LAT ELISA Kit for Human(Homo sapiens) | EIAab.comLAT ELISA Kit for Human(Homo sapiens)

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Index > Protein center > LAT(Gene name) > Human

LAT (Gene name),

Linker for activation of T-cells family member 1 (Protein name ), LAT_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

LAT;

Protein name:

Linker for activation of T-cells family member 1;

Alternative:

p36-38;36 kDa phospho-tyrosine adapter protein(pp36);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

When phosphorylated, interacts directly with the PIK3R1 subunit of phosphoinositide 3-kinase and the SH2 domains of GRB2, GRAP, GRAP2, PLCG1 and PLCG2. Interacts indirectly with CBL, SOS, VAV, and LCP2. Interacts with SHB, SKAP2 and CLNK (By similarity). Interacts with FCGR1A.

Function:

Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules.

Subcellular Location:

Cell membrane Single-pass type III membrane protein Present in lipid rafts.

Protein Attributes:

Sequence length:

262

Sequence:

50:

100:

150:

200:

250:

262:

GAPDYENLQE | LN

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

hsa:27040

UniGene:

Hs.632179

String:

O43561

STRING:

9606.ENSP00000354119

MIM:

602354

Pfam:

PF15234

Uniprot:

O43561

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ELISA Kit for Human Linker for activation of T-cells family member 1

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E0270h

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96T

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ELISA Kit for Human Linker for activation of T-cells family member 1

Cat.:

E0270m

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96T

ELISA Kit for Human Linker for activation of T-cells family member 1

Cat.:

E0270r

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96T

CLIA Kit for Human Linker for activation of T-cells family member 1

Cat.:

U0270m

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96T

CLIA Kit for Human Linker for activation of T-cells family member 1

Cat.:

U0270h

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human Linker for activation of T-cells family member 1

Cat.:

U0270r

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96T

Polyclonal Antibody for Human Linker for activation of T-cells family member 1

Cat.:

P0270Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human Linker for activation of T-cells family member 1

Cat.:

P0270Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Linker for activation of T-cells family member 1

Cat.:

P0270Rb-h

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Linker for activation of T-cells family member 1

Protein for Human Linker for activation of T-cells family member 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation."
Zhang W. , Sloan-Lancaster J. , Kitchen J. , Trible R.P. , Samelson L.E.
Cell92:83-92(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);PROTEIN SEQUENCE OF 32-47 AND 219-233;PHOSPHORYLATION AT TYR-200;IDENTIFICATION BY MASS SPECTROMETRY;MUTAGENESIS OF TYR-200 AND TYR-220;TISSUE SPECIFICITY;SUBCELLULAR LOCATION;INTERACTION WITH PIK3R1; GRB2; GRAP AND PLCG1
tissue: Leukemia.
2.

"Molecular cloning of the cDNA encoding pp36, a tyrosine-phosphorylated adaptor protein selectively expressed by T cells and natural killer cells."
Weber J.R. , Orstavik S. , Torgersen K.M. , Danbolt N.C. , Berg S.F. , Ryan J.C. , Tasken K. , Imboden J.B. , Vaage J.T.
J. Exp. Med.187:1157-1161(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
tissue: Thymus.
3.

"Inactivation of pre-B cell receptor-mediated tumor suppression by aberrant splicing in Ph+ acute lymphoblastic leukemia."
Muschen M.
Submitted (2009-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5)
tissue: Bone marrow.
4.

"The sequence and analysis of duplication-rich human chromosome 16."
Martin J. , Han C. , Gordon L.A. , Terry A. , Prabhakar S. , She X. , Xie G. , Hellsten U. , Chan Y.M. , Altherr M. , Couronne O. , Aerts A. , Bajorek E. , Black S. , Blumer H. , Branscomb E. , Brown N.C. , Bruno W.J. , more...
Nature432:988-994(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue: Colon.
7.

"LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation."
Zhang W. , Trible R.P. , Samelson L.E.
Immunity9:239-246(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;PALMITOYLATION AT CYS-26 AND CYS-29;MUTAGENESIS OF CYS-26 AND CYS-29
8.

"Requirement of the Src homology 2 domain protein Shb for T cell receptor-dependent activation of the interleukin-2 gene nuclear factor for activation of T cells element in Jurkat T cells."
Lindholm C.K. , Gylfe E. , Zhang W. , Samelson L.E. , Welsh M.
J. Biol. Chem.274:28050-28057(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SHB
9.

