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Index > Protein center > Lpl(Gene name) > Mouse
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  • Lpl (Gene name),
  • Lipoprotein lipase (Protein name ),  LIPL_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Lpl;
    Protein name:
    Lipoprotein lipase(LPL);
    Alternative:

    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Homodimer (By similarity). Interacts with APOC2; the interaction activates LPL activity in the presence of lipids (By similarity). Interacts with GPIHBP1.
    Function:
    The primary function of this lipase is the hydrolysis of triglycerides of circulating chylomicrons and very low density lipoproteins (VLDL). Binding to heparin sulfate proteogylcans at the cell surface is vital to the function. The apolipoprotein, APOC2, acts as a coactivator of LPL activity in the presence of lipids on the luminal surface of vascular endothelium.
    Subcellular Location:
    Cell membrane Lipid-anchor GPI-anchor Secreted Locates to the plasma membrane of microvilli of hepatocytes with triacyl-glycerol-rich lipoproteins (TRL). Some of the bound LPL is then internalized and located inside non-coated endocytic vesicles.
    Protein Attributes:
    Sequence length:
    474
    Sequence:
    50:
    MESKALLLVV | LGVWLQSLTA | FRGGVAAADA | GRDFSDIESK | FALRTPEDTA | 
    100:
    EDTCHLIPGL | ADSVSNCHFN | HSSKTFVVIH | GWTVTGMYES | WVPKLVAALY | 
    150:
    KREPDSNVIV | VDWLYRAQQH | YPVSAGYTKL | VGNDVARFIN | WMEEEFNYPL | 
    200:
    DNVHLLGYSL | GAHAAGVAGS | LTNKKVNRIT | GLDPAGPNFE | YAEAPSRLSP | 
    250:
    DDADFVDVLH | TFTRGSPGRS | IGIQKPVGHV | DIYPNGGTFQ | PGCNIGEAIR | 
    300:
    VIAERGLGDV | DQLVKCSHER | SIHLFIDSLL | NEENPSKAYR | CNSKEAFEKG | 
    350:
    LCLSCRKNRC | NNLGYEINKV | RAKRSSKMYL | KTRSQMPYKV | FHYQVKIHFS | 
    400:
    GTEDGKQHNQ | AFEISLYGTV | AESENIPFTL | PEVSTNKTYS | FLIYTEVDIG | 
    450:
    ELLMMKLKWI | SDSYFSWPDW | WSSPSFVIER | IRVKAGETQK | KVIFCAREKV | 
    474:
    SHLQKGKDSA | VFVKCHDKSL | KKSG
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    KEGG:
    UniGene:
    SMR:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse LPL
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    ELISA Kit for Mouse LPL
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    ELISA Kit for Mouse LPL
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    ELISA Kit for Mouse LPL
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    ELISA Kit for Mouse LPL
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    ELISA Kit for Mouse LPL
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    E0386c
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    96T
    CLIA Kit for Mouse LPL
    Cat.:
    U0386m
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    96T
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    CLIA Kit for Mouse LPL
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    U0386p
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    Please sign in first.
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    Packing:
    96T
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    CLIA Kit for Mouse LPL
    Cat.:
    U0386r
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Mouse LPL
    Cat.:
    U0386b
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Mouse LPL
    Cat.:
    U0386h
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Mouse LPL
    Cat.:
    U0386c
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Mouse LPL
    Cat.:
    P0386Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse LPL
    Polyclonal Antibody for Mouse LPL
    Polyclonal Antibody for Mouse LPL
    Polyclonal Antibody for Mouse LPL
    Cat.:
    P0386Rb-r
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse LPL
    Cat.:
    P0386Rb-m
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse LPL
    Monoclonal Antibody for Mouse LPL
    Monoclonal Antibody for Mouse LPL
    Monoclonal Antibody for Mouse LPL
    Monoclonal Antibody for Mouse LPL
    Monoclonal Antibody for Mouse LPL
    Protein for Mouse LPL
    Protein for Mouse LPL
    Protein for Mouse LPL
    Protein for Mouse LPL
    Protein for Mouse LPL
    Protein for Mouse LPL

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    Linearity
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    References
    1. 1.
      "Lipoprotein lipase and hepatic lipase mRNA tissue specific expression, developmental regulation, and evolution."
      Semenkovich C.F. , Chen S.H. , Wims M. , Luo C.C. , Li W.H. , Chan L.
      J. Lipid Res.30:423-431(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
      tissue: Macrophage.
    2. 2.
      "The structure of the mouse lipoprotein lipase gene: a B1 repetitive element is inserted into the 3' untranslated region of the mRNA."
      Zechner R. , Newman T.C. , Steiner E. , Breslow J.L.
      Genomics11:62-76(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    3. 3.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      strain: NOD.
      tissue: Bone marrow.
      tissue: Embryo.
      tissue: Head.
      tissue: Heart.
      tissue: Kidney.
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    5. 5.
      "Adipogenesis in a myeloid supporting bone marrow stromal cell line."
      Gimble J.M. , Hua X. , Youkhana K. , Bass H.W. , Medina K. , Sullivan M. , Greenberger J.S. , Wang C.S.
      J. Cell. Biochem.50:73-82(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-183
    6. 6.
      "Cloning and characterization of the promoter of the murine lipoprotein lipase-encoding gene: structural and functional analysis."
      Hua X. , Enerbaeck S. , Hudson J. , Youkhana K. , Gimble J.M.
      Gene107:247-258(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-29
      strain: BALB/c.
      tissue: Liver.
    7. 7.
      "The sequence of cDNA encoding lipoprotein lipase. A member of a lipase gene family."
      Kirchgessner T.G. , Svenson K.L. , Lusis A.J. , Schotz M.C.
      J. Biol. Chem.262:8463-8466(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 9-474
    8. 8.
      "Glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 plays a critical role in the lipolytic processing of chylomicrons."
      Beigneux A.P. , Davies B.S.J. , Gin P. , Weinstein M.M. , Farber E. , Qiao X. , Peale F. , Bunting S. , Walzem R.L. , Wong J.S. , Blaner W.S. , Ding Z.-M. , Melford K. , Wongsiriroj N. , Shu X. , de Sauvage F. , Ryan R.O. , Fong L.G. , more...
      Cell Metab.5:279-291(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GPIHBP1
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