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Index > Protein center > LAMA5(Gene name) > Human
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  • LAMA5 (Gene name),
  • Laminin subunit alpha-5 (Protein name ),  LAMA5_HUMAN from NCBI database.
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  • General Annotation
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  • Gene name:
    LAMA5(KIAA0533;KIAA1907);
    Protein name:
    Laminin subunit alpha-5;
    Alternative:
    Laminin-11 subunit alpha;Laminin-10 subunit alpha;Laminin-15 subunit alpha;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Alpha-5 is a subunit of laminin-10 (laminin-511), laminin-11 (laminin-521) and laminin-15 (laminin-523).
    Function:
    Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
    Subcellular Location:
    Secreted extracellular space extracellular matrix basement membrane Major component.
    Protein Attributes:
    Sequence length:
    3695
    Sequence:
    50:
    MAKRLCAGSA | LCVRGPRGPA | PLLLVGLALL | GAARAREEAG | GGFSLHPPYF | 
    100:
    NLAEGARIAA | SATCGEEAPA | RGSPRPTEDL | YCKLVGGPVA | GGDPNQTIRG | 
    150:
    QYCDICTAAN | SNKAHPASNA | IDGTERWWQS | PPLSRGLEYN | EVNVTLDLGQ | 
    200:
    VFHVAYVLIK | FANSPRPDLW | VLERSMDFGR | TYQPWQFFAS | SKRDCLERFG | 
    250:
    PQTLERITRD | DAAICTTEYS | RIVPLENGEI | VVSLVNGRPG | AMNFSYSPLL | 
    300:
    REFTKATNVR | LRFLRTNTLL | GHLMGKALRD | PTVTRRYYYS | IKDISIGGRC | 
    350:
    VCHGHADACD | AKDPTDPFRL | QCTCQHNTCG | GTCDRCCPGF | NQQPWKPATA | 
    400:
    NSANECQSCN | CYGHATDCYY | DPEVDRRRAS | QSLDGTYQGG | GVCIDCQHHT | 
    450:
    TGVNCERCLP | GFYRSPNHPL | DSPHVCRRCN | CESDFTDGTC | EDLTGRCYCR | 
    500:
    PNFSGERCDV | CAEGFTGFPS | CYPTPSSSND | TREQVLPAGQ | IVNCDCSAAG | 
    550:
    TQGNACRKDP | RVGRCLCKPN | FQGTHCELCA | PGFYGPGCQP | CQCSSPGVAD | 
    600:
    DRCDPDTGQC | RCRVGFEGAT | CDRCAPGYFH | FPLCQLCGCS | PAGTLPEGCD | 
    650:
    EAGRCLCQPE | FAGPHCDRCR | PGYHGFPNCQ | ACTCDPRGAL | DQLCGAGGLC | 
    700:
    RCRPGYTGTA | CQECSPGFHG | FPSCVPCHCS | AEGSLHAACD | PRSGQCSCRP | 
    750:
    RVTGLRCDTC | VPGAYNFPYC | EAGSCHPAGL | APVDPALPEA | QVPCMCRAHV | 
    800:
    EGPSCDRCKP | GFWGLSPSNP | EGCTRCSCDL | RGTLGGVAEC | QPGTGQCFCK | 
    850:
    PHVCGQACAS | CKDGFFGLDQ | ADYFGCRSCR | CDIGGALGQS | CEPRTGVCRC | 
    900:
    RPNTQGPTCS | EPARDHYLPD | LHHLRLELEE | AATPEGHAVR | FGFNPLEFEN | 
    950:
    FSWRGYAQMA | PVQPRIVARL | NLTSPDLFWL | VFRYVNRGAM | SVSGRVSVRE | 
    1000:
    EGRSATCANC | TAQSQPVAFP | PSTEPAFITV | PQRGFGEPFV | LNPGTWALRV | 
    1050:
    EAEGVLLDYV | VLLPSAYYEA | ALLQLRVTEA | CTYRPSAQQS | GDNCLLYTHL | 
    1100:
