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Index > Protein center > LIPC(Gene name) > Human
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  • LIPC (Gene name),
  • Hepatic triacylglycerol lipase (Protein name ),  LIPC_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Citations  (1)
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  • Gene name:
    LIPC(HTGL);
    Protein name:
    Hepatic triacylglycerol lipase(HL;Hepatic lipase);
    Alternative:
    Lipase member C;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-CoA thioesters. It is an important enzyme in HDL metabolism. Hepatic lipase binds heparin.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    499
    Sequence:
    50:
    MDTSPLCFSI | LLVLCIFIQS | SALGQSLKPE | PFGRRAQAVE | TNKTLHEMKT | 
    100:
    RFLLFGETNQ | GCQIRINHPD | TLQECGFNSS | LPLVMIIHGW | SVDGVLENWI | 
    150:
    WQMVAALKSQ | PAQPVNVGLV | DWITLAHDHY | TIAVRNTRLV | GKEVAALLRW | 
    200:
    LEESVQLSRS | HVHLIGYSLG | AHVSGFAGSS | IGGTHKIGRI | TGLDAAGPLF | 
    250:
    EGSAPSNRLS | PDDANFVDAI | HTFTREHMGL | SVGIKQPIGH | YDFYPNGGSF | 
    300:
    QPGCHFLELY | RHIAQHGFNA | ITQTIKCSHE | RSVHLFIDSL | LHAGTQSMAY | 
    350:
    PCGDMNSFSQ | GLCLSCKKGR | CNTLGYHVRQ | EPRSKSKRLF | LVTRAQSPFK | 
    400:
    VYHYQFKIQF | INQTETPIQT | TFTMSLLGTK | EKMQKIPITL | GKGIASNKTY | 
    450:
    SFLITLDVDI | GELIMIKFKW | ENSAVWANVW | DTVQTIIPWS | TGPRHSGLVL | 
    499:
    KTIRVKAGET | QQRMTFCSEN | TDDLLLRPTQ | EKIFVKCEIK | SKTSKRKIR
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    SMR:
    KEGG:
    String:
    MIM:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human HL
    Cat.:
    E0769h
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    Packing:
    96T
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    ELISA Kit for Human HL
    Cat.:
    E0769r
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human HL
    Cat.:
    E0769b
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    MSDS:
    Please sign in first.
    Packing:
    96T
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    ELISA Kit for Human HL
    Cat.:
    E0769m
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    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human HL
    MSDS:
    Please sign in first.
    CLIA Kit for Human HL
    MSDS:
    Please sign in first.
    CLIA Kit for Human HL
    Cat.:
    U0769b
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human HL
    Cat.:
    U0769r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human HL
    Cat.:
    U0769m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human HL
    Cat.:
    U0769h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human HL
    Cat.:
    P0769Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human HL
    Polyclonal Antibody for Human HL
    Cat.:
    P0769Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human HL
    Polyclonal Antibody for Human HL
    Cat.:
    P0769Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human HL
    Monoclonal Antibody for Human HL
    Monoclonal Antibody for Human HL
    Monoclonal Antibody for Human HL
    Monoclonal Antibody for Human HL
    Protein for Human HL
    Protein for Human HL
    Cat.:
    R0769h
    Price:
    Please sign in first.
    Packing:
    1mg
    Purity:
    >90%
    Protein for Human HL
    Protein for Human HL
    Protein for Human HL

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    References
    1. 1.
      "Human hepatic triglyceride lipase: cDNA cloning, amino acid sequence and expression in a cultured cell line."
      Stahnke G. , Sprengel R. , Augustin J. , Will H.
      Differentiation35:45-52(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANTS SER-215 AND LEU-356
      tissue: Liver.
    2. 2.
      "Human hepatic lipase. Cloned cDNA sequence, restriction fragment length polymorphisms, chromosomal localization, and evolutionary relationships with lipoprotein lipase and pancreatic lipase."