"A role for the adaptor protein LAT in human NK cell-mediated cytotoxicity."
Jevremovic D. , Billadeau D.D. , Schoon R.A. , Dick C.J. , Irvin B.J. , Zhang W. , Samelson L.E. , Abraham R.T. , Leibson P.J.
J. Immunol.162:2453-2456(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN NK CELLS;INTERACTION WITH PLCG1
10.

"Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell antigen receptor-mediated signaling."
Zhang W. , Trible R.P. , Zhu M. , Liu S.K. , McGlade C.J. , Samelson L.E.
J. Biol. Chem.275:23355-23361(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GRB2; GRAP2 AND PLCG1
11.

"The adapter protein LAT enhances fcgamma receptor-mediated signal transduction in myeloid cells."
Tridandapani S. , Lyden T.W. , Smith J.L. , Carter J.E. , Coggeshall K.M. , Anderson C.L.
J. Biol. Chem.275:20480-20487(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FCGR1A
12.

"Interaction of linker for activation of T cells with multiple adapter proteins in platelets activated by the glycoprotein VI-selective ligand, convulxin."
Asazuma N. , Wilde J.I. , Berlanga O. , Leduc M. , Leo A. , Schweighoffer E. , Tybulewicz V. , Bon C. , Liu S.K. , McGlade C.J. , Schraven B. , Watson S.P.
J. Biol. Chem.275:33427-33434(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION;INTERACTION WITH LCP2; SKAP2; GRB2; PLCG2 AND CBL
13.

"Mapping the Zap-70 phosphorylation sites on LAT (linker for activation of T cells) required for recruitment and activation of signalling proteins in T cells."
Paz P.E. , Wang S. , Clarke H. , Lu X. , Stokoe D. , Abo A.
Biochem. J.356:461-471(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PIK3R1 AND PLCG1;MUTAGENESIS OF TYR-161
14.

"Protein tyrosine phosphatase CD148-mediated inhibition of T-cell receptor signal transduction is associated with reduced LAT and phospholipase Cgamma1 phosphorylation."
Baker J.E. , Majeti R. , Tangye S.G. , Weiss A.
Mol. Cell. Biol.21:2393-2403(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROBABLE DEPHOSPHORYLATION BY PTPRJ
15.

"Phosphorylation of the linker for activation of T-cells by Itk promotes recruitment of Vav."
Perez-Villar J.J. , Whitney G.S. , Sitnick M.T. , Dunn R.J. , Venkatesan S. , O'Day K. , Schieven G.L. , Lin T.A. , Kanner S.B.
Biochemistry41:10732-10740(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION BY ITK
16.

"The tyrosine phosphatase CD148 is excluded from the immunologic synapse and down-regulates prolonged T cell signaling."
Lin J. , Weiss A.
J. Cell Biol.162:673-682(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROBABLE DEPHOSPHORYLATION BY PTPRJ
17.

"Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."
Brill L.M. , Salomon A.R. , Ficarro S.B. , Mukherji M. , Stettler-Gill M. , Peters E.C.
Anal. Chem.76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
18.

"LAT: a T lymphocyte adapter protein that couples the antigen receptor to downstream signaling pathways."
Sommers C.L. , Samelson L.E. , Love P.E.
Bioessays26:61-67(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION IN T-CELLS
19.

"Transmembrane adaptor molecules: a new category of lymphoid-cell markers."
Tedoldi S. , Paterson J.C. , Hansmann M.-L. , Natkunam Y. , Rudiger T. , Angelisova P. , Du M.Q. , Roberton H. , Roncador G. , Sanchez L. , Pozzobon M. , Masir N. , Barry R. , Pileri S. , Mason D.Y. , Marafioti T. , Horejsi V.
Blood107:213-221(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
20.

"Phosphoproteome of resting human platelets."
Zahedi R.P. , Lewandrowski U. , Wiesner J. , Wortelkamp S. , Moebius J. , Schuetz C. , Walter U. , Gambaryan S. , Sickmann A.
J. Proteome Res.7:526-534(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-84; SER-101 AND SER-224;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Platelet.
21.

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-39; SER-40; SER-41; SER-43; SER-101; SER-106; SER-240; SER-241 AND TYR-255;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.

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