Protein name:
Kelch-like protein 17 ;
Alternative:
Actinfilin ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with F-actin; the interaction disruptes the F-actin structures and leads to marked changes of neuronal morphology. Component of a complex, composed of PDZK1, SYNGAP1, KLHL17 and NMDA receptors. Interacts directly with PDZK1 (via PDZ1 domain); the interaction is important for integrity of actin cytoskeleton structures in neurons. Interacts with DLG4 and SYNGAP1. Interacts (via kelch repeats) with GRIK2 (via C-terminus); the interaction targets GRIK2 for degradation via ubiquitin-proteasome pathway. Interacts with GRIK1. Interacts with (via BTB domain) CUL3; the inteaction regulates surface GRIK2 expression.
Function:
Substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(KLHL17) mediates the ubiquitination and subsequenct degradation of GLUR6. May play a role in the actin-based neuronal function.
Subcellular Location:
Cell junction
synapse
postsynaptic cell membrane
postsynaptic density
Cell junction
synapse
Postsynaptic density.
Protein Attributes:
50:
MQPRSERPAG | RTQSPEHGSP | GPGPEAPPPP | PPQPPAPEAE | RTRPRQARPA |
100:
APMEGAVQLL | SREGHSVAHN | SKRHYHDAFV | AMSRMRQRGL | LCDIVLHVAA |
150:
KEIRAHKVVL | ASCSPYFHAM | FTNEMSESRQ | THVTLHDIDP | QALDQLVQFA |
200:
YTAEIVVGEG | NVQTLLPAAS | LLQLNGVRDA | CCKFLLSQLD | PSNCLGIRGF |
250:
ADAHSCSDLL | KAAHRYVLQH | FVDVAKTEEF | MLLPLKQVLE | LVSSDSLNVP |
300:
SEEEVYRAVL | SWVKHDVDAR | RQHVPRLMKC | VRLPLLSRDF | LLGHVDAESL |
350:
VRHHPDCKDL | LIEALKFHLL | PEQRGVLGTS | RTRPRRCEGA | GPVLFAVGGG |
400:
SLFAIHGDCE | AYDTRTDRWH | VVASMSTRRA | RVGVAAVGNR | LYAVGGYDGT |
450:
SDLATVESYD | PVTNTWQPEV | SMGTRRSCLG | VAALHGLLYS | AGGYDGASCL |
500:
NSAERYDPLT | GTWTSVAAMS | TRRRYVRVAT | LDGNLYAVGG | YDSSSHLATV |
550:
EKYEPQVNVW | SPVASMLSRR | SSAGVAVLEG | ALYVAGGNDG | TSCLNSVERY |
600:
SPKAGAWESV | APMNIRRSTH | DLVAMDGWLY | AVGGNDGSSS | LNSIEKYNPR |
642:
TNKWVAASCM | FTRRSSVGVA | VLELLNFPPP | SSPTLSVSST | SL
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Mouse
ELISA Kit for Human Kelch-like protein 17
ELISA Kit for Human Kelch-like protein 17
ELISA Kit for Human Kelch-like protein 17
CLIA Kit for Human Kelch-like protein 17
CLIA Kit for Human Kelch-like protein 17
CLIA Kit for Human Kelch-like protein 17
Polyclonal Antibody for Human Kelch-like protein 17
Polyclonal Antibody for Human Kelch-like protein 17
Polyclonal Antibody for Human Kelch-like protein 17
Monoclonal Antibody for Human Kelch-like protein 17
Monoclonal Antibody for Human Kelch-like protein 17
Monoclonal Antibody for Human Kelch-like protein 17
Protein for Human Kelch-like protein 17
Protein for Human Kelch-like protein 17
Protein for Human Kelch-like protein 17
R&D Technical Data
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Precision
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Recovery
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Linearity
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Cited for : NUCLEOTIDE SEQUENCE [MRNA]
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