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Index > Protein center > LAMB3(Gene name) > Human
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  • LAMB3 (Gene name),
  • Laminin subunit beta-3 (Protein name ),  LAMB3_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    LAMB3(LAMNB1);
    Protein name:
    Laminin subunit beta-3;
    Alternative:
    Kalinin B1 chain;Epiligrin subunit bata;Laminin B1k chain;Kalinin subunit beta;Nicein subunit beta;Laminin-5 subunit beta;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Beta-3 is a subunit of laminin-5 (laminin-332 or epiligrin/kalinin/nicein). Interacts with ECM1.
    Function:
    Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
    Subcellular Location:
    Secreted extracellular space extracellular matrix basement membrane
    Protein Attributes:
    Sequence length:
    1172
    Sequence:
    50:
    MRPFFLLCFA | LPGLLHAQQA | CSRGACYPPV | GDLLVGRTRF | LRASSTCGLT | 
    100:
    KPETYCTQYG | EWQMKCCKCD | SRQPHNYYSH | RVENVASSSG | PMRWWQSQND | 
    150:
    VNPVSLQLDL | DRRFQLQEVM | MEFQGPMPAG | MLIERSSDFG | KTWRVYQYLA | 
    200:
    ADCTSTFPRV | RQGRPQSWQD | VRCQSLPQRP | NARLNGGKVQ | LNLMDLVSGI | 
    250:
    PATQSQKIQE | VGEITNLRVN | FTRLAPVPQR | GYHPPSAYYA | VSQLRLQGSC | 
    300:
    FCHGHADRCA | PKPGASAGPS | TAVQVHDVCV | CQHNTAGPNC | ERCAPFYNNR | 
    350:
    PWRPAEGQDA | HECQRCDCNG | HSETCHFDPA | VFAASQGAYG | GVCDNCRDHT | 
    400:
    EGKNCERCQL | HYFRNRRPGA | SIQETCISCE | CDPDGAVPGA | PCDPVTGQCV | 
    450:
    CKEHVQGERC | DLCKPGFTGL | TYANPQGCHR | CDCNILGSRR | DMPCDEESGR | 
    500:
    CLCLPNVVGP | KCDQCAPYHW | KLASGQGCEP | CACDPHNSLS | PQCNQFTGQC | 
    550:
    PCREGFGGLM | CSAAAIRQCP | DRTYGDVATG | CRACDCDFRG | TEGPGCDKAS | 
    600:
    GRCLCRPGLT | GPRCDQCQRG | YCNRYPVCVA | CHPCFQTYDA | DLREQALRFG | 
    650:
    RLRNATASLW | SGPGLEDRGL | ASRILDAKSK | IEQIRAVLSS | PAVTEQEVAQ | 
    700:
    VASAILSLRR | TLQGLQLDLP | LEEETLSLPR | DLESLDRSFN | GLLTMYQRKR | 
    750:
    EQFEKISSAD | PSGAFRMLST | AYEQSAQAAQ | QVSDSSRLLD | QLRDSRREAE | 
    800:
    RLVRQAGGGG | GTGSPKLVAL | RLEMSSLPDL | TPTFNKLCGN | SRQMACTPIS | 
    850:
    CPGELCPQDN | GTACGSRCRG | VLPRAGGAFL | MAGQVAEQLR | GFNAQLQRTR | 
    900:
    QMIRAAEESA | SQIQSSAQRL | ETQVSASRSQ | MEEDVRRTRL | LIQQVRDFLT | 
    950:
    DPDTDAATIQ | EVSEAVLALW | LPTDSATVLQ | KMNEIQAIAA | RLPNVDLVLS | 
    1000:
    QTKQDIARAR | RLQAEAEEAR | SRAHAVEGQV | EDVVGNLRQG | TVALQEAQDT | 
    1050:
    MQGTSRSLRL | IQDRVAEVQQ | VLRPAEKLVT | SMTKQLGDFW | TRMEELRHQA | 
    1100:
    RQQGAEAVQA | QQLAEGASEQ | ALSAQEGFER | IKQKYAELKD | RLGQSSMLGE | 
    1150:
    QGARIQSVKT | EAEELFGETM | EMMDRMKDME | LELLRGSQAI | MLRSADLTGL | 
    1172:
    EKRVEQIRDH | INGRVLYYAT | CK
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    KEGG:
    MIM:
    String:
    UniGene:
    SMR:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Laminin subunit beta-3
    Cat.:
    E1471h
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human Laminin subunit beta-3
    MSDS:
    Please sign in first.
    CLIA Kit for Human Laminin subunit beta-3
    Cat.:
    U1471h
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Laminin subunit beta-3
    Cat.:
    U1471m
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Laminin subunit beta-3
    Cat.:
    P1471Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Laminin subunit beta-3
    Cat.:
    P1471Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Laminin subunit beta-3
    Monoclonal Antibody for Human Laminin subunit beta-3
    Protein for Human Laminin subunit beta-3
    Protein for Human Laminin subunit beta-3

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    Precision
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    Recovery
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "The complete primary structure for a novel laminin chain, the laminin B1k chain."
      Gerecke D.R. , Wagman D.W. , Champliaud M.-F. , Burgeson R.E.
      J. Biol. Chem.269:11073-11080(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 172-190
    2. 2.
      "Cloning of the beta 3 chain gene (LAMB3) of human laminin 5, a candidate gene in junctional epidermolysis bullosa."
      Pulkkinen L. , Gerecke D.R. , Christiano A.M. , Wagman D.W. , Burgeson R.E. , Uitto J.
      Genomics25:192-198(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    3. 3.
      "Chromosomal loci of 50 human keratinocyte cDNAs assigned by fluorescence in situ hybridization."
      Morishima Y. , Ariyama T. , Yamanishi K. , Abe T. , Ueda E. , Yasuno H. , Inazawa J.
      Genomics28:273-279(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Epidermis.
    4. 4.
      "In vivo restoration of laminin 5 beta 3 expression and function in junctional epidermolysis bullosa."
      Robbins P.B. , Lin Q. , Goodnough J.B. , Tian H. , Chen X. , Khavari P.A.
      Proc. Natl. Acad. Sci. U.S.A.98:5193-5198(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    5. 5.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT LEU-852
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Eye.
    8. 8.
      "ECM1 interacts with fibulin-3 and the beta 3 chain of laminin 332 through its serum albumin subdomain-like 2 domain."
      Sercu S. , Lambeir A.M. , Steenackers E. , El Ghalbzouri A. , Geentjens K. , Sasaki T. , Oyama N. , Merregaert J.
      Matrix Biol.28:160-169(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ECM1
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    10. 10.
      "Detection of sequence variants in the gene encoding the beta 3 chain of laminin 5 (LAMB3)."
      Pulkkinen L. , McGrath J.A. , Christiano A.M. , Uitto J.
      Hum. Mutat.6:77-84(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT H-JEB LEU-679
    11. 11.
      "E210K mutation in the gene encoding the beta3 chain of laminin-5 (LAMB3) is predictive of a phenotype of generalized atrophic benign epidermolysis bullosa."
      Mellerio J.E. , Eady R.A.J. , Atherton D.J. , Lake B.D. , McGrath J.A.
      Br. J. Dermatol.139:325-331(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GABEB LYS-210
    12. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] CYS-450
    13. 13.
      "Revertant mosaicism in junctional epidermolysis bullosa due to multiple correcting second-site mutations in LAMB3."
      Pasmooij A.M.G. , Pas H.H. , Bolling M.C. , Jonkman M.F.
      J. Clin. Invest.117:1240-1248(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS GABEB ALA-199; GLN-207 AND LYS-210
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