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Index > Protein center > GLO1(Gene name) > Human
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  • GLO1 (Gene name),
  • Lactoylglutathione lyase (Protein name ),  LGUL_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Gene name:
    GLO1;
    Protein name:
    Lactoylglutathione lyase;
    Alternative:
    Glyoxalase I(Glx I);Aldoketomutase;Methylglyoxalase;Ketone-aldehyde mutase;S-D-lactoylglutathione methylglyoxal lyase;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer.
    Function:
    Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B.
    Subcellular Location:
    N/A
    Protein Attributes:
    Sequence length:
    184
    Sequence:
    50:
    MAEPQPPSGG | LTDEAALSCC | SDADPSTKDF | LLQQTMLRVK | DPKKSLDFYT | 
    100:
    RVLGMTLIQK | CDFPIMKFSL | YFLAYEDKND | IPKEKDEKIA | WALSRKATLE | 
    150:
    LTHNWGTEDD | ETQSYHNGNS | DPRGFGHIGI | AVPDVYSACK | RFEELGVKFV | 
    184:
    KKPDDGKMKG | LAFIQDPDGY | WIEILNPNKM | ATLM
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    MIM:
    KEGG:
    UniGene:
    SMR:
    String:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Lactoylglutathione lyase
    MSDS:
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    ELISA Kit for Human Lactoylglutathione lyase
    Cat.:
    E15003h
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human Lactoylglutathione lyase
    MSDS:
    Please sign in first.
    CLIA Kit for Human Lactoylglutathione lyase
    MSDS:
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    CLIA Kit for Human Lactoylglutathione lyase
    MSDS:
    Please sign in first.
    CLIA Kit for Human Lactoylglutathione lyase
    Cat.:
    U15003h
    Price:
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human Lactoylglutathione lyase
    Polyclonal Antibody for Human Lactoylglutathione lyase
    Polyclonal Antibody for Human Lactoylglutathione lyase
    Monoclonal Antibody for Human Lactoylglutathione lyase
    Monoclonal Antibody for Human Lactoylglutathione lyase
    Monoclonal Antibody for Human Lactoylglutathione lyase
    Protein for Human Lactoylglutathione lyase
    Protein for Human Lactoylglutathione lyase
    Protein for Human Lactoylglutathione lyase

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Human glyoxalase I. cDNA cloning, expression, and sequence similarity to glyoxalase I from Pseudomonas putida."
      Kim N.-S. , Umezawa Y. , Ohmura S. , Kato S.
      J. Biol. Chem.268:11217-11221(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT ALA-111
    2. 2.
      "Cloning and characterization of human colon glyoxalase-I."
      Ranganathan S. , Walsh E.S. , Godwin A.K. , Tew K.D.
      J. Biol. Chem.268:5661-5667(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT ALA-111
      tissue: Colon.
    3. 3.
      "Optimized heterologous expression of the human zinc enzyme glyoxalase I."
      Ridderstroem M. , Mannervik B.
      Biochem. J.314:463-467(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    4. 4.
      "Genomic sequence of human glyoxalase-I: analysis of promoter activity and its regulation."
      Ranganathan S. , Ciaccio P.J. , Walsh E.S. , Tew K.D.
      Gene240:149-155(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT ALA-111
    5. 5.
      Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S. , Ohara O. , Nagase T. , Kikuno R.F.
      Submitted (2005-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Brain.
    6. 6.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2);VARIANTS TYR-19 AND ALA-111
    7. 7.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2004-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    8. 8.
      "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
      Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    9. 9.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANTS TYR-19 AND ALA-111
      tissue: Brain.
      tissue: Eye.
      tissue: Uterus.
    10. 10.
      "Posttranslational modification of human glyoxalase 1 indicates redox-dependent regulation."
      Birkenmeier G. , Stegemann C. , Hoffmann R. , Gunther R. , Huse K. , Birkemeyer C.
      PLoS ONE5:E10399-E10399(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 13-18 AND 128-135;ENZYME REGULATION;BIOPHYSICOCHEMICAL PROPERTIES;MASS SPECTROMETRY;CLEAVAGE OF INITIATOR METHIONINE;ACETYLATION AT ALA-2;GLUTATHIONYLATION AT CYS-139;DISULFIDE BONDS
      tissue: Erythrocyte.
    11. 11.
      "Tumour necrosis factor induces phosphorylation primarily of the nitric-oxide-responsive form of glyoxalase I."
      de Hemptinne V. , Rondas D. , Vandekerckhove J. , Vancompernolle K.
      Biochem. J.407:121-128(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION OF NITRIC OXIDE-MODIFIED FORM;PHOSPHORYLATION;MUTAGENESIS OF CYS-19; CYS-20; CYS-61 AND CYS-139
    12. 12.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    13. 13.
      "Phosphorylation on Thr-106 and NO-modification of glyoxalase I suppress the TNF-induced transcriptional activity of NF-kappaB."
      de Hemptinne V. , Rondas D. , Toepoel M. , Vancompernolle K.
      Mol. Cell. Biochem.325:169-178(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION AT THR-107;MUTAGENESIS OF CYS-19; CYS-20; SER-45; SER-69; SER-94; THR-98; THR-102; THR-107 AND CYS-139
    14. 14.
      "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
      Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-148;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    15. 15.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    16. 16.
      "Crystal structure of human glyoxalase I -- evidence for gene duplication and 3D domain swapping."
      Cameron A.D. , Olin B. , Ridderstroem M. , Mannervik B. , Jones T.A.
      EMBO J.16:3386-3395(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) IN COMPLEX WITH S-BENZYL-GLUTATHIONE AND ZINC
    17. 17.
      "Involvement of an active-site Zn2+ ligand in the catalytic mechanism of human glyoxalase I."
      Ridderstroem M. , Cameron A.D. , Jones T.A. , Mannervik B.
      J. Biol. Chem.273:21623-21628(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) IN COMPLEX WITH ZINC AND S-HEXYLGLUTATHIONE;CATALYTIC ACTIVITY;FUNCTION;COFACTOR;ACTIVE SITE;SUBUNIT;MUTAGENESIS OF GLN-34; GLU-100 AND GLU-173
    18. 18.
      "Reaction mechanism of glyoxalase I explored by an X-ray crystallographic analysis of the human enzyme in complex with a transition state analogue."
      Cameron A.D. , Ridderstroem M. , Olin B. , Kavarana M.J. , Creighton D.J. , Mannervik B.
      Biochemistry38:13480-13490(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.72 ANGSTROMS) IN COMPLEXES WITH S-(N-HYDROXY-N-IODOPHENYLCARBAMOYL)GLUTATHIONE; S-P-NITROBENZYLOXYCARBONYLGLUTATHIONE AND ZINC;ACTIVE SITE
    19. 19.
      "Design and evaluation of azaindole-substituted N-hydroxypyridones as glyoxalase I inhibitors."
      Chiba T. , Ohwada J. , Sakamoto H. , Kobayashi T. , Fukami T.A. , Irie M. , Miura T. , Ohara K. , Koyano H.
      Bioorg. Med. Chem. Lett.22:7486-7489(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.47 ANGSTROMS) IN COMPLEX WITH SYNTHETIC INHIBITOR AND ZINC;FUNCTION;CATALYTIC ACTIVITY;SUBUNIT;COFACTOR
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