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Index > Protein center > LAMP2(Gene name) > Human
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  • LAMP2 (Gene name),
  • Lysosome-associated membrane glycoprotein 2 (Protein name ),  LAMP2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    LAMP2;
    Protein name:
    Lysosome-associated membrane glycoprotein 2(LAMP-2;Lysosome-associated membrane protein 2);
    Alternative:
    CD107 antigen-like family member B;
    CD:
    CD107b;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter-and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens.
    Subcellular Location:
    Cell membrane Single-pass type I membrane protein Endosome membrane Single-pass type I membrane protein Lysosome membrane Single-pass type I membrane protein This protein shuttles between lysosomes, endosomes, and the plasma membrane.
    Protein Attributes:
    Sequence length:
    410
    Sequence:
    50:
    MVCFRLFPVP | GSGLVLVCLV | LGAVRSYALE | LNLTDSENAT | CLYAKWQMNF | 
    100:
    TVRYETTNKT | YKTVTISDHG | TVTYNGSICG | DDQNGPKIAV | QFGPGFSWIA | 
    150:
    NFTKAASTYS | IDSVSFSYNT | GDNTTFPDAE | DKGILTVDEL | LAIRIPLNDL | 
    200:
    FRCNSLSTLE | KNDVVQHYWD | VLVQAFVQNG | TVSTNEFLCD | KDKTSTVAPT | 
    250:
    IHTTVPSPTT | TPTPKEKPEA | GTYSVNNGND | TCLLATMGLQ | LNITQDKVAS | 
    300:
    VININPNTTH | STGSCRSHTA | LLRLNSSTIK | YLDFVFAVKN | ENRFYLKEVN | 
    350:
    ISMYLVNGSV | FSIANNNLSY | WDAPLGSSYM | CNKEQTVSVS | GAFQINTFDL | 
    400:
    RVQPFNVTQG | KYSTAQDCSA | DDDNFLVPIA | VGAALAGVLI | LVLLAYFIGL | 
    410:
    KHHHAGYEQF | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    SMR:
    MIM:
    UniGene:
    Pfam:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human LAMP-2
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    E1464h
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    ELISA Kit for Human LAMP-2
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    E1464r
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    ELISA Kit for Human LAMP-2
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    E1464c
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    ELISA Kit for Human LAMP-2
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    E1464m
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    96T
    CLIA Kit for Human LAMP-2
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    U1464c
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    CLIA Kit for Human LAMP-2
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    U1464m
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    CLIA Kit for Human LAMP-2
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    U1464h
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    CLIA Kit for Human LAMP-2
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    U1464r
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    96T
    Polyclonal Antibody for Human LAMP-2
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    P1464Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human LAMP-2
    Cat.:
    P1464Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human LAMP-2
    Polyclonal Antibody for Human LAMP-2
    Cat.:
    P1464Rb-r
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human LAMP-2
    Monoclonal Antibody for Human LAMP-2
    Monoclonal Antibody for Human LAMP-2
    Monoclonal Antibody for Human LAMP-2
    Protein for Human LAMP-2
    Protein for Human LAMP-2
    Protein for Human LAMP-2
    Protein for Human LAMP-2

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    References
    1. 1.
      "Cloning of cDNAs encoding human lysosomal membrane glycoproteins, h-lamp-1 and h-lamp-2. Comparison of their deduced amino acid sequences."
      Fukuda M. , Viitala J. , Matteson J. , Carlsson S.R.
      J. Biol. Chem.263:18920-18928(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LAMP-2A);PROTEIN SEQUENCE OF 29-64; 216-223 AND 238-256
    2. 2.
      "The genes of major lysosomal membrane glycoproteins, lamp-1 and lamp-2. 5'-flanking sequence of lamp-2 gene and comparison of exon organization in two genes."
      Sawada R. , Jardine K.A. , Fukuda M.
      J. Biol. Chem.268:9014-9022(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM LAMP-2A)
      tissue: Placenta.
    3. 3.
      "Molecular and cellular characterization of Mex-/methylation-resistant phenotype. Gene and cDNA cloning, serum dependence, and tumor suppression of transfectant strains."
