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Index > Protein center > LGALS1(Gene name) > Human
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  • LGALS1 (Gene name),
  • Galectin-1 (Protein name ),  LEG1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    LGALS1;
    Protein name:
    Galectin-1(Gal-1);
    Alternative:
    S-Lac lectin 1;14 kDa lectin;14 kDa laminin-binding protein(HLBP14);Galaptin;Beta-galactoside-binding lectin L-14-I;HPL;HBL;Lectin galactoside-binding soluble 1;Lactose-binding lectin 1;Putative MAPK-activating protein PM12;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer. Binds LGALS3BP. Interacts with CD2, CD3, CD4, CD7, CD43 and CD45. Interacts with laminin (via poly-N-acetyllactosamine).
    Function:
    May regulate apoptosis, cell proliferation and cell differentiation. Binds beta-galactoside and a wide array of complex carbohydrates. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase.
    Subcellular Location:
    Secreted extracellular space extracellular matrix
    Protein Attributes:
    Sequence length:
    135
    Sequence:
    50:
    MACGLVASNL | NLKPGECLRV | RGEVAPDAKS | FVLNLGKDSN | NLCLHFNPRF | 
    100:
    NAHGDANTIV | CNSKDGGAWG | TEQREAVFPF | QPGSVAEVCI | TFDQANLTVK | 
    135:
    LPDGYEFKFP | NRLNLEAINY | MAADGDFKIK | CVAFD
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    KEGG:
    MIM:
    Pfam:
    UniGene:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human Gal-1
    Cat.:
    E2165h
    Price:
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human Gal-1
    Cat.:
    E2165b
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human Gal-1
    Cat.:
    E2165m
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human Gal-1
    Cat.:
    E2165r
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human Gal-1
    Cat.:
    E2165p
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Gal-1
    Cat.:
    U2165p
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Gal-1
    Cat.:
    U2165h
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Gal-1
    Cat.:
    U2165m
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Gal-1
    Cat.:
    U2165b
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Gal-1
    Cat.:
    U2165r
    Price:
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human Gal-1
    Cat.:
    P2165Rb-r
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Gal-1
    Polyclonal Antibody for Human Gal-1
    Polyclonal Antibody for Human Gal-1
    Cat.:
    P2165Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Gal-1
    Cat.:
    P2165Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Gal-1
    Monoclonal Antibody for Human Gal-1
    Monoclonal Antibody for Human Gal-1
    Monoclonal Antibody for Human Gal-1
    Monoclonal Antibody for Human Gal-1
    Protein for Human Gal-1
    Protein for Human Gal-1
    Protein for Human Gal-1
    Protein for Human Gal-1
    Protein for Human Gal-1

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Cloning and nucleotide sequence of a full-length cDNA for human 14 kDa beta-galactoside-binding lectin."
      Hirabayashi J. , Ayaki K. , Soma G. , Kasai K.
      Biochim. Biophys. Acta1008:85-91(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Lung.
    2. 2.
      "Molecular cloning, characterization, and expression of a human 14-kDa lectin."
      Couraud P.-O. , Casentini-Borocz D. , Bringman T.S. , Griffith J. , McGrogan M. , Nedwin G.E.
      J. Biol. Chem.264:1310-1316(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Placenta.
      tissue: Promyelocytic leukemia.
    3. 3.
      "Evidence that the 14 kDa soluble beta-galactoside-binding lectin in man is encoded by a single gene."
      Abbott W.M. , Feizi T.
      Biochem. J.259:291-294(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Hepatoma.
    4. 4.
      "Emergence of hormonal and redox regulation of galectin-1 in placental mammals: implication in maternal-fetal immune tolerance."
      Than N.G. , Romero R. , Erez O. , Weckle A. , Tarca A.L. , Hotra J. , Abbas A. , Han Y.M. , Kim S.S. , Kusanovic J.P. , Gotsch F. , Hou Z. , Santolaya-Forgas J. , Benirschke K. , Papp Z. , Grossman L.I. , Goodman M. , Wildman D.E.
      Proc. Natl. Acad. Sci. U.S.A.105:15819-15824(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY
      tissue: Placenta.
    5. 5.
      "Genomic sequence and organization of two members of a human lectin gene family."
      Gitt M.A. , Barondes S.H.
      Biochemistry30:82-89(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
      tissue: Lymphocyte.
    6. 6.
      "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways."
      Matsuda A. , Suzuki Y. , Honda G. , Muramatsu S. , Matsuzaki O. , Nagano Y. , Doi T. , Shimotohno K. , Harada T. , Nishida E. , Hayashi H. , Sugano S.
      Oncogene22:3307-3318(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Lung fibroblast.
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    8. 8.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Thalamus.
    9. 9.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2003-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    10. 10.
      "The DNA sequence of human chromosome 22."
      Dunham I. , Hunt A.R. , Collins J.E. , Bruskiewich R. , Beare D.M. , Clamp M. , Smink L.J. , Ainscough R. , Almeida J.P. , Babbage A.K. , Bagguley C. , Bailey J. , Barlow K.F. , Bates K.N. , Beasley O.P. , Bird C.P. , Blakey S.E. , Bridgeman A.M. , more...
      Nature402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    11. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    12. 12.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Placenta.
      tissue: Skin.
    13. 13.
      "Complete amino acid sequence of a beta-galactoside-binding lectin from human placenta."
      Hirabayashi J. , Kasai K.
