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Index > Protein center > LIPE(Gene name) > Human
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  • LIPE (Gene name),
  • Hormone-sensitive lipase (Protein name ),  LIPS_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    LIPE;
    Protein name:
    Hormone-sensitive lipase(HSL);
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with PTRF in the adipocyte cytoplasm.
    Function:
    In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production.
    Subcellular Location:
    Cell membrane Membrane caveola Cytoplasm cytosol Found in the high-density caveolae. Translocates to the cytoplasm from the caveolae upon insulin stimulation.
    Protein Attributes:
    Sequence length:
    1076
    Sequence:
    50:
    MEPGSKSVSR | SDWQPEPHQR | PITPLEPGPE | KTPIAQPESK | TLQGSNTQQK | 
    100:
    PASNQRPLTQ | QETPAQHDAE | SQKEPRAQQK | SASQEEFLAP | QKPAPQQSPY | 
    150:
    IQRVLLTQQE | AASQQGPGLG | KESITQQEPA | LRQRHVAQPG | PGPGEPPPAQ | 
    200:
    QEAESTPAAQ | AKPGAKREPS | APTESTSQET | PEQSDKQTTP | VQGAKSKQGS | 
    250:
    LTELGFLTKL | QELSIQRSAL | EWKALSEWVT | DSESESDVGS | SSDTDSPATM | 
    300:
    GGMVAQGVKL | GFKGKSGYKV | MSGYSGTSPH | EKTSARNHRH | YQDTASRLIH | 
    350:
    NMDLRTMTQS | LVTLAEDNIA | FFSSQGPGET | AQRLSGVFAG | VREQALGLEP | 
    400:
    ALGRLLGVAH | LFDLDPETPA | NGYRSLVHTA | RCCLAHLLHK | SRYVASNRRS | 
    450:
    IFFRTSHNLA | ELEAYLAALT | QLRALVYYAQ | RLLVTNRPGV | LFFEGDEGLT | 
    500:
    ADFLREYVTL | HKGCFYGRCL | GFQFTPAIRP | FLQTISIGLV | SFGEHYKRNE | 
    550:
    TGLSVAASSL | FTSGRFAIDP | ELRGAEFERI | TQNLDVHFWK | AFWNITEMEV | 
    600:
    LSSLANMASA | TVRVSRLLSL | PPEAFEMPLT | ADPTLTVTIS | PPLAHTGPGP | 
    650:
    VLVRLISYDL | REGQDSEELS | SLIKSNGQRS | LELWPRPQQA | PRSRSLIVHF | 
    700:
    HGGGFVAQTS | RSHEPYLKSW | AQELGAPIIS | IDYSLAPEAP | FPRALEECFF | 
    750:
    AYCWAIKHCA | LLGSTGERIC | LAGDSAGGNL | CFTVALRAAA | YGVRVPDGIM | 
    800:
    AAYPATMLQP | AASPSRLLSL | MDPLLPLSVL | SKCVSAYAGA | KTEDHSNSDQ | 
    850:
    KALGMMGLVR | RDTALLLRDF | RLGASSWLNS | FLELSGRKSQ | KMSEPIAEPM | 
    900:
    RRSVSEAALA | QPQGPLGTDS | LKNLTLRDLS | LRGNSETSSD | TPEMSLSAET | 
    950:
    LSPSTPSDVN | FLLPPEDAGE | EAEAKNELSP | MDRGLGVRAA | FPEGFHPRRS | 
    1000:
    SQGATQMPLY | SSPIVKNPFM | SPLLAPDSML | KSLPPVHIVA | CALDPMLDDS | 
    1050:
    VMLARRLRNL | GQPVTLRVVE | DLPHGFLTLA | ALCRETRQAA | ELCVERIRLV | 
    1076:
    LTPPAGAGPS | GETGAAGVDG | GCGGRH
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    SMR:
    String:
    MIM:
    Pfam:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human HSL
    Cat.:
    E1276m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human HSL
    Cat.:
    E1276r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human HSL
    Cat.:
    E1276b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human HSL
    Cat.:
    E1276h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human HSL
    Cat.:
    E1276p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human HSL
    Cat.:
    U1276p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human HSL
    Cat.:
    U1276r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human HSL
    Cat.:
    U1276h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human HSL
    Cat.:
    U1276m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human HSL
    Cat.:
    U1276b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human HSL
    Polyclonal Antibody for Human HSL
    Polyclonal Antibody for Human HSL
    Cat.:
    P1276Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human HSL
    Cat.:
    P1276Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human HSL
    Cat.:
    P1276Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human HSL
    Monoclonal Antibody for Human HSL
    Monoclonal Antibody for Human HSL
    Monoclonal Antibody for Human HSL
    Monoclonal Antibody for Human HSL
    Protein for Human HSL
    Protein for Human HSL
    Protein for Human HSL
    Protein for Human HSL
    Protein for Human HSL

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    References
    1. 1.
      "Gene organization and primary structure of human hormone-sensitive lipase: possible significance of a sequence homology with a lipase of Moraxella TA144, an antarctic bacterium."
      Langin D. , Laurell H. , Stenson Holst L. , Belfrage P. , Holm C.
      Proc. Natl. Acad. Sci. U.S.A.90:4897-4901(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    2. 2.
      "Molecular cloning, genomic organization, and expression of a testicular isoform of hormone-sensitive lipase."
      Holst L.S. , Langin D. , Mulder H. , Laurell H. , Grober J. , Bergh A. , Mohrenweiser H.W. , Edgren G. , Holm C.
      Genomics35:441-447(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Testis.
    3. 3.
      SeattleSNPs variation discovery resource
      Submitted (2005-08) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS HIS-100; HIS-127; SER-146; THR-177; VAL-194; GLN-217; ASN-497; HIS-499 AND SER-938
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Testis.
    5. 5.
      "Association and insulin regulated translocation of hormone-sensitive lipase with PTRF."
      Aboulaich N. , Oertegren U. , Vener A.V. , Stralfors P.
      Biochem. Biophys. Res. Commun.350:657-661(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PTRF;SUBCELLULAR LOCATION
    6. 6.
      "Separation and characterization of caveolae subclasses in the plasma membrane of primary adipocytes; segregation of specific proteins and functions."
      Oertegren U. , Yin L. , Oest A. , Karlsson H. , Nystrom F.H. , Stralfors P.
      FEBS J.273:3381-3392(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
    7. 7.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] GLN-146
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