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Index > Protein center > KLHL17(Gene name) > Human
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  • KLHL17 (Gene name),
  • Kelch-like protein 17 (Protein name ),  KLH17_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    KLHL17;
    Protein name:
    Kelch-like protein 17;
    Alternative:
    Actinfilin;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with F-actin; the interaction disruptes the F-actin structures and leads to marked changes of neuronal morphology. Component of a complex, composed of PDZK1, SYNGAP1, KLHL17 and NMDA receptors. Interacts directly with PDZK1 (via PDZ1 domain); the interaction is important for integrity of actin cytoskeleton structures in neurons. Interacts with DLG4 and SYNGAP1. Interacts (via kelch repeats) with GRIK2 (via C-terminus); the interaction targets GRIK2 for degradation via ubiquitin-proteasome pathway. Interacts with GRIK1. Interacts with (via BTB domain) CUL3; the inteaction regulates surface GRIK2 expression.
    Function:
    Substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(KLHL17) mediates the ubiquitination and subsequenct degradation of GLUR6. May play a role in the actin-based neuronal function.
    Subcellular Location:
    Cell junction synapse postsynaptic cell membrane postsynaptic density Cell junction synapse Postsynaptic density.
    Protein Attributes:
    Sequence length:
    642
    Sequence:
    50:
    MQPRSERPAG | RTQSPEHGSP | GPGPEAPPPP | PPQPPAPEAE | RTRPRQARPA | 
    100:
    APMEGAVQLL | SREGHSVAHN | SKRHYHDAFV | AMSRMRQRGL | LCDIVLHVAA | 
    150:
    KEIRAHKVVL | ASCSPYFHAM | FTNEMSESRQ | THVTLHDIDP | QALDQLVQFA | 
    200:
    YTAEIVVGEG | NVQTLLPAAS | LLQLNGVRDA | CCKFLLSQLD | PSNCLGIRGF | 
    250:
    ADAHSCSDLL | KAAHRYVLQH | FVDVAKTEEF | MLLPLKQVLE | LVSSDSLNVP | 
    300:
    SEEEVYRAVL | SWVKHDVDAR | RQHVPRLMKC | VRLPLLSRDF | LLGHVDAESL | 
    350:
    VRHHPDCKDL | LIEALKFHLL | PEQRGVLGTS | RTRPRRCEGA | GPVLFAVGGG | 
    400:
    SLFAIHGDCE | AYDTRTDRWH | VVASMSTRRA | RVGVAAVGNR | LYAVGGYDGT | 
    450:
    SDLATVESYD | PVTNTWQPEV | SMGTRRSCLG | VAALHGLLYS | AGGYDGASCL | 
    500:
    NSAERYDPLT | GTWTSVAAMS | TRRRYVRVAT | LDGNLYAVGG | YDSSSHLATV | 
    550:
    EKYEPQVNVW | SPVASMLSRR | SSAGVAVLEG | ALYVAGGNDG | TSCLNSVERY | 
    600:
    SPKAGAWESV | APMNIRRSTH | DLVAMDGWLY | AVGGNDGSSS | LNSIEKYNPR | 
    642:
    TNKWVAASCM | FTRRSSVGVA | VLELLNFPPP | SSPTLSVSST | SL
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    UniGene:
    Pfam:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human Kelch-like protein 17
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    E1567h
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    ELISA Kit for Human Kelch-like protein 17
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    E1567r
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    ELISA Kit for Human Kelch-like protein 17
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    CLIA Kit for Human Kelch-like protein 17
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    U1567m
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    CLIA Kit for Human Kelch-like protein 17
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    U1567r
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    CLIA Kit for Human Kelch-like protein 17
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    U1567h
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    Packing:
    96T
    Polyclonal Antibody for Human Kelch-like protein 17
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    P1567Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Kelch-like protein 17
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    P1567Rb-h
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    Polyclonal Antibody for Human Kelch-like protein 17
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    P1567Rb-r
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Kelch-like protein 17
    Monoclonal Antibody for Human Kelch-like protein 17
    Monoclonal Antibody for Human Kelch-like protein 17
    Protein for Human Kelch-like protein 17
    Protein for Human Kelch-like protein 17
    Protein for Human Kelch-like protein 17

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    References
    1. 1.
      Huang C.Q. , Wu S.L. , Shan Y.X.
      Submitted (2003-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
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