      J. Biochem.104:1-4(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-135
      tissue: Placenta.
    14. 14.
      "Beta-galactosidase soluble lectin from human brain: complete amino acid sequence."
      Bladier D. , le Caer J.-P. , Joubert R. , Caron M. , Rossier J.
      Neurochem. Int.18:275-281(1991)
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-135
      tissue: Brain.
    15. 15.
      "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
      Gevaert K. , Goethals M. , Martens L. , Van Damme J. , Staes A. , Thomas G.R. , Vandekerckhove J.
      Nat. Biotechnol.21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-19
      tissue: Platelet.
    16. 16.
      Lubec G. , Vishwanath V. , Chen W.-Q. , Sun Y.
      Submitted (2008-12) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 38-49; 101-108 AND 113-128;IDENTIFICATION BY MASS SPECTROMETRY
      tissue: Brain.
      tissue: Cajal-Retzius cell.
      tissue: Fetal brain cortex.
    17. 17.
      "Further characterization and structural studies on human placenta lectin."
      Hirabayashi J. , Kawasaki H. , Suzuki K. , Kasai K.
      J. Biochem.101:987-995(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 70-87 AND 122-133
      tissue: Placenta.
    18. 18.
      "Identification of a 14-kDa laminin binding protein (HLBP14) in human melanoma cells that is identical to the 14-kDa galactoside binding lectin."
      Castronovo V. , Luyten F. , van den Brule F. , Sobel M.E.
      Arch. Biochem. Biophys.297:132-138(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 20-29; 50-74 AND 132-135;INTERACTION WITH LAMININ
      tissue: Melanoma.
    19. 19.
      "Human splenic galaptin: physicochemical characterization."
      Sharma A. , Chemelli R. , Allen H.J.
      Biochemistry29:5309-5314(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL PROTEIN SEQUENCE
      tissue: Spleen.
    20. 20.
      "Apoptosis of T cells mediated by galectin-1."
      Perillo N.L. , Pace K.E. , Seilhamer J.J. , Baum L.G.
      Nature378:736-739(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION
    21. 21.
      "Galectin-1, a natural ligand for the receptor-type protein tyrosine phosphatase CD45."
      Walzel H. , Schulz U. , Neels P. , Brock J.
      Immunol. Lett.67:193-202(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION
      tissue: Placenta.
    22. 22.
      "Regulation of CD45-induced signaling by galectin-1 in Burkitt lymphoma B cells."
      Fouillit M. , Joubert-Caron R. , Poirier F. , Bourin P. , Monostori E. , Levi-Strauss M. , Raphael M. , Bladier D. , Caron M.
      Glycobiology10:413-419(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION
    23. 23.
      "Glycoprotein 90K/MAC-2BP interacts with galectin-1 and mediates galectin-1-induced cell aggregation."
      Tinari N. , Kuwabara I. , Huflejt M.E. , Shen P.F. , Iacobelli S. , Liu F.-T.
      Int. J. Cancer91:167-172(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LGALS3BP
    24. 24.
      "Presentation of galectin-1 by extracellular matrix triggers T cell death."
      He J. , Baum L.G.
      J. Biol. Chem.279:4705-4712(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;FUNCTION
    25. 25.
      "Abnormal proteins in primary breast cancer tissues from 25 Sudanese patients."
      Ahamed M.E. , Ahmed M.E. , Eltoum A.M. , Altahir G.O. , Ahmed K.M. , Harbi S.O. , Stansalas J. , Mohamed A.O.
      Eur. J. Inflamm.6:115-121(2008)
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY
      tissue: Mammary cancer.
    26. 26.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
    27. 27.
      "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
      Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-29;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    28. 28.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    29. 29.
      "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V. , Sumpton D. , Martinez A. , Lilla S. , Espagne C. , Meinnel T. , Giglione C.
      Mol. Cell. Proteomics11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
    30. 30.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    31. 31.
      "Multiple functions of sushi domain containing 2 (SUSD2) in breast tumorigenesis."
      Watson A.P. , Evans R.L. , Egland K.A.
      Mol. Cancer Res.11:74-85(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SUSD2
    32. 32.
      "Growth-regulatory human galectin-1: crystallographic characterisation of the structural changes induced by single-site mutations and their impact on the thermodynamics of ligand binding."
      Lopez-Lucendo M.F. , Solis D. , Andre S. , Hirabayashi J. , Kasai K. , Kaltner H. , Gabius H.-J. , Romero A.
      J. Mol. Biol.343:957-970(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) IN COMPLEX WITH CARBOHYDRATE;SUBUNIT
    33. 33.
      "Functional and structural bases of a cysteine-less mutant as a long-lasting substitute for galectin-1."
      Nishi N. , Abe A. , Iwaki J. , Yoshida H. , Itoh A. , Shoji H. , Kamitori S. , Hirabayashi J. , Nakamura T.
      Glycobiology18:1065-1073(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.86 ANGSTROMS) OF 2-135 IN COMPLEX WITH LACTOSE;INTERACTION WITH CD2; CD3; CD7; CD43 AND CD45;SUBUNIT;FUNCTION
    34. 34.
      "Critical role of the solvent environment in galectin-1 binding to the disaccharide lactose."
      Di Lella S. , Ma L. , Ricci J.C. , Rabinovich G.A. , Asher S.A. , Alvarez R.M.S.
      Biochemistry48:786-791(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.65 ANGSTROMS)
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