    PLDGFPSAAG | LEALCRQDNS | LPRPCPTEQL | SPSHPPLITC | TGSDVDVQLQ | 
    1150:
    VAVPQPGRYA | LVVEYANEDA | RQEVGVAVHT | PQRAPQQGLL | SLHPCLYSTL | 
    1200:
    CRGTARDTQD | HLAVFHLDSE | ASVRLTAEQA | RFFLHGVTLV | PIEEFSPEFV | 
    1250:
    EPRVSCISSH | GAFGPNSAAC | LPSRFPKPPQ | PIILRDCQVI | PLPPGLPLTH | 
    1300:
    AQDLTPAMSP | AGPRPRPPTA | VDPDAEPTLL | REPQATVVFT | THVPTLGRYA | 
    1350:
    FLLHGYQPAH | PTFPVEVLIN | AGRVWQGHAN | ASFCPHGYGC | RTLVVCEGQA | 
    1400:
    LLDVTHSELT | VTVRVPKGRW | LWLDYVLVVP | ENVYSFGYLR | EEPLDKSYDF | 
    1450:
    ISHCAAQGYH | ISPSSSSLFC | RNAAASLSLF | YNNGARPCGC | HEVGATGPTC | 
    1500:
    EPFGGQCPCH | AHVIGRDCSR | CATGYWGFPN | CRPCDCGARL | CDELTGQCIC | 
    1550:
    PPRTIPPDCL | LCQPQTFGCH | PLVGCEECNC | SGPGIQELTD | PTCDTDSGQC | 
    1600:
    KCRPNVTGRR | CDTCSPGFHG | YPRCRPCDCH | EAGTAPGVCD | PLTGQCYCKE | 
    1650:
    NVQGPKCDQC | SLGTFSLDAA | NPKGCTRCFC | FGATERCRSS | SYTRQEFVDM | 
    1700:
    EGWVLLSTDR | QVVPHERQPG | TEMLRADLRH | VPEAVPEAFP | ELYWQAPPSY | 
    1750:
    LGDRVSSYGG | TLRYELHSET | QRGDVFVPME | SRPDVVLQGN | QMSITFLEPA | 
    1800:
    YPTPGHVHRG | QLQLVEGNFR | HTETRNTVSR | EELMMVLASL | EQLQIRALFS | 
    1850:
    QISSAVFLRR | VALEVASPAG | QGALASNVEL | CLCPASYRGD | SCQECAPGFY | 
    1900:
    RDVKGLFLGR | CVPCQCHGHS | DRCLPGSGVC | VDCQHNTEGA | HCERCQAGFV | 
    1950:
    SSRDDPSAPC | VSCPCPLSVP | SNNFAEGCVL | RGGRTQCLCK | PGYAGASCER | 
    2000:
    CAPGFFGNPL | VLGSSCQPCD | CSGNGDPNLL | FSDCDPLTGA | CRGCLRHTTG | 
    2050:
    PRCEICAPGF | YGNALLPGNC | TRCDCTPCGT | EACDPHSGHC | LCKAGVTGRR | 
    2100:
    CDRCQEGHFG | FDGCGGCRPC | ACGPAAEGSE | CHPQSGQCHC | RPGTMGPQCR | 
    2150:
    ECAPGYWGLP | EQGCRRCQCP | GGRCDPHTGR | CNCPPGLSGE | RCDTCSQQHQ | 
    2200:
    VPVPGGPVGH | SIHCEVCDHC | VVLLLDDLER | AGALLPAIHE | QLRGINASSM | 
    2250:
    AWARLHRLNA | SIADLQSQLR | SPLGPRHETA | QQLEVLEQQS | TSLGQDARRL | 
    2300:
    GGQAVGTRDQ | ASQLLAGTEA | TLGHAKTLLA | AIRAVDRTLS | ELMSQTGHLG | 
    2350:
    LANASAPSGE | QLLRTLAEVE | RLLWEMRARD | LGAPQAAAEA | ELAAAQRLLA | 
    2400:
    RVQEQLSSLW | EENQALATQT | RDRLAQHEAG | LMDLREALNR | AVDATREAQE | 
    2450:
    LNSRNQERLE | EALQRKQELS | RDNATLQATL | HAARDTLASV | FRLLHSLDQA | 
    2500:
    KEELERLAAS | LDGARTPLLQ | RMQTFSPAGS | KLRLVEAAEA | HAQQLGQLAL | 
    2550:
    NLSSIILDVN | QDRLTQRAIE | ASNAYSRILQ | AVQAAEDAAG | QALQQADHTW | 
    2600:
    ATVVRQGLVD | RAQQLLANST | ALEEAMLQEQ | QRLGLVWAAL | QGARTQLRDV | 
    2650:
    RAKKDQLEAH | IQAAQAMLAM | DTDETSKKIA | HAKAVAAEAQ | DTATRVQSQL | 
    2700:
    QAMQENVERW | QGQYEGLRGQ | DLGQAVLDAG | HSVSTLEKTL | PQLLAKLSIL | 
    2750:
    ENRGVHNASL | ALSASIGRVR | ELIAQARGAA | SKVKVPMKFN | GRSGVQLRTP | 
    2800:
    RDLADLAAYT | ALKFYLQGPE | PEPGQGTEDR | FVMYMGSRQA | TGDYMGVSLR | 
    2850:
    DKKVHWVYQL | GEAGPAVLSI | DEDIGEQFAA | VSLDRTLQFG | HMSVTVERQM | 
    2900:
    IQETKGDTVA | PGAEGLLNLR | PDDFVFYVGG | YPSTFTPPPL | LRFPGYRGCI | 
    2950:
    EMDTLNEEVV | SLYNFERTFQ | LDTAVDRPCA | RSKSTGDPWL | TDGSYLDGTG | 
    3000:
    FARISFDSQI | STTKRFEQEL | RLVSYSGVLF | FLKQQSQFLC | LAVQEGSLVL | 
    3050:
    LYDFGAGLKK | AVPLQPPPPL | TSASKAIQVF | LLGGSRKRVL | VRVERATVYS | 
    3100:
    VEQDNDLELA | DAYYLGGVPP | DQLPPSLRRL | FPTGGSVRGC | VKGIKALGKY | 
    3150:
    VDLKRLNTTG | VSAGCTADLL | VGRAMTFHGH | GFLRLALSNV | APLTGNVYSG | 
    3200:
    FGFHSAQDSA | LLYYRASPDG | LCQVSLQQGR | VSLQLLRTEV | KTQAGFADGA | 
    3250:
    PHYVAFYSNA | TGVWLYVDDQ | LQQMKPHRGP | PPELQPQPEG | PPRLLLGGLP | 
    3300:
    ESGTIYNFSG | CISNVFVQRL | LGPQRVFDLQ | QNLGSVNVST | GCAPALQAQT | 
    3350:
    PGLGPRGLQA | TARKASRRSR | QPARHPACML | PPHLRTTRDS | YQFGGSLSSH | 
    3400:
    LEFVGILARH | RNWPSLSMHV | LPRSSRGLLL | FTARLRPGSP | SLALFLSNGH | 
    3450:
    FVAQMEGLGT | RLRAQSRQRS | RPGRWHKVSV | RWEKNRILLV | TDGARAWSQE | 
    3500:
    GPHRQHQGAE | HPQPHTLFVG | GLPASSHSSK | LPVTVGFSGC | VKRLRLHGRP | 
    3550:
    LGAPTRMAGV | TPCILGPLEA | GLFFPGSGGV | ITLDLPGATL | PDVGLELEVR | 
    3600:
    PLAVTGLIFH | LGQARTPPYL | QLQVTEKQVL | LRADDGAGEF | STSVTRPSVL | 
    3650:
    CDGQWHRLAV | MKSGNVLRLE | VDAQSNHTVG | PLLAAAAGAP | APLYLGGLPE | 
    3695:
    PMAVQPWPPA | YCGCMRRLAV | NRSPVAMTRS | VEVHGAVGAS | GCPAA
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    KEGG:
    UniGene:
    SMR:
    Pfam:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human Laminin subunit alpha-5
    Cat.:
    E1474h
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human Laminin subunit alpha-5
    Cat.:
    E1474m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Laminin subunit alpha-5
    Cat.:
    U1474m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Laminin subunit alpha-5
    Cat.:
    U1474h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    Polyclonal Antibody for Human Laminin subunit alpha-5
    Cat.:
    P1474Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Laminin subunit alpha-5
    Cat.:
    P1474Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Laminin subunit alpha-5
    Monoclonal Antibody for Human Laminin subunit alpha-5
    Protein for Human Laminin subunit alpha-5
    Protein for Human Laminin subunit alpha-5

    R&D Technical Data
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Precision
