GLO1 ELISA Kit for Human(Homo sapiens) | EIAab.comGLO1 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > GLO1(Gene name) > Human

GLO1 (Gene name),

Lactoylglutathione lyase (Protein name ), LGUL_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

GLO1;

Protein name:

Lactoylglutathione lyase;

Alternative:

Glyoxalase I(Glx I);Aldoketomutase;Methylglyoxalase;Ketone-aldehyde mutase;S-D-lactoylglutathione methylglyoxal lyase;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer.

Function:

Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B.

Subcellular Location:

N/A

Protein Attributes:

Sequence length:

184

Sequence:

50:

100:

150:

184:

KKPDDGKMKG | LAFIQDPDGY | WIEILNPNKM | ATLM

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

MIM:

138750

KEGG:

hsa:2739

UniGene:

Hs.268849

SMR:

Q04760

String:

Q04760

STRING:

9606.ENSP00000362463

Pfam:

PF00903

Uniprot:

Q04760

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ELISA Kit for Human Lactoylglutathione lyase

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ELISA Kit for Human Lactoylglutathione lyase

Cat.:

E15003h

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Manual:

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Packing:

96T

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ELISA Kit for Human Lactoylglutathione lyase

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CLIA Kit for Human Lactoylglutathione lyase

MSDS:

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CLIA Kit for Human Lactoylglutathione lyase

MSDS:

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CLIA Kit for Human Lactoylglutathione lyase

Cat.:

U15003h

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human Lactoylglutathione lyase

Monoclonal Antibody for Human Lactoylglutathione lyase

Protein for Human Lactoylglutathione lyase

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Human glyoxalase I. cDNA cloning, expression, and sequence similarity to glyoxalase I from Pseudomonas putida."
Kim N.-S. , Umezawa Y. , Ohmura S. , Kato S.
J. Biol. Chem.268:11217-11221(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT ALA-111
2.

"Cloning and characterization of human colon glyoxalase-I."
Ranganathan S. , Walsh E.S. , Godwin A.K. , Tew K.D.
J. Biol. Chem.268:5661-5667(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT ALA-111
tissue: Colon.
3.

"Optimized heterologous expression of the human zinc enzyme glyoxalase I."
Ridderstroem M. , Mannervik B.
Biochem. J.314:463-467(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
4.

"Genomic sequence of human glyoxalase-I: analysis of promoter activity and its regulation."
Ranganathan S. , Ciaccio P.J. , Walsh E.S. , Tew K.D.
Gene240:149-155(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT ALA-111
5.

Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S. , Ohara O. , Nagase T. , Kikuno R.F.
Submitted (2005-03) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Brain.
6.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2);VARIANTS TYR-19 AND ALA-111
7.

"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
Submitted (2004-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
8.

"The DNA sequence and analysis of human chromosome 6."
Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
9.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANTS TYR-19 AND ALA-111
tissue: Brain.
tissue: Eye.
tissue: Uterus.
10.

"Posttranslational modification of human glyoxalase 1 indicates redox-dependent regulation."
Birkenmeier G. , Stegemann C. , Hoffmann R. , Gunther R. , Huse K. , Birkemeyer C.
PLoS ONE5:E10399-E10399(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 13-18 AND 128-135;ENZYME REGULATION;BIOPHYSICOCHEMICAL PROPERTIES;MASS SPECTROMETRY;CLEAVAGE OF INITIATOR METHIONINE;ACETYLATION AT ALA-2;GLUTATHIONYLATION AT CYS-139;DISULFIDE BONDS
tissue: Erythrocyte.
11.

"Tumour necrosis factor induces phosphorylation primarily of the nitric-oxide-responsive form of glyoxalase I."
de Hemptinne V. , Rondas D. , Vandekerckhove J. , Vancompernolle K.
Biochem. J.407:121-128(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION OF NITRIC OXIDE-MODIFIED FORM;PHOSPHORYLATION;MUTAGENESIS OF CYS-19; CYS-20; CYS-61 AND CYS-139
12.

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
13.

"Phosphorylation on Thr-106 and NO-modification of glyoxalase I suppress the TNF-induced transcriptional activity of NF-kappaB."
de Hemptinne V. , Rondas D. , Toepoel M. , Vancompernolle K.
Mol. Cell. Biochem.325:169-178(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION AT THR-107;MUTAGENESIS OF CYS-19; CYS-20; SER-45; SER-69; SER-94; THR-98; THR-102; THR-107 AND CYS-139
14.

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-148;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
15.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
16.

"Crystal structure of human glyoxalase I -- evidence for gene duplication and 3D domain swapping."
Cameron A.D. , Olin B. , Ridderstroem M. , Mannervik B. , Jones T.A.
EMBO J.16:3386-3395(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) IN COMPLEX WITH S-BENZYL-GLUTATHIONE AND ZINC
17.

"Involvement of an active-site Zn2+ ligand in the catalytic mechanism of human glyoxalase I."
Ridderstroem M. , Cameron A.D. , Jones T.A. , Mannervik B.
J. Biol. Chem.273:21623-21628(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) IN COMPLEX WITH ZINC AND S-HEXYLGLUTATHIONE;CATALYTIC ACTIVITY;FUNCTION;COFACTOR;ACTIVE SITE;SUBUNIT;MUTAGENESIS OF GLN-34; GLU-100 AND GLU-173
18.

"Reaction mechanism of glyoxalase I explored by an X-ray crystallographic analysis of the human enzyme in complex with a transition state analogue."
Cameron A.D. , Ridderstroem M. , Olin B. , Kavarana M.J. , Creighton D.J. , Mannervik B.
Biochemistry38:13480-13490(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.72 ANGSTROMS) IN COMPLEXES WITH S-(N-HYDROXY-N-IODOPHENYLCARBAMOYL)GLUTATHIONE; S-P-NITROBENZYLOXYCARBONYLGLUTATHIONE AND ZINC;ACTIVE SITE
19.

"Design and evaluation of azaindole-substituted N-hydroxypyridones as glyoxalase I inhibitors."
Chiba T. , Ohwada J. , Sakamoto H. , Kobayashi T. , Fukami T.A. , Irie M. , Miura T. , Ohara K. , Koyano H.
Bioorg. Med. Chem. Lett.22:7486-7489(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.47 ANGSTROMS) IN COMPLEX WITH SYNTHETIC INHIBITOR AND ZINC;FUNCTION;CATALYTIC ACTIVITY;SUBUNIT;COFACTOR

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