      Datta S. , Luo C.C. , Li W.H. , VanTuinen P. , Ledbetter D.H. , Brown M.A. , Chen S.H. , Liu S. , Chan L.
      J. Biol. Chem.263:1107-1110(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANTS SER-215 AND LEU-356
      tissue: Liver.
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PARTIAL PROTEIN SEQUENCE;VARIANT LEU-356
      tissue: Liver.
    4. 4.
      "Structure of the human hepatic triglyceride lipase gene."
      Cai S.J. , Wong D.M. , Chen S.H. , Chan L.
      Biochemistry28:8966-8971(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT LEU-356
    5. 5.
      "Isolation and characterization of the human hepatic lipase gene."
      Ameis D. , Stahnke G. , Kobayashi J. , McLean J. , Lee G. , Buscher M. , Schotz M.C. , Will H.
      J. Biol. Chem.265:6552-6555(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS SER-215 AND LEU-356
    6. 6.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANTS SER-215 AND LEU-356
      tissue: Kidney.
      tissue: Thymus.
    7. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT LEU-356
    8. 9.
      "18 bp insertion/duplication with internal missense mutation in human hepatic lipase gene exon 3."
      Tiebel O. , Gehrisch S. , Pietzsch J. , Gromeier S. , Jaross W.
      Hum. Mutat.12:216-216(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 92-152;VARIANT HL DEFICIENCY HIS-TYR-THR-VAL-ALA-VAL-134 INS
    9. 10.
      "Identification of a BstNI polymorphism in exon 9 of the human hepatic triglyceride lipase gene."
      Takagi A. , Ikeda Y. , Mori A. , Ashida Y. , Yamamoto A.
      Mol. Cell. Probes10:313-314(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 464-499
    10. 11.
      "The G-250A promoter polymorphism of the hepatic lipase gene predicts the conversion from impaired glucose tolerance to type 2 diabetes mellitus: the Finnish diabetes prevention study."
      Todorova B. , Kubaszek A. , Pihlajamaki J. , Lindstrom J. , Eriksson J. , Valle T.T. , Hamalainen H. , Ilanne-Parikka P. , Keinanen-Kiukaanniemi S. , Tuomilehto J. , Uusitupa M. , Laakso M.
      J. Clin. Endocrinol. Metab.89:2019-2023(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ASSOCIATION WITH NIDDM SUSCEPTIBILITY
    11. 12.
      "The -250G>A promoter variant in hepatic lipase associates with elevated fasting serum high-density lipoprotein cholesterol modulated by interaction with physical activity in a study of 16,156 Danish subjects."
      Grarup N. , Andreasen C.H. , Andersen M.K. , Albrechtsen A. , Sandbaek A. , Lauritzen T. , Borch-Johnsen K. , Jorgensen T. , Schmitz O. , Hansen T. , Pedersen O.
      J. Clin. Endocrinol. Metab.93:2294-2299(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN HDLCQ12
    12. 13.
      "Human hepatic lipase mutations and polymorphisms."
      Hegele R.A. , Tu L. , Connelly P.W.
      Hum. Mutat.1:320-324(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HL DEFICIENCY PHE-289 AND MET-405
    13. 14.
      "Genetic variants affecting human lipoprotein and hepatic lipases."
      Hayden M.R. , Ma Y. , Brunzell J. , Henderson H.E.
      Curr. Opin. Lipidol.2:104-109(1991)
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON POLYMORPHISM
    14. 15.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MET-95; SER-215 AND ASN-440
    15. 16.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
    16. 17.
      "Association of extreme blood lipid profile phenotypic variation with 11 reverse cholesterol transport genes and 10 non-genetic cardiovascular disease risk factors."
      Morabia A. , Cayanis E. , Costanza M.C. , Ross B.M. , Flaherty M.S. , Alvin G.B. , Das K. , Gilliam T.C.
      Hum. Mol. Genet.12:2733-2743(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MET-95; SER-215; PHE-289; ILE-342; LEU-356; MET-405 AND ALA-409
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