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Recombinant human laminin-10 (alpha5beta1gamma1). Production, purification, and migration-promoting activity on vascular endothelial cells."
      Doi M. , Thyboll J. , Kortesmaa J. , Jansson K. , Iivanainen A. , Parvardeh M. , Timpl R. , Hedin U. , Swedenborg J. , Tryggvason K.
      J. Biol. Chem.277:12741-12748(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANTS ALA-401; THR-1258; GLU-1367; SER-1807; MET-1900; ASN-2062 AND TRP-3079
    2. 2.
      "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P. , Matthews L.H. , Ashurst J.L. , Burton J. , Gilbert J.G.R. , Jones M. , Stavrides G. , Almeida J.P. , Babbage A.K. , Bagguley C.L. , Bailey J. , Barlow K.F. , Bates K.N. , Beard L.M. , Beare D.M. , Beasley O.P. , Bird C.P. , Blakey S.E. , more...
      Nature414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);VARIANT ALA-401
      tissue: Mammary gland.
    4. 4.
      "Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins."
      Nagase T. , Kikuno R. , Ohara O.
      DNA Res.8:179-187(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 197-1934 (ISOFORM 1);VARIANTS MET-889; GLU-1367 AND SER-1807
      tissue: Brain.
    5. 5.
      "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
      Nagase T. , Ishikawa K. , Miyajima N. , Tanaka A. , Kotani H. , Nomura N. , Ohara O.
      DNA Res.5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2051-3695 (ISOFORM 1);VARIANTS ASN-2062 AND TRP-3079
      tissue: Brain.
    6. 6.
      "Tissue-specific expression of the human laminin alpha5-chain, and mapping of the gene to human chromosome 20q13.2-13.3 and to distal mouse chromosome 2 near the locus for the ragged (Ra) mutation."
      Durkin M.E. , Loechel F. , Mattei M.-G. , Gilpin B.J. , Albrechtsen R. , Wewer U.M.
      FEBS Lett.411:296-300(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2743-3695 (ISOFORM 1);VARIANT TRP-3079
      tissue: Placenta.
    7. 7.
      "Laminin expression in adult and developing retinae: evidence of two novel CNS laminins."
      Libby R.T. , Champliaud M.-F. , Claudepierre T. , Xu Y. , Gibbons E.P. , Koch M. , Burgeson R.E. , Hunter D.D. , Brunken W.J.
      J. Neurosci.20:6517-6528(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: EXPRESSION IN RETINA
    8. 8.
      "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
      J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-2209; ASN-2303; ASN-2423; ASN-2501; ASN-2568; ASN-2707 AND ASN-3107
      tissue: Liver.
    9. 9.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    10. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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