LILRB4 ELISA Kit for Human(Homo sapiens) | EIAab.comLILRB4 ELISA Kit for Human(Homo sapiens)

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LILRB4 (Gene name),

Leukocyte immunoglobulin-like receptor subfamily B member 4 (Protein name ), LIRB4_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

LILRB4(ILT3;LIR5);

Protein name:

Leukocyte immunoglobulin-like receptor subfamily B member 4;

Alternative:

Immunoglobulin-like transcript 3(ILT-3);CD85 antigen-like family member K;Monocyte inhibitory receptor HM18;Leukocyte immunoglobulin-like receptor 5(LIR-5);

CD:

CD85k;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Binds PTPN6 when phosphorylated.

Function:

Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance, e.g. towards transplants. Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation. Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.

Subcellular Location:

Cell membrane Single-pass type I membrane protein Ligand binding leads to internalization and translocation to an antigen-processing compartment.

Protein Attributes:

Sequence length:

448

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

448:

AAASEAPQDV | TYAQLHSFTL | RQKATEPPPS | QEGASPAEPS | VYATLAIH

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

hsa:11006

STRING:

9606.ENSP00000270452

SMR:

Q8NHJ6

UniGene:

Hs.67846

MIM:

604821

Pfam:

PF00047

String:

Q8NHJ6

Uniprot:

Q8NHJ6

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ELISA Kit for Human Leukocyte immunoglobulin-like receptor subfamily B member 4

Cat.:

E5609h

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96T

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ELISA Kit for Human Leukocyte immunoglobulin-like receptor subfamily B member 4

Cat.:

E5609m

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Manual:

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96T

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CLIA Kit for Human Leukocyte immunoglobulin-like receptor subfamily B member 4

Cat.:

U5609h

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Manual:

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Packing:

96T

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CLIA Kit for Human Leukocyte immunoglobulin-like receptor subfamily B member 4

Cat.:

U5609m

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human Leukocyte immunoglobulin-like receptor subfamily B member 4

Cat.:

P5609Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Leukocyte immunoglobulin-like receptor subfamily B member 4

Cat.:

P5609Rb-m

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Leukocyte immunoglobulin-like receptor subfamily B member 4

Protein for Human Leukocyte immunoglobulin-like receptor subfamily B member 4

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Molecular identification of a novel family of human Ig superfamily members that possess immunoreceptor tyrosine-based inhibition motifs and homology to the mouse gp49B1 inhibitory receptor."
Arm J.P. , Nwankwo C. , Austen K.F.
J. Immunol.159:2342-2349(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY;VARIANT GLY-223
tissue: Monocyte.
2.

"A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules."
Borges L. , Hsu M.-L. , Fanger N. , Kubin M. , Cosman D.
J. Immunol.159:5192-5196(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANTS GLY-223 AND ARG-414;TISSUE SPECIFICITY
tissue: Peripheral blood leukocyte.
3.

"Genomic organization of the human leukocyte immunoglobulin-like receptors within the leukocyte receptor complex on chromosome 19q13.4."
Liu W.R. , Kim J. , Nwankwo C. , Ashworth L.K. , Arm J.P.
Immunogenetics51:659-669(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1);VARIANTS LEU-5; GLY-223 AND GLU-362
4.

Canavez F.C.
Submitted (2000-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
5.

"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Halleck A. , Ebert L. , Mkoundinya M. , Schick M. , Eisenstein S. , Neubert P. , Kstrang K. , Schatten R. , Shen B. , Henze S. , Mar W. , Korn B. , Zuo D. , Hu Y. , LaBaer J.
Submitted (2004-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
6.

"Full-length cDNA libraries and normalization."
Li W.B. , Gruber C. , Jessee J. , Polayes D.
Submitted (2004-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
tissue: Placenta.
7.

"The DNA sequence and biology of human chromosome 19."
Grimwood J. , Gordon L.A. , Olsen A.S. , Terry A. , Schmutz J. , Lamerdin J.E. , Hellsten U. , Goodstein D. , Couronne O. , Tran-Gyamfi M. , Aerts A. , Altherr M. , Ashworth L. , Bajorek E. , Black S. , Branscomb E. , Caenepeel S. , Carrano A.V. , more...
Nature428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANTS ASP-20; GLY-223 AND ARG-414
tissue: Brain.
9.

"A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing."
Cella M. , Doehring C. , Samaridis J. , Dessing M. , Brockhaus M. , Lanzavecchia A. , Colonna M.
J. Exp. Med.185:1743-1751(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH PTPN6;PHOSPHORYLATION;TISSUE SPECIFICITY;SUBCELLULAR LOCATION
10.

"Tolerization of dendritic cells by T(S) cells: the crucial role of inhibitory receptors ILT3 and ILT4."
Chang C.C. , Ciubotariu R. , Manavalan J.S. , Yuan J. , Colovai A.I. , Piazza F. , Lederman S. , Colonna M. , Cortesini R. , Dalla-Favera R. , Suciu-Foca N.
Nat. Immunol.3:237-243(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
11.

"Crystal structure of leukocyte Ig-like receptor LILRB4 (ILT3/LIR-5/CD85k): a myeloid inhibitory receptor involved in immune tolerance."
Cheng H. , Mohammed F. , Nam G. , Chen Y. , Qi J. , Garner L.I. , Allen R.L. , Yan J. , Willcox B.E. , Gao G.F.
J. Biol. Chem.286:18013-18025(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 24-219;DISULFIDE BONDS

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