      Fritz G. , Dosch J. , Thielmann H.W. , Kaina B.
      J. Biol. Chem.268:21102-21112(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LAMP-2B);FUNCTION
      tissue: Fibroblast.
    4. 4.
      "Complete cDNA sequence of human lysosome-associated membrane protein-2."
      Konecki D.S. , Foetisch K. , Schlotter M. , Lichter-Konecki U.
      Biochem. Biophys. Res. Commun.205:1-5(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LAMP-2A)
      tissue: Liver.
    5. 5.
      "An alternatively spliced form of the human lysosome-associated membrane protein-2 gene is expressed in a tissue-specific manner."
      Konecki D.S. , Foetisch K. , Zimmer K.P. , Schlotter M. , Lichter-Konecki U.
      Biochem. Biophys. Res. Commun.215:757-767(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LAMP-2B)
    6. 6.
      "Lamp-2 isoforms play different roles in lysosomal biogenesis."
      Zhou D. , Blum J.S.
      Submitted (2004-02) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LAMP-2C)
    7. 7.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LAMP-2A)
    8. 8.
      "The DNA sequence of the human X chromosome."
      Ross M.T. , Grafham D.V. , Coffey A.J. , Scherer S. , McLay K. , Muzny D. , Platzer M. , Howell G.R. , Burrows C. , Bird C.P. , Frankish A. , Lovell F.L. , Howe K.L. , Ashurst J.L. , Fulton R.S. , Sudbrak R. , Wen G. , Jones M.C. , more...
      Nature434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    10. 10.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LAMP-2B)
      tissue: Lymph.
    11. 11.
      "Purification and characterization of human lysosomal membrane glycoproteins."
      Mane S.M. , Marzella L. , Bainton D.F. , Holt V.K. , Cha Y. , Hildreth J.E.K. , August J.T.
      Arch. Biochem. Biophys.268:360-378(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 29-66
    12. 12.
      "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z. , Henzel W.J.
      Protein Sci.13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 29-43
    13. 13.
      "The polylactosaminoglycans of human lysosomal membrane glycoproteins lamp-1 and lamp-2. Localization on the peptide backbones."
      Carlsson S.R. , Fukuda M.
      J. Biol. Chem.265:20488-20495(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POLYLACTOSAMINOGLYCANS
    14. 14.
      "Assignment of O-glycan attachment sites to the hinge-like regions of human lysosomal membrane glycoproteins lamp-1 and lamp-2."
      Carlsson S.R. , Lycksell P.-O. , Fukuda M.
      Arch. Biochem. Biophys.304:65-73(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION OF HINGE REGION;PROTEIN SEQUENCE OF 187-215
    15. 15.
      "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."
      Zhang H. , Li X.-J. , Martin D.B. , Aebersold R.
      Nat. Biotechnol.21:660-666(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-49 AND ASN-101
    16. 16.
      "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
      J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-32; ASN-38; ASN-49; ASN-101; ASN-123 AND ASN-257
      tissue: Plasma.
    17. 17.
      "Unifying nomenclature for the isoforms of the lysosomal membrane protein LAMP-2."
      Eskelinen E.L. , Cuervo A.M. , Taylor M.R. , Nishino I. , Blum J.S. , Dice J.F. , Sandoval I.V. , Lippincott-Schwartz J. , August J.T. , Saftig P.
      Traffic6:1058-1061(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NOMENCLATURE
    18. 18.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]
      tissue: Placenta.
    19. 19.
      "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
      J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-101; ASN-123; ASN-257 AND ASN-356
      tissue: Liver.
    20. 20.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    21. 21.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT DAND ARG-321
    22. 22.
      "Asymptomatic hyperCKemia in a case of Danon disease due to a missense mutation in Lamp-2 gene."
      Musumeci O. , Rodolico C. , Nishino I. , Di Guardo G. , Migliorato A. , Aguennouz M. , Mazzeo A. , Messina C. , Vita G. , Toscano A.
      Neuromuscul. Disord.15:409-411(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT DAND ARG-321
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