Protein name:
Hormone-sensitive lipase (HSL) ;
Alternative:
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with PTRF in the adipocyte cytoplasm.
Function:
In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production.
Subcellular Location:
Cell membrane
Membrane
caveola
Cytoplasm
cytosol
Found in the high-density caveolae. Translocates to the cytoplasm from the caveolae upon insulin stimulation.
Protein Attributes:
50:
MEPGSKSVSR | SDWQPEPHQR | PITPLEPGPE | KTPIAQPESK | TLQGSNTQQK |
100:
PASNQRPLTQ | QETPAQHDAE | SQKEPRAQQK | SASQEEFLAP | QKPAPQQSPY |
150:
IQRVLLTQQE | AASQQGPGLG | KESITQQEPA | LRQRHVAQPG | PGPGEPPPAQ |
200:
QEAESTPAAQ | AKPGAKREPS | APTESTSQET | PEQSDKQTTP | VQGAKSKQGS |
250:
LTELGFLTKL | QELSIQRSAL | EWKALSEWVT | DSESESDVGS | SSDTDSPATM |
300:
GGMVAQGVKL | GFKGKSGYKV | MSGYSGTSPH | EKTSARNHRH | YQDTASRLIH |
350:
NMDLRTMTQS | LVTLAEDNIA | FFSSQGPGET | AQRLSGVFAG | VREQALGLEP |
400:
ALGRLLGVAH | LFDLDPETPA | NGYRSLVHTA | RCCLAHLLHK | SRYVASNRRS |
450:
IFFRTSHNLA | ELEAYLAALT | QLRALVYYAQ | RLLVTNRPGV | LFFEGDEGLT |
500:
ADFLREYVTL | HKGCFYGRCL | GFQFTPAIRP | FLQTISIGLV | SFGEHYKRNE |
550:
TGLSVAASSL | FTSGRFAIDP | ELRGAEFERI | TQNLDVHFWK | AFWNITEMEV |
600:
LSSLANMASA | TVRVSRLLSL | PPEAFEMPLT | ADPTLTVTIS | PPLAHTGPGP |
650:
VLVRLISYDL | REGQDSEELS | SLIKSNGQRS | LELWPRPQQA | PRSRSLIVHF |
700:
HGGGFVAQTS | RSHEPYLKSW | AQELGAPIIS | IDYSLAPEAP | FPRALEECFF |
750:
AYCWAIKHCA | LLGSTGERIC | LAGDSAGGNL | CFTVALRAAA | YGVRVPDGIM |
800:
AAYPATMLQP | AASPSRLLSL | MDPLLPLSVL | SKCVSAYAGA | KTEDHSNSDQ |
850:
KALGMMGLVR | RDTALLLRDF | RLGASSWLNS | FLELSGRKSQ | KMSEPIAEPM |
900:
RRSVSEAALA | QPQGPLGTDS | LKNLTLRDLS | LRGNSETSSD | TPEMSLSAET |
950:
LSPSTPSDVN | FLLPPEDAGE | EAEAKNELSP | MDRGLGVRAA | FPEGFHPRRS |
1000:
SQGATQMPLY | SSPIVKNPFM | SPLLAPDSML | KSLPPVHIVA | CALDPMLDDS |
1050:
VMLARRLRNL | GQPVTLRVVE | DLPHGFLTLA | ALCRETRQAA | ELCVERIRLV |
1076:
LTPPAGAGPS | GETGAAGVDG | GCGGRH
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Rat
Bovine
Human
Pig
Polyclonal Antibody for Human HSL
Polyclonal Antibody for Human HSL
Polyclonal Antibody for Human HSL
Polyclonal Antibody for Human HSL
Polyclonal Antibody for Human HSL
Monoclonal Antibody for Human HSL
Monoclonal Antibody for Human HSL
Monoclonal Antibody for Human HSL
Monoclonal Antibody for Human HSL
Monoclonal Antibody for Human HSL
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
2.
"Molecular cloning, genomic organization, and expression of a testicular isoform of hormone-sensitive lipase."
Holst L.S.
,
Langin D.
,
Mulder H.
,
Laurell H.
,
Grober J.
,
Bergh A.
,
Mohrenweiser H.W.
,
Edgren G.
,
Holm C.
Genomics35:441-447(1996)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue :
Testis .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS HIS-100; HIS-127; SER-146; THR-177; VAL-194; GLN-217; ASN-497; HIS-499 AND SER-938
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Testis .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH PTRF;SUBCELLULAR LOCATION
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Leukemic T-cell .
8.
"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T.
,
Jones S.
,
Wood L.D.
,
Parsons D.W.
,
Lin J.
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Barber T.D.
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Mandelker D.
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Leary R.J.
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Ptak J.
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Silliman N.
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Szabo S.
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Buckhaults P.
,
Farrell C.
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Meeh P.
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Markowitz S.D.
,
Willis J.
,
Dawson D.
,
Willson J.K.V.
,
Gazdar A.F.
,
Hartigan J.
,
Wu L.
,
Liu C.
,
Parmigiani G.
,
Park B.H.
,
Bachman K.E.
,
Papadopoulos N.
,
Vogelstein B.
,
Kinzler K.W.
,
Velculescu V.E.
more...
Science314:268-274(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT [LARGE SCALE ANALYSIS] GLN-146