Gene name:
KLK6 (PRSS18;PRSS9) ;
Protein name:
Kallikrein-6 ;
Alternative:
Protease M ;Neurosin ;Serine protease 18 ;SP59 ;Zyme ;Serine protease 9 ;
Organism:
Human (Homo sapiens).
General Annotation
Function:
Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis.
Subcellular Location:
Secreted
Nucleus
nucleolus
Cytoplasm
Mitochondrion
Microsome
In brain, detected in the nucleus of glial cells and in the nucleus and cytoplasm of neurons. Detected in the mitochondrial and microsomal fractions of HEK-293 cells and released into the cytoplasm following cell stress.
Protein Attributes:
50:
MKKLMVVLSL | IAAAWAEEQN | KLVHGGPCDK | TSHPYQAALY | TSGHLLCGGV |
100:
LIHPLWVLTA | AHCKKPNLQV | FLGKHNLRQR | ESSQEQSSVV | RAVIHPDYDA |
150:
ASHDQDIMLL | RLARPAKLSE | LIQPLPLERD | CSANTTSCHI | LGWGKTADGD |
200:
FPDTIQCAYI | HLVSREECEH | AYPGQITQNM | LCAGDEKYGK | DSCQGDSGGP |
244:
LVCGDHLRGL | VSWGNIPCGS | KEKPGVYTNV | CRYTNWIQKT | IQAK
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Human
ELISA Kit for Human Kallikrein-6
ELISA Kit for Human Kallikrein-6
CLIA Kit for Human Kallikrein-6
CLIA Kit for Human Kallikrein-6
Polyclonal Antibody for Human Kallikrein-6
Polyclonal Antibody for Human Kallikrein-6
Monoclonal Antibody for Human Kallikrein-6
Monoclonal Antibody for Human Kallikrein-6
Protein for Human Kallikrein-6
Protein for Human Kallikrein-6
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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