Protein name:
Linker for activation of T-cells family member 1 ;
Alternative:
p36-38 ;36 kDa phospho-tyrosine adapter protein (pp36) ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
When phosphorylated, interacts directly with the PIK3R1 subunit of phosphoinositide 3-kinase and the SH2 domains of GRB2, GRAP, GRAP2, PLCG1 and PLCG2. Interacts indirectly with CBL, SOS, VAV, and LCP2. Interacts with SHB and SKAP2. Interacts with FCGR1A (By similarity). Interacts with CLNK.
Function:
Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules.
Subcellular Location:
Cell membrane
Single-pass type III membrane protein
Present in lipid rafts.
Protein Attributes:
50:
MEADALSPVG | LGLLLLPFLV | TLLAALCVRC | RELPVSYDST | STESLYPRSI |
100:
LIKPPQITVP | RTPAVSYPLV | TSFPPLRQPD | LLPIPRSPQP | LGGSHRMPSS |
150:
QQNSDDANSV | ASYENQEPAC | KNVDADEDED | DYPNGYLVVL | PDSSPAAVPV |
200:
VSSAPVPSNP | DLGDSAFSVE | SCEDYVNVPE | SEESAEASLD | GSREYVNVSP |
242:
EQQPVTRAEL | ASVNSQEVED | EGEEEGVDGE | EAPDYENLQE | LN
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
ELISA Kit for Mouse Linker for activation of T-cells family member 1
ELISA Kit for Mouse Linker for activation of T-cells family member 1
ELISA Kit for Mouse Linker for activation of T-cells family member 1
CLIA Kit for Mouse Linker for activation of T-cells family member 1
CLIA Kit for Mouse Linker for activation of T-cells family member 1
CLIA Kit for Mouse Linker for activation of T-cells family member 1
Polyclonal Antibody for Mouse Linker for activation of T-cells family member 1
Polyclonal Antibody for Mouse Linker for activation of T-cells family member 1
Polyclonal Antibody for Mouse Linker for activation of T-cells family member 1
Monoclonal Antibody for Mouse Linker for activation of T-cells family member 1
Monoclonal Antibody for Mouse Linker for activation of T-cells family member 1
Monoclonal Antibody for Mouse Linker for activation of T-cells family member 1
Protein for Mouse Linker for activation of T-cells family member 1
Protein for Mouse Linker for activation of T-cells family member 1
Protein for Mouse Linker for activation of T-cells family member 1
R&D Technical Data
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Precision
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Recovery
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Linearity
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
tissue :
Thymus .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
FVB/N .
tissue :
Salivary gland .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN MAST CELLS;TISSUE SPECIFICITY
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH CLNK
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PALMITOYLATION
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW ON FUNCTION IN T-CELLS
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PALMITOYLATION AT CYS-27 AND CYS-30
8.
"Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling."
Wang D.
,
Zheng M.
,
Lei L.
,
Ji J.
,
Yao Y.
,
Qiu Y.
,
Ma L.
,
Lou J.
,
Ouyang C.
,
Zhang X.
,
He Y.
,
Chi J.
,
Wang L.
,
Kuang Y.
,
Wang J.
,
Cao X.
,
Lu L.
Nat. Immunol.13:560-568(2012)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH GRB2; PLCG1 AND THEMIS
tissue :
Thymocyte .