Protein name:
Beta-klotho (BKL;BetaKlotho) ;
Alternative:
Klotho beta-like protein ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with FGFR1 and FGFR4 (By similarity). Interacts with FGF19; this interaction is direct. Interacts (via C-terminus) with FGF21; this interaction is direct.
Function:
Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21.
Subcellular Location:
Cell membrane
Single-pass type III membrane protein
Protein Attributes:
50:
MKPGCAAGSP | GNEWIFFSTD | EITTRYRNTM | SNGGLQRSVI | LSALILLRAV |
100:
TGFSGDGRAI | WSKNPNFTPV | NESQLFLYDT | FPKNFFWGIG | TGALQVEGSW |
150:
KKDGKGPSIW | DHFIHTHLKN | VSSTNGSSDS | YIFLEKDLSA | LDFIGVSFYQ |
200:
FSISWPRLFP | DGIVTVANAK | GLQYYSTLLD | ALVLRNIEPI | VTLYHWDLPL |
250:
ALQEKYGGWK | NDTIIDIFND | YATYCFQMFG | DRVKYWITIH | NPYLVAWHGY |
300:
GTGMHAPGEK | GNLAAVYTVG | HNLIKAHSKV | WHNYNTHFRP | HQKGWLSITL |
350:
GSHWIEPNRS | ENTMDIFKCQ | QSMVSVLGWF | ANPIHGDGDY | PEGMRKKLFS |
400:
VLPIFSEAEK | HEMRGTADFF | AFSFGPNNFK | PLNTMAKMGQ | NVSLNLREAL |
450:
NWIKLEYNNP | RILIAENGWF | TDSRVKTEDT | TAIYMMKNFL | SQVLQAIRLD |
500:
EIRVFGYTAW | SLLDGFEWQD | AYTIRRGLFY | VDFNSKQKER | KPKSSAHYYK |
550:
QIIRENGFSL | KESTPDVQGQ | FPCDFSWGVT | ESVLKPESVA | SSPQFSDPHL |
600:
YVWNATGNRL | LHRVEGVRLK | TRPAQCTDFV | NIKKQLEMLA | RMKVTHYRFA |
650:
LDWASVLPTG | NLSAVNRQAL | RYYRCVVSEG | LKLGISAMVT | LYYPTHAHLG |
700:
LPEPLLHADG | WLNPSTAEAF | QAYAGLCFQE | LGDLVKLWIT | INEPNRLSDI |
750:
YNRSGNDTYG | AAHNLLVAHA | LAWRLYDRQF | RPSQRGAVSL | SLHADWAEPA |
800:
NPYADSHWRA | AERFLQFEIA | WFAEPLFKTG | DYPAAMREYI | ASKHRRGLSS |
850:
SALPRLTEAE | RRLLKGTVDF | CALNHFTTRF | VMHEQLAGSR | YDSDRDIQFL |
900:
QDITRLSSPT | RLAVIPWGVR | KLLRWVRRNY | GDMDIYITAS | GIDDQALEDD |
950:
RLRKYYLGKY | LQEVLKAYLI | DKVRIKGYYA | FKLAEEKSKP | RFGFFTSDFK |
1000:
AKSSIQFYNK | VISSRGFPFE | NSSSRCSQTQ | ENTECTVCLF | LVQKKPLIFL |
1044:
GCCFFSTLVL | LLSIAIFQRQ | KRRKFWKAKN | LQHIPLKKGK | RVVS
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Polyclonal Antibody for Human BKL
Polyclonal Antibody for Human BKL
Monoclonal Antibody for Human BKL
Monoclonal Antibody for Human BKL
R&D Technical Data
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Precision
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Recovery
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Linearity
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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References
1.
"Klotho beta like protein."
Hayashi A.
,
Saito T.
Submitted (2002-02) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Liver .
3.
"C-terminal tail of FGF19 determines its specificity toward Klotho co-receptors."
Wu X.
,
Lemon B.
,
Li X.
,
Gupte J.
,
Weiszmann J.
,
Stevens J.
,
Hawkins N.
,
Shen W.
,
Lindberg R.
,
Chen J.-L.
,
Tian H.
,
Li Y.
J. Biol. Chem.283:33304-33309(2008)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH FGF19 AND FGF21
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH FGF21