LAIR1 ELISA Kit for Human(Homo sapiens) | EIAab.comLAIR1 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > LAIR1(Gene name) > Human

LAIR1 (Gene name),

Leukocyte-associated immunoglobulin-like receptor 1 (Protein name ), LAIR1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Citations (1)

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Gene name:

LAIR1(CD305);

Protein name:

Leukocyte-associated immunoglobulin-like receptor 1(LAIR-1;hLAIR1);

Alternative:

CD:

CD305;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with SH2 domains of tyrosine-protein phosphatases PTPN6 and PTPN11. The interaction with PTPN6 is constitutive. Interacts with the SH2 domain of CSK.

Function:

Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, downregulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells.

Subcellular Location:

Cell membrane Single-pass type I membrane protein

Protein Attributes:

Sequence length:

287

Sequence:

50:

100:

150:

200:

250:

287:

YAQLDHWALT | QRTARAVSPQ | STKPMAESIT | YAAVARH

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

hsa:3903

String:

Q6GTX8

UniGene:

Hs.572535

MIM:

602992

SMR:

Q6GTX8

STRING:

9606.ENSP00000375622

Uniprot:

Q6GTX8

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ELISA Kit for Human LAIR-1

Cat.:

E9027h

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96T

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ELISA Kit for Human LAIR-1

Cat.:

E9027m

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96T

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ELISA Kit for Human LAIR-1

Cat.:

E9027r

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Packing:

96T

CLIA Kit for Human LAIR-1

Cat.:

U9027h

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Manual:

Looking for manual.

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Packing:

96T

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CLIA Kit for Human LAIR-1

Cat.:

U9027m

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MSDS:

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Packing:

96T

CLIA Kit for Human LAIR-1

Cat.:

U9027r

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Packing:

96T

Polyclonal Antibody for Human LAIR-1

Cat.:

P9027Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human LAIR-1

Cat.:

P9027Rb-m

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human LAIR-1

Monoclonal Antibody for Human LAIR-1

Protein for Human LAIR-1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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Citations

[1].

"白细胞相关免疫球蛋白样受体-1 在免疫性血小板减少症患儿中的表达"

黄美玲, 李长钢, 王国兵, et al.

From:中国当代儿科杂志

References

1.

"LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes."
Meyaard L. , Adema G.J. , Chang C. , Woollatt E. , Sutherland G.R. , Lanier L.L. , Phillips J.H.
Immunity7:283-290(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);GLYCOSYLATION;SUBCELLULAR LOCATION;DOMAIN ITIM MOTIF;INTERACTION WITH PTPN6 AND PTPN11;FUNCTION
2.

"Leukocyte-associated Ig-like receptor-1 functions as an inhibitory receptor on cytotoxic T cells."
Meyaard L. , Hurenkamp J. , Clevers H. , Lanier L.L. , Phillips J.H.
J. Immunol.162:5800-5804(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);FUNCTION;SUBCELLULAR LOCATION
3.

"Identification and characterization of leukocyte-associated Ig-like receptor-1 as a major anchor protein of tyrosine phosphatase SHP-1 in hematopoietic cells."
Xu M.-J. , Zhao R. , Zhao Z.J.
J. Biol. Chem.275:17440-17446(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4);FUNCTION;PHOSPHORYLATION AT TYR-251 AND TYR-281;MUTAGENESIS OF TYR-251 AND TYR-281;INTERACTION WITH PTPN6
4.

"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Halleck A. , Ebert L. , Mkoundinya M. , Schick M. , Eisenstein S. , Neubert P. , Kstrang K. , Schatten R. , Shen B. , Henze S. , Mar W. , Korn B. , Zuo D. , Hu Y. , LaBaer J.
Submitted (2004-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Pancreas.
6.

"p40/LAIR-1 regulates the differentiation of peripheral blood precursors to dendritic cells induced by granulocyte-monocyte colony-stimulating factor."
Poggi A. , Tomasello E. , Ferrero E. , Zocchi M.R. , Moretta L.
Eur. J. Immunol.28:2086-2091(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
7.

"Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is differentially expressed during human B cell differentiation and inhibits B cell receptor-mediated signaling."
van der Vuurst de Vries A.-R. , Clevers H. , Logtenberg T. , Meyaard L.
Eur. J. Immunol.29:3160-3167(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
8.

"Engagement of the leukocyte-associated Ig-like receptor-1 induces programmed cell death and prevents NF-kappaB nuclear translocation in human myeloid leukemias."
Poggi A. , Pellegatta F. , Leone B.E. , Moretta L. , Zocchi M.R.
Eur. J. Immunol.30:2751-2758(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
9.

"Constitutive association of SHP-1 with leukocyte-associated Ig-like receptor-1 in human T cells."
Sathish J.G. , Johnson K.G. , Fuller K.J. , LeRoy F.G. , Meyaard L. , Sims M.J. , Matthews R.J.
J. Immunol.166:1763-1770(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;INTERACTION WITH PTPN6;FUNCTION
10.

"Surface density expression of the leukocyte-associated Ig-like receptor-1 is directly related to inhibition of human T-cell functions."
Saverino D. , Fabbi M. , Merlo A. , Ravera G. , Grossi C.E. , Ciccone E.
Hum. Immunol.63:534-546(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
11.

"Differential contribution of the immunoreceptor tyrosine-based inhibitory motifs of human leukocyte-associated Ig-like receptor-1 to inhibitory function and phosphatase recruitment."
Verbrugge A. , de Ruiter T. , Clevers H. , Meyaard L.
Int. Immunol.15:1349-1358(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF TYR-251 AND TYR-281
12.

"Chronic active Epstein-Barr virus infection associated with low expression of leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) on natural killer cells."
Aoukaty A. , Lee I.-F. , Wu J. , Tan R.
J. Clin. Immunol.23:141-145(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
13.

"Mechanisms of hypergammaglobulinemia and impaired antigen-specific humoral immunity in HIV-1 infection."
De Milito A. , Nilsson A. , Titanji K. , Thorstensson R. , Reizenstein E. , Narita M. , Grutzmeier S. , Sonnerborg A. , Chiodi F.
Blood103:2180-2186(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
14.

"Inhibitory receptors CD85j, LAIR-1, and CD152 down-regulate immunoglobulin and cytokine production by human B lymphocytes."
Merlo A. , Tenca C. , Fais F. , Battini L. , Ciccone E. , Grossi C.E. , Saverino D.
Clin. Diagn. Lab. Immunol.12:705-712(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
15.

"The inhibitory leukocyte-associated Ig-like receptor-1 (LAIR-1) is expressed at high levels by human naive T cells and inhibits TCR mediated activation."
Maasho K. , Masilamani M. , Valas R. , Basu S. , Coligan J.E. , Borrego F.
Mol. Immunol.42:1521-1530(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION;TISSUE SPECIFICITY
16.

"Leukocyte-associated Ig-like receptor-1 has SH2 domain-containing phosphatase-independent function and recruits C-terminal Src kinase."
Verbrugge A. , Rijkers E.S.K. , de Ruiter T. , Meyaard L.
Eur. J. Immunol.36:190-198(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CSK;MUTAGENESIS OF TYR-251 AND TYR-281;FUNCTION
17.

"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
Wollscheid B. , Bausch-Fluck D. , Henderson C. , O'Brien R. , Bibel M. , Schiess R. , Aebersold R. , Watts J.D.
Nat. Biotechnol.27:378-386(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-69
tissue: Leukemic T-cell.
18.

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
19.

"Crystal structure and collagen-binding site of immune inhibitory receptor LAIR-1: unexpected implications for collagen binding by platelet receptor GPVI."
Brondijk T.H. , de Ruiter T. , Ballering J. , Wienk H. , Lebbink R.J. , van Ingen H. , Boelens R. , Farndale R.W. , Meyaard L. , Huizinga E.G.
Blood115:1364-1373(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 22-122;INTERACTION WITH COLLAGENS;DISULFIDE BOND

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