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Index > Protein center > PKM2(Gene name) > Human
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  • PKM2 (Gene name),
  • Pyruvate kinase isozymes M1/M2 (Protein name ),  KPYM_HUMAN from NCBI database.
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  • Gene name:
    PKM2(OIP3;PK2;PK3;PKM);
    Protein name:
    Pyruvate kinase isozymes M1/M2;
    Alternative:
    Opa-interacting protein 3(OIP-3);Cytosolic thyroid hormone-binding protein(CTHBP);Pyruvate kinase muscle isozyme;Pyruvate kinase 2/3;Tumor M2-PK;Thyroid hormone-binding protein 1(THBP1);p58;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Monomer and homotetramer. Exists as a monomer in the absence of FBP, and reversibly associates to form a homotetramer in the presence of FBP. The monomeric form binds T3. Tetramer formation induces pyruvate kinase activity. The tetrameric form has high affinity for the substrate and is associated within the glycolytic enzyme complex. Exists in a nearly inactive dimeric form in tumor cells and the dimeric form has less affinity for the substrate. Binding to certain oncoproteins such as HPV-16 E7 oncoprotein can trigger dimerization. FBP stimulates the formation of tetramers from dimers. Interacts with HERC1, POU5F1 and PML.
    Function:
    Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.
    Subcellular Location:
    Cytoplasm Nucleus Translocates to the nucleus in response to different apoptotic stimuli. Nuclear translocation is sufficient to induce cell death that is caspase independent, isoform-specific and independent of its enzymatic actvity.
    Protein Attributes:
    Sequence length:
    531
    Sequence:
    50:
    MSKPHSEAGT | AFIQTQQLHA | AMADTFLEHM | CRLDIDSPPI | TARNTGIICT | 
    100:
    IGPASRSVET | LKEMIKSGMN | VARLNFSHGT | HEYHAETIKN | VRTATESFAS | 
    150:
    DPILYRPVAV | ALDTKGPEIR | TGLIKGSGTA | EVELKKGATL | KITLDNAYME | 
    200:
    KCDENILWLD | YKNICKVVEV | GSKIYVDDGL | ISLQVKQKGA | DFLVTEVENG | 
    250:
    GSLGSKKGVN | LPGAAVDLPA | VSEKDIQDLK | FGVEQDVDMV | FASFIRKASD | 
    300:
    VHEVRKVLGE | KGKNIKIISK | IENHEGVRRF | DEILEASDGI | MVARGDLGIE | 
    350:
    IPAEKVFLAQ | KMMIGRCNRA | GKPVICATQM | LESMIKKPRP | TRAEGSDVAN | 
    400:
    AVLDGADCIM | LSGETAKGDY | PLEAVRMQHL | IAREAEAAIY | HLQLFEELRR | 
    450:
    LAPITSDPTE | ATAVGAVEAS | FKCCSGAIIV | LTKSGRSAHQ | VARYRPRAPI | 
    500:
    IAVTRNPQTA | RQAHLYRGIF | PVLCKDPVQE | AWAEDVDLRV | NFAMNVGKAR | 
    531:
    GFFKKGDVVI | VLTGWRPGSG | FTNTMRVVPV | P
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    MIM:
    Pfam:
    String:
    UniGene:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Pyruvate kinase isozymes M1/M2
    Cat.:
    E0588h
    Price:
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human Pyruvate kinase isozymes M1/M2
    Cat.:
    E0588r
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    ELISA Kit for Human Pyruvate kinase isozymes M1/M2
    Cat.:
    E0588m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    ELISA Kit for Human Pyruvate kinase isozymes M1/M2
    MSDS:
    Please sign in first.
    ELISA Kit for Human Pyruvate kinase isozymes M1/M2
    Cat.:
    E0588c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Pyruvate kinase isozymes M1/M2
    Cat.:
    U0588r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Pyruvate kinase isozymes M1/M2
    Cat.:
    U0588h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Pyruvate kinase isozymes M1/M2
    MSDS:
    Please sign in first.
    CLIA Kit for Human Pyruvate kinase isozymes M1/M2
    Cat.:
    U0588m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Pyruvate kinase isozymes M1/M2
    Cat.:
    U0588c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Pyruvate kinase isozymes M1/M2
    Cat.:
    P0588Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Pyruvate kinase isozymes M1/M2
    Cat.:
    P0588Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Pyruvate kinase isozymes M1/M2
    Polyclonal Antibody for Human Pyruvate kinase isozymes M1/M2
    Polyclonal Antibody for Human Pyruvate kinase isozymes M1/M2
    Cat.:
    P0588Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Pyruvate kinase isozymes M1/M2
    Monoclonal Antibody for Human Pyruvate kinase isozymes M1/M2
    Monoclonal Antibody for Human Pyruvate kinase isozymes M1/M2
    Monoclonal Antibody for Human Pyruvate kinase isozymes M1/M2
    Monoclonal Antibody for Human Pyruvate kinase isozymes M1/M2
    Protein for Human Pyruvate kinase isozymes M1/M2
    Protein for Human Pyruvate kinase isozymes M1/M2
    Protein for Human Pyruvate kinase isozymes M1/M2
    Protein for Human Pyruvate kinase isozymes M1/M2
    Protein for Human Pyruvate kinase isozymes M1/M2

    R&D Technical Data

    s

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    Precision

    Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

    Intra-Assay CV: ≤3.9%

    Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

    Inter-Assay CV: ≤7.7%

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    Recovery

    Recovery was determined by spiking various levels of ACE into serum and plasma .

    Sample Type

    Average(%)

    Recovery Range(%)

    Serum

    99

    91-103

    Plasma

    98

    93-106

     

     

     

     

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    Linearity

     

    The linearity of the kit was assayed by testing samples spiked with appropriate concentration of ACE and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.  

     

    Sample

    1:2

    1:4

    1:8

    1:16

    serum(n=5)

    92-105%

    90-101%

    95-105%

    92-109%

    EDTA plasma(n=5)

    89-95%

    93105%

    89-94%

    90-106%

    heparin plasma(n=5)

    93-104%

     

    94-110%

    101-111%

    91-110%

     

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    References
    1. 1.
      "Human M2-type pyruvate kinase: cDNA cloning, chromosomal assignment and expression in hepatoma."
      Tani K. , Yoshida M.C. , Satoh H. , Mitamura K. , Noguchi T. , Tanaka T. , Fujii H. , Miwa S.
      Gene73:509-516(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM M2)
      tissue: Liver.
    2. 2.
      "Cytosolic thyroid hormone-binding protein is a monomer of pyruvate kinase."
      Kato H. , Fukuda T. , Parkison C. , McPhie P. , Cheng S.-Y.
      Proc. Natl. Acad. Sci. U.S.A.86:7861-7865(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM M2);PROTEIN SEQUENCE OF 70-98;SUBUNIT;ENZYME REGULATION
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
    4. 4.
      "Isolation and characterization of the human pyruvate kinase M gene."
      Takenaka M. , Noguchi T. , Sadahiro S. , Hirai H. , Yamada K. , Matsuda T. , Imai E. , Tanaka T.
      Eur. J. Biochem.198:101-106(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];ALTERNATIVE SPLICING
    5. 5.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS M1 AND 3)
      tissue: Astrocyte.
      tissue: Fetal brain.
    6. 6.
      Suzuki Y. , Sugano S. , Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S.
      Submitted (2005-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM M2)
      tissue: Kidney.
    7. 7.
      NIEHS SNPs program
      Submitted (2003-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    8. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    9. 10.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM M2);VARIANT VAL-204
      tissue: Kidney.
      tissue: Lung carcinoma.
      tissue: Ovary.
      tissue: Retina.
      tissue: Rhabdomyosarcoma.
    10. 11.
      Bienvenut W.V.
      Submitted (2005-07) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-43; 57-73; 93-115; 126-135; 167-186; 231-246; 271-311; 401-422; 448-455 AND 490-498;CLEAVAGE OF INITIATOR METHIONINE;ACETYLATION AT SER-2;IDENTIFICATION BY MASS SPECTROMETRY
      tissue: B-cell lymphoma.
    11. 12.
      "An in vitro novel mechanism of regulating the activity of pyruvate kinase M2 by thyroid hormone and fructose 1, 6-bisphosphate."
      Ashizawa K. , McPhie P. , Lin K.-H. , Cheng S.-Y.
      Biochemistry30:7105-7111(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-18;CATALYTIC ACTIVITY;ENZYME REGULATION;BIOPHYSICOCHEMICAL PROPERTIES;SUBUNIT;INTERACTION WITH THYROID HORMONE
    12. 13.
      "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
      Gevaert K. , Goethals M. , Martens L. , Van Damme J. , Staes A. , Thomas G.R. , Vandekerckhove J.
      Nat. Biotechnol.21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-32
      tissue: Platelet.
    13. 14.
      Lubec G. , Vishwanath V.
      Submitted (2007-03) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 74-89;IDENTIFICATION BY MASS SPECTROMETRY
      tissue: Brain.
      tissue: Cajal-Retzius cell.
    14. 15.
      "Using the yeast two-hybrid system to identify human epithelial cell proteins that bind gonococcal Opa proteins: intracellular gonococci bind pyruvate kinase via their Opa proteins and require host pyruvate for growth."
      Williams J.M. , Chen G.-C. , Zhu L. , Rest R.F.
      Mol. Microbiol.27:171-186(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 368-531 (ISOFORM M2)
    15. 16.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HERC1
    16. 17.
      "Proteomic identification of proteins conjugated to ISG15 in mouse and human cells."
      Giannakopoulos N.V. , Luo J.K. , Papov V. , Zou W. , Lenschow D.J. , Jacobs B.S. , Borden E.C. , Li J. , Virgin H.W. , Zhang D.E.
      Biochem. Biophys. Res. Commun.336:496-506(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ISGYLATION
