVFGQCPF | MDERIMCLHS |
450:
KIKSQALEFP | DQPDIAEDLK | DLITRMLDKN | PESRIVVPEI | KLHPWVTRHG |
500:
AEPLPSEDEN | CTLVEVTEEE | VENSVKHIPS | LATVILVKTM | IRKRSFGNPF |
550:
EGSRREERSL | SAPGNLLTKK | PTRECESLSE | LKEARQRRQP | PGHRPAPRGG |
588:
GGSALVRGSP | CVESCWAPAP | GSPARMHPLR | PEEAMEPE
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
ELISA Kit for Human CaM-KK 2
ELISA Kit for Human CaM-KK 2
ELISA Kit for Human CaM-KK 2
CLIA Kit for Human CaM-KK 2
CLIA Kit for Human CaM-KK 2
CLIA Kit for Human CaM-KK 2
Polyclonal Antibody for Human CaM-KK 2
Polyclonal Antibody for Human CaM-KK 2
Polyclonal Antibody for Human CaM-KK 2
Monoclonal Antibody for Human CaM-KK 2
Monoclonal Antibody for Human CaM-KK 2
Monoclonal Antibody for Human CaM-KK 2
Protein for Human CaM-KK 2
Protein for Human CaM-KK 2
Protein for Human CaM-KK 2
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1; 2; 3; 4; 5 AND 6);FUNCTION;VARIANT SER-85
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7);VARIANT SER-85
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
tissue :
Stomach .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 233-588 (ISOFORM 5);VARIANT SER-85
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Placenta .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 117-588 (ISOFORM 2);FUNCTION IN PHOSPHORYLATION OF CAMK1;TISSUE SPECIFICITY
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[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 254-588 (ISOFORM 7)
tissue :
Amygdala .
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 338-533 (ISOFORM 2)
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-495;PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-522 (ISOFORM 3);PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-479 (ISOFORM 5);IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cervix carcinoma .
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION;AUTOPHOSPHORYLATION;PHOSPHORYLATION BY PKA;INDUCTION OF ISOFORM 1
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Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
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Nature446:153-158(2007)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : VARIANTS [LARGE SCALE ANALYSIS] ASN-10; SER-85; TYR-123; LEU-127; THR-182 AND HIS-492