PKLR ELISA Kit for Human(Homo sapiens) | EIAab.comPKLR ELISA Kit for Human(Homo sapiens)

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PKLR (Gene name),

Pyruvate kinase isozymes R/L (Protein name ), KPYR_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

PKLR(PK1;PKL);

Protein name:

Pyruvate kinase isozymes R/L;

Alternative:

R-type/L-type pyruvate kinase;Pyruvate kinase 1;Red cell/liver pyruvate kinase;Red cell/liver pyruvate kinase;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homotetramer.

Function:

Plays a key role in glycolysis.

Subcellular Location:

N/A

Protein Attributes:

Sequence length:

574

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

574:

LVIVVTGWRP | GSGYTNIMRV | LSIS

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

P30613

Pfam:

PF00224

MIM:

102900

STRING:

9606.ENSP00000339933

KEGG:

hsa:5313

UniGene:

Hs.95990

SMR:

P30613

Uniprot:

P30613

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ELISA Kit for Human Pyruvate kinase isozymes R/L

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E0208h

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96T

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ELISA Kit for Human Pyruvate kinase isozymes R/L

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E0208r

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96T

ELISA Kit for Human Pyruvate kinase isozymes R/L

Cat.:

E0208m

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96T

ELISA Kit for Human Pyruvate kinase isozymes R/L

Cat.:

E0208d

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96T

CLIA Kit for Human Pyruvate kinase isozymes R/L

Cat.:

U0208d

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96T

CLIA Kit for Human Pyruvate kinase isozymes R/L

Cat.:

U0208h

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96T

CLIA Kit for Human Pyruvate kinase isozymes R/L

Cat.:

U0208m

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96T

CLIA Kit for Human Pyruvate kinase isozymes R/L

Cat.:

U0208r

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96T

Polyclonal Antibody for Human Pyruvate kinase isozymes R/L

Cat.:

P0208Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human Pyruvate kinase isozymes R/L

Cat.:

P0208Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human Pyruvate kinase isozymes R/L

Cat.:

P0208Rb-r

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Pyruvate kinase isozymes R/L

Protein for Human Pyruvate kinase isozymes R/L

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"cDNA cloning of human R-type pyruvate kinase and identification of a single amino acid substitution (Thr384-->Met) affecting enzymatic stability in a pyruvate kinase variant (PK Tokyo) associated with hereditary hemolytic anemia."
Kanno H. , Fujii H. , Hirono A. , Miwa S.
Proc. Natl. Acad. Sci. U.S.A.88:8218-8221(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT PKRD MET-384
2.

"Human liver type pyruvate kinase: complete amino acid sequence and the expression in mammalian cells."
Tani K. , Fujii H. , Nagata S. , Miwa S.
Proc. Natl. Acad. Sci. U.S.A.85:1792-1795(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
3.

Kanno H.
Submitted (1998-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION TO 130 AND 232
4.

"Structural analysis of human pyruvate kinase L-gene and identification of the promoter activity in erythroid cells."
Kanno H. , Fujii H. , Miwa S.
Biochem. Biophys. Res. Commun.188:516-523(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
5.

NIEHS SNPs program
Submitted (2003-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT ILE-506
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM R-TYPE)
tissue: Pancreas.
7.

"Human liver type pyruvate kinase: cDNA cloning and chromosomal assignment."
Tani K. , Fujii H. , Tsutsumi H. , Sukegawa J. , Toyoshima K. , Yoshida M.C. , Noguchi T. , Tanaka T. , Miwa S.
Biochem. Biophys. Res. Commun.143:431-438(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 470-574
8.

"Molecular basis of impaired pyruvate kinase isozyme conversion in erythroid cells: a single amino acid substitution near the active site and decreased mRNA content of the R-type PK."
Kanno H. , Fujii H. , Tsujino G. , Miwa S.
Biochem. Biophys. Res. Commun.192:46-52(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 365-431;VARIANT PKRD PHE-368
9.

"Mutations in pyruvate kinase."
Beutler E. , Baronciani L.
Hum. Mutat.7:1-6(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON VARIANTS
10.

"Hematologically important mutations: red cell pyruvate kinase."
Baronciani L. , Bianchi P. , Zanella A.
Blood Cells Mol. Dis.22:85-89(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON VARIANTS
11.

"Hematologically important mutations: red cell pyruvate kinase (1st update)."
Baronciani L. , Bianchi P. , Zanella A.
Blood Cells Mol. Dis.22:259-264(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON VARIANTS
12.

"Hematologically important mutations: red cell pyruvate kinase (2nd update)."
Baronciani L. , Bianchi P. , Zanella A.
Blood Cells Mol. Dis.24:273-279(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON VARIANTS
13.

"Hematologically important mutations: red cell pyruvate kinase (third update)."
Bianchi P. , Zanella A.
Blood Cells Mol. Dis.26:47-53(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON VARIANTS
14.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
15.

"Structure and function of human erythrocyte pyruvate kinase. Molecular basis of nonspherocytic hemolytic anemia."
Valentini G. , Chiarelli L.R. , Fortin R. , Dolzan M. , Galizzi A. , Abraham D.J. , Wang C. , Bianchi P. , Zanella A. , Mattevi A.
J. Biol. Chem.277:23807-23814(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.73 ANGSTROMS) OF 47-574 IN COMPLEX WITH FRUCTOSE 1,6-BISPHOSPHATE;ALLOSTERIC ACTIVATION;ENZYME REGULATION;CHARACTERIZATION OF VARIANTS PKRD SER-332; ASP-364; ASN-390; HIS-479; TRP-486; LEU-504 AND TRP-532;CHARACTERIZATION OF VARIANT MET-384;SUBUNIT
16.

"Point mutations in the L-type pyruvate kinase gene of two children with hemolytic anemia caused by pyruvate kinase deficiency."
Neubauer B. , Lakomek M. , Winkler H. , Parke M. , Hofferbert S. , Schroter W.
Blood77:1871-1875(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PKRD CYS-163 AND MET-384
17.

"Identical point mutations of the R-type pyruvate kinase (PK) cDNA found in unrelated PK variants associated with hereditary hemolytic anemia."
Kanno H. , Fujii H. , Hirono A. , Omine M. , Miwa S.
Blood79:1347-1350(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PKRD LYS-421
18.

"Low substrate affinity of pyruvate kinase variant (PK Sapporo) caused by a single amino acid substitution (426 Arg-->Gln) associated with hereditary hemolytic anemia."
Kanno H. , Fujii H. , Miwa S.
Blood81:2439-2441(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PKRD GLN-426
19.

"Analysis of pyruvate kinase-deficiency mutations that produce nonspherocytic hemolytic anemia."
Baronciani L. , Beutler E.
Proc. Natl. Acad. Sci. U.S.A.90:4324-4327(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PKRD ASP-134; PRO-155; HIS-359; TRP-486; VAL-495 AND GLN-510
20.

"Molecular abnormality of erythrocyte pyruvate kinase deficiency in the Amish."
Kanno H. , Ballas S.K. , Miwa S. , Fujii H. , Bowman H.S.
Blood83:2311-2316(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PKRD HIS-479
21.

"Mutations in the pyruvate kinase L gene in patients with hereditary hemolytic anemia."
Lenzner C. , Nuernberg P. , Thiele B.-J. , Reis A. , Brabec V. , Sakalova A. , Jacobasch G.
Blood83:2817-2822(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PKRD SER-332; SER-336; LYS-354 DEL; ASP-361; THR-392; HIS-498; GLN-510 AND TRP-532
22.

"Molecular study of pyruvate kinase deficient patients with hereditary nonspherocytic hemolytic anemia."
Baronciani L. , Beutler E.
J. Clin. Invest.95:1702-1709(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PKRD GLU-331; ALA-341; LYS-393; SER-393; ASP-458; MET-460 AND HIS-498
23.

"Study of the molecular defects in pyruvate kinase (PK) deficient patients affected by hereditary nonspherocytic hemolytic anemia (HNHA)."
Baronciani L. , Westwood B. , Beutler E.
J. Invest. Med.43:341A-341A(1995)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PKRD
24.

"G-to-T transition at cDNA nt 110 (K37Q) in the PKLR (pyruvate kinase) gene is the molecular basis of a case of hereditary increase of red blood cell ATP."
Beutler E. , Westwood B. , van Zwieten R. , Roos D.
Hum. Mutat.9:282-285(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PKHYP GLU-37
25.

"Molecular characterization of the PK-LR gene in pyruvate kinase deficient Spanish patients."
Zarza R. , Alvarez R. , Pujades A. , Nomdedeu B. , Carrera A. , Estella J. , Remacha A. , Sanchez J.M. , Morey M. , Cortes T. , Perez Lungmus G. , Bureo E. , Vives Corrons J.L.
Br. J. Haematol.103:377-382(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PKRD GLN-172; GLN-337; HIS-339; THR-357; ILE-408; THR-431; TRP-486 AND GLN-532
26.

"A new sickle cell disease phenotype associating Hb S trait, severe pyruvate kinase deficiency (PK Conakry), and an alpha-2 globin gene variant (Hb Conakry)."
Cohen-Solal M. , Prehu C. , Wajcman H. , Poyart C. , Bardakdjian-Michau J. , Kister J. , Prome D. , Valentin C. , Bachir D. , Galacteros F.
Br. J. Haematol.103:950-956(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PKRD TYR-130
27.

"Novel mutations and structural implications in R-type pyruvate kinase-deficient patients from Southern Italy."
Pastore L. , della Morte R. , Frisso G. , Alfinito F. , Vitale D. , Calise R.M. , Ferraro F. , Zagari A. , Rotoli B. , Salvatore F.
Hum. Mutat.11:127-134(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PKRD SER-332; PRO-337; TRP-486; CYS-498 AND GLN-510
28.

"Molecular characterization of the PK-LR gene in sixteen pyruvate kinase-deficient patients."
Zanella A. , Bianchi P. , Fermo E. , Iurlo A. , Zappa M. , Vercellati C. , Boschetti C. , Baronciani L. , Cotton F.
Br. J. Haematol.113:43-48(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PKRD MET-335; LYS-348 DEL; GLY-387; ASP-394 AND VAL-394
29.

"Fifteen novel mutations in PKLR associated with pyruvate kinase (PK) deficiency: structural implications of amino acid substitutions in PK."
van Wijk R. , Huizinga E.G. , van Wesel A.C.W. , van Oirschot B.A. , Hadders M.A. , van Solinge W.W.
Hum. Mutat.30:446-453(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PKRD TRP-40; 48-THR--THR-53 DEL; PRO-73; ASN-90; ARG-111; THR-154; LEU-163; VAL-165; VAL-272; ASN-310; LEU-320; GLU-358 AND PRO-374
30.

"Exome sequencing and unrelated findings in the context of complex disease research: ethical and clinical implications."
Lyon G.J. , Jiang T. , Van Wijk R. , Wang W. , Bodily P.M. , Xing J. , Tian L. , Robison R.J. , Clement M. , Lin Y. , Zhang P. , Liu Y. , Moore B. , Glessner J.T. , Elia J. , Reimherr F. , van Solinge W.W. , Yandell M. , more...
Discov. Med.12:41-55(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PKRD ALA-341 AND GLN-569

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