    17. 18.
      "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
      Rush J. , Moritz A. , Lee K.A. , Guo A. , Goss V.L. , Spek E.J. , Zhang H. , Zha X.-M. , Polakiewicz R.D. , Comb M.J.
      Nat. Biotechnol.23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-105;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    18. 19.
      "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
      Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    19. 20.
      "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
      Beausoleil S.A. , Villen J. , Gerber S.A. , Rush J. , Gygi S.P.
      Nat. Biotechnol.24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    20. 21.
      "Nuclear translocation of the tumor marker pyruvate kinase M2 induces programmed cell death."
      Stetak A. , Veress R. , Ovadi J. , Csermely P. , Keri G. , Ullrich A.
      Cancer Res.67:1602-1608(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
    21. 22.
      "Modulation of M2-type pyruvate kinase activity by the cytoplasmic PML tumor suppressor protein."
      Shimada N. , Shinagawa T. , Ishii S.
      Genes Cells13:245-254(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PML;ENZYME REGULATION;SUBUNIT;SUBCELLULAR LOCATION
    22. 23.
      "Pyruvate kinase isozyme type M2 (PKM2) interacts and cooperates with Oct-4 in regulating transcription."
      Lee J. , Kim H.K. , Han Y.-M. , Kim J.
      Int. J. Biochem. Cell Biol.40:1043-1054(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH POU5F1;IDENTIFICATION BY MASS SPECTROMETRY;FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    23. 24.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Platelet.
    24. 25.
      "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H. , Olsen J.V. , Bairlein M. , Gnad F. , Oppermann F.S. , Korner R. , Greff Z. , Keri G. , Stemmann O. , Mann M.
      Mol. Cell31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    25. 26.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    26. 27.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    27. 28.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37; TYR-175 AND THR-195;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    28. 29.
      "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
      Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-62; LYS-89; LYS-166; LYS-266 AND LYS-433;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    29. 30.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    30. 31.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    31. 32.
      "Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1."
      Luo W. , Hu H. , Chang R. , Zhong J. , Knabel M. , O'Meally R. , Cole R.N. , Pandey A. , Semenza G.L.
      Cell145:732-744(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH EGLN3 AND HIF1A;SUBCELLULAR LOCATION;INDUCTION;FUNCTION;IDENTIFICATION BY MASS SPECTROMETRY;HYDROXYLATION AT PRO-403 AND PRO-408;MUTAGENESIS OF PRO-403 AND PRO-408
    32. 33.
      "The oxygen sensor PHD3 limits glycolysis under hypoxia via direct binding to pyruvate kinase."
      Chen N. , Rinner O. , Czernik D. , Nytko K.J. , Zheng D. , Stiehl D.P. , Zamboni N. , Gstaiger M. , Frei C.
      Cell Res.21:983-986(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH EGLN3
    33. 34.
      "Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth."
      Lv L. , Li D. , Zhao D. , Lin R. , Chu Y. , Zhang H. , Zha Z. , Liu Y. , Li Z. , Xu Y. , Wang G. , Huang Y. , Xiong Y. , Guan K.L. , Lei Q.Y.
      Mol. Cell42:719-730(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION AT LYS-305
    34. 35.
      "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
      Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    35. 36.
      "Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis."
      Dombrauckas J.D. , Santarsiero B.D. , Mesecar A.D.
      Biochemistry44:9417-9429(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.82 ANGSTROMS) OF ISOFORM M2 IN COMPLEX WITH OXALATE AND FBP;CATALYTIC ACTIVITY;SUBUNIT;ENZYME MECHANISM;ENZYME REGULATION;BIOPHYSICOCHEMICAL PROPERTIES
    36. 37.
      "Structure of human muscle pyruvate kinase (PKM2)."
      Structural genomics consortium (SGC)
      Submitted (2005-05) to the PDB data bank
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS)
    37. 38.
      "Pyruvate kinase M2 is a phosphotyrosine-binding protein."
      Christofk H.R. , Vander Heiden M.G. , Wu N. , Asara J.M. , Cantley L.C.
      Nature452:181-186(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.03 ANGSTROMS) OF 14-531 ALONE AND IN COMPLEX WITH FBP;ENZYME REGULATION
    38. 39.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 2-531;ENZYME REGULATION BY SERINE;MAGNESIUM-BINDING SITES;SUBUNIT;MUTAGENESIS OF SER-437 AND HIS-464
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