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Index > Protein center > KYNU(Gene name) > Human
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  • KYNU (Gene name),
  • Kynureninase (Protein name ),  KYNU_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    KYNU;
    Protein name:
    Kynureninase;
    Alternative:
    L-kynurenine hydrolase;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer.
    Function:
    Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity.
    Subcellular Location:
    Cytoplasm
    Protein Attributes:
    Sequence length:
    465
    Sequence:
    50:
    MEPSSLELPA | DTVQRIAAEL | KCHPTDERVA | LHLDEEDKLR | HFRECFYIPK | 
    100:
    IQDLPPVDLS | LVNKDENAIY | FLGNSLGLQP | KMVKTYLEEE | LDKWAKIAAY | 
    150:
    GHEVGKRPWI | TGDESIVGLM | KDIVGANEKE | IALMNALTVN | LHLLMLSFFK | 
    200:
    PTPKRYKILL | EAKAFPSDHY | AIESQLQLHG | LNIEESMRMI | KPREGEETLR | 
    250:
    IEDILEVIEK | EGDSIAVILF | SGVHFYTGQH | FNIPAITKAG | QAKGCYVGFD | 
    300:
    LAHAVGNVEL | YLHDWGVDFA | CWCSYKYLNA | GAGGIAGAFI | HEKHAHTIKP | 
    350:
    ALVGWFGHEL | STRFKMDNKL | QLIPGVCGFR | ISNPPILLVC | SLHASLEIFK | 
    400:
    QATMKALRKK | SVLLTGYLEY | LIKHNYGKDK | AATKKPVVNI | ITPSHVEERG | 
    450:
    CQLTITFSVP | NKDVFQELEK | RGVVCDKRNP | NGIRVAPVPL | YNSFHDVYKF | 
    465:
    TNLLTSILDS | AETKN
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    MIM:
    SMR:
    Pfam:
    String:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Kynureninase
    Cat.:
    E10551h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Kynureninase
    Cat.:
    E10551m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Kynureninase
    Cat.:
    E10551r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Kynureninase
    Cat.:
    U10551h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Kynureninase
    Cat.:
    U10551m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Kynureninase
    Cat.:
    U10551r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Kynureninase
    Polyclonal Antibody for Human Kynureninase
    Polyclonal Antibody for Human Kynureninase
    Cat.:
    P10551Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Kynureninase
    Monoclonal Antibody for Human Kynureninase
    Monoclonal Antibody for Human Kynureninase
    Protein for Human Kynureninase
    Protein for Human Kynureninase
    Protein for Human Kynureninase

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Isolation and expression of a cDNA clone encoding human kynureninase."
      Alberati-Giani D. , Buchli R. , Malherbe P. , Broger C. , Lang G. , Koehler C. , Lahm H.-W. , Cesura A.M.
      Eur. J. Biochem.239:460-468(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);SUBCELLULAR LOCATION;TISSUE SPECIFICITY;CATALYTIC ACTIVITY;ENZYME REGULATION;BIOPHYSICOCHEMICAL PROPERTIES
      tissue: Hepatoma.
    2. 2.
      "Cloning and recombinant expression of rat and human kynureninase."
      Toma S. , Nakamura M. , Tone S. , Okuno E. , Kido R. , Breton J. , Avanzi N. , Cozzi L. , Speciale C. , Mostardini M. , Gatti S. , Benatti L.
      FEBS Lett.408:5-10(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY;CATALYTIC ACTIVITY;ENZYME REGULATION;BIOPHYSICOCHEMICAL PROPERTIES
      tissue: Liver.
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT GLU-412
      tissue: Synovium.
    4. 4.
      "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    5. 5.
      "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
      Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Cervix.
    8. 8.
      "Purification and biochemical characterization of some of the properties of recombinant human kynureninase."
      Walsh H.A. , Botting N.P.
      Eur. J. Biochem.269:2069-2074(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MASS SPECTROMETRY;CATALYTIC ACTIVITY;BIOPHYSICOCHEMICAL PROPERTIES
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    10. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    11. 11.
      "Crystal structure of Homo sapiens kynureninase."
      Lima S. , Khristoforov R. , Momany C. , Phillips R.S.
      Biochemistry46:2735-2744(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) IN COMPLEX WITH PYRIDOXAL PHOSPHATE;HOMODIMERIZATION;CATALYTIC ACTIVITY;BIOPHYSICOCHEMICAL PROPERTIES
    12. 12.
      "Xanthurenic aciduria due to a mutation in KYNU encoding kynureninase."
      Christensen M. , Duno M. , Lund A.M. , Skovby F. , Christensen E.
      J. Inherit. Metab. Dis.30:248-255(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ALA-198;POSSIBLE INVOLVEMENT IN XANTHURENIC ACIDURIA
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