SPN ELISA Kit for Human(Homo sapiens) | EIAab.comSPN ELISA Kit for Human(Homo sapiens)

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Index > Protein center > SPN(Gene name) > Human

SPN (Gene name),

Leukosialin (Protein name ), LEUK_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

SPN(CD43);

Protein name:

Leukosialin;

Alternative:

Leukocyte sialoglycoprotein;Galactoglycoprotein(GALGP);Sialophorin;

CD:

CD43;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with HIPK2 via the cytoplasmic domain. Interacts with RDX.

Function:

One of the major glycoproteins of thymocytes and T lymphocytes. Plays a role in the physicochemical properties of the T-cell surface and in lectin binding. Presents carbohydrate ligands to selectins. Has an extended rodlike structure that could protrude above the glycocalyx of the cell and allow multiple glycan chains to be accessible for binding. Is a counter receptor for SN/Siglec-1 (By similarity). During T-cell activation is actively removed from the T-cell-APC (antigen-presenting cell) contact site thus suggesting a negative regulatory role in adaptive immune response.

Subcellular Location:

Membrane Single-pass type I membrane protein

Protein Attributes:

Sequence length:

400

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

MIM:

182160

STRING:

9606.ENSP00000353238

String:

P16150

UniGene:

Hs.632188

KEGG:

hsa:6693

KEGG:

hsa:101929889

Uniprot:

P16150

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ELISA Kit for Human Leukosialin

Cat.:

E1778m

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Packing:

96T

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ELISA Kit for Human Leukosialin

Cat.:

E1778h

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96T

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ELISA Kit for Human Leukosialin

Cat.:

E1778r

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MSDS:

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Packing:

96T

CLIA Kit for Human Leukosialin

Cat.:

U1778r

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Packing:

96T

CLIA Kit for Human Leukosialin

Cat.:

U1778h

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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CLIA Kit for Human Leukosialin

Cat.:

U1778m

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96T

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Polyclonal Antibody for Human Leukosialin

Cat.:

P1778Rb-h

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Leukosialin

Cat.:

P1778Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Leukosialin

Cat.:

P1778Rb-m

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Leukosialin

Protein for Human Leukosialin

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"Characterization of cDNAs encoding human leukosialin and localization of the leukosialin gene to chromosome 16."
Pallant A. , Eskenazi A. , Mattei M.-G. , Fournier R.E.K. , Carlsson S.R. , Fukuda M. , Frelinger J.G.
Proc. Natl. Acad. Sci. U.S.A.86:1328-1332(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

"Molecular characterization of sialophorin (CD43), the lymphocyte surface sialoglycoprotein defective in Wiskott-Aldrich syndrome."
Shelley C.S. , Remold-O'Donnell E. , Davis A.E. III , Bruns G.A.P. , Rosen F.S. , Carroll M.C. , Whitehead D.A.S.
Proc. Natl. Acad. Sci. U.S.A.86:2819-2823(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
3.

"Structure of the human sialophorin (CD43) gene. Identification of features atypical of genes encoding integral membrane proteins."
Shelley C.S. , Remold-O'Donnell E. , Rosen F.S. , Whitehead D.A.S.
Biochem. J.270:569-576(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
4.

"A short, novel promoter sequence confers the expression of human leukosialin, a major sialoglycoprotein on leukocytes."
Kudo S. , Fukuda M.
J. Biol. Chem.266:8483-8489(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
5.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Spleen.
tissue: Thymus.
6.

Mural R.J. , Istrail S. , Sutton G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Kidney.
8.

"Amino acid sequence of human plasma galactoglycoprotein: identity with the extracellular region of CD43 (sialophorin)."
Schmid K. , Hediger M.A. , Brossmer R. , Collins J.H. , Haupt H. , Marti T. , Offner G.D. , Schaller J. , Takagaki K. , Walsh M.T. , Schwick H.G. , Rose F.S. , Remold-O'Donnell E.
Proc. Natl. Acad. Sci. U.S.A.89:663-667(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 20-245;GLYCOSYLATION AT THR-21; THR-22; THR-26; THR-28; SER-29; SER-35; THR-36; SER-37; SER-41; SER-42; THR-46; THR-47; SER-48; THR-50; THR-58; THR-69; SER-99; SER-103; THR-109; THR-113; SER-114; THR-136; THR-137; THR-173; THR-178 AND ASN-239
9.

"Phosphorylation of the major leukocyte surface sialoglycoprotein, leukosialin, is increased by phorbol 12-myristate 13-acetate."
Piller V. , Piller F. , Fukuda M.
J. Biol. Chem.264:18824-18831(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-291 AND SER-351
10.

"Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment."
Carrascal M. , Ovelleiro D. , Casas V. , Gay M. , Abian J.
J. Proteome Res.7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: T-cell.
11.

"Phosphoproteome of resting human platelets."
Zahedi R.P. , Lewandrowski U. , Wiesner J. , Wortelkamp S. , Moebius J. , Schuetz C. , Walter U. , Gambaryan S. , Sickmann A.
J. Proteome Res.7:526-534(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-355;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Platelet.
12.

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-368;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
